The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes
Open accessAbstract
Galectin-7 is a β-galactoside binding protein specifically expressed in stratified epithelia and notably in epidermis, but barely detectable in epidermal tumors and absent from squamous carcinoma cell lines. Galectin-7 gene is an early transcriptional target of the tumor suppressor protein P53 [Polyak, K., Xia, Y., Zweier, J., Kinzler, K. & Vogelstein, B. (1997) Nature (London) 389, 300–305]. Because p53 transcriptional activity is increased by genotoxic stresses we have examined the possible effects of ultraviolet radiations (UVB) on galectin-7 expression in epidermal keratinocytes. The amounts of galectin-7 mRNA and protein are increased rapidly after UVB irradiation of epidermal keratinocytes. The increase of galectin-7 is parallel to P53 stabilization. UVB irradiation of skin reconstructed in vitro and of human skin ex vivo demonstrates that galectin-7 overexpression is associated with sunburn/apoptotic keratinocytes. Transfection of a galectin-7 expression vector results in a significant increase in terminal deoxynucleotidyltransferase-mediated UTP end labeling-positive keratinocytes. The present findings demonstrate a keratinocyte-specific protein involved in the UV-induced apoptosis, an essential process in the maintenance of epidermal homeostasis.
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Cites
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Sunburn and p53 in the onset of skin cancer
Ziegler, A., Jonason, A. S., Leffellt, D. J., Simon, J. A., Sharma, H. W., Kimmelman, J., Remington, L., Jacks, T., & Brash, D. E. (1994) · Nature · doi:10.1038/372773a0 · Cited by 1,497
Frequent clones of p53-mutated keratinocytes in normal human skin
Jonason, A. S., Kunala, S., Price, G. J., Restifo, R. J., Spinelli, H. M., Persing, J. A., Leffell, D. J., Tarone, R. E., & Brash, D. E. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14025 · Cited by 685
Cited by
Galectins as modulators of tumour progression
Liu, F.-T., & Rabinovich, G. A. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1527 · Cited by 1,439
When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again
Di Lella, S., Sundblad, V., Cerliani, J. P., Guardia, C. M., Estrin, D. A., Vasta, G. R., & Rabinovich, G. A. (2011) · Biochemistry · doi:10.1021/bi201121m · Cited by 282
Glycobiology of cell death: when glycans and lectins govern cell fate
Lichtenstein, R. G., & Rabinovich, G. A. (2013) · Cell Death & Differentiation · doi:10.1038/cdd.2013.50 · Cited by 107
An organotypic model of skin to study photodamage and photoprotection in vitro
Bernerd, F., & Asselineau, D. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2007.08.050 · Cited by 86
Self-citationBernerd, F., Marionnet, C., & Duval, C. (2012) · Indian Journal of Dermatology Venereology and Leprology · doi:10.4103/0378-6323.97351 · Cited by 54
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Metadata
- Authors
- Bernerd, F., Sarasin, A., & Magnaldo, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1999-09-28
- Volume
- 96
- Issue
- 20
- Pages
- 11329-11334
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043812306
- Cited by
- 198
- References
- 4
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Bernerd, F., Sarasin, A., & Magnaldo, T. (1999). Galectin-7 overexpression is associated with the apoptotic process in UVB-induced sunburn keratinocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.96.20.11329
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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