Stat1 Depends on Transcriptional Synergy with Sp1

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

Wen, Z., Zhong, Z., & Darnell, J. E. (1995) · Cell · doi:10.1016/0092-8674(95)90311-9 · Cited by 1,974

TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

Schindler, C., & Darnell, J. E. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003201 · Cited by 1,808

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins

Dynan, W. S., & Tjian, R. (1985) · Nature · doi:10.1038/316774a0 · Cited by 1,147

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

Akira, S., Nishio, Y., Inoue, M., Wang, X.-J., We, S., Matsusaka, T., Yoshida, K., Sudo, T., Naruto, M., & Kishimoto, T. (1994) · Cell · doi:10.1016/0092-8674(94)90235-6 · Cited by 1,019

Transcriptional regulation

Helntz, N. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90161-n · Cited by 892

An Interleukin-4-Induced Transcription Factor: IL-4 Stat

Hou, J., Schindler, U., Henzel, W. J., Ho, T. C., Brasseur, M., & McKnight, S. L. (1994) · Science · doi:10.1126/science.8085155 · Cited by 849

Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.

Wakao, H., Gouilleux, F., & Groner, B. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06495.x · Cited by 825

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Shuai, K., Horvath, C. M., Huang, L. H. T., Qureshi, S. A., Cowburn, D., & Darnell, J. E. (1994) · Cell · doi:10.1016/0092-8674(94)90357-3 · Cited by 807

Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.

Shuai, K., Schindler, C., Prezioso, V., & Darnell, J. (1992) · Science · doi:10.1126/science.1281555 · Cited by 784

Specific DNA binding of GAL4, a positive regulatory protein of yeast

Giniger, E., Varnum, S. M., & Ptashne, M. (1985) · Cell · doi:10.1016/0092-8674(85)90336-8 · Cited by 768

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha.

Schindler, C., Fu, X.-Y., Improta, T., Aebersold, R. H., & Darnell, J. E., Jr. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7836 · Cited by 647

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

Zhang, X., Blenis, J., Li, H., Schindler, C., & Chen‐Kiang, S. (1995) · Science · doi:10.1126/science.7701321 · Cited by 573

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

Heim, M. H., Kerr, L. M., Stark, G. R., & Darnell, J. E., Jr. (1995) · Science · doi:10.1126/science.7871432 · Cited by 430

Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5’-regulatory region. Induction by cytokines and phorbol ester

Voraberger, G., Schäfer, R., & Stratowa, C. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.8.2777 · Cited by 410

Subunit of an Alpha-Interferon-Responsive Transcription Factor Is Related to Interferon Regulatory Factor and Myb Families of DNA-Binding Proteins

Veals, S. A., Schindler, C., Leonard, D. G. B., Fu, X.-Y., Aebersold, R. H., Darnell, J. E., Jr., & Levy, D. E. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.8.3315 · Cited by 384

Different activation domains stimulate transcription from remote (‘enhancer’) and proximal (‘promoter’) positions.

Seipel, K., Georgiev, O., & Schaffner, W. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05603.x · Cited by 359

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF‐1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

Pine, R., Canova, A., & Schindler, C. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06245.x · Cited by 347

Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process

Greenlund, A. C., Morales, M. O., Viviano, B. L., Yan, H., Krolewski, J. J., & Schreiber, R. D. (1995) · Immunity · doi:10.1016/1074-7613(95)90012-8 · Cited by 306

Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

Li, R., Knight, J. D., Jackson, S. P., Tjian, R., & Botchan, M. R. (1991) · Cell · doi:10.1016/0092-8674(91)90467-d · Cited by 303

Overlapping Elements in the Guanylate-Binding Protein Gene Promoter Mediate Transcriptional Induction by Alpha and Gamma Interferons

Lew, D. J., Decker, T., Strehlow, I., & Darnell, J. E., Jr. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.1.182 · Cited by 277

A Novel Interferon-Inducible Domain: Structural and Functional Analysis of the Human Interferon Regulatory Factor 1 Gene Promoter

Sims, S. H., Cha, Y., Romine, M. F., Gao, P. Q., Gottlieb, K., & Deisseroth, A. B. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.690 · Cited by 262

A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage

Breitbart, R. E., Liang, C., Smoot, L. B., Laheru, D. A., Mahdavi, V., & Nadal‐Ginard, B. (1993) · Development · doi:10.1242/dev.118.4.1095 · Cited by 223

Evidence for interaction of different eukaryotic transcriptional activators with distinct cellular targets

Martin, K. J., Lillie, J. W., & Green, M. R. (1990) · Nature · doi:10.1038/346147a0 · Cited by 219

Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule 1.

