The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
A conserved family of elav-like genes in vertebrates.
Open accessAbstract
A large family of genes encodes proteins with RNA recognition motifs that are presumed to bind RNA and to function in posttranscriptional regulation. Neural-specific members of this family include elav, a gene required for correct differentiation and maintenance of neurons in Drosophila melanogaster, and a related gene, HuD, which is expressed in human neuronal cells. I have identified genes related to elav and HuD in Xenopus laevis, zebrafish, and mouse that define a family of four closely related vertebrate elav-like genes (elrA, elrB, elrC, and elrD) in fish, frogs, and mammals. In addition to protein sequence conservation, a segment of the 3'-untranslated sequence of elrD is also conserved, implying a functional role in elrD expression. In adult frogs, elrC and elrD are exclusively expressed in the brain, whereas elrB is expressed in brain, testis, and ovary. During Xenopus development, elrC and elrD RNAs are detected by late gastrula and late neurula stages, respectively, whereas a nervous system-specific elrB RNA species is expressed by early tadpole stage. Additional elrB transcripts are detected in the ovary and early embryo, demonstrating a maternal supply of mRNA and possibly of protein. These expression patterns suggest a role for different elav-like genes in early development and neuronal differentiation. Surprisingly, elrA is expressed in all adult tissues tested and at all times during development. Thus, the widely expressed elrA is expected to have a related function in all cells.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The HuD protein, like all Hu members, has a molecular weight of ∼40 kDa and contains three RNA recognition motifs (RRMs) with a linker region separating the second and third RRM (Fig. 1C; Good 1995; Liu et al. 1995; Okano and Darnell 1997).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Good 1995
In the citing paper
“Converging findings suggest that HuD is one of the earliest markers of the neuronal phenotype (Good 1995; Okano and Darnell 1997; Wakamatsu and Weston 1997; Hambardzumyan et al. 2009).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Good 1995
In the citing paper
“Analysis of the Xenopus HuD homolog elrD sequence illustrated that the 3′ UTR contains an ∼100-nt stretch of nucleotides with 90% identity to the human HuD 3′ UTR, implying that this fragment encompasses an important evolutionarily conserved regulatory structure and/or cis-element(s) (Good 1995).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Good 1995
In the citing paper
“The ELAVL (also known as Hu) family of proteins consists of four highly homologous members109–111”
From The neurogenetics of alternative splicing (2016) · cites this paper as [109]
Citations
Cites
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222
Conserved Structures and Diversity of Functions of RNA-Binding Proteins
Burd, C. G., & Dreyfuss, G. (1994) · Science · doi:10.1126/science.8036511 · Cited by 1,886
Messenger RNA degradation in eukaryotes
Sachs, A. B. (1993) · Cell · doi:10.1016/0092-8674(93)80043-e · Cited by 846
RNA recognition: towards identifying determinants of specificity
Kenan, D. J., Query, C. C., & Keene, J. D. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90088-d · Cited by 724
Birney, E., Kumar, S., & Krainer, A. R. (1993) · Nucleic Acids Research · doi:10.1093/nar/21.25.5803 · Cited by 665
RNA-binding proteins as developmental regulators.Preprint
Bandziulis, R. J., Swanson, M. S., & Dreyfuss, G. (1989) · Genes & Development · doi:10.1101/gad.3.4.431 · Cited by 631
Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B., & Furneaux, H. M. (1991) · Cell · doi:10.1016/0092-8674(91)90184-z · Cited by 553
Robinow, S., & White, K. (1991) · Journal of Neurobiology · doi:10.1002/neu.480220503 · Cited by 503
Hu neuronal proteins are expressed in proliferating neurogenic cells
Marusich, M. F., Furneaux, H. M., Henion, P. D., & Weston, J. A. (1994) · Journal of Neurobiology · doi:10.1002/neu.480250206 · Cited by 485
Taira, M., Jamrich, M., Good, P. J., & Dawid, I. B. (1992) · Genes & Development · doi:10.1101/gad.6.3.356 · Cited by 371
