The role of cancer-derived microRNAs in cancer immune escape

Oncology meets immunology: the cancer-immunity cycle.

Chen, D. S., & Mellman, I. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.012 · Cited by 6,929 · see citing works

Myeloid-derived-suppressor cells as regulators of the immune system

Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753 · see citing works

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474 · see citing works

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature · doi:10.1038/nature25501 · Cited by 5,400 · see citing works

Elements of cancer immunity and the cancer–immune set point

Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352 · see citing works

The Immunobiology of Cancer Immunosurveillance and Immunoediting

Dunn, G. P., Old, L. J., & Schreiber, R. D. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.017 · Cited by 3,036 · see citing works

Neoadjuvant PD-1 Blockade in Resectable Lung Cancer

Forde, P. M., Chaft, J. E., Smith, K. N., Anagnostou, V., Cottrell, T. R., Hellmann, M. D., Zahurak, M., Yang, S. C., Jones, D. R., Broderick, S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1716078 · Cited by 2,099 · see citing works

Adjuvant pembrolizumab versus placebo in resected stage III melanoma

Eggermont, A. M. M., Blank, C. U., Mandala, M., Long, G. V., Atkinson, V., Dalle, S., Haydon, A., Lichinitser, M., Khattak, A., Carlino, M. S., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1802357 · Cited by 1,906 · see citing works

Immune evasion in cancer: mechanistic basis and therapeutic strategies

Vinay, D. S., Ryan, E. P., Pawelec, G., Talib, W. H., Stagg, J., Elkord, E., Lichtor, T., Decker, W. K., Whelan, R. L., Kumara, H. M. C. S., et al. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.03.004 · Cited by 1,625 · see citing works

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

Lin, Y., Xu, J., & Lan, H. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0760-3 · Cited by 1,398 · see citing works

Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer

Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176 · see citing works

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

Fang, T., Lv, H., Lv, G., Li, T., Wang, C., Han, Q., Yu, L., Su, B., Guo, L., Huang, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02583-0 · Cited by 995 · see citing works

Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Chen, L., Gibbons, D. L., Goswami, S., Cortez, M. A., Ahn, Y., Byers, L. A., Zhang, X., Yi, X., Dwyer, D. W., Lin, W., et al. (2014) · Nature Communications · doi:10.1038/ncomms6241 · Cited by 972 · see citing works

Treg cells expressing the co-inhibitory molecule TIGIT selectively inhibit pro-inflammatory Th1 and Th17 cell responses

Joller, N., Lozano, E., Burkett, P. R., Patel, B., Xiao, S., Zhu, C., Xia, J., Tan, T.-G., Sefik, E., Yajnik, V., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.012 · Cited by 904 · see citing works

TGF-β Activation and Function in Immunity

Travis, M. A., & Sheppard, D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120257 · Cited by 856 · see citing works

Tumor-associated macrophages: from basic research to clinical application

Yang, L., & Zhang, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0430-2 · Cited by 847 · see citing works

Next generation of immune checkpoint therapy in cancer: new developments and challenges

Marin-Acevedo, J. A., Dholaria, B., Soyano, A. E., Knutson, K. L., Chumsri, S., & Lou, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0582-8 · Cited by 802 · see citing works

Effect of exosomal miRNA on cancer biology and clinical applications

Sun, Z., Shi, K., Yang, S., Liu, J., Zhou, Q., Wang, G., Song, J., Li, Z., Zhang, Z., & Yuan, W. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0897-7 · Cited by 800 · see citing works

Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors

Yi, M., Jiao, D., Xu, H., Liu, Q., Zhao, W., Han, X., & Wu, K. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0864-3 · Cited by 756 · see citing works

Mechanisms of immune suppression by interleukin‐10 and transforming growth factor‐β: the role of T regulatory cells

Taylor, A., Verhagen, J., Blaser, K., Akdis, M., & Akdiş, C. A. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02321.x · Cited by 721 · see citing works

VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses

Wang, L. L., Rubinstein, R., Lines, J. L., Wasiuk, A., Ahonen, C. L., Guo, Y., Lu, L., Gondek, D. C., Wang, Y., Fava, R. A., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100619 · Cited by 713 · see citing works

Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer

Liang, G., Zhu, Y., Ali, D. J., Tian, T., Xu, H., Si, K., Sun, B., Chen, B., & Xiao, Z. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0563-2 · Cited by 687 · see citing works

PDL1 Regulation by p53 via miR-34

Cortez, M. A., Ivan, C., Valdecanas, D., Wang, X., Peltier, H. J., Ye, Y., Araujo, L., Carbone, D. P., Shilo, K., Giri, D. K., et al. (2016) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djv303 · Cited by 683 · see citing works

Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)

Kim, J. M., & Chen, D. S. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw217 · Cited by 648 · see citing works

Identification of human cancers deficient in antigen processing.

Restifo, N. P., Esquivel-Guadarrama, F. R., Kawakami, Y., Yewdell, J. W., Mulé, J. J., Rosenberg, S. A., & Bennink, J. R. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.2.265 · Cited by 624 · see citing works

Synergistic effect of immune checkpoint blockade and anti-angiogenesis in cancer treatment

Yi, M., Jiao, D., Qin, S., Chu, Q., Wu, K., & Li, A. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0974-6 · Cited by 608 · see citing works

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

Lan, Y., Zhang, D., Xu, C., Hance, K. W., Marelli, B., Qi, J., Yu, H., Qin, G., Sircar, A., Hernández, V. M., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan5488 · Cited by 494 · see citing works

Targeting the IDO1/TDO2–KYN–AhR Pathway for Cancer Immunotherapy – Challenges and Opportunities

Cheong, J. E., & Sun, L. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.11.007 · Cited by 489 · see citing works

Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246

Cooks, T., Pateras, I. S., Jenkins, L. M. M., Patel, K., Robles, A. I., Morris, J., Forshew, T., Appella, E., Gorgoulis, V. G., & Harris, C. C. (2018) · Nature Communications · doi:10.1038/s41467-018-03224-w · Cited by 483 · see citing works

Hepatocellular carcinoma-derived exosomal miRNA-21 contributes to tumor progression by converting hepatocyte stellate cells to cancer-associated fibroblasts

Zhou, Y., Ren, H., Dai, B., Li, J., Shang, L., Huang, J., & Shi, X. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0965-2 · Cited by 457 · see citing works

Tumor-Driven Evolution of Immunosuppressive Networks during Malignant Progression

Kim, R., Emi, M., Tanabe, K., & Arihiro, K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4128 · Cited by 446 · see citing works

HLA-G expression in melanoma: A way for tumor cells to escape from immunosurveillance

Paul, P., Rouas‐Freiss, N., Khalil, I., Moreau, P., Riteau, B., Gal, F. A. L., Avril, M.-F., Dausset, J. B., Guillet, J. G., & Carosella, E. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4510 · Cited by 432 · see citing works

HLA-G

Carosella, E. D., Rouas‐Freiss, N., Roux, D. T., Moreau, P., & LeMaoult, J. (2015) · Advances in immunology · doi:10.1016/bs.ai.2015.04.001 · Cited by 395 · see citing works

PD-L1hi B cells are critical regulators of humoral immunity

Khan, A. R., Hams, E., Floudas, A., Sparwasser, T. D., Weaver, C. T., & Fallon, P. G. (2015) · Nature Communications · doi:10.1038/ncomms6997 · Cited by 386 · see citing works

Epithelial ovarian cancer-secreted exosomal miR-222-3p induces polarization of tumor-associated macrophages

Ying, X., Wu, Q., Wu, X., Zhu, Q., Wang, X., Jiang, L., Chen, X., & Wang, X. (2016) · Oncotarget · doi:10.18632/oncotarget.9246 · Cited by 349 · see citing works

Tumor-derived exosomes promote tumor progression and T-cell dysfunction through the regulation of enriched exosomal microRNAs in human nasopharyngeal carcinoma

Ye, S., Li, Z.-L., Luo, D., Huang, B., Chen, Y.-S., Zhang, X.-S., Cui, J., Zeng, Y.-X., & Li, J. (2014) · Oncotarget · doi:10.18632/oncotarget.2118 · Cited by 346 · see citing works

Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment

Marzagalli, M., Ebelt, N. D., & Manuel, E. R. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.002 · Cited by 345 · see citing works

The Promise of Targeting Macrophages in Cancer Therapy

Brown, J. M., Recht, L. D., & Strober, S. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3122 · Cited by 321 · see citing works

Human microRNAs regulate stress-induced immune responses mediated by the receptor NKG2D

