A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms.
Open accessAbstract
Matrix metalloproteinase 9 (MMP-9) has recently emerged as a molecule that contributes to pathological synaptic plasticity in schizophrenia, but explanation of the underlying mechanisms has been missing.In the present study, we performed a phenotypebased genetic association study (PGAS) in > 1,000 schizophrenia patients from the Göttingen Research Association for Schizophrenia (GRAS) data collection and found an association between the MMP-9 rs20544 C/T single-nucleotide polymorphism (SNP) located in the 3 0 untranslated region (UTR) and the severity of a chronic delusional syndrome.In cultured neurons, the rs20544 SNP influenced synaptic MMP-9 activity and the morphology of dendritic spines.We demonstrated that Fragile X mental retardation protein (FMRP) bound the MMP-9 3 0 UTR.We also found dramatic changes in RNA structure folding and alterations in the affinity of FMRP for MMP-9 RNA, depending on the SNP variant.Finally, we observed greater sensitivity to psychosis-related locomotor hyperactivity in Mmp-9 heterozygous mice.We propose a novel mechanism that involves MMP-9-dependent changes in dendritic spine morphology and the pathophysiology of schizophrenia, providing the first mechanistic insights into the way in which the single base change in the MMP-9 gene (rs20544) influences gene function and results in phenotypic changes observed in schizophrenia patients.
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A functional polymorphism of the MMP-9 gene was discovered in human schizophrenia patients.
“A functional polymorphism of the MMP-9 gene was discovered in human schizophrenia patients (Rybakowski et al., 2009; Lepeta et al., 2017).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Lepeta et al., 2017
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Psychosocial Stress Induces Schizophrenia-Like Behavior in Mice With Reduced MMP-9 Activity
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Self-citationDendritic spines and their role in the pathogenesis of neurodevelopmental and neurological disorders
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Dysregulation of Synaptic Plasticity Markers in Schizophrenia
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Lcn2 deficiency leads to long-lasting social impairments independent of maternal immune activation
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Self-citation
- Authors
- Lepeta, K., Purzycka, K. J., Pachulska‐Wieczorek, K., Mitjans, M., Begemann, M., Vafadari, B., Bijata, K., Adamiak, R. W., Ehrenreich, H., Dziembowska, M., & Kaczmarek, L.
- Affiliations
- Institute of Bioorganic Chemistry, Polish Academy of Sciences (PL)
- Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 (DE)
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences (PL)
- Corresponding author
- Ehrenreich, Hannelore
- Dziembowska, Magdalena
- Kaczmarek, Leszek
- ORCID
- Venue
- EMBO Molecular Medicine
- Published
- 2017-06-16
- Volume
- 9
- Issue
- 8
- Pages
- 1100-1116
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC5538295
- OpenAlex
- W2624795293
- Cited by
- 39
- References
- 76
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 5 · 2021: 1 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 1
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Max Planck Digital Library (submittedVersion, other-oa)
- GRO (submittedVersion)
- Funders
- EXTRABRAIN 7th Framework Marie Curie European Union Initial Training Network
- Polish Ministry of Science and Higher Education (UMOWA Nr 2948/7.PR/2013/2)
- Fundacja na rzecz Nauki Polskiej (TEAM Grant)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- schizophrenia, MMP-9, single nucleotide polymorphisms, 3' untranslated region, FMRP, dendritic spine morphology, synaptic plasticity, delusional symptoms, genotype-phenotype correlation
- MeSH terms
- Adolescent, Adult, Aged, Animals, Cells, Cultured, Chronic Disease, Disease Models, Animal, Female, Humans, Male, Middle Aged, Neurons, Nucleic Acid Conformation, Protein Binding, RNA, Messenger, Schizophrenia, Paranoid, Synapses, 3' Untranslated Regions, Polymorphism, Single Nucleotide, Matrix Metalloproteinase 9, Mice, Fragile X Messenger Ribonucleoprotein 1, Young Adult, Genetic Association Studies
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