Persistent cortical plasticity by upregulation of chondroitin 6-sulfation
Abstract
Cortical plasticity is most evident during a critical period in early life, but the mechanisms that restrict plasticity after the critical period are poorly understood. We found that a developmental increase in the 4-sulfation/6-sulfation (4S/6S) ratio of chondroitin sulfate proteoglycans (CSPGs), which are components of the brain extracellular matrix, leads to the termination of the critical period for ocular dominance plasticity in the mouse visual cortex. Condensation of CSPGs into perineuronal nets that enwrapped synaptic contacts on parvalbumin-expressing interneurons was prevented by cell-autonomous overexpression of chondroitin 6-sulfation, which maintains a low 4S/6S ratio. Furthermore, the increase in the 4S/6S ratio was required for the accumulation of Otx2, a homeoprotein that activates the development of parvalbumin-expressing interneurons, and for functional maturation of the electrophysiological properties of these cells. Our results indicate that the critical period for cortical plasticity is regulated by the 4S/6S ratio of CSPGs, which determines the maturation of parvalbumin-expressing interneurons.
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Transgenic mice overexpressing C6ST-1 retain a juvenile level of ocular dominance plasticity even in adulthood.
“As a result, transgenic mice overexpressing C6ST--1 retain a juvenile level of ocular dominance plasticity even in adulthood (Miyata et al., 2012).”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Miyata et al., 2012
There is a substantial increase in the 4-sulfation/6-sulfation (C4S/C6S) ratio during brain development.
“Overall then, there is a substantial increase in the 4--sulfation/6-sulfation (C4S/C6S) ratio during brain development (Kitagawa et al., 1997;Miyata et al., 2012).”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Miyata et al., 2012
6-O-sulfation is dominant in the juvenile brain to produce C6S, which is more permissive.
“Specifically, 6--O--sulfation is dominant in the juvenile brain to produce C6S, which is more permissive (Lin et al., 2011;Miyata et al., 2012)”
From Casting a Wide Net: Role of Perineuronal Nets in Neural Plasticity (2016) · cites this paper as Miyata et al., 2012
Chondroitin 4-sulphates are inhibitory, chondroitin 6-sulphates are more permissive to plasticity and regeneration, and the balance between C6S and C4S regulates neuroplasticity.
“While chondroitin 4-sulphates (C4S) are inhibitory [5], chondroitin 6-sulphates (C6S) are more permissive to plasticity and regeneration [173, 174], and the balance between C6S and C4S regulates neuroplasticity.”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [173]
The relative abundance of CS isomers incorporated into CS-GAG chains has been linked to key biological functions within the brain, including charged molecule diffusion (0S-CS), neurocircuit plasticity (4S-CS and 6S-CS), glial scarring (4S6S-CS), and neurite outgrowth (2S6S-CS).
“The relative abundance of CS isomers incorporated into the CS-GAG chains has been linked to key biological functions within the brain including charged molecule diffusion (0S-CS (Nicholson & Hrabětová 2017)), neurocircuit plasticity (4S-CS and 6S-CS (Miyata et al. 2012; Yang et al. 2021)), glial scarring (4S6S-CS (Brown et al. 2012)), and neurite outgrowth (2S6S-CS (Shida et al. 2019; Clement et a”
From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Miyata et al. 2012
Microgliosis represents a potential mechanism driving PNN loss in models of neurodegeneration.
“Recent work suggests that microgliosis represents a potential mechanism driving PNN loss in models of neurodegeneration (Miyata et al. 2012; Miyata & Kitagawa 2016; Crapser et al. 2021)”
From Perineuronal net deglycosylation associates with tauopathy‐induced gliosis and neurodegeneration (2024) · cites this paper as Miyata et al. 2012
PNN disruption prevents persistent uptake of Otx2 homeoprotein into enwrapped PV cells required for their maintenance.
“Second, PNN disruption prevents the persistent uptake of Otx2 homeoprotein into the enwrapped PV-cells required for their maintenance (27, 40, 41) (Fig. S3).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [40]
Compromised PNNs prevent persistent uptake of Otx2 homeoprotein into enwrapped PV cells needed for their maturation, including PNN maintenance.
“Compromised PNNs prevent the persistent uptake of Otx2 homeoprotein into the enwrapped PV-cells needed for their maturation (including PNN maintenance itself) (27, 40, 41).”
From Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons (2015) · cites this paper as [40]
Knockout of specific sulfotransferases that modify perineuronal net structure interferes with Otx2 internalization and critical period closure.
“This is further supported by the demonstration that the knock-out of specific sulfotranferases that modify the PNN structure interferes with Otx2 internalization and CP closure (Miyata et al., 2012)”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Miyata et al., 2012
Early sensory experience initiates expression of Otx2 binding sites on nascent perineuronal nets, facilitating Otx2 import and opening a period of plasticity.
“The model also stipulates that early sensory experience (sensory input) initiates expression of Otx2 binding sites on nascent PNNs (Beurdeley et al., 2012; Miyata et al., 2012), facilitating Otx2 import and opening a period of plasticity.”
From Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity (2013) · cites this paper as Miyata et al., 2012
PNNs form a reticular dendrosomatic structure around mostly parvalbumin-expressing interneurons, thought to lock synapses during development.
“where they form a reticular dendrosomatic structure around largely parvalbumin-expressing interneurons”
From Microglial depletion prevents extracellular matrix changes and striatal volume reduction in a model of Huntington's disease (2020) · cites this paper as Miyata et al., 2012
CS-4 and CS-6 are the two most common sulfation patterns in the brain.
“Chondroitin-4-sulfation (CS-4) and chondroitin-6 sulfation (CS-6) are the two most common sulfation patterns in the brain, with several variations depending on the position of the sulfation on the CS chains43, 44”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [43]
Numbers of CS chains and their patterns of sulfation fundamentally affect their functions, such as their ability to interact with growth factors and cytokines.
“Numbers of CS chains and their patterns of sulfation fundamentally affect their functions, such as their ability to interact with other molecules including growth factors and cytokines.43”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [43]
Disruption of perineuronal nets can alter the resting membrane potential of parvalbumin neurons and decrease the amplitudes of both inhibitory and excitatory postsynaptic currents.
“Fourth, disruption of PNNs can alter the resting membrane potential of PV neurons (Miyata et al, 2012) and decrease the amplitudes of both inhibitory (Liu et al, 2013) and excitatory (Pyka et al, 2011) postsynaptic currents.”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Miyata et al, 2012
Extracellular matrix components, including perineuronal nets, are critical regulators of synaptic plasticity.
“Several studies suggest that ECM components, including PNNs, are critical regulators of synaptic plasticity (Do et al, 2015;Miyata et al, 2012;Morishita et al, 2015).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Miyata et al, 2012
Altered sulfation of N-acetylgalactosamine results in greatly reduced Wisteria floribunda agglutinin labeling.
“For example, altered sulfation of N-acetylgalactosamine (GalNAc, a major disaccharide found in CSPGs) results in greatly reduced WFA labeling (Miyata et al, 2012).”
From Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia (2016) · cites this paper as Miyata et al, 2012
A developmental increase in the 4-sulfation/6-sulfation ratio of chondroitin sulfate proteoglycans has a role in closure of the critical period for ocular dominance plasticity in the mouse visual cortex.
“Interestingly, it has been recently shown that a developmental increase in the 4-sulfation/6-sulfation (4S/6S) ratio of CSPGs has a role in the closure of the critical period for ocular dominance plasticity in the mouse visual cortex, and condensation of CSPGs into PNNs is prevented by cell-autonomous overexpression of chondroitin 6-sulfation, which maintains a low 4S/6S ratio (Miyata et al., 2012”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Miyata et al., 2012
The maturation and phenotypic maintenance of parvalbumin interneurons require incorporation of the non-cell autonomous homeobox protein Otx2 through its affinity with perineuronal nets.
“Indeed, the maturation and phenotypic maintenance of PVI require incorporation of a non-cell autonomous homeobox protein, Otx2, through its affinity with PNN (Beurdeley et al., 2012; Miyata et al., 2012).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Miyata et al., 2012
Dysregulation of the redox, neuroimmune, and glutamatergic hub could yield the slow emergence of clinical symptoms by altering the timing of key windows of critical periods of brain plasticity.
“Given the pivotal role of PVI, PNN, and myelin in regulating brain plasticity dynamics and active epochs (McGee et al., 2005; Miyata et al., 2012; Morishita and Hensch, 2008), the dysregulation of this “hub” could yield the slow emergence of clinical symptoms by altering the timing of key windows of critical period of brain plasticity (Morishita et al., 2010, abstract Neuroscience Meeting, 62.30).”
