The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Mechanisms for induction of acquired host immunity by neutrophil peptide defensins
Open accessAbstract
Human neutrophil peptide (HNP) defensins were studied to determine their potential effects on adaptive mucosal immunity. Intranasal delivery of HNPs plus ovalbumin (OVA) enhanced OVA-specific serum IgG antibody (Ab) responses. However, OVA-specific IgA Abs were not induced in mucosal secretions or in serum. CD4+T cells of intranasally immunized mice displayed higher OVA-specific proliferative responses and elevated production of interferon γ, interleukin (IL) 5, IL-6, and IL-10 when compared with control groups receiving OVA alone.In vitro, HNPs also enhanced both proliferative responses and T helper (Th) cytokine secretion profiles of CD3ɛ-stimulated spleen- and Peyer’s patch-derived naive CD4+T cells. HNPs modulated the expression of costimulatory molecules by lipopolysaccharide- or CD3ɛ-stimulated splenic and Peyer’s patch B or T cell populations, respectively. These studies show that defensins enhance systemic IgG, but not IgA, Ab responses through help provided by CD4+Th1- and Th2-type cytokines and foster B and T cell interactions to link innate immunity with the adaptive immune system.
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Cites
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Self-citationhBD‐1: a novel β‐defensin from human plasma
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Cited by
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809
Self-citationHow dying cells alert the immune system to danger
Kono, H., & Rock, K. L. (2008) · Nature Reviews Immunology · doi:10.1038/nri2215 · Cited by 1,737
The Inflammatory Response to Cell Death
Rock, K. L., & Kono, H. (2008) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151456 · Cited by 912
Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R., Jörnvall, H., Wigzell, H., & Gudmundsson, G. H. (2000) · Blood · doi:10.1182/blood.v96.9.3086 · Cited by 758
Mammalian defensins in immunity: more than just microbicidal
Yang, D., Biragyn, A., Kwak, L. W., & Oppenheim, J. J. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02246-9 · Cited by 696
Self-citation
Metadata
- Authors
- Lillard, J. W., Boyaka, P. N., Chertov, O., Oppenheim, J. J., & McGhee, J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-01-19
- Volume
- 96
- Issue
- 2
- Pages
- 651-656
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2087976424
- Cited by
- 305
- References
- 40
- FWCI
- 11.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Lillard, J. W., Boyaka, P. N., Chertov, O., Oppenheim, J. J., & McGhee, J. R. (1999). Mechanisms for induction of acquired host immunity by neutrophil peptide defensins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.2.651
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