Stern‐Ginossar, N., Gur, C., Biton, M., Horwitz, E. P., Elboim, M., Stanietsky, N., Mandelboim, M., & Mandelboim, O. (2008) · Nature Immunology · doi:10.1038/ni.1642 · Cited by 316 · see citing works

Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia

Wang, X., Li, J., Dong, K., Fang, L., Long, M., Ouyang, Y., Wei, J., Chen, X., Weng, Y., He, T., et al. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.12.003 · Cited by 313 · see citing works

HLA-G: At the Interface of Maternal–Fetal Tolerance

Ferreira, L. M. R., Meissner, T. B., Tilburgs, T., & Strominger, J. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.01.009 · Cited by 295 · see citing works

Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression

Saleh, R., & Elkord, E. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.017 · Cited by 292 · see citing works

Immunosuppressive effects of hypoxia-induced glioma exosomes through myeloid-derived suppressor cells via the miR-10a/Rora and miR-21/Pten Pathways

Guo, X., Qiu, W., Liu, Q., Qian, M., Wang, S., Zhang, Z., Gao, X. C., Chen, Z., Xue, H., & Li, G. (2018) · Oncogene · doi:10.1038/s41388-018-0261-9 · Cited by 287 · see citing works

Exosomes derived from hypoxic epithelial ovarian cancer cells deliver microRNAs to macrophages and elicit a tumor-promoted phenotype

Chen, X., Zhou, J., Li, X., Wang, X., Lin, Y., & Wang, X. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.08.001 · Cited by 287 · see citing works

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

Jang, J.-Y., Lee, J.-K., Jeon, Y., & Kim, C. W. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-421 · Cited by 270 · see citing works

Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization

Chen, X., Xiang, Y., Wang, X., Wu, X., Zhu, Q., & Wang, X. (2017) · Oncology Reports · doi:10.3892/or.2017.5697 · Cited by 269 · see citing works

Noncoding RNAs in cancer therapy resistance and targeted drug development

Wang, W., Han, C., Sun, Y., Chen, T.-Q., & Chen, Y. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0748-z · Cited by 266 · see citing works

The Clinical Relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 Network in Chemoresistant Non-small-cell Lung Cancer

Fujita, Y., Yagishita, S., Hagiwara, K., Yoshioka, Y., Kosaka, N., Takeshita, F., Fujiwara, T., Tsuta, K., Nokihara, H., Tamura, T., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.10 · Cited by 262 · see citing works

Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment

Tian, X., Shen, H., Li, Z., Wang, T., & Wang, S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0772-z · Cited by 261 · see citing works

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

Huber, V., Vallacchi, V., Fleming, V., Hu, X., Cova, A., Dugo, M., Shahaj, E., Sulsenti, R., Vergani, E., Filipazzi, P., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98060 · Cited by 253 · see citing works

Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells

Zhang, P., Pei, X., Li, K., Jin, L., Wang, F., Wu, J., & Zhang, X. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1111-2 · Cited by 248 · see citing works

Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR‐138 targets TERT and PD‐L1

Zhang, X., Xu, L., & Wang, F. (2017) · Cell Biology International · doi:10.1002/cbin.10826 · Cited by 241 · see citing works

Treg-mediated acquired resistance to immune checkpoint inhibitors

Saleh, R., & Elkord, E. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.003 · Cited by 238 · see citing works

The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer

Zhao, L., Yu, H., Yi, S., Peng, X., Su, P., Xiao, Z., Liu, R., Tang, A., Li, X., Liu, F., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.9659 · Cited by 227 · see citing works

Cancer immunotherapy beyond immune checkpoint inhibitors

Marin-Acevedo, J. A., Soyano, A. E., Dholaria, B., Knutson, K. L., & Lou, Y. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0552-6 · Cited by 213 · see citing works

Exosomes, DAMPs and miRNA: Features of Stress Physiology and Immune Homeostasis

Fleshner, M., & Crane, C. R. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.002 · Cited by 212 · see citing works

The serum miR‐21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR‐21 expression confers chemoresistance by targeting FasL

Wang, P., Zhuang, L., Zhang, J., Fan, J., Luo, J., Chen, H., Wang, K., Liu, L., Chen, Z., & Meng, Z. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.10.011 · Cited by 186 · see citing works

Snail-overexpressing Cancer Cells Promote M2-Like Polarization of Tumor-Associated Macrophages by Delivering MiR-21-Abundant Exosomes

Hsieh, C.-H., Tai, S., & Yang, M. (2018) · Neoplasia · doi:10.1016/j.neo.2018.06.004 · Cited by 186 · see citing works

Microenvironmental oxygen pressure orchestrates an anti- and pro-tumoral γδ T cell equilibrium via tumor-derived exosomes

Li, L., Cao, B., Liang, X., Lu, S., Luo, H., Wang, Z., Wang, S., Jiang, J. D., Lang, J., & Zhu, G. (2018) · Oncogene · doi:10.1038/s41388-018-0627-z · Cited by 180 · see citing works

MiR-9 promotes tumorigenesis and angiogenesis and is activated by MYC and OCT4 in human glioma

Chen, X., Yang, F., Zhang, T., Wang, W., Xi, W., Li, Y., Zhang, D., Huo, Y., Zhang, J., Yang, A., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1078-2 · Cited by 179 · see citing works

Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis

Ou, Z., Luo, Z., Wei, W., Liang, S., Gao, T.-L., & Lu, Y. (2019) · RNA Biology · doi:10.1080/15476286.2019.1649585 · Cited by 172 · see citing works

Epstein−Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas

Anastasiadou, E., Stroopinsky, D., Alimperti, S., Jiao, A. L., Pyzer, A. R., Cippitelli, C., Pepe, G., Severa, M., Rosenblatt, J. M., Etna, M. P., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0178-x · Cited by 168 · see citing works

NKG2D Ligands–Critical Targets for Cancer Immune Escape and Therapy

Schmiedel, D., & Mandelboim, O. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02040 · Cited by 165 · see citing works

Glioma exosomes mediate the expansion and function of myeloid‐derived suppressor cells through microRNA‐29a/Hbp1 and microRNA‐92a/Prkar1a pathways

Guo, X., Qiu, W., Wang, J., Liu, Q., Qian, M., Wang, S., Zhang, Z., Gao, X. C., Chen, Z., Guo, Q., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.32052 · Cited by 162 · see citing works

miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity

Jia, L., Xi, Q., Wang, H., Zhang, Z., Liu, H., Cheng, Y., Guo, X., Zhang, J., Zhang, Q., Zhang, L., et al. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.074 · Cited by 159 · see citing works

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape

Eichmüller, S. B., Osen, W., Mandelboim, O., & Seliger, B. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx034 · Cited by 156 · see citing works

MiR-873/PD-L1 axis regulates the stemness of breast cancer cells

Gao, L., Guo, Q., Li, X., Yang, X., Ni, H., Wang, T., Zhao, Q., Liu, H., Xing, Y., Xi, T., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.02.034 · Cited by 156 · see citing works

The Unfolded Protein Response (UPR)-activated Transcription Factor X-box-binding Protein 1 (XBP1) Induces MicroRNA-346 Expression That Targets the Human Antigen Peptide Transporter 1 (TAP1) mRNA and Governs Immune Regulatory Genes

Bartoszewski, R., Brewer, J. W., Rab, A., Crossman, D. K., Bartoszewska, S., Kapoor, N., Fuller, C. M., Collawn, J. F., & Bebők, Z. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.304956 · Cited by 153 · see citing works

Tumor Suppressor microRNAs Contribute to the Regulation of PD-L1 Expression in Malignant Pleural Mesothelioma

Kao, S., Cheng, Y. Y., Williams, M., Kirschner, M. B., Madore, J., Lum, T., Sarun, K. H., Linton, A., McCaughan, B. C., Klebe, S., et al. (2017) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2017.05.024 · Cited by 149 · see citing works

MiR-9, miR-21, and miR-155 as potential biomarkers for HPV positive and negative cervical cancer

Park, S., Eom, K., Kim, J., Bang, H., Wang, H.-Y., Ahn, S., Kim, G., Jang, H., Kim, S., Lee, D., et al. (2017) · BMC Cancer · doi:10.1186/s12885-017-3642-5 · Cited by 149 · see citing works

NKG2D Ligands in Tumor Immunity: Two Sides of a Coin

Zhang, J., Basher, F., & Wu, J. D. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00097 · Cited by 146 · see citing works

MiRNA-Mediated Control of HLA-G Expression and Function

Manaster, I., Goldman‐Wohl, D., Greenfield, C., Nachmani, D., Tsukerman, P., Hamani, Y., Yagel, S., & Mandelboim, O. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033395 · Cited by 144 · see citing works

The effect of tumor-derived exosomes on immune regulation and cancer immunotherapy.