From Redox dysregulation, neuroinflammation, and NMDA receptor hypofunction: A “central hub” in schizophrenia pathophysiology? (2016) · cites this paper as Miyata et al., 2012
Cites
Efficient selection for high-expression transfectants with a novel eukaryotic vector
Niwa, H., Yamamura, K., & Miyazaki, J. (1991) · Gene · doi:10.1016/0378-1119(91)90434-d · Cited by 5,135 · see citing works
SINGLE-CELL RESPONSES IN STRIATE CORTEX OF KITTENS DEPRIVED OF VISION IN ONE EYE
Wiesel, T. N., & Hubel, D. H. (1963) · Journal of Neurophysiology · doi:10.1152/jn.1963.26.6.1003 · Cited by 2,628 · see citing works
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357 · see citing works
Critical period plasticity in local cortical circuits
Hensch, T. K. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1787 · Cited by 2,323 · see citing works
Cortical inhibitory neurons and schizophrenia
Lewis, D. A., Hashimoto, T., & Volk, D. W. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1648 · Cited by 2,297 · see citing works
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679 · see citing works
Intrinsic firing patterns of diverse neocortical neurons
Connors, B. W., & Gutnick, M. J. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90185-d · Cited by 1,440 · see citing works
A long, remarkable journey: Tangential migration in the telencephalon
Marín, Ó., & Rubenstein, J. L. R. (2001) · Nature reviews. Neuroscience · doi:10.1038/35097509 · Cited by 1,050 · see citing works
Local GABA Circuit Control of Experience-Dependent Plasticity in Developing Visual Cortex
Hensch, T. K., Fagiolini, M., Mataga, N., Stryker, M. P., Baekkeskov, S., & Kash, S. F. (1998) · Science · doi:10.1126/science.282.5393.1504 · Cited by 910 · see citing works
Experience-Dependent Plasticity of Binocular Responses in the Primary Visual Cortex of the Mouse
Gordon, J. A., & Stryker, M. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03274.1996 · Cited by 856 · see citing works
Kv3 channels: voltage-gated K+ channels designed for high-frequency repetitive firing
Rudy, B., & McBain, C. J. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01892-0 · Cited by 781 · see citing works
Experience-driven plasticity of visual cortex limited by myelin and nogo receptor
McGee, A. W., Yang, Y., Fischer, Q. S., Daw, N. W., & Strittmatter, S. M. (2005) · Science · doi:10.1126/science.1114362 · Cited by 643 · see citing works
Removing brakes on adult brain plasticity: From molecular to behavioral interventions
Bavelier, D., Levi, D. M., Li, R. W., Dan, Y., & Hensch, T. K. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4812-10.2010 · Cited by 589 · see citing works
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575 · see citing works
Sulfation patterns of glycosaminoglycans encode molecular recognition and activity
Gama, C. I., Tully, S. E., Sotogaku, N., Clark, P. M., Rawat, M., Vaidehi, N., Goddard, W. A., Nishi, A., & Hsieh‐Wilson, L. C. (2006) · Nature Chemical Biology · doi:10.1038/nchembio810 · Cited by 561 · see citing works
Kawaguchi, Y. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-04-02638.1995 · Cited by 533 · see citing works
Perineuronal nets: past and present
Celio, M. R., Spreafico, R., De Biasi, S., & Vitellaro-Zuccarello, L. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01298-3 · Cited by 497 · see citing works
Animals lacking link protein have attenuated perineuronal nets and persistent plasticity
Carulli, D., Pizzorusso, T., Kwok, J. C. F., Putignano, E., Poli, A., Forostyak, S., Andrews, M. R., Deepa, S. S., Glant, T. T., & Fawcett, J. W. (2010) · Brain · doi:10.1093/brain/awq145 · Cited by 495 · see citing works
Sugiyama, S., Di Nardo, A. A., Aizawa, S., Matsuo, I., Volovitch, M., Prochiantz, A., & Hensch, T. K. (2008) · Cell · doi:10.1016/j.cell.2008.05.054 · Cited by 491 · cited 1× · see citing works
“In particular, maturation of a subset of inhibitory interneurons expressing the calcium-binding protein parvalbumin has been proposed to be crucial for defining the timing of the critical perio”
BackgroundWisteria floribunda agglutinin-labelled nets surround parvalbumin-containing neurons
Härtig, W., Brauer, K., & Brückner, G. (1992) · NeuroReport · doi:10.1097/00001756-199210000-00012 · Cited by 440 · see citing works
How Monocular Deprivation Shifts Ocular Dominance in Visual Cortex of Young Mice
Frenkel, M. Y., & Bear, M. F. (2004) · Neuron · doi:10.1016/j.neuron.2004.12.003 · Cited by 412 · see citing works
Kawaguchi, Y., & Kondo, S. (2002) · Journal of Neurocytology · doi:10.1023/a:1024126110356 · Cited by 395 · see citing works
Prenatal and postnatal development of retinogeniculate and retinocollicular projections in the mouse
Godement, P., Salaün, J., & Imbert, M. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902300406 · Cited by 378 · see citing works
Lynx1, a Cholinergic Brake, Limits Plasticity in Adult Visual Cortex
Morishita, H., Miwa, J. M., Heintz, N., & Hensch, T. K. (2010) · Science · doi:10.1126/science.1195320 · Cited by 365 · see citing works
Aggrecan Glycoforms Contribute to the Molecular Heterogeneity of Perineuronal Nets
Matthews, R. T., Kelly, G. M., Zerillo, C. A., Gray, G., Tiemeyer, M., & Hockfield, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07536.2002 · Cited by 341 · see citing works
