Caenorhabditis elegans embryonic axial patterning requires two recently discovered posterior-group Hox genes
Open accessAbstract
Hox genes encode highly conserved transcription factors that control regional identities of cells and tissues along the developing anterior-posterior axis, probably in all bilaterian metazoans. However, in invertebrate embryos other than Drosophila, Hox gene functions remain largely unknown except by inference from sequence similarities and expression patterns. Recent genomic sequencing has shown that Caenorhabditis elegans has three Hox genes of the posterior paralog group [Ruvkun, G. & Hobert, O. (1998) Science 282, 2033-2041]. However, only one has been previously identified genetically, and it is not required for embryonic development [Chisholm, A. (1991) Development (Cambridge, U.K.) 111, 921-932]. Herein, we report identification of the remaining two posterior paralogs as the nob-1 gene and the neighboring php-3 gene. Elimination of nob-1 and php-3 functions causes gross embryonic defects in both posterior patterning and morphogenetic movements of the posterior hypodermis, as well as posterior-to-anterior cell fate transformations and lethality. The only other Hox gene essential for embryogenesis is the labial/Hox1 homolog ceh-13, required for more anterior patterning [Brunschwig, K., Wittmann, C., Schnabel, R., Burglin, T. R., Tobler, H. & Muller, F. (1999) Development (Cambridge, U.K.) 126, 1537-1546]. Therefore, essential embryonic patterning in C. elegans requires only Hox genes of the anterior and posterior paralog groups, raising interesting questions about evolution of the medial-group genes.
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In Caenorhabditis elegans, essential embryonic patterning requires only Hox genes from the anterior and posterior paralog groups.
“In Caenorhabditis elegans, essential embryonic patterning requires only Hox genes from the anterior (PG-1) and posterior (PG-9,13) paralog groups (Van Auken et al., 2000).”
From Conservation of Hox/ParaHox-Related Genes in the Early Development of a Cnidarian (2001) · cites this paper as Van Auken et al., 2000
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Flagged first, then by citations
- Authors
- Van Auken, K., Weaver, D. C., Edgar, L. G., & Wood, W. B.
- Affiliations
- Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309-0347
- University of Colorado Boulder (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-04-25
- Volume
- 97
- Issue
- 9
- Pages
- 4499-4503
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC18263
- OpenAlex
- W2133523759
- Cited by
- 89
- References
- 31
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 4 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD014958, HD-14958)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Hox genes, anterior-posterior axis, morphogenetic movements, Caenorhabditis elegans, Hox gene evolution
- MeSH terms
- Amino Acid Sequence, Animals, Cloning, Molecular, Drosophila, Embryo, Nonmammalian, Genes, Homeobox, Molecular Sequence Data, Transcription Factors, Sequence Alignment, Caenorhabditis elegans, Sequence Homology, Amino Acid, Protein Structure, Secondary, Body Patterning, Genes, Essential, Caenorhabditis elegans Proteins
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