The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Regulating ankyrin dynamics: Roles of sigma-1 receptors
Open accessAbstract
Ankyrin is a cytoskeletal adaptor protein that controls important cellular functions, including Ca 2+ efflux at inositol 1,4,5-trisphosphate receptors (IP 3 R) on the endoplasmic reticulum. The present study found that sigma-1 receptors (Sig-1R), unique endoplasmic reticulum proteins that bind certain steroids, neuroleptics, and psychotropic drugs, form a trimeric complex with ankyrin B and IP 3 R type 3 (IP 3 R-3) in NG-108 cells. The trimeric complex could be coimmunoprecipitated by antibodies against any of the three proteins. Sig-1R agonists such as pregnenolone sulfate and cocaine caused the dissociation of an ankyrin B isoform (ANK 220) from IP 3 R-3. This effect caused by Sig-1R agonists was blocked by a Sig-1R antagonist. The degree of dissociation of ANK 220 from IP 3 R-3 caused by Sig-1R ligands correlates excellently with the ligands' efficacies in potentiating the bradykinin-induced increase in cytosolic free Ca 2+ concentration. Immunocytohistochemistry showed that Sig-1R, ankyrin B, and IP 3 R-3 are colocalized in NG-108 cells in perinuclear areas and in regions of cell-to-cell communication. These results suggest that Sig-1R and associated ligands may play important roles in cells by controlling the function of cytoskeletal proteins and that the Sig-1R/ANK220/IP 3 R-3 complex regulating Ca 2+ signaling may represent a site of action for neurosteroids and cocaine.
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Cites
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Cited by
Hayashi, T., & Su, T.-P. (2007) · Cell · doi:10.1016/j.cell.2007.08.036 · Cited by 1,826
Self-citationInositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells
Wieckowski, M. R., Giorgi, C., Lebiedzinska, M., Duszynski, J., & Pinton, P. (2009) · Nature Protocols · doi:10.1038/nprot.2009.151 · Cited by 979
The neurobiology and control of anxious states
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The pharmacology of sigma-1 receptors.
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Metadata
- Authors
- Hayashi, T., & Su, T.-P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-09
- Volume
- 98
- Issue
- 2
- Pages
- 491-496
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2046475919
- Cited by
- 329
- References
- 38
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- green
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