The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase
Open accessAbstract
Pressure overload cardiac hypertrophy in the mouse was achieved following 7 days of transverse aortic constriction. This was associated with marked beta-adrenergic receptor (beta-AR) desensitization in vivo, as determined by a blunted inotropic response to dobutamine. Extracts from hypertrophied hearts had approximately 3-fold increase in cytosolic and membrane G protein-coupled receptor kinase (GRK) activity. Incubation with specific monoclonal antibodies to inhibit different GRK subtypes showed that the increase in activity could be attributed predominately to the beta-adrenergic receptor kinase (betaARK). Although overexpression of a betaARK inhibitor in hearts of transgenic mice did not alter the development of cardiac hypertrophy, the beta-AR desensitization associated with pressure overload hypertrophy was prevented. To determine whether the induction of betaARK occurred because of a generalized response to cellular hypertrophy, betaARK activity was measured in transgenic mice homozygous for oncogenic ras overexpression in the heart. Despite marked cardiac hypertrophy, no difference in betaARK activity was found in these mice overexpressing oncogenic ras compared with controls. Taken together, these data suggest that betaARK is a central molecule involved in alterations of beta-AR signaling in pressure overload hypertrophy. The mechanism for the increase in betaARK activity appears not to be related to the induction of cellular hypertrophy but to possibly be related to neurohumoral activation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Rockman, H. A., Ross, R. S., Harris, A. N., Knowlton, K. U., Steinhelper, M. E., Field, L. J., Ross, J., & Chien, K. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.18.8277 · Cited by 797
Self-citationRetractedWall stress and patterns of hypertrophy in the human left ventricle.
Grossman, W., Jones, D., & McLaurin, L. P. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108079 · Cited by 2,403
Sadoshima, J.-I., Xu, Y., Slayter, H. S., & Izumo, S. (1993) · Cell · doi:10.1016/0092-8674(93)90541-w · Cited by 1,348
Ungerer, M., Böhm, M., Elce, J. S., Erdmann, E., & Lohse, M. J. (1993) · Circulation · doi:10.1161/01.cir.87.2.454 · Cited by 878
Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor
Koch, W. J., Rockman, H. A., Samama, P., Hamilton, R., Bond, R. A., Milano, C. A., & Lefkowitz, R. J. (1995) · Science · doi:10.1126/science.7761854 · Cited by 719
Self-citationPitcher, J. A., Inglese, J., Higgins, J. B., Arriza, J. L., Casey, P. J., Kim, C., Benovic, J. L., Kwatra, M. M., Caron, M. G., & Lefkowitz, R. J. (1992) · Science · doi:10.1126/science.1325672 · Cited by 717
Anderson, E. A., Sinkey, C. A., Lawton, W. J., & Mark, A. L. (1989) · Hypertension · doi:10.1161/01.hyp.14.2.177 · Cited by 632
Levy, D., Salomon, M., D'Agostino, R. B., Belanger, A. J., & Kannel, W. B. (1994) · Circulation · doi:10.1161/01.cir.90.4.1786 · Cited by 619
Role of Blood Pressure in the Development of Congestive Heart Failure: The Framingham Study
Kannel, W. B., Castelli, W. P., McNamara, P. M., McKee, P. A., & Feinleib, M. (1972) · New England Journal of Medicine · doi:10.1056/nejm197210192871601 · Cited by 603
Structure and mechanism of the G protein-coupled receptor kinases.
Inglese, J., Freedman, N. J., Koch, W. J., & Lefkowitz, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80439-6 · Cited by 479
Self-citation
Cited by
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
Bohn, L. M., Lefkowitz, R. J., Gainetdinov, R. R., Peppel, K., Caron, M. G., & Lin, F.-T. (1999) · Science · doi:10.1126/science.286.5449.2495 · Cited by 1,077
Seven-transmembrane-spanning receptors and heart function
Rockman, H. A., Koch, W. J., & Lefkowitz, R. J. (2002) · Nature · doi:10.1038/415206a · Cited by 938
Self-citationRockman, H. A., Chien, K. R., Choi, D.-J., Iaccarino, G., Hunter, J. J., Ross, J., Lefkowitz, R. J., & Koch, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7000 · Cited by 489
Self-citationRole of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease
Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410
Liggett, S. B., Tepe, N. M., Lorenz, J. N., Canning, A. M., Jantz, T. D., Mitarai, S., Yatani, A., & Dorn, G. W. (2000) · Circulation · doi:10.1161/01.cir.101.14.1707 · Cited by 395
Metadata
- Authors
- Choi, D.-J., Koch, W. J., Hunter, J. J., & Rockman, H. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 272
- Issue
- 27
- Pages
- 17223-17229
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2055375040
- Cited by
- 261
- References
- 32
- FWCI
- 5.96
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase. https://app.cochat.ai/papers/10.1074/jbc.272.27.17223
- The paper
- Choi, D.-J., Koch, W. J., Hunter, J. J., & Rockman, H. A. (1997). Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.27.17223
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