Carulli, D., Rhodes, K. E., Brown, D. J., Bonnert, T. P., Pollack, S. J., Oliver, K., Strata, P., & Fawcett, J. W. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20822 · Cited by 341 · see citing works
Reducing Intracortical Inhibition in the Adult Visual Cortex Promotes Ocular Dominance Plasticity
Harauzov, A., Spolidoro, M., DiCristo, G., De Pasquale, R., Cancedda, L., Pizzorusso, T., Viegi, A., Berardi, N., & Maffei, L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2233-09.2010 · Cited by 319 · see citing works
Narp regulates homeostatic scaling of excitatory synapses on parvalbumin-expressing interneurons
Chang, M. C., Park, J. M., Pelkey, K. A., Grabenstatter, H. L., Xu, D., Linden, D. J., Sutula, T. P., McBain, C. J., & Worley, P. F. (2010) · Nature Neuroscience · doi:10.1038/nn.2621 · Cited by 316 · see citing works
Pantazopoulos, H., Woo, T.-U. W., Lim, M. P., Lange, N., & Berretta, S. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2009.196 · Cited by 296 · see citing works
Chondroitin/dermatan sulfate in the central nervous system
Sugahara, K., & Mikami, T. (2007) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2007.08.015 · Cited by 274 · see citing works
Distinctive Features of Adult Ocular Dominance Plasticity
Sato, M., & Stryker, M. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2451-08.2008 · Cited by 263 · see citing works
A Comparison of Experience-Dependent Plasticity in the Visual and Somatosensory Systems
Fox, K. D., & Wong, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.013 · Cited by 232 · see citing works
Tropea, D., Kreiman, G., Lyckman, A., Mukherjee, S., Yu, H., Horng, S., & Sur, M. (2006) · Nature Neuroscience · doi:10.1038/nn1689 · Cited by 226 · see citing works
Bidirectional plasticity in fast-spiking GABA circuits by visual experience
Yazaki-Sugiyama, Y., Kang, S., Câteau, H., Fukai, T., & Hensch, T. K. (2009) · Nature · doi:10.1038/nature08485 · Cited by 200 · see citing works
Properzi, G., Carulli, D., Asher, R. A., Muir, E. M., Camargo, L. M., Kuppevelt, T. H. V., ten Dam, G. B., Furukawa, Y., Mikami, T., Sugahara, K., et al. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03876.x · Cited by 187 · see citing works
Kitagawa, H., Tsutsumi, K., Tone, Y., & Sugahara, K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.50.31377 · Cited by 187 · see citing works
Self-citationSchwaller, B., Tetko, I. V., Tandon, P., Silveira, D. C., Vreugdenhil, M., Henzi, T., Potier, M.-C., Celio, M. R., & Villa, A. E. P. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.12.006 · Cited by 169 · see citing works
Rapid Developmental Maturation of Neocortical FS Cell Intrinsic Excitability
Goldberg, E. M., Jeong, H.-Y., Kruglikov, I., Tremblay, R., Lazarenko, R. M., & Rudy, B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq138 · Cited by 132 · see citing works
Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E
Mikami, T., Yasunaga, D., & Kitagawa, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809227200 · Cited by 124 · see citing works
Self-citationTargeted gene delivery to telencephalic inhibitory neurons by directional in utero electroporation
Borrell, V., Yoshimura, Y., & Callaway, E. M. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.09.027 · Cited by 116 · see citing works
Self-citationKitagawa, H., Kinoshita, A., & Sugahara, K. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.9952 · Cited by 115 · see citing works
Self-citationMaturation of GABAergic transmission and the timing of plasticity in visual cortex
Jiang, B., Huang, Z. J., Morales, B., & Kirkwood, A. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.05.007 · Cited by 108 · see citing works
Tanaka, D. H., Yanagida, M., Zhu, Y., Mikami, S., Nagasawa, T., Miyazaki, J., Yanagawa, Y., Obata, K., & Murakami, F. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5446-08.2009 · Cited by 107 · see citing works
Neurons Produce a Neuronal Cell Surface-Associated Chondroitin Sulfate Proteoglycan
Lander, C., Zhang, H., & Hockfield, S. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-01-00174.1998 · Cited by 107 · see citing works
Maeda, N., He, J., Yajima, Y., Mikami, T., Sugahara, K., & Yabe, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305530200 · Cited by 96 · see citing works
Nadanaka, S., Ishida, M., Ikegami, M., & Kitagawa, H. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802997200 · Cited by 93 · see citing works
Self-citationConstruction of perineuronal net-like structure by cortical neurons in culture
Miyata, S., Nishimura, Y., Hayashi, N., & Oohira, A. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.07.031 · Cited by 75 · see citing works
Self-citationErişir, A., & Dreusicke, M. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20507 · Cited by 52 · see citing works
Yoshimura, Y., Inaba, M., Yamada, K., Kurotani, T., Begum, T., Reza, F., Maruyama, T., & Komatsu, Y. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06384.x · Cited by 30 · see citing works
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Werker, J. F., & Hensch, T. K. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-010814-015104 · Cited by 774 · see citing works
Balancing Plasticity/Stability Across Brain Development
Takesian, A. E., & Hensch, T. K. (2013) · Progress in Brain Research · doi:10.1016/b978-0-444-63327-9.00001-1 · Cited by 667 · see citing works