Hou, J., Baichwal, V. R., & Cao, Z. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.24.11641 · Cited by 217

GAL4 fusion vectors for expression in yeast or mammalian cells

Sadowski, I., Bell, B., Broad, P. M., & Hollis, M. (1992) · Gene · doi:10.1016/0378-1119(92)90261-m · Cited by 209

The Signalling Pathways of Interleukin-6 and Gamma Interferon Converge by the Activation of Different Transcription Factors Which Bind to Common Responsive DNA Elements

Yuan, J., Wegenka, U. M., Lütticken, C., Buschmann, J., Decker, T., Schindler, C., Heinrich, P. C., & Horn, F. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.3.1657 · Cited by 179

Interferon gamma-induced transcription of the high-affinity Fc receptor for IgG requires assembly of a complex that includes the 91-kDa subunit of transcription factor ISGF3.

Pearse, R. N., Feinman, R., Shuai, K., Darnell, J. E., Jr., & Ravetch, J. V. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4314 · Cited by 179

Characterization of the promoter of the human gene encoding the high-affinity IgG receptor: transcriptional induction by gamma-interferon is mediated through common DNA response elements.

Pearse, R. N., Feinman, R., & Ravetch, J. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11305 · Cited by 166

Selective interaction of a subset of interferon-gamma response element-binding proteins with the intercellular adhesion molecule-1 (ICAM-1) gene promoter controls the pattern of expression on epithelial cells.

Look, D. C., Pelletier, M. R., & Holtzman, M. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37060-6 · Cited by 118

The Jak Kinases Differentially Associate with the and (Accessory Factor) Chains of the Interferon Receptor to Form a Functional Receptor Unit Capable of Activating STAT Transcription Factors (*)

Sakatsume, M., Igarashi, K., Winestock, K., Garotta, G., Larner, A., & Finbloom, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17528 · Cited by 118

Synergistic activation of intercellular adhesion molecule 1 (ICAM‐1) by TNF‐α and IFN‐γ is mediated by p65/p50 and p65/c‐Rel and interferon‐responsive factor Statlα (p91) that can be activated by both IFN‐γ and IFN‐α

Jahnke, A., & Johnson, J. P. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)01130-3 · Cited by 113

Conserved motifs in Fos and Jun define a new class of activation domain.Preprint

Sutherland, J. A., Cook, A., Bannister, A. J., & Kouzarides, T. (1992) · Genes & Development · doi:10.1101/gad.6.9.1810 · Cited by 107

Two cis-DNA Elements Involved in Myeloid-Cell-Specific Expression and Gamma Interferon (IFN-γ) Activation of the Human High-Affinity Fcγ Receptor Gene: a Novel IFN Regulatory Mechanism

Perez, C., Wietzerbin, J., & Benech, P. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2182 · Cited by 73

The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor

Strehlow, I., Seegert, D., Frick, C., Bange, F. C., Schindler, C., Böttger, E. C., & Decker, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85460-1 · Cited by 66

A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells.

Shornick, L. P., & Holtzman, M. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54160-0 · Cited by 55

In vivo footprinting of the IRF-1 promoter: inducible occupation of a GAS element next to a persistent structural alteration of the DNA

Rein, T., Müller, M. M., & Zorbas, H. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.3033 · Cited by 41

STATs and Gene Regulation

Darnell, J. E. (1997) · Science · doi:10.1126/science.277.5332.1630 · Cited by 3,979

HOW CELLS RESPOND TO INTERFERONS

Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.227 · Cited by 3,932

STATs: transcriptional control and biological impact

Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130

FOCAL ADHESIONS, CONTRACTILITY, AND SIGNALING

Burridge, K., & Chrzanowska‐Wodnicka, M. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.463 · Cited by 1,957

Stat2 Is a Transcriptional Activator That Requires Sequence-specific Contacts Provided by Stat1 and p48 for Stable Interaction with DNA

Bluyssen, H. R., & Levy, D. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.4600 · Cited by 150

STAT dynamics

Reich, N. C. (2007) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2007.06.021 · Cited by 55

A Stat3-interacting protein (StIP1) regulates cytokine signal transduction

Collum, R. G., Brutsaert, S., Lee, G., & Schindler, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.170192197 · Cited by 114

Gene Activation by the Cytokine-Driven Transcription Factor STAT1

Nast, R., Staab, J., & Meyer, T. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82699 · Cited by 4

A Conserved Motif in the Linker Domain of STAT1 Transcription Factor Is Required for Both Recognition and Release from High-Affinity DNA-Binding Sites

Hüntelmann, B., Staab, J., Herrmann‐Lingen, C., & Meyer, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097633 · Cited by 31