Cited by 129Marine Invertebrate Physiology and EcologyDevelopmental Biology and Gene RegulationPlanarian Biology and Electrostimulation

Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?

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Steele, Robert E.·2002·Developmental Biology

Abstract

Developmental processes in multicellular animals depend on an array of signal transduction pathways. Studies of model organisms have identified a number of such pathways and dissected them in detail. However, these model organisms are all bilaterians. Investigations of the roles of signal transduction pathways in the early-diverging metazoan Hydra have revealed that a number of the well-known developmental signaling pathways were already in place in the last common ancestor of Hydra and bilaterians. In addition to these shared pathways, it appears that developmental processes in Hydra make use of pathways involving a variety of peptides. Such pathways have not yet been identified as developmental regulators in more recently diverged animals. In this review I will summarize work to date on developmental signaling pathways in Hydra and discuss the future directions in which such work will need to proceed to realize the potential that lies in this simple animal.

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Crossref · 10.1006/dbio.2002.0744

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  • Representatives of all reported superfamilies and groups of eukaryotic DNA transposons, excluding the Transib superfamily and the Mariner group of the Mariner superfamily, are present in the anemone genome.

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Authors
Steele, R. E.
Affiliations
University of California, Irvine (US)
Corresponding author
Steele, Robert E.
Venue
Developmental Biology
Publisher
Elsevier BV
Published
2002-08
Volume
248
Issue
2
Pages
199-219
ISSN
0012-1606 (ISSN-L)
OpenAlex
W1985366893
Cited by
129
References
163
Citations by year
2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 8 · 2013: 3 · 2012: 7
FWCI
1.28
Type
journal article
Language
en
Open access
Locations
  • Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
Keywords
Hydra, developmental signaling pathways, signal transduction, bilaterian evolution, last common ancestor, peptide signaling, early-diverging metazoans, evolutionary developmental biology, ctenophores
MeSH terms
Animals, Biological Evolution, Hydra, Membrane Proteins, Oligopeptides, Peptides, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Signal Transduction, Transforming Growth Factor beta, Endothelins, ras Proteins, Zebrafish Proteins, Wnt Proteins, Receptors, Notch

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