The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
Fawcett, J. W., Oohashi, T., & Pizzorusso, T. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0196-3 · Cited by 589 · see citing works
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Cabungcal, J.-H., Steullet, P., Morishita, H., Kraftsik, R., Cuenod, M., Hensch, T. K., & Do, K. Q. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300454110 · Cited by 512 · see citing works
Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex
Sipe, G. O., Lowery, Tremblay, M.-È., Kelly, E. A., Lamantia, C. E., & Majewska, A. K. (2016) · Nature Communications · doi:10.1038/ncomms10905 · Cited by 512 · see citing works
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Mikami, T., & Kitagawa, H. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.06.006 · Cited by 505 · see citing works
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Paul, A., Crow, M., Raudales, R., He, M., Gillis, J., & Huang, Z. J. (2017) · Cell · doi:10.1016/j.cell.2017.08.032 · Cited by 421 · see citing works
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Mauney, S. A., Athanas, K. M., Pantazopoulos, H., Shaskan, N., Passeri, E., Berretta, S., & Woo, T.-U. W. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.007 · Cited by 291 · see citing works
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Enwright, J. F., Sanapala, S., Foglio, A., Berry, R., Fish, K. N., & Lewis, D. A. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.24 · Cited by 223 · see citing works
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Rowlands, D., Lensjø, K. K., Dinh, T., Yang, S., Andrews, M. R., Hafting, T., Fyhn, M., Fawcett, J. W., & Dick, G. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.1122-18.2018 · Cited by 204 · see citing works
Mizumoto, S., Yamada, S., & Sugahara, K. (2015) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2015.06.004 · Cited by 199 · see citing works
Dyck, S. M., & Karimi‐Abdolrezaee, S. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.04.006 · Cited by 189 · see citing works
The extracellular matrix and perineuronal nets in memory
Fawcett, J. W., Fyhn, M., Jendelova, P., Kwok, J. C. F., Ruzicka, J., & Sorg, B. A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01634-3 · Cited by 169 · see citing works
Choroid-Plexus-Derived Otx2 Homeoprotein Constrains Adult Cortical Plasticity
Spatazza, J., Lee, H. H. C., Di Nardo, A. A., Tibaldi, L., Joliot, A., Hensch, T. K., & Prochiantz, A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.014 · Cited by 176 · see citing works
Miyata, S., & Kitagawa, H. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.010 · Cited by 171 · see citing works
Self-citationPantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153 · see citing works
Orlando, C., Ster, J., Gerber, U., Fawcett, J. W., & Raineteau, O. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2406-12.2012 · Cited by 153 · see citing works
Krishnan, K., Wang, B.-S., Lu, J., Wang, L., Maffei, A., Cang, J., & Huang, Z. J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1506499112 · Cited by 146 · see citing works
Do, K. Q., Cuenod, M., & Hensch, T. K. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv065 · Cited by 158 · see citing works
Crapser, J. D., Ochaba, J., Soni, N., Reidling, J. C., Thompson, L. M., & Green, K. N. (2020) · Brain · doi:10.1093/brain/awz363 · Cited by 157 · see citing works
Burnside, E. R., & Bradbury, E. J. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12114 · Cited by 153 · see citing works
Berretta, S., Pantazopoulos, H., Markota, M., Brown, C., & Batzianouli, E. T. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2014.12.040 · Cited by 152 · see citing works
de Vivo, L., Landi, S., Panniello, M., Baroncelli, L., Chierzi, S., Mariotti, L., Spolidoro, M., Pizzorusso, T., Maffei, L., & Ratto, G. M. (2013) · Nature Communications · doi:10.1038/ncomms2491 · Cited by 148 · see citing works
Perineuronal nets in brain physiology and disease
Testa, D., Prochiantz, A., & Nardo, A. A. D. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.09.011 · Cited by 141 · see citing works
Chondroitin sulfates and their binding molecules in the central nervous system
Djerbal, L., Lortat-Jacob, H., & Kwok, J. (2017) · Glycoconjugate Journal · doi:10.1007/s10719-017-9761-z · Cited by 144 · see citing works
Rapid transformation of Chlamydomonas reinhardtii without cell-wall removal
Yamano, T., Iguchi, H., & Fukuzawa, H. (2013) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2012.12.020 · Cited by 142 · see citing works
Wingert, J. C., & Sorg, B. A. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.673210 · Cited by 129 · see citing works
Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory
Foscarin, S., Raha-Chowdhury, R., Fawcett, J. W., & Kwok, J. C. F. (2017) · Aging · doi:10.18632/aging.101256 · Cited by 139 · see citing works
Dzyubenko, E., Gottschling, C., & Faissner, A. (2016) · Neural Plasticity · doi:10.1155/2016/5214961 · Cited by 134 · see citing works
Oohashi, T., Edamatsu, M., Bekku, Y., & Carulli, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.09.010 · Cited by 131 · see citing works
Cuénod, M., Steullet, P., Cabungcal, J.-H., Dwir, D., Khadimallah, I., Klauser, P., Conus, P., & Kim, Q. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01374-w · Cited by 129 · see citing works
