Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?
Open accessAbstract
Developmental processes in multicellular animals depend on an array of signal transduction pathways. Studies of model organisms have identified a number of such pathways and dissected them in detail. However, these model organisms are all bilaterians. Investigations of the roles of signal transduction pathways in the early-diverging metazoan Hydra have revealed that a number of the well-known developmental signaling pathways were already in place in the last common ancestor of Hydra and bilaterians. In addition to these shared pathways, it appears that developmental processes in Hydra make use of pathways involving a variety of peptides. Such pathways have not yet been identified as developmental regulators in more recently diverged animals. In this review I will summarize work to date on developmental signaling pathways in Hydra and discuss the future directions in which such work will need to proceed to realize the potential that lies in this simple animal.
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Representatives of all reported superfamilies and groups of eukaryotic DNA transposons, excluding the Transib superfamily and the Mariner group of the Mariner superfamily, are present in the anemone genome.
“Representatives of all reported superfamilies and groups of eukaryotic DNA transposons (14-16), excluding the Transib superfamily and the Mariner group of the Mariner superfamily, are present in the anemone genome.”
From Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization (2007) · cites this paper as [16]
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Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
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Unraveling the non-senescence phenomenon in Hydra
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The Developmental Origins of Animal Bodyplans
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The Hydra stem cell system – Revisited
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Aging and Potential for Self-Renewal: Hydra Living in the Age of Aging - A Mini-Review
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Linalool acts as a fast and reversible anesthetic in Hydra
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The cellular basis of bioadhesion of the freshwater polyp Hydra
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Hydra Molecular Network Reaches Criticality at the Symmetry-Breaking Axis-Defining Moment
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Model Systems for Environmental Signaling
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Genetic knockdown and knockout approaches in HydraPreprint
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Trembley’s polyps go transgenic
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Self-citationTowards the standardization of Hydra vulgaris bioassay for toxicity assessments of liquid samples
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- Authors
- Steele, R. E.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Steele, Robert E.
- ORCID
- Steele, Robert E.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2002-08
- Volume
- 248
- Issue
- 2
- Pages
- 199-219
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W1985366893
- Cited by
- 129
- References
- 163
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 8 · 2013: 3 · 2012: 7
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Earth and Planetary Sciences › Paleontology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- Hydra, developmental signaling pathways, signal transduction, bilaterian evolution, last common ancestor, peptide signaling, early-diverging metazoans, evolutionary developmental biology, ctenophores
- MeSH terms
- Animals, Biological Evolution, Hydra, Membrane Proteins, Oligopeptides, Peptides, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Signal Transduction, Transforming Growth Factor beta, Endothelins, ras Proteins, Zebrafish Proteins, Wnt Proteins, Receptors, Notch
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