Whiteside, T. (2017) · Future Oncology · doi:10.2217/fon-2017-0343 · Cited by 141 · see citing works

miR-153 suppresses IDO1 expression and enhances CAR T cell immunotherapy

Huang, Q., Xia, J., Wang, L., Wang, X., Ma, X., Deng, Q., Lu, Y., Kumar, M., Zhou, Z., Li, L., et al. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0600-x · Cited by 137 · see citing works

The immune regulation in cancer by the amino acid metabolizing enzymes ARG and IDO

Mondanelli, G., Ugel, S., Grohmann, U., & Bronte, V. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.05.002 · Cited by 136 · see citing works

Tim-3 expression and its role in hepatocellular carcinoma

Liu, F., Liu, Y., & Chen, Z. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0667-4 · Cited by 136 · see citing works

miR-9 modulates the expression of interferon-regulated genes and MHC class I molecules in human nasopharyngeal carcinoma cells.

Gao, F., Zhao, Z.-L., Zhao, W.-T., Fan, Q., Wang, S.-C., Li, J., Zhang, Y.-Q., Shi, J.-W., Lin, X.-L., Yang, S., et al. (2013) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2012.12.097 · Cited by 133 · see citing works

The role of neoantigen in immune checkpoint blockade therapy

Yi, M., Qin, S., Zhao, W., Yu, S., Chu, Q., & Wu, K. (2018) · Experimental Hematology and Oncology · doi:10.1186/s40164-018-0120-y · Cited by 133 · see citing works

Limitations and Off-Target Effects of Tryptophan-Related IDO Inhibitors in Cancer Treatment

Günther, J., Däbritz, J., & Wirthgen, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01801 · Cited by 133 · see citing works

Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4–miR-18a pathway in cervical cancer

Dong, P., Xiong, Y., Yu, J., Chen, L., Tang, T., Song, Y., Hanley, S. J. B., Yue, J., Watari, H., & Sakuragi, N. (2018) · Oncogene · doi:10.1038/s41388-018-0347-4 · Cited by 132 · see citing works

Exosomal miR-27a Derived from Gastric Cancer Cells Regulates the Transformation of Fibroblasts into Cancer-Associated Fibroblasts

Wang, J., Guan, X., Zhang, Y., Ge, S., Zhang, L., Li, H., Wang, X., Liu, R., Ning, T., Deng, T., et al. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000493218 · Cited by 125 · see citing works

MicroRNA-519a-3p mediates apoptosis resistance in breast cancer cells and their escape from recognition by natural killer cells

Breunig, C., Pahl, J. H. W., Kueblbeck, M., Miller, M., Antonelli, D., Erdem, N., Wirth, C., Will, R. D., Bott, A., Cerwenka, A., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.364 · Cited by 121 · see citing works

MiR155 sensitized B-lymphoma cells to anti-PD-L1 antibody via PD-1/PD-L1-mediated lymphoma cell interaction with CD8+T cells

Zheng, Z., Sun, R., Zhao, H., Fu, D., Zhong, H., Weng, X., Qu, B., Zhao, Y. F., Wang, L., & Zhao, W. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0977-3 · Cited by 121 · see citing works

Ovarian tumor-associated microRNA-20a decreases natural killer cell cytotoxicity by downregulating MICA/B expression

Xie, J., Liu, M., Li, Y., Nie, Y., Mi, Q., & Zhao, S. (2014) · Cellular and Molecular Immunology · doi:10.1038/cmi.2014.30 · Cited by 120 · see citing works

MicroRNA expression patterns and signalling pathways in the development and progression of childhood solid tumours

Leichter, A. L., Sullivan, M. J., Eccles, M. R., & Chatterjee, A. (2017) · Molecular Cancer · doi:10.1186/s12943-017-0584-0 · Cited by 120 · see citing works

Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma

Yang, H., Lan, P., Hou, Z., Guan, Y., Zhang, J., Xu, W., Tian, Z., & Zhang, C. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.547 · Cited by 115 · see citing works

PD-L1 up-regulation in melanoma increases disease aggressiveness and is mediated through miR-17-5p

Audrito, V., Serra, S., Stingi, A., Orso, F., Gaudino, F., Bologna, C., Neri, F., Garaffo, G., Nassini, R., Baroni, G., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15213 · Cited by 115 · see citing works

miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair–Deficient Colorectal Cancer by Targeting PD-L1

Ashizawa, M., Okayama, H., Ishigame, T., Min, A. K. T., Saito, K., Ujiie, D., Murakami, Y., Kikuchi, T., Nakayama, Y., Noda, M., et al. (2019) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-18-0831 · Cited by 115 · see citing works

Foxo3a Regulates Apoptosis by Negatively Targeting miR-21

Wang, K., & Li, P.-F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.093005 · Cited by 114 · see citing works

Immunoregulatory functions and the therapeutic implications of GARP-TGF-β in inflammation and cancer

Metelli, A., Salem, M. A., Wallace, C. H., Wu, B. X., Li, A., Li, X., & Li, Z. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0570-z · Cited by 114 · see citing works

Exosomal miRNA-107 induces myeloid-derived suppressor cell expansion in gastric cancer

Ren, W., Zhang, X., Li, W., Feng, Q., Feng, H., Tong, Y., Rong, H., Wang, W., Zhang, D., Zhang, Z., et al. (2019) · Cancer Management and Research · doi:10.2147/cmar.s198886 · Cited by 114 · see citing works

Long noncoding RNA LINC00473 drives the progression of pancreatic cancer via upregulating programmed death‐ligand 1 by sponging microRNA‐195‐5p

Zhou, W., Zhang, M., Liu, C., Kang, Y., Wang, J., & Yang, X. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28884 · Cited by 110 · see citing works

Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing

Chang, Y.-Y., Kuo, W., Hung, J.-H., Lee, C., Lee, Y.-H., Chang, Y., Lin, W., Shen, C., Huang, C., Hsieh, F., et al. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0301-9 · Cited by 109 · see citing works

Targeting myeloid-derived suppressor cells for cancer immunotherapy

Liu, Y., Wei, G., Cheng, W. A., Dong, Z., Sun, H., Lee, V. Y., Cha, S.-C., Smith, D. L., Kwak, L. W., & Qin, H. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2175-3 · Cited by 107 · see citing works

Evidence that miR-133a causes recurrent spontaneous abortion by reducing HLA-G expression

Wang, X., Li, B., Wang, J., Lei, J., Liu, C., Ma, Y., & Zhao, H. (2012) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2012.06.022 · Cited by 105 · see citing works

CBX7 regulates stem cell-like properties of gastric cancer cells via p16 and AKT-NF-κB-miR-21 pathways

Ni, S.-J., Zhao, L.-Q., Wang, X. F., Wu, Z.-H., Hua, R., Wan, C., Zhang, J., Zhang, X.-W., Huang, M., Gan, L., et al. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0562-z · Cited by 104 · see citing works

Cutting Edge: Down-Regulation of MHC Class I-Related Chain A on Tumor Cells by IFN-γ-Induced MicroRNA

Yadav, D., Ngolab, J., Lim, R. S.-H., Krishnamurthy, S. R., & Bui, J. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.39 · Cited by 103 · see citing works

miR-448 targets IDO1 and regulates CD8+ T cell response in human colon cancer

Lou, Q., Liu, R., Yang, X., Li, W., Huang, L. J., Wei, L., Tan, H., Xiang, N., Chan, K., Chen, J., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0691-0 · Cited by 103 · see citing works

Oncofetal gene SALL4 reactivation by hepatitis B virus counteracts miR-200c in PD-L1-induced T cell exhaustion

Sun, C., Lan, P., Han, Q., Huang, M., Zhang, Z., Xu, G., Song, J., Wang, J., Wei, H., Zhang, J., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03584-3 · Cited by 102 · see citing works

miR-146a Controls Immune Response in the Melanoma Microenvironment

Mastroianni, J., Stickel, N., Andrlová, H., Hanke, K., Melchinger, W., Duquesne, S., Schmidt, D., Falk, M., Andrieux, G., Pfeifer, D., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-1397 · Cited by 102 · see citing works

APRIL Induces a Novel Subset of IgA+ Regulatory B Cells That Suppress Inflammation via Expression of IL-10 and PD-L1

Fehres, C. M., van Uden, N. O. P., Yeremenko, N. G., Fernandez, L., FrancoSalinas, G., van Duivenvoorde, L. M., Huard, B., Morel, J., Spits, H., Hahne, M., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01368 · Cited by 102 · see citing works

Blockade of lncRNA‐ASLNCS5088–enriched exosome generation in M2 macrophages by GW4869 dampens the effect of M2 macrophages on orchestrating fibroblast activation

