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Formation, Prevention, and Repair of DNA Damage by Iron/Hydrogen Peroxide

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Henle, Ernst S., Linn, Stuart·1997·Journal of Biological Chemistry
DOI 10.1074/jbc.272.31.19095
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Abstract

Although oxygen is a powerful oxidant, the triplet ground state of dioxygen constitutes a kinetic barrier for oxidation of biological molecules, which are mostly singlet state (1). However, the unpaired orbitals of dioxygen can sequentially accommodate single electrons to yield O·̄2, H2O2, the very reactive ⋅OH, and water (Fig. 1,Reaction 1). The oxidative potential of atmospheric oxygen is maintained by the non-alignment of electron spins, and aerobic life is based upon harnessing energy via the catalytic spin pairing of triplet oxygen by the electron transport chain (2).

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Metadata

Authors
Henle, E. S., & Linn, S.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1997-08
Volume
272
Issue
31
Pages
19095-19098
ISSN
0021-9258 (ISSN-L)
DOI
10.1074/jbc.272.31.19095
OpenAlex
W1982870743
Cited by
591
References
11
FWCI
26.46
Type
journal article
Language
en
Open access
hybrid
Licence

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CoChat. (2026). Citation check: Formation, Prevention, and Repair of DNA Damage by Iron/Hydrogen Peroxide. https://app.cochat.ai/papers/10.1074/jbc.272.31.19095
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Henle, E. S., & Linn, S. (1997). Formation, Prevention, and Repair of DNA Damage by Iron/Hydrogen Peroxide. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.31.19095

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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