An Extracellular Perspective on CNS Maturation: Perineuronal Nets and the Control of Plasticity
Carulli, D., & Verhaagen, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052434 · Cited by 123 · see citing works
Morawski, M., Reinert, T., Meyer-Klaucke, W., Wagner, F. E., Tröger, W., Reinert, A., Jäger, C., Brückner, G., & Arendt, T. (2015) · Scientific Reports · doi:10.1038/srep16471 · Cited by 116 · see citing works
In Sickness and in Health: Perineuronal Nets and Synaptic Plasticity in Psychiatric Disorders
Pantazopoulos, H., & Berretta, S. (2015) · Neural Plasticity · doi:10.1155/2016/9847696 · Cited by 118 · see citing works
Sigal, Y. M., Bae, H., Bogart, L. J., Hensch, T. K., & Zhuang, X. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817222116 · Cited by 118 · see citing works
“GAG-ing with the neuron”: The role of glycosaminoglycan patterning in the central nervous system
Smith, P. D., Coulson‐Thomas, V. J., Foscarin, S., Kwok, J. C. F., & Fawcett, J. W. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.004 · Cited by 112 · see citing works
Cerebellar plasticity and associative memories are controlled by perineuronal nets
Carulli, D., Broersen, R., de Winter, F., Muir, E. M., Mešković, M., de Waal, M., de Vries, S., Boele, H.-J., Canto, C. B., De Zeeuw, C. I., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916163117 · Cited by 110 · see citing works
Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential
Glykys, J. C., Dzhala, V. I., Egawa, K., Kahle, K. T., Delpire, E. J., & Staley, K. J. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.03.006 · Cited by 109 · see citing works
Tewari, B. P., Chaunsali, L., Prim, C. E., & Sontheimer, H. W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1022754 · Cited by 107 · see citing works
Lupori, L., Totaro, V., Cornuti, S., Ciampi, L., Carrara, F., Grilli, E., Viglione, A., Tozzi, F., Putignano, E., Mazziotti, R. M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112788 · Cited by 106 · see citing works
Involvement of cortical fast-spiking parvalbumin-positive basket cells in epilepsy
Jiang, X., Lachance, M., & Rossignol, E. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.04.012 · Cited by 98 · see citing works
Otx2-PNN interaction to regulate cortical plasticity
Bernard, C., & Prochiantz, A. (2016) · Neural Plasticity · doi:10.1155/2016/7931693 · Cited by 102 · see citing works
Miller, G. M., & Hsieh‐Wilson, L. C. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.015 · Cited by 98 · see citing works
MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
Krishnan, K., Lau, B. Y. B., Ewall, G., Huang, Z. J., & Shea, S. D. (2017) · Nature Communications · doi:10.1038/ncomms14077 · Cited by 94 · see citing works
Perineuronal nets and schizophrenia: The importance of neuronal coatings
Bitanihirwe, B. K. Y., & Woo, T.-U. W. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.018 · Cited by 95 · see citing works
Neural ECM molecules in synaptic plasticity, learning, and memory
Senkov, O., Anđjus, P. R., Radenović, L., Soriano, E., & Dityatev, A. E. (2014) · Progress in brain research · doi:10.1016/b978-0-444-63486-3.00003-7 · Cited by 94 · see citing works
Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons
Morishita, H., Cabungcal, J.-H., Chen, Y., Do, K. Q., & Hensch, T. K. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.026 · Cited by 92 · see citing works
Bozzelli, P. L., Alaiyed, S., Kim, E., Villapol, S., & Conant, K. E. (2018) · Neural Plasticity · doi:10.1155/2018/5735789 · Cited by 90 · see citing works
Santiago, A. N., Lim, K. Y., Opendak, M., Sullivan, R. M., & Aoki, C. (2018) · Journal of Comparative Neurology · doi:10.1002/cne.24522 · Cited by 87 · see citing works
Cortical plasticity induced by transplantation of embryonic somatostatin or parvalbumin interneurons
Tang, Y., Stryker, M. P., Álvarez-Buylla, A., & Espinosa, J. S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421844112 · Cited by 84 · see citing works
Nabel, E. M., & Morishita, H. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00146 · Cited by 85 · see citing works
A Sweet Talk: The Molecular Systems of Perineuronal Nets in Controlling Neuronal Communication
Spijker, H. M. V. ‘., & Kwok, J. C. F. (2017) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2017.00033 · Cited by 82 · see citing works
Enzymatic Synthesis of Homogeneous Chondroitin Sulfate Oligosaccharides
Li, J., Su, G., & Liu, J. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201705638 · Cited by 84 · see citing works
Directing Neuronal Signaling through Cell-Surface Glycan Engineering
Pulsipher, A., Griffin, M. E., Stone, S. E., Brown, J. M., & Hsieh‐Wilson, L. C. (2014) · Journal of the American Chemical Society · doi:10.1021/ja5005174 · Cited by 83 · see citing works
Mizumoto, S., Fongmoon, D., & Sugahara, K. (2012) · Glycoconjugate Journal · doi:10.1007/s10719-012-9463-5 · Cited by 82 · see citing works
Genetic Otx2 mis-localization delays critical period plasticity across brain regions
Lee, H. H. C., Bernard, C., Ye, Z., Acampora, D., Simeone, A., Prochiantz, A., Di Nardo, A. A., & Hensch, T. K. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.1 · Cited by 82 · see citing works
