Cited by 320RNA Research and SplicingDevelopmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanisms

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A conserved family of elav-like genes in vertebrates.

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Good, P J·1995·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.92.10.4557PMC PMC41983

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Abstract

A large family of genes encodes proteins with RNA recognition motifs that are presumed to bind RNA and to function in posttranscriptional regulation. Neural-specific members of this family include elav, a gene required for correct differentiation and maintenance of neurons in Drosophila melanogaster, and a related gene, HuD, which is expressed in human neuronal cells. I have identified genes related to elav and HuD in Xenopus laevis, zebrafish, and mouse that define a family of four closely related vertebrate elav-like genes (elrA, elrB, elrC, and elrD) in fish, frogs, and mammals. In addition to protein sequence conservation, a segment of the 3'-untranslated sequence of elrD is also conserved, implying a functional role in elrD expression. In adult frogs, elrC and elrD are exclusively expressed in the brain, whereas elrB is expressed in brain, testis, and ovary. During Xenopus development, elrC and elrD RNAs are detected by late gastrula and late neurula stages, respectively, whereas a nervous system-specific elrB RNA species is expressed by early tadpole stage. Additional elrB transcripts are detected in the ovary and early embryo, demonstrating a maternal supply of mRNA and possibly of protein. These expression patterns suggest a role for different elav-like genes in early development and neuronal differentiation. Surprisingly, elrA is expressed in all adult tissues tested and at all times during development. Thus, the widely expressed elrA is expected to have a related function in all cells.

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Authors: Good, P. J.
Affiliations: National Institutes of Health (US)
Corresponding author: Good, P J
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1995-05-09
Volume: 92
Issue: 10
Pages: 4557-4561
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.92.10.4557
PMC: PMC41983
OpenAlex: W1982369409
Cited by: 319
References: 39
Citations by year: 2026: 7 · 2025: 10 · 2024: 7 · 2023: 4 · 2022: 7 · 2021: 9 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 14 · 2013: 14 · 2012: 13
FWCI: 5.20
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: ELRA, HUD, RNA recognition motif, post-transcriptional regulation, RNA-binding proteins, neuronal differentiation, brain expression, maternal mRNA, Xenopus development, zebrafish, mice, frogs, sequence conservation, 3' untranslated region
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Brain, Embryo, Nonmammalian, Female, Gastrula, Multigene Family, Humans, Male, Mammals, Molecular Sequence Data, Nervous System, Ovary, Ranidae, Ribonucleoproteins, Sequence Homology, Nucleic Acid, Testis, Vertebrates, Xenopus laevis, Zebrafish, Conserved Sequence, Sequence Homology, Amino Acid, Mice, ELAV Proteins

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A conserved family of elav-like genes in vertebrates.

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