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–320 of 320
Cloning of human and mouseGRY-RBP cDNA
Du, G., Pan, M., Zhou, Y., Chen, J., Yao, H., Yuan, J., & Qiang, B. (2000) · Chinese Science Bulletin · doi:10.1007/bf02909766
Wang, J., Sun, S., Cao, X., Deng, X., Zhang, Y., & Zhu, Q. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.02.006
RetractedRegulation of matrix-metalloproteinase 9 (MMP-9) in glomerular mesangial cells
Akool, E. (2004) · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)
Chow, M. C. E. (2012) · TSpace (University of Toronto)
Mapping of Post-Transcriptional Regulatory Networks by Means of Mechanistic and High Throughput Data
Dassi, E. (2012) · Unitn-eprints PhD (University of Trento) · doi:10.15168/11572_368833
Barnhart, M. D., Wilusz, J., Wilusz, C. J., & Laybourn, P. J. (2007) · Digital Collections of Colorado (Colorado State University) · doi:10.25675/3.024410
Use of delivery technologies to mediate RNA degradation
Lai, W. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816485-3.00008-8
mRNA Stabilizing Factor HuR, a Crucial Player in ROS-Mediated Cancer Progression
De, S., & Dey, K. (2021) · Springer eBooks · doi:10.1007/978-981-15-4501-6_97-1
mRNA Stabilizing Factor HuR: A Crucial Player in ROS-Mediated Cancer Progression
De, S., & Dey, K. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_97
Kairišs, K., Sokolova, N., Žílová, L., Schlagheck, C., Reinhardt, R., Baumbach, T., Faragó, T., van de Kamp, T., Wittbrodt, J., & Weinhardt, V. (2024) · Microscopy and Microanalysis · doi:10.1093/mam/ozae044.1043
Elavl1 is dispensable for appendicular skeletal developmentPreprint
Parsha, R., & Kota, S. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.23.614008
Kang, S., Larbi, D., Bruns, E., Hahne, K., Andrade, M. D., Batsuuri, K., Chen, S., Jager, J., Viswanáthan, S., & Wohl, S. G. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5133415
Elavl1 deletion in limb mesenchyme is dispensable for skeletal morphogenesis
Parsha, R., & Kota, S. K. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1501837
HuD and alpha-crystallin A axis protects neuro-retinal cells in early diabetes
Kim, C., Oh, S., & Park, Y. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05364-2
RNA-Binding Proteins: Modulators of Canonical Wnt Signaling Pathway
Czap, M. S., Singh, V., & Spiegelman, V. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010205
Hao, L., Kawato, S., Nozaki, R., Furukawa, M., Kondo, H., & Hırono, I. (2026) · Genome Biology and Evolution · doi:10.1093/gbe/evag010
Rôle de la protéine HuR et de ses gènes cibles dans le carcinome hépatocellulaire
Valbuzzi, T. (2010) · theses.fr (ABES) · doi:10.70675/43f491f9zdc42z412ez8874zc384bc8a2087
Rea, J. N., Stortini, G., Santini, T., Setti, A., Bernardi, M., Cantisani, P., Fucci, L., Mariani, D., Tollis, P., Vitiello, E., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.08.715854
Daigle, D., Creasy-Marrazzo, A., Gradoville, L., El-Guindy, A. S., Mukherjee, R., Das, S., Baral, B., Rousseau, B. A., Park, R., McIntosh, M. T., et al. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1014211
Wilhelm, C. (2002) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-142
Metadata
- Authors
- Good, P. J.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Good, P J
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1995-05-09
- Volume
- 92
- Issue
- 10
- Pages
- 4557-4561
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC41983
- OpenAlex
- W1982369409
- Cited by
- 319
- References
- 39
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 14 · 2013: 14 · 2012: 13
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- ELRA, HUD, RNA recognition motif, post-transcriptional regulation, RNA-binding proteins, neuronal differentiation, brain expression, maternal mRNA, Xenopus development, zebrafish, mice, frogs, sequence conservation, 3' untranslated region
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Brain, Embryo, Nonmammalian, Female, Gastrula, Multigene Family, Humans, Male, Mammals, Molecular Sequence Data, Nervous System, Ovary, Ranidae, Ribonucleoproteins, Sequence Homology, Nucleic Acid, Testis, Vertebrates, Xenopus laevis, Zebrafish, Conserved Sequence, Sequence Homology, Amino Acid, Mice, ELAV Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