Chen, J., Zhou, R.-P., Liang, Y.-M., Fu, X.-J., Wang, D.-R., & Wang, C. (2019) · The FASEB Journal · doi:10.1096/fj.201901610 · Cited by 97 · see citing works

Balancing cancer immunotherapy and immune-related adverse events: The emerging role of regulatory T cells

Alissafi, T., Hatzioannou, A., Legaki, A. I., Varveri, A., & Verginis, P. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102310 · Cited by 96 · see citing works

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

Abruzzese, M. P., Bilotta, M. T., Fionda, C., Zingoni, A., Soriani, A., Vulpis, E., Borrelli, C., Zitti, B., Petrucci, M. T., Ricciardi, M. R., et al. (2016) · Journal of Hematology & Oncology · doi:10.1186/s13045-016-0362-2 · Cited by 94 · see citing works

Nano-Strategies to Target Breast Cancer-Associated Fibroblasts: Rearranging the Tumor Microenvironment to Achieve Antitumor Efficacy

Truffi, M., Mazzucchelli, S., Bonizzi, A., Sorrentino, L., Allevi, R., Vanna, R., Morasso, C., & Corsi, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061263 · Cited by 92 · see citing works

microRNA 125a Regulates MHC-I Expression on Esophageal Adenocarcinoma Cells, Associated With Suppression of Antitumor Immune Response and Poor Outcomes of Patients

Mari, L., Hoefnagel, S. J. M., Zito, D., van de Meent, M., Endert, P. V., Calpe, S., Sancho‐Serra, M. D. C., Heemskerk, M. H. M., van Laarhoven, H. W. M., Hulshof, M. C. C. M., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.030 · Cited by 91 · see citing works

MiR-195/-16 Family Enhances Radiotherapy via T Cell Activation in the Tumor Microenvironment by Blocking the PD-L1 Immune Checkpoint

Tao, Z., Xu, S., Ruan, H., Wang, T., Song, W., Li, Q., & Chen, K. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000491909 · Cited by 91 · see citing works

Human regulatory B cells control the TFH cell response

Achour, A., Simon, Q., Mohr, A., Séïté, J.-F., Youinou, P., Bendaoud, B., Ghédira, I., Pers, J., & Jamin, C. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.09.042 · Cited by 89 · see citing works

Combination regimens with PD-1/PD-L1 immune checkpoint inhibitors for gastrointestinal malignancies

Wang, D., Lin, J., Yang, X., Long, J., Bai, Y., Yang, X., Mao, Y., Sang, X., Seery, S., & Zhao, H. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0730-9 · Cited by 89 · see citing works

The miR-25-93-106b cluster regulates tumor metastasis and immune evasion via modulation of CXCL12 and PD-L1

Cioffi, M., Trabulo, S. M. D., Vallespinós, M., Raj, D., Kheir, T. B., Lin, M.-L., Begum, J., Baker, A., Amgheib, A., Saif, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15450 · Cited by 88 · see citing works

Immunomodulatory MicroRNAs in cancer: targeting immune checkpoints and the tumor microenvironment

Omar, H. A., El-Serafi, A. T., Hersi, F., Arafa, E. A., Zaher, D. M., Madkour, M. I., Arab, H. H., & Tolba, M. F. (2019) · FEBS Journal · doi:10.1111/febs.15000 · Cited by 88 · see citing works

Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer

Colangelo, T., Polcaro, G., Ziccardi, P., Pucci, B., Muccillo, L., Galgani, M., Fucci, A., Milone, M. R., Budillon, A., Santopaolo, M., et al. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.28 · Cited by 87 · see citing works

Silencing NKG2D ligand-targeting miRNAs enhances natural killer cell-mediated cytotoxicity in breast cancer

Shen, J., Pan, J., Du, C., Si, W., Yao, M., Xu, L., Zheng, H., Xu, M., Chen, D., Wang, S., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.158 · Cited by 87 · see citing works

miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism

Zhang, T., Zhang, Z., Li, F., Ping, Y., Qin, G., Zhang, C., & Zhang, Y. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800230 · Cited by 82 · see citing works

Overexpression of miR-152 leads to reduced expression of human leukocyte antigen-G and increased natural killer cell mediated cytolysis in JEG-3 cells

Zhu, X., Han, T., Wang, X., Li, Y.-H., Yang, H., Luo, Y., Yin, G.-W., & Yao, Y. (2010) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2010.03.002 · Cited by 81 · see citing works

MiR-140 Expression Regulates Cell Proliferation and Targets PD-L1 in NSCLC

Xie, W., Liang, L., Wu, K.-G., Wang, L.-X., He, X., Song, C., Wang, Y., & Li, Y. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000488634 · Cited by 80 · see citing works

The miR‐3127‐5p/p‐ STAT 3 axis up‐regulates PD ‐L1 inducing chemoresistance in non‐small‐cell lung cancer

Tang, D., Zhao, D., Wu, Y., Yao, R., Zhou, L., Lu, L., Gao, W., & Sun, Y. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13657 · Cited by 80 · see citing works

CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D

Bruns, H., Böttcher, M., Qorraj, M., Fabri, M., Jitschin, S., Dindorf, J., Busch, L., Jitschin, R., Mackensen, A., & Mougiakakos, D. (2016) · Leukemia · doi:10.1038/leu.2016.378 · Cited by 79 · see citing works

Downregulation of miR-302c and miR-520c by 1,25(OH)2D3 treatment enhances the susceptibility of tumour cells to natural killer cell-mediated cytotoxicity

Min, D., Lu, X., Wang, X., Zhang, B., Meng, W., Yu, F., & Hu, H. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.337 · Cited by 76 · see citing works

MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs

Pyzer, A. R., Stroopinsky, D., Rosenblatt, J. M., Anastasiadou, E., Rajabi, H. N., Washington, A. J., Tagde, A., Chu, J.-H., Coll, M. D., Jiao, A. L., et al. (2017) · Leukemia · doi:10.1038/leu.2017.163 · Cited by 76 · see citing works

The emerging role of exosome and microvesicle- (EMV-) based cancer therapeutics and immunotherapy

Moore, C., Kosgodage, U. S., Lange, S., & Inal, J. M. (2017) · International Journal of Cancer · doi:10.1002/ijc.30672 · Cited by 73 · see citing works

Melanoma-released exosomes directly activate the mitochondrial apoptotic pathway of CD4+ T cells through their microRNA cargo

Zhou, J. Y., Yang, Y., Wang, W., Zhang, Y., Chen, Z., Hao, C., & Zhang, J. (2018) · Experimental Cell Research · doi:10.1016/j.yexcr.2018.08.030 · Cited by 71 · see citing works

miR-21 Down-Regulation Suppresses Cell Growth, Invasion and Induces Cell Apoptosis by Targeting FASL, TIMP3, and RECK Genes in Esophageal Carcinoma

Wang, N., Zhang, C., He, J. H., Duan, X.-F., Wang, Y., Ji, X., Zang, W., Li, M., Ma, Y., Wang, T., et al. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2612-2 · Cited by 70 · see citing works

Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art

Fanini, F., & Fabbri, M. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.12.004 · Cited by 69 · see citing works

MiR‐9 is involved in TGF ‐β1‐induced lung cancer cell invasion and adhesion by targeting SOX 7

Han, L., Wang, W., Ding, W., & Zhang, L. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13120 · Cited by 69 · see citing works

MiR-451 Suppresses Cell Proliferation and Metastasis in A549 Lung Cancer Cells

Yin, P., Peng, R., Peng, H., Li, Y., Sun, Y., Wen, L., Wu, T., Zhou, J., & Zhang, Z. (2014) · Molecular Biotechnology · doi:10.1007/s12033-014-9796-3 · Cited by 64 · see citing works

MicroRNA-497-5p down-regulation increases PD-L1 expression in clear cell renal cell carcinoma

Qu, F., Ye, J., Pan, X., Wang, J., Gan, S., Chu, C., Chu, J., Zhang, X., Liu, M., He, H., et al. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1479755 · Cited by 60 · see citing works

IKK/Nuclear Factor-kappaB and Oncogenesis

Bradford, J. W., & Baldwin, A. S. (2014) · Advances in cancer research · doi:10.1016/b978-0-12-800249-0.00003-2 · Cited by 58 · see citing works

Human leukocyte antigen-G in cancer: Are they clinically relevant?