Izumikawa, T., Sato, B., & Kitagawa, H. (2014) · Scientific Reports · doi:10.1038/srep03701 · Cited by 79 · see citing works
Self-citationMirzadeh, Z., Alonge, K. M., Cabrales, E., Herranz‐Pérez, V., Scarlett, J. M., Brown, J. M., Hassouna, R., Matsen, M. E., Hồng, N. T., García‐Verdugo, J. M., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0029-0 · Cited by 76 · see citing works
Circadian Rhythms of Perineuronal Net Composition
Pantazopoulos, H., Gisabella, B., Rexrode, L., Benefield, D., Yıldız, E., Seltzer, P., Valeri, J., Chelini, G., Reich, A., Ardelt, M., et al. (2020) · eNeuro · doi:10.1523/eneuro.0034-19.2020 · Cited by 73 · see citing works
Regulation of Perineuronal Nets in the Adult Cortex by the Activity of the Cortical Network
Devienne, G. F., Picaud, S., Cohen, I., Piquet, J., Tricoire, L., Testa, D., Nardo, A. A. D., Rossier, J., Cauli, B., & Lambolez, B. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0434-21.2021 · Cited by 78 · see citing works
Where no synapses go: gatekeepers of circuit remodeling and synaptic strength
Mironova, Y. A., & Giger, R. J. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.003 · Cited by 75 · see citing works
Identification of a critical sulfation in chondroitin that inhibits axonal regeneration
Pearson, C. S., Mencio, C. P., Barber, A. C., Martin, K. R., & Geller, H. M. (2018) · eLife · doi:10.7554/elife.37139 · Cited by 75 · see citing works
Morikawa, S., Ikegaya, Y., Narita, M., & Tamura, H. (2017) · Scientific Reports · doi:10.1038/srep46024 · Cited by 74 · see citing works
Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex
Hou, X., Yoshioka, N., Tsukano, H., Sakai, A., Miyata, S., Watanabe, Y., Yanagawa, Y., Sakimura, K., Takeuchi, K., Kitagawa, H., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04007-x · Cited by 75 · see citing works
Self-citationChondroitin 6-sulphate is required for neuroplasticity and memory in ageing
Yang, S., Gigout, S., Molinaro, A., Naito-Matsui, Y., Hilton, S., Foscarin, S., Nieuwenhuis, B., Tan, C. L., Verhaagen, J., Pizzorusso, T., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01208-9 · Cited by 70 · see citing works
Self-citationThe tetrapartite synapse: a key concept in the pathophysiology of schizophrenia
Chelini, G., Pantazopoulos, H., Durning, P. T., & Berretta, S. (2018) · European Psychiatry · doi:10.1016/j.eurpsy.2018.02.003 · Cited by 73 · see citing works
Miyata, S., & Kitagawa, H. (2016) · Neural Plasticity · doi:10.1155/2016/1305801 · Cited by 70 · see citing works
Self-citationThe Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity
de Winter, F., Kwok, J. C. F., Fawcett, J. W., Vo, T. T., Carulli, D., & Verhaagen, J. (2016) · Neural Plasticity · doi:10.1155/2016/3679545 · Cited by 84 · see citing works
Mechanisms for modulation of neural plasticity and axon regeneration by chondroitin sulphate
Miyata, S., & Kitagawa, H. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu067 · Cited by 70 · see citing works
Self-citationHomeoprotein Signaling in the Developing and Adult Nervous System
Prochiantz, A., & Nardo, A. A. D. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.019 · Cited by 67 · see citing works
Miyata, S., Nadanaka, S., Igarashi, M., & Kitagawa, H. (2018) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2018.00003 · Cited by 68 · see citing works
Self-citationNadanaka, S., Kinouchi, H., & Kitagawa, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.814509 · Cited by 67 · see citing works
Self-citationFlexible Roles for Proteoglycan Sulfation and Receptor Signaling
Yu, P., Pearson, C. S., & Geller, H. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.005 · Cited by 67 · see citing works
Astroglial Scarring and Seizures
Robel, S. (2016) · The Neuroscientist · doi:10.1177/1073858416645498 · Cited by 64 · see citing works
Yang, S., Hilton, S., Alves, J. N., Saksida, L. M., Bussey, T., Matthews, R. T., Kitagawa, H., Spillantini, M. G., Kwok, J. C. F., & Fawcett, J. W. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.08.002 · Cited by 61 · see citing works
Self-citationThe role of human natural killer-1 (HNK-1) carbohydrate in neuronal plasticity and disease
Morise, J., Takematsu, H., & Oka, S. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.025 · Cited by 63 · see citing works
Alonge, K. M., Mirzadeh, Z., Scarlett, J. M., Logsdon, A. F., Brown, J. M., Cabrales, E., Chan, C. K., Kaiyala, K. J., Bentsen, M. A., Banks, W. A., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00275-6 · Cited by 63 · see citing works
The “Loss” of Perineuronal Nets in Alzheimer's Disease: Missing or Hiding in Plain Sight?
Scarlett, J. M., Hu, S. J., & Alonge, K. M. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.896400 · Cited by 61 · see citing works
Perineuronal Net Dynamics in the Pathophysiology of Epilepsy
Chaunsali, L., Tewari, B. P., & Sontheimer, H. W. (2021) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597211018688 · Cited by 60 · see citing works
Spatazza, J., Lullo, E. D., Joliot, A., Dupont, E., Moya, K. L., & Prochiantz, A. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006577 · Cited by 58 · see citing works
Hirono, M., Watanabe, S., Karube, F., Fujiyama, F., Kawahara, S., Nagao, S., Yanagawa, Y., & Misonou, H. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.3238-17.2018 · Cited by 53 · see citing works
Cortical maps: a role for astrocytes?
