The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.
Open accessAbstract
Immunization with irradiated sporozoites protects animals and humans against malaria, and the circumsporozoite protein is a target of this protective immunity. We now report that adjuvant-free intramuscular injection of mice with plasmid DNA encoding the Plasmodium yoelii circumsporozoite protein induced higher levels of antibodies and cytotoxic T lymphocytes against the P. yoelii circumsporozoite protein than did immunization with irradiated sporozoites. Mice immunized with this vaccine had an 86% reduction in liver-stage parasite burden after challenge with 5 x 10(5) sporozoites (> 10(5) median infectious doses). Eighteen (68%) of 28 mice that received two or three doses of vaccine were protected against challenge with 10(2) sporozoites, and the protection was dependent on CD8+ T cells. These studies demonstrate the utility of plasmid DNA immunization against a nonviral infection. By obviating the requirement for peptide synthesis, expression and purification of recombinant proteins, and adjuvants, this method of immunization provides an important alternative for rapid identification of protective B- and T-cell epitopes and for construction of vaccines to prevent malaria and other infectious diseases.
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Cites
Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein
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Cited by
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Induction of Antigen-Specific Cytotoxic T Lymphocytes in Humans by a Malaria DNA Vaccine
Wang, R., Doolan, D. L., Le, T. P., Hedstrom, R. C., Coonan, K. M., Charoenvit, Y., Jones, T. R., Hobart, P., Margalith, M., Ng, J., et al. (1998) · Science · doi:10.1126/science.282.5388.476 · Cited by 833
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Metadata
- Authors
- Sedegah, M., Hedstrom, R., Hobart, P., & Hoffman, S. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-10-11
- Volume
- 91
- Issue
- 21
- Pages
- 9866-9870
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2065849927
- Cited by
- 447
- References
- 15
- FWCI
- 52.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Sedegah, M., Hedstrom, R., Hobart, P., & Hoffman, S. L. (1994). Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.21.9866
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