Yan, W. (2011) · Cancer Letters · doi:10.1016/j.canlet.2011.07.019 · Cited by 58 · see citing works

The Fas/Fas Ligand System and Cancer: Immune Privilege and Apoptosis

Abrahams, V. M., Kamsteeg, M., & Mor, G. (2003) · Molecular Biotechnology · doi:10.1385/mb:25:1:19 · Cited by 58 · see citing works

MiR-218 produces anti-tumor effects on cervical cancer cells in vitro

Zhu, L., Tu, H., Liang, Y.-M., & Tang, D. (2018) · World Journal of Surgical Oncology · doi:10.1186/s12957-018-1506-3 · Cited by 54 · see citing works

miR3609 sensitizes breast cancer cells to adriamycin by blocking the programmed death-ligand 1 immune checkpoint

Li, D., Wang, X., Yang, M., Kan, Q., & Duan, Z. (2019) · Experimental Cell Research · doi:10.1016/j.yexcr.2019.03.025 · Cited by 54 · see citing works

GPER mediated estradiol reduces miR-148a to promote HLA-G expression in breast cancer

Tao, S., He, H., Chen, Q., & Yue, W. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.07.073 · Cited by 52 · see citing works

miR-142-5p regulates CD4+ T cells in human non-small cell lung cancer through PD-L1 expression via the PTEN pathway

Wan, J., Ling, X., Peng, B., & Ding, G. (2018) · Oncology Reports · doi:10.3892/or.2018.6439 · Cited by 50 · see citing works

Regulation of the expression of the liver cancer susceptibility gene MICA by microRNAs

Kishikawa, T., Otsuka, M., Yoshikawa, T., Ohno, M., Takata, A., Shibata, C., Kondo, Y., Akanuma, M., Yoshida, H., & Koike, K. (2013) · Scientific Reports · doi:10.1038/srep02739 · Cited by 43 · see citing works

Overexpressed miR-195 attenuated immune escape of diffuse large B-cell lymphoma by targeting PD-L1

He, B., Yan, F., & Wu, C. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.11.146 · Cited by 42 · see citing works

The possibility of cancer immune editing in gliomas. A critical review

Arrieta, V. A., Díaz, B. C., Zhao, J., Rabadán, R., Chen, L., & Sonabend, A. M. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1445458 · Cited by 42 · see citing works

Hepatitis B surface antigen inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells

Wu, J., Zhang, X., Shi, K., Chen, Y., Ren, Y.-F., Song, Y., Li, G., Xue, Y.-F., Fang, Y., Deng, Z., et al. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt268 · Cited by 40 · see citing works

Upregulation of PD-L1 predicts poor prognosis and is associated with miR-191-5p dysregulation in colon adenocarcinoma

Chen, X., Zhang, J., Hou, L., Zhang, R., Chen, W., Fan, H., Huang, Y., Liu, H., & Zhu, J. (2018) · International Journal of Immunopathology and Pharmacology · doi:10.1177/2058738418790318 · Cited by 39 · see citing works

miR-20a regulates sensitivity of colorectal cancer cells to NK cells by targeting MICA

Tang, S., Fu, H., Xu, Q., & Zhou, Y. (2019) · Bioscience Reports · doi:10.1042/bsr20180695 · Cited by 31 · see citing works

MicroRNA-155 Controls T Helper Cell Activation During Viral Infection

Gonçalves‐Alves, E., Saferding, V., Schliehe, C., Benson, R. A., Kurowska‐Stolarska, M., Brunner, J. S., Puchner, A., Podesser, B. K., Smolen, J. S., Redlich, K., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01367 · Cited by 30 · see citing works

miR-21 targets Fas ligand-mediated apoptosis in breast cancer cell line MCF-7

Wu, M., Yang, J., Tao, X., Shi, Y., & Liú, L. (2014) · Journal of Huazhong University of Science and Technology [Medical Sciences] · doi:10.1007/s11596-014-1257-5 · Cited by 28 · see citing works

Identification of a miR-146b-Fas ligand axis in the development of neutropenia in T large granular lymphocyte leukemia

Mariotti, B., Calabretto, G., Rossato, M., Teramo, A., Castellucci, M., Barilà, G., Leoncin, M., Vicenzetto, C., Facco, M., Semenzato, G., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.225060 · Cited by 28 · see citing works

MicroRNA in Immune Regulation

Wu, C.-J., & Lu, L. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_65 · Cited by 27 · see citing works

miR-375 inhibits IFN-γ-induced programmed death 1 ligand�1 surface expression in head and neck squamous cell carcinoma cells by blocking JAK2/STAT1 signaling

Wu, Q., Zhao, Y., Sun, Y., Yan, X., & Wang, P. (2018) · Oncology Reports · doi:10.3892/or.2018.6177 · Cited by 27 · see citing works

Identification of 14-3-3β Gene as a Novel miR-152 Target Using a Proteome-based Approach

Jasinski‐Bergner, S., Stehle, F., Gonschorek, E., Kalich, J., Schulz, K., Hüttelmaier, S., Braun, J., & Seliger, B. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556290 · Cited by 26 · see citing works

Immune modulatory microRNAs as a novel mechanism to revert immune escape of tumors

Seliger, B. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.07.001 · Cited by 20 · see citing works

MicroRNAs that predict the effectiveness of anti-PD-1 therapies in patients with advanced melanoma

Nakahara, S., Fukushima, S., Okada, E., Morinaga, J., Kubo, Y., Tokuzumi, A., Matsumoto, S., Tsuruta, M., Kimura, T., Kuriyama, H., et al. (2019) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2019.11.010 · Cited by 20 · see citing works

miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas

Xie, Z., Chen, W., Chen, Y., Wang, X., Gao, W., & Liu, Y. (2017) · International Journal of Oncology · doi:10.3892/ijo.2017.4133 · Cited by 13 · see citing works

DHA Abolishes the Detrimental Effect of Docetaxel on Downregulation of the MICA via Decreasing the Expression Level of MicroRNA-20a in Gastric Cancer

Shekari, N., Javadian, M., Ghaffari, S., Baradaran, B., Darabi, M., & Kazemi, T. (2019) · Journal of Gastrointestinal Cancer · doi:10.1007/s12029-019-00280-3 · Cited by 11 · see citing works

Combination strategies with PD-1/PD-L1 blockade: current advances and future directions

Yi, M., Zheng, X., Niu, M., Zhu, S., Ge, H., & Wu, K. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01489-2 · Cited by 1,445 · see citing works

Regulation of PD-L1 expression in the tumor microenvironment

Yi, M., Niu, M., Xu, L., Luo, S., & Wu, K. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-01027-5 · Cited by 681 · see citing works

Aspects of the Tumor Microenvironment Involved in Immune Resistance and Drug Resistance

Khalaf, K., Hana, D., Chou, J. T.-T., Singh, C., Mackiewicz, A. A., & Kaczmarek, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656364 · Cited by 526 · see citing works

Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers

Zhang, H., Liu, L., Liu, J., Dang, P., Hu, S., Yuan, W., Sun, Z., Liu, Y., & Wang, C. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01725-x · Cited by 399 · see citing works

Immune evasion in cancer: mechanisms and cutting-edge therapeutic approaches

Tufail, M., Jiang, C., & Li, N. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02280-1 · Cited by 424 · see citing works

Breast cancer heterogeneity and its implication in personalized precision therapy

Guo, L., Kong, D., Liu, J., Zhan, L., Luo, L., Zheng, W., Zheng, Q., Chen, C., & Sun, S. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00363-1 · Cited by 355 · see citing works

Antigen presentation in cancer — mechanisms and clinical implications for immunotherapy

Yang, K., Halima, A., & Chan, T. A.-T. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00789-4 · Cited by 333 · see citing works

Mechanisms of MHC-I Downregulation and Role in Immunotherapy Response

Taylor, B. C., & Balko, J. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.844866 · Cited by 307 · see citing works

Deregulation of HLA-I in cancer and its central importance for immunotherapy

Hazini, A., Fisher, K., & Seymour, L. W. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-002899 · Cited by 208 · see citing works

CRISPR/Cas12a-based photoelectrochemical sensing of microRNA on reduced graphene oxide-anchored Bi2WO6 coupling with catalytic hairpin assembly

Gong, H., Hu, X., Zeng, R., Li, Y., Xu, J., Li, M., & Tang, D. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132307 · Cited by 196 · see citing works

Cancer-associated fibroblasts induce monocytic myeloid-derived suppressor cell generation via IL-6/exosomal miR-21-activated STAT3 signaling to promote cisplatin resistance in esophageal squamous cell carcinoma

Zhao, Q., Huang, L., Qin, G., Qiao, Y., Ren, F., Shen, C., Wang, S., Liu, S., Lian, J., Wang, D., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.06.009 · Cited by 190 · see citing works

Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1

Chamoto, K., Yaguchi, T., Tajima, M., & Honjo, T. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00867-9 · Cited by 185 · see citing works