López-Hidalgo, M. A., & Schummers, J. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.11.001 · Cited by 56 · see citing works
Koike, T., Izumikawa, T., Tamura, J., & Kitagawa, H. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.03.024 · Cited by 58 · see citing works
Self-citationOTX2 Signals from the Choroid Plexus to Regulate Adult Neurogenesis
Planques, A., Moreira, V. O., Dubreuil, C., Prochiantz, A., & Nardo, A. A. D. (2019) · eNeuro · doi:10.1523/eneuro.0262-18.2019 · Cited by 57 · see citing works
Incubation of depression: ECM assembly and parvalbumin interneurons after stress
Spijker, S., Koskinen, M.-K., & Riga, D. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.07.015 · Cited by 55 · see citing works
Decoding perineuronal net glycan sulfation patterns in the Alzheimer's disease brain
Logsdon, A. F., Francis, K. L., Richardson, N. E., HU, S. J. W., Faber, C. L., Phan, B. A., Nguyen, V., Setthavongsack, N., Banks, W. A., Woltjer, R. L., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12451 · Cited by 55 · see citing works
Human genetic disorders and knockout mice deficient in glycosaminoglycan
Mizumoto, S., Yamada, S., & Sugahara, K. (2014) · BioMed Research International · doi:10.1155/2014/495764 · Cited by 54 · see citing works
Diurnal changes in perineuronal nets and parvalbumin neurons in the rat medial prefrontal cortex
Harkness, J. H., Gonzalez, A. E., Bushana, P. N., Jorgensen, E. T., Hegarty, D. M., Nardo, A. A. D., Prochiantz, A., Wisor, J. P., Aicher, S. A., Brown, T. E., et al. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02229-4 · Cited by 51 · see citing works
Mapping pathologic circuitry in schizophrenia
Glausier, J. R., & Lewis, D. A. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63639-3.00025-6 · Cited by 52 · see citing works
Yu, Z., Chen, N., Hu, D., Chen, W., Yuan, Y., Meng, S., Zhang, W., Lu, L., Han, Y., & Shi, J. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00004 · Cited by 52 · see citing works
Ryu, Y., Iwashita, M., Lee, W., Uchimura, K., & Kosodo, Y. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.709620 · Cited by 51 · see citing works
Liu, C., Fan, L., Xing, J., Wang, Q., Lin, C., Liu, C., Deng, X., Ning, C., Zhou, L., Rong, L., et al. (2019) · Biomaterials Science · doi:10.1039/c8bm01363b · Cited by 51 · see citing works
Ribic, A., Crair, M. C., & Biederer, T. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.069 · Cited by 47 · see citing works
Proteoglycan Sulphation in the Function of the Mature Central Nervous System
Fawcett, J. W., & Kwok, J. C. F. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.895493 · Cited by 48 · see citing works
Involvement of chondroitin 6-sulfation in temporal lobe epilepsy
Yutsudo, N., & Kitagawa, H. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.07.009 · Cited by 48 · see citing works
Self-citation
- Authors
- Miyata, S., Komatsu, Y., Yoshimura, Y., Taya, C., & Kitagawa, H.
- Affiliations
- Kobe Pharmaceutical University (JP)
- Research Institute of Environmental Medicine, Nagoya University (JP)
- National Institutes of Natural Sciences (JP)
- Tokyo Metropolitan Institute of Medical Science (JP)
- Corresponding author
- Kitagawa, Hiroshi
- Venue
- Nature Neuroscience
- Published
- 2012-01-15
- Volume
- 15
- Issue
- 3
- Pages
- 414-422
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2078474557
- Cited by
- 365
- References
- 49
- Citations by year
- 2026: 19 · 2025: 22 · 2024: 23 · 2023: 22 · 2022: 23 · 2021: 38 · 2020: 36 · 2019: 25 · 2018: 25 · 2017: 26 · 2016: 18 · 2015: 28 · 2014: 28 · 2013: 26 · 2012: 6
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University Research Committee, Emory University
- Japan Society for the Promotion of Science (21390025, 23110003)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- chondroitin sulfate proteoglycans, ocular dominance plasticity, critical period, visual cortex, parvalbumin interneurons, perineuronal nets, extracellular matrix, Otx2, interneuron maturation, cortical plasticity
- MeSH terms
- Carbohydrate Sulfotransferases, Action Potentials, Age Factors, Amphetamines, Animals, Animals, Newborn, Astrocytes, Bacterial Proteins, Cells, Cultured, Chlorocebus aethiops, Chondroitin Sulfates, Humans, Functional Laterality, Luminescent Proteins, Mice, Transgenic, Nerve Tissue Proteins, Neuronal Plasticity, Parvalbumins, Chondroitin Sulfate Proteoglycans, Sensory Deprivation, Time Factors, Visual Cortex, Visual Pathways, Sulfotransferases, Up-Regulation, Electroporation, Patch-Clamp Techniques, Gene Expression Regulation, Developmental, Receptors, N-Acetylglucosamine, Plant Lectins, Vesicular Glutamate Transport Protein 2, Mice, Otx Transcription Factors, Aggrecans, In Vitro Techniques
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