The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease
Open accessAbstract
An unresolved question in cystic fibrosis (CF) research is how mutations of the CF transmembrane conductance regulator, a Cl ion channel, cause airway mucus obstruction leading to fatal lung disease. Recent evidence has linked the CF transmembrane conductance regulator mutation to the onset and persistence of Pseudomonas aeruginosa infection in the airways, and here we provide evidence directly linking P. aeruginosa infection to mucus overproduction. We show that P. aeruginosa lipopolysaccharide profoundly up-regulates transcription of the mucin gene MUC 2 in epithelial cells via inducible enhancer elements and that this effect is blocked by the tyrosine kinase inhibitors genistein and tyrphostin AG 126. These findings improve our understanding of CF pathogenesis and suggest that the attenuation of mucin production by lipopolysaccharide antagonists and tyrosine kinase inhibitors could reduce morbidity and mortality in this disease.
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Cites
Tyrosine Kinase Inhibition: An Approach to Drug Development
Levitzki, A., & Gazit, A. (1995) · Science · doi:10.1126/science.7892601 · Cited by 1,635
Raetz, C. R. H. (1990) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.59.070190.001021 · Cited by 1,230
Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid
Smith, J. J., Travis, S. M., Greenberg, E. P., & Welsh, M. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81099-5 · Cited by 1,039
Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.
Pearson, J. P., Gray, K. M., Passador, L., Tucker, K. D., Eberhard, A., Iglewski, B. H., & Greenberg, E. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.197 · Cited by 990
Textbook of Respiratory Medicine.
(1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-3-506_11 · Cited by 812
Gambello, M. J., & Iglewski, B. H. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.9.3000-3009.1991 · Cited by 725
Molecular Cloning of Human Intestinal Mucin cDNAs
Gum, J. R., Byrd, J. C., Hicks, J. W., Toribara, N. W., Lamport, D. T. A., & Kim, Y. S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83373-7 · Cited by 541
Self-citationRole of Mutant CFTR in Hypersusceptibility of Cystic Fibrosis Patients to Lung Infections
Pier, G. B., Grout, M., Zaidi, T. S., Olsen, J. C., Johnson, L. G., Yankaskas, J. R., & Goldberg, J. B. (1996) · Science · doi:10.1126/science.271.5245.64 · Cited by 440
Gum, J. R., Hicks, J. W., Toribara, N. W., Siddiki, B., & Kim, Y. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41965-x · Cited by 433
Self-citationDiMango, E., Zar, H. J., Bryan, R., & Prince, A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118275 · Cited by 433
Self-citation
Cited by
Intestinal barrier dysfunction in inflammatory bowel diseases
McGuckin, M. A., Eri, R., Simms, L. A., Florin, T. H. J., & Radford-Smith, G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20539 · Cited by 627
Liévin-Le Moal, V., & Servin, A. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.315-337.2006 · Cited by 568
Voynow, J. A., & Rubin, B. K. (2009) · Chest · doi:10.1378/chest.08-0412 · Cited by 504
Cystic fibrosis: a mucosal immunodeficiency syndrome
Cohen, T. S., & Prince, A. (2012) · Nature Medicine · doi:10.1038/nm.2715 · Cited by 484
Self-citationThe innate immune response of the respiratory epithelium: Innate immunity in the airway
Diamond, G., Legarda, D., & Ryan, L. K. (2000) · Immunological Reviews · doi:10.1034/j.1600-065x.2000.917304.x · Cited by 422
Metadata
- Authors
- Li, J.-D., Dohrman, A. F., Gallup, M., Miyata, S., Gum, J. R., Kim, Y. S., Nadel, J. A., Prince, A., & Basbaum, C. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1997-02-04
- Volume
- 94
- Issue
- 3
- Pages
- 967-972
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080797320
- Cited by
- 288
- References
- 22
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. https://app.cochat.ai/papers/10.1073/pnas.94.3.967
- The paper
- Li, J.-D., Dohrman, A. F., Gallup, M., Miyata, S., Gum, J. R., Kim, Y. S., Nadel, J. A., Prince, A., & Basbaum, C. B. (1997). Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.94.3.967
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