Natural killer cells: a promising immunotherapy for cancer

Chu, J., Gao, F., Yan, M., Zhao, S., Yan, Z., Shi, B., & Liu, Y. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03437-0 · Cited by 189 · see citing works

The role of exosomes in liquid biopsy for cancer diagnosis and prognosis prediction

Li, S., Yi, M., Dong, B., Tan, X., Luo, S., & Wu, K. (2020) · International Journal of Cancer · doi:10.1002/ijc.33386 · Cited by 181 · see citing works

Roles of tumor-associated macrophages in tumor progression: implications on therapeutic strategies

Zhu, S., Yi, M., Wu, Y., Dong, B., & Wu, K. (2021) · Experimental Hematology and Oncology · doi:10.1186/s40164-021-00252-z · Cited by 178 · see citing works

Combine and conquer: manganese synergizing anti-TGF-β/PD-L1 bispecific antibody YM101 to overcome immunotherapy resistance in non-inflamed cancers

Yi, M., Niu, M., Zhang, J., Li, S., Zhu, S., Yan, Y., Li, N., Zhou, P., Chu, Q., & Wu, K. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01155-6 · Cited by 163 · see citing works

Mechanisms underlying low-clinical responses to PD-1/PD-L1 blocking antibodies in immunotherapy of cancer: a key role of exosomal PD-L1

Yin, Z., Yu, M., Ma, T., Zhang, C., Huang, S., Karimzadeh, M. R., Momtazi‐Borojeni, A. A., & Chen, S. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001698 · Cited by 154 · see citing works

Emerging role of exosomes as biomarkers in cancer treatment and diagnosis

Hanjani, N. A., Esmaelizad, N., Zanganeh, S., Gharavi, A. T., Heidarizadeh, P., Radfar, M., Omidi, F., MacLoughlin, R. J., & Doroudian, M. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103565 · Cited by 129 · see citing works

MiRNA-mediated EMT and CSCs in cancer chemoresistance

Dong, B., Li, S., Zhu, S., Yi, M., Luo, S., & Wu, K. (2021) · Experimental Hematology and Oncology · doi:10.1186/s40164-021-00206-5 · Cited by 127 · see citing works

Predictive biomarkers of anti-PD-1/PD-L1 therapy in NSCLC

Niu, M., Yi, M., Li, N., Luo, S., & Wu, K. (2021) · Experimental Hematology and Oncology · doi:10.1186/s40164-021-00211-8 · Cited by 125 · see citing works

Role of Methylation in Pro- and Anti-Cancer Immunity

Mehdi, A., & Rabbani, S. A. (2021) · Cancers · doi:10.3390/cancers13030545 · Cited by 102 · see citing works

Tumor immune evasion through loss of MHC class-I antigen presentation

Sarı, G., & Rock, K. L. (2023) · Current Opinion in Immunology · doi:10.1016/j.coi.2023.102329 · Cited by 102 · see citing works

Balancing cancer immunotherapy and immune-related adverse events: The emerging role of regulatory T cells

Alissafi, T., Hatzioannou, A., Legaki, A. I., Varveri, A., & Verginis, P. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102310 · Cited by 96 · see citing works

The roles of exosomes in cancer drug resistance and its therapeutic application

Li, S., Yi, M., Dong, B., Jiao, Y., Luo, S., & Wu, K. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.257 · Cited by 96 · see citing works

Targeting PD-1/PD-L1 pathway in myelodysplastic syndromes and acute myeloid leukemia

Yang, X., Ma, L., Zhang, X., Huang, L., & Wei, J. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00263-4 · Cited by 98 · see citing works

RNA-mediated immunotherapy regulating tumor immune microenvironment: next wave of cancer therapeutics

Pandey, P. R., Young, K. H., Kumar, D., & Jain, N. K. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01528-6 · Cited by 87 · see citing works

Exosomal miRNAs as biomarkers for diagnostic and prognostic in lung cancer

Wu, J., & Shen, Z. (2020) · Cancer Medicine · doi:10.1002/cam4.3379 · Cited by 82 · see citing works

The role of microRNAs in the gastric cancer tumor microenvironment

Yu, X., Zhang, Y., Luo, F., Zhou, Q., & Zhu, L. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02084-x · Cited by 80 · see citing works

Progress in the research of nanomaterial-based exosome bioanalysis and exosome-based nanomaterials tumor therapy

Sun, Z., Yang, J., Li, H., Wang, C., Fletcher, C., Li, J., Zhan, Y., Du, L., Wang, F., & Jiang, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120873 · Cited by 74 · see citing works

HIF: a master regulator of nutrient availability and metabolic cross‐talk in the tumor microenvironment

Missiaen, R., Lesner, N. P., & Simon, M. C. (2023) · The EMBO Journal · doi:10.15252/embj.2022112067 · Cited by 74 · see citing works

Quantifying PD-L1 Expression to Monitor Immune Checkpoint Therapy: Opportunities and Challenges

Nimmagadda, S. (2020) · Cancers · doi:10.3390/cancers12113173 · Cited by 67 · see citing works

The Role of miR-155 in Antitumor Immunity

Kalkusova, K., Táborská, P., Stakheev, D., & Smrž, D. (2022) · Cancers · doi:10.3390/cancers14215414 · Cited by 67 · see citing works

Recent progress of prognostic biomarkers and risk scoring systems in chronic lymphocytic leukemia

Yun, X., Zhang, Y., & Wang, X. (2020) · Biomarker Research · doi:10.1186/s40364-020-00222-3 · Cited by 66 · see citing works

Hypoxia induces immunosuppression, metastasis and drug resistance in pancreatic cancers

Zhang, H., Cao, K., Xiang, J., Zhang, M., Zhu, M., & Xi, Q. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216345 · Cited by 67 · see citing works

Circulating exosomal microRNAs as novel potential detection biomarkers in pancreatic cancer

Wu, L., Zhou, W., Zhou, J., Wei, Y., Wang, H., Liu, X., Chen, X., Wang, W., Ye, L., Li, Y., et al. (2020) · Oncology Letters · doi:10.3892/ol.2020.11691 · Cited by 62 · see citing works

Roles of Microvesicles in Tumor Progression and Clinical Applications

Zhu, S., Li, S., Yi, M., Li, N., & Wu, K. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s325448 · Cited by 63 · see citing works

Circular RNAs: Emerging roles and new insights in human cancers

He, Z., & Zhu, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115217 · Cited by 61 · see citing works

Tumor Immune Microenvironment and Genetic Alterations in Mesothelioma

Hiltbrunner, S., Mannarino, L., Kirschner, M. B., Opitz, I., Rigutto, A., Laure, A., Lia, M., Nozza, P., Maconi, A., Marchini, S., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.660039 · Cited by 56 · see citing works

PD-L1 regulation revisited: impact on immunotherapeutic strategies

Lucibello, G., Mograbi, B., Milano, G. A., Hofman, P. M., & Brest, P. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.06.005 · Cited by 56 · see citing works

Electrochemical nanobiosensors for the detection of cancer biomarkers in real samples: Trends and challenges

Achi, F., Attar, A. M., & Lahcen, A. A. (2023) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2023.117423 · Cited by 54 · see citing works

Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454–3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC

Xia, Y., Wang, W., Shen, W., Xu, K., Hu, Y., Han, G., & Liu, Y.-B. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109652 · Cited by 53 · see citing works

Size‐Controlled DNA Tile Self‐Assembly Nanostructures Through Caveolae‐Mediated Endocytosis for Signal‐Amplified Imaging of MicroRNAs in Living Cells

Peng, Y., Gao, Z., Qiao, B., Li, D., Pang, H., Lai, X., Pu, Q., Zhang, R., Zhao, X., Zhao, G., et al. (2023) · Advanced Science · doi:10.1002/advs.202300614 · Cited by 52 · see citing works

COX 2-inhibitors; a thorough and updated survey into combinational therapies in cancers

Rodrigues, P., Bangali, H., Hammoud, A., Mustafa, Y. F., Al‐Hetty, H. R. A. K., Alkhafaji, A. T., Deorari, M. M., Al‐Taee, M. M., Zabibah, R. S., & Alsalamy, A. (2024) · Medical Oncology · doi:10.1007/s12032-023-02256-7 · Cited by 51 · see citing works

Extracellular Vesicle (EV) biohybrid systems for cancer therapy: Recent advances and future perspectives

Ou, Y.-H., Liang, J., Czarny, B., Wacker, M. G., Yu, V. C. K., Wang, J., & Pastorin, G. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.02.006 · Cited by 51 · see citing works

The Emerging Role of Exosomes in Cancer Chemoresistance

Li, J., Gao, N., Gao, Z., Liu, W., Pang, B., Dong, X., Li, Y., & Fan, T. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.737962 · Cited by 50 · see citing works

Immunotherapy resistance in solid tumors: mechanisms and potential solutions

Lefler, D. S., Manobianco, S. A., & Bashir, B. (2024) · Cancer Biology & Therapy · doi:10.1080/15384047.2024.2315655 · Cited by 47 · see citing works

Regulators at Every Step—How microRNAs Drive Tumor Cell Invasiveness and Metastasis

Grzywa, T. M., Klicka, K., & Wlodarski, P. K. (2020) · Cancers · doi:10.3390/cancers12123709 · Cited by 44 · see citing works

MiR-200c-3p Contrasts PD-L1 Induction by Combinatorial Therapies and Slows Proliferation of Epithelial Ovarian Cancer through Downregulation of β-Catenin and c-Myc

Anastasiadou, E., Messina, E., Sanavia, T., Mundo, L., Farinella, F., Lazzi, S., Megiorni, F., Ceccarelli, S., Pontecorvi, P., Marampon, F., et al. (2021) · Cells · doi:10.3390/cells10030519 · Cited by 44 · see citing works

Phytochemicals mediated modulation of microRNAs and long non‐coding RNAs in cancer prevention and therapy

Ruiz‐Manriquez, L. M., Estrada‐Meza, C., Benavides‐Aguilar, J. A., Ledesma‐Pacheco, S. J., Torres‐Copado, A., Serrano‐Cano, F. I., Bandyopadhyay, A., Pathak, S., Chakraborty, S., Srivastava, A., et al. (2021) · Phytotherapy Research · doi:10.1002/ptr.7338 · Cited by 44 · see citing works

Crosstalk of Exosomal Non-Coding RNAs in The Tumor Microenvironment: Novel Frontiers

Jia, Z., Jia, J., Yao, L., & Li, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.900155 · Cited by 43 · see citing works

Nanomaterials as an advanced nano-tool for the Doxorubicin delivery/ Co-Delivery—A Comprehensive Review

Arshad, R., Arshad, M. S., Rahdar, A., Hassan, D., Behzadmehr, R., Ghotekar, S. K., Medina, D. I., & Pandey, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104432 · Cited by 42 · see citing works

miR ‐223‐3p targets FBXW7 to promote epithelial‐mesenchymal transition and metastasis in breast cancer

Wang, Y., Shi, S., Wang, Y., Zhang, X., Liu, X., Li, J., Li, P., Du, L., & Wang, C. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.14284 · Cited by 39 · see citing works

Targeting the PD-1/PD-L1 Signaling Pathway for Cancer Therapy: Focus on Biomarkers

Strati, A. D., Adamopoulos, C., Kotsantis, I., Psyrri, A. K., Lianidou, E. S., & Papavassiliou, A. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031235 · Cited by 41 · see citing works

Gastric cancer-derived exosomal miR-135b-5p impairs the function of Vγ9Vδ2 T cells by targeting specificity protein 1

Li, J., Sun, L., Chen, Y., Zhu, J., Shen, J., Wang, J., Gu, Y., Zhang, G., Wang, M., Shi, T., et al. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-021-02991-8 · Cited by 39 · see citing works

Breast Cancer Subtype-Specific miRNAs: Networks, Impacts, and the Potential for Intervention

Arun, R. P., Cahill, H. F., & Marcato, P. (2022) · Biomedicines · doi:10.3390/biomedicines10030651 · Cited by 38 · see citing works

CRISPR/Cas13-Based Platforms for a Potential Next-Generation Diagnosis of Colorectal Cancer through Exosomes Micro-RNA Detection: A Review

Durán‐Vinet, B., Araya‐Castro, K., Calderón, J. F., Vergara, L. F., Weber, H. L., Retamales, J., Araya-Castro, P., & Leal, P. (2021) · Cancers · doi:10.3390/cancers13184640 · Cited by 38 · see citing works

Hypoxia-regulated microRNAs: the molecular drivers of tumor progression

Sawai, S., Wong, P., & Ramasamy, T. S. (2022) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2022.2088684 · Cited by 35 · see citing works

Single-Cell Analysis in Immuno-Oncology

Christodoulou, M., & Zaravinos, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24098422 · Cited by 35 · see citing works

Non-coding RNA derived from extracellular vesicles in cancer immune escape: Biological functions and potential clinical applications

Huang, M., Peng, X., Yang, L., Yang, S., Li, X., Tang, S., Li, B., Jin, H., Wu, B., Liu, J., et al. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.11.005 · Cited by 35 · see citing works

The Interplay Between Epigenetic Regulation and CD8+ T Cell Differentiation/Exhaustion for T Cell Immunotherapy

Wong, W., Yin, B., Lam, C. Y. K., Huang, Y., Yan, J., Tan, Z., & Wong, S. H. D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.783227 · Cited by 35 · see citing works

Extracellular Vesicle-Mediated Mitochondrial Reprogramming in Cancer

Carles-Fontana, R., Heaton, N. D., Palma, E., & Khorsandi, S. E. (2022) · Cancers · doi:10.3390/cancers14081865 · Cited by 34 · see citing works

MicroRNAs in Cancer Immunology: Master Regulators of the Tumor Microenvironment and Immune Evasion, with Therapeutic Potential

Zare, E., Yaghoubi, S. M., Khoshnazar, M., Dargahlou, S. J., Machhar, J. S., Zheng, Z., Duijf, P. H. G., & Mansoori, B. (2025) · Cancers · doi:10.3390/cancers17132172 · Cited by 34 · see citing works

Binding of RNA Aptamers to Membrane Lipid Rafts: Implications for Exosomal miRNAs Transfer from Cancer to Immune Cells

Janas, T., Janas, P., Sapoń, K., & Janas, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228503 · Cited by 34 · see citing works

Active ingredients of traditional Chinese medicine for enhancing the effect of tumor immunotherapy

Yang, C., Li, D., Ko, C.-N., Wang, K., & Wang, H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133050 · Cited by 35 · see citing works

Immune escape of head and neck cancer mediated by the impaired MHC-I antigen presentation pathway

Luo, X., Qiu, Y., Fitzsimonds, Z. R., Wang, Q., Chen, Q., & Lei, Y. L. (2024) · Oncogene · doi:10.1038/s41388-023-02912-2 · Cited by 34 · see citing works

MicroRNA-155 Controls T Helper Cell Activation During Viral Infection

Gonçalves‐Alves, E., Saferding, V., Schliehe, C., Benson, R. A., Kurowska‐Stolarska, M., Brunner, J. S., Puchner, A., Podesser, B. K., Smolen, J. S., Redlich, K., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01367 · Cited by 30 · see citing works

Remodeling of Bone Marrow Niches and Roles of Exosomes in Leukemia

Yamaguchi, T., Kawamoto, E., Gaowa, A., Park, E. J., & Shimaoka, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041881 · Cited by 29 · see citing works

miR-146a inhibits ovarian tumor growth in vivo via targeting immunosuppressive neutrophils and enhancing CD8+ T cell infiltration

Chen, R., Coleborn, E., Bhavsar, C., Wang, Y., Alim, L., Wilkinson, A., Tran, M. A., Irgam, G., Atluri, S. C., Wong, K., et al. (2023) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2023.09.001 · Cited by 28 · see citing works

Colorectal cancer cell-derived exosomal miRNA-372-5p induces immune escape from colorectal cancer via PTEN/AKT/NF-κB/PD-L1 pathway

Wu, Y., Xiao, Y., Ding, Y., Ran, R., Wei, K., Tao, S., Mao, H., Wang, J., Pang, S., Shi, J., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113261 · Cited by 28 · see citing works

The Role of Exosomes in Thyroid Cancer and Their Potential Clinical Application

Feng, K., Ma, R., Zhang, L., Li, H., Tang, Y., Du, G., Niu, D., & Yin, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.596132 · Cited by 28 · see citing works

Evaluation Expression of miR-146a and miR-155 in Non-Small-Cell Lung Cancer Patients

Dezfuli, N. K., Alipoor, S. D., Roofchayee, N. D., Seyfi, S., Salimi, B., Adcock, I. M., & Mortaz, E. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.715677 · Cited by 26 · see citing works

Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach

Bano, A., Vats, R., Yadav, P., & Bhardwaj, R. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103799 · Cited by 27 · see citing works

Drug Resistance: The Role of Exosomal miRNA in the Microenvironment of Hematopoietic Tumors

Cariello, M., Squilla, A., Piacente, M., Venutolo, G., & Fasano, A. (2022) · Molecules · doi:10.3390/molecules28010116 · Cited by 27 · see citing works

The miRNA and PD-1/PD-L1 signaling axis: an arsenal of immunotherapeutic targets against lung cancer

Yadav, R., Khatkar, R., Yap, K. C.-Y., Kang, C., Lyu, J., SINGH, R. K., Mandal, S., Mohanta, A., Lam, H. Y., Okina, E., et al. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02182-1 · Cited by 27 · see citing works

Secondary Resistant Mutations to Small Molecule Inhibitors in Cancer Cells

Hamid, A. B., & Petreaca, R. C. (2020) · Cancers · doi:10.3390/cancers12040927 · Cited by 26 · see citing works

MicroRNA-1: Diverse role of a small player in multiple cancers

Κhan, P., Ebenezer, N. S., Siddiqui, J. A., Maurya, S. K., Lakshmanan, I., Salgia, R., Batra, S. K., & Nasser, M. W. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.05.020 · Cited by 26 · see citing works

Boosting Anti-tumour Immunity Using Adjuvant Apigenin

Xiao, C., Najafi, M., Huang, J., Chen, X., & Chang, Z. (2022) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520622666220523151409 · Cited by 25 · see citing works

miRNAs as novel immunoregulators in cancer

Lone, S. N., Bhat, A. A., Wani, N. A., Karedath, T., Hashem, S., Nisar, S., Singh, M. K., Bagga, P., Das, B. C., Bedognetti, D., et al. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.04.013 · Cited by 25 · see citing works

The Features of Immune Checkpoint Gene Regulation by microRNA in Cancer

Кипкеева, Ф. М., Музаффарова, Т. А., Коротаева, А. А., Mansorunov, D., Апанович, П. В., Nikulin, M. P., Malikhova, O. A., Стилиди, И. С., & Karpukhin, A. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169324 · Cited by 24 · see citing works

Application and development of noninvasive biomarkers for colorectal cancer screening: a systematic review

Song, D., Wang, F., Ju, Y., He, Q., Sun, T., Deng, W., Ding, R., Zhang, C., Xu, Q., Qi, C., et al. (2023) · International Journal of Surgery · doi:10.1097/js9.0000000000000260 · Cited by 25 · see citing works

Delivery of miRNAs Using Nanoparticles for the Treatment of Osteosarcoma

Wang, C., Zhang, Y., Kong, W., Rong, X., Zhong, Z., Jiang, L., Chen, S., Li, C., Zhang, F., & Jiang, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s471900 · Cited by 24 · see citing works

Interaction of Gut Microbiome and Host microRNAs with the Occurrence of Colorectal and Breast Cancer and Their Impact on Patient Immunity

Silva, S. D., Tennekoon, K. H., & Karunanayake, E. H. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s329383 · Cited by 23 · see citing works

Metabolic reprogramming by miRNAs in the tumor microenvironment: Focused on immunometabolism

Alshahrani, S. H., Ibrahim, Y. S., Jalil, A. T., Altoum, A. A., Achmad, H., Zabibah, R. S., Gabr, G. A., Ramírez‐Coronel, A. A., Alameri, A. A., Qasim, Q. A., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1042196 · Cited by 23 · see citing works

Harnessing the power of exosomes for diagnosis, prognosis, and treatment of hematological malignancies

Mohseni, A., Salehi, F., Rostami, S. M., Hadiloo, K., Hashemi, M., Baridjavadi, Z., Ahangari, F., Karami, N., Samani, F. A., Tahmasebi, S., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-04125-0 · Cited by 22 · see citing works

Functional and Clinical Significance of Dysregulated microRNAs in Liver Cancer

Huang, P.-S., Liao, C., Huang, Y., Yeh, C., Chen, C., Tang, H.-C., Chang, C., & Lin, K. (2021) · Cancers · doi:10.3390/cancers13215361 · Cited by 22 · see citing works

miRNAs in the Regulation of Cancer Immune Response: Effect of miRNAs on Cancer Immunotherapy

Pottoo, F. H., Iqubal, A., Iqubal, M. K., Salahuddin, M., Rahman, J. U., Alhajri, N., & Shehadeh, M. (2021) · Cancers · doi:10.3390/cancers13236145 · Cited by 22 · see citing works

The Role of miRNAs in the Development, Proliferation, and Progression of Endometrial Cancer

Bogaczyk, A., Zawlik, I., Zuzak, T., Kluz, M., Potocka, N., & Kluz, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411489 · Cited by 22 · see citing works

The potential roles of exosomal noncoding RNAs in osteosarcoma

Li, S., & Wang, X. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30101 · Cited by 22 · see citing works

MKNK2 enhances chemoresistance of ovarian cancer by suppressing autophagy via miR-125b

Wang, J., Da, C., Su, Y., Song, R., & Bai, Z. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.02.084 · Cited by 21 · see citing works

Application of Extracellular Vesicles in Aquatic Animals: A Review of the Latest Decade

Zhao, N., Deng, Q., Zhu, C., & Zhang, B. (2021) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2021.1985429 · Cited by 21 · see citing works

Network Pharmacology Combined with Bioinformatics to Investigate the Mechanisms and Molecular Targets of Astragalus Radix-Panax notoginseng Herb Pair on Treating Diabetic Nephropathy

Zhao, J., Mo, C., Shi, W., Meng, L., & Ai, J. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/9980981 · Cited by 20 · see citing works

Treatment Failure in Acute Myeloid Leukemia: Focus on the Role of Extracellular Vesicles

Mirfakhraie, R., Noorazar, L., Mohammadian, M., Hajifathali, A., Gholizadeh, M., Salimi, M., Sankanian, G., Roshandel, E., & Mehdizadeh, M. (2021) · Leukemia Research · doi:10.1016/j.leukres.2021.106751 · Cited by 20 · see citing works

Cortisol affects macrophage polarization by inducing miR-143/145 cluster to reprogram glucose metabolism and by promoting TCA cycle anaplerosis

Sharma, A., Vikramdeo, K. S., Sudan, S. K., Anand, S., Deshmukh, S. K., Singh, A. P., & Singh, S. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107753 · Cited by 20 · see citing works

Role of p53-miRNAs circuitry in immune surveillance and cancer development: A potential avenue for therapeutic intervention

Singh, D., Khan, M. A., & Siddique, H. R. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.04.003 · Cited by 20 · see citing works

Remodeling of Effector and Regulatory T Cells by Capture and Utilization of miRNAs Using Nanocomposite Hydrogel for Tumor-Specific Photothermal Immunotherapy

Chen, L., Zhu, M., Zhang, H., Tang, W., Liu, J., Tang, X., Chang, X., Zhu, Z., Liu, T., Weng, L., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c18801 · Cited by 19 · see citing works

Impact of Bone Marrow miR-21 Expression on Acute Myeloid Leukemia T Lymphocyte Fragility and Dysfunction

Agha, D. M., Rouas, R., Najar, M., Bouhtit, F., Fayyad‐Kazan, H., Lagneaux, L., Bron, D., Meuleman, N., Lewalle, P., & Merimi, M. (2020) · Cells · doi:10.3390/cells9092053 · Cited by 19 · see citing works

Research progress on anti-ovarian cancer mechanism of miRNA regulating tumor microenvironment

Cui, M., Liu, Y., Li, C., Li, T., Deng, Y., & Liu, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1050917 · Cited by 19 · see citing works

Melatonin Engineered Adipose-Derived Biomimetic Nanovesicles Regulate Mitochondrial Functions and Promote Myocardial Repair in Myocardial Infarction

Zhang, Y., Yang, N., Huang, X., Zhu, Y., Gao, S., Liu, Z., Cao, F., & Wang, Y. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.789203 · Cited by 18 · see citing works

miR-1306-3p directly activates P2X3 receptors in primary sensory neurons to induce visceral pain in rats

Wu, Y., Wang, Q., Zhang, P., Zhu, C., & Xu, G.-Y. (2022) · Pain · doi:10.1097/j.pain.0000000000002853 · Cited by 18 · see citing works

Immune Modulatory microRNAs Involved in Tumor Attack and Tumor Immune Escape

Eichmüller, S. B., Osen, W., Mandelboim, O., & Seliger, B. (2017) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djx034 · Cited by 156 · see citing works

Immune modulatory microRNAs as a novel mechanism to revert immune escape of tumors

Seliger, B. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.07.001 · Cited by 20 · see citing works

The Role of Immune Modulatory MicroRNAs in Tumors

Seliger, B., Meinhardt, A., & Falke, D. (2016) · InTech eBooks · doi:10.5772/61805 · Cited by 1 · see citing works

Immunomodulatory MicroRNAs in cancer: targeting immune checkpoints and the tumor microenvironment

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