Secreted β-Amyloid Precursor Protein Counteracts the Proapoptotic Action of Mutant Presenilin-1 by Activation of NF-κB and Stabilization of Calcium Homeostasis

Guo, Qing; Robinson, Nic; Mattson, Mark P.

doi:10.1074/jbc.273.20.12341

Cited by 196Alzheimer's disease research and treatmentsNF-κB Signaling PathwaysNeuroinflammation and Neurodegeneration Mechanisms

Secreted β-Amyloid Precursor Protein Counteracts the Proapoptotic Action of Mutant Presenilin-1 by Activation of NF-κB and Stabilization of Calcium Homeostasis

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Guo, Qing, Robinson, Nic, Mattson, Mark P.·1998·Journal of Biological Chemistry

DOI 10.1074/jbc.273.20.12341

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Abstract

Mutations in the presenilin-1 (PS-1) gene account for approximately 50% of the cases of autosomal dominant, early onset, inherited forms of Alzheimer's disease (AD). PS-1 is an integral membrane protein expressed in neurons and is localized primarily in the endoplasmic reticulum (ER). PS-1 mutations may promote neuronal degeneration by altering the processing of the beta-amyloid precursor protein (APP) and/or by engaging apoptotic pathways. Alternative processing of APP in AD may increase production of neurotoxic amyloid beta-peptide (Abeta) and reduce production of the neuroprotective alpha-secretase-derived form of APP (sAPPalpha). In differentiated PC12 cells expressing an AD-linked PS-1 mutation (L286V), sAPPalpha activated the transcription factor NF-kappaB and prevented apoptosis induced by Abeta. Treatment of cells with kappaB decoy DNA blocked the antiapoptotic action of sAPPalpha, demonstrating the requirement for NF-kappaB activation in the cytoprotective action of sAPPalpha. Cells expressing mutant PS-1 exhibited an aberrant pattern of NF-kappaB activity following exposure to Abeta, which was characterized by enhanced early activation of NF-kappaB followed by a prolonged depression of activity. Blockade of NF-kappaB activity in cells expressing mutant PS-1 by kappaB decoy DNA was associated with enhanced Abeta-induced increases of [Ca2+]i and mitochondrial dysfunction. Treatment of cells with sAPPalpha stabilized [Ca2+]i and mitochondrial function and suppressed oxidative stress by a mechanism involving activation of NF-kappaB. Blockade of ER calcium release prevented (and stimulation of ER calcium release by thapsigargin induced) apoptosis in cells expressing mutant PS-1, suggesting a pivotal role for ER calcium release in the proapoptotic action of mutant PS-1. Finally, a role for NF-kappaB in preventing apoptosis induced by ER calcium release was demonstrated by data showing that sAPPalpha prevents thapsigargin-induced apoptosis, an effect blocked by kappaB decoy DNA. We conclude that sAPPalpha stabilizes cellular calcium homeostasis and protects neural cells against the proapoptotic action of mutant PS-1 by a mechanism involving activation of NF-kappaB. The data further suggest that PS-1 mutations result in aberrant NF-kappaB regulation that may render neurons vulnerable to apoptosis.

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Aβ42-mediated upregulation occurred in expression of genes encoding cytokines IL-1β, CEX-1, TNF-α, COX-2, B94, and proapoptotic Bax and Bik proteins.
“These analyses indicated significant Aβ42-mediated upregulation in the expression of a family of genes encoding the cytokines IL-1β, CEX-1, and TNF-α, COX-2, B94, and the proapoptotic Bax and Bik proteins (Guo et al., 1998; Metcalfe et al., 2004; Tarte et al., 2004).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
The amyloid plaque of AD shows an Aβ40/Aβ42 enriched ratio.
“The amyloid plaque of AD shows Aβ40/Aβ42 enriched ratio (Guo et al., 1998; Selkoe and Kopan, 2003)”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
sAPPα promotes neuritogenesis and long-term survival of neurons in culture and protects brain cells against toxicity of Aβ40 and Aβ42 peptides and excitotoxic and ischemic injury both in cell cultures and in vivo.
“sAPPα promotes neuritogenesis and long-term survival of neurons in culture and protects brain cells against the toxicity of Aβ40 and Aβ42 peptides and excitotoxic and ischemic injury both in cell cultures and in vivo (Guo et al., 1998; Stein and Johnson, 2003).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
sAPPα protects neural cells against proapoptotic thapsigargin, and the adverse effect of thapsigargin can be abolished in cells overexpressing antiapoptotic Bcl-2.
“sAPPα also protect neural cells against the proapoptotic thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+-ATPase, and the adverse effect of thapsigargin can be abolished in cells overexpressing antiapoptotic Bcl-2 (Guo et al., 1998).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
NPD1 biosynthesis is enhanced by the neurotrophic peptide sAPPα, a 612-amino acid fragment derived from α-secretase-mediated cleavage of βAPP.
“Furthermore, NPD1 biosynthesis is enhanced by the neurotrophic peptide sAPPα, a 612-amino acid fragment derived from α-secretase-mediated cleavage of βAPP (Guo et al., 1998; Selkoe and Kopan, 2003).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051 · see citing works
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047 · see citing works
Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599 · see citing works
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581 · see citing works
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383 · see citing works
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074 · see citing works
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/386855a0 · Cited by 1,754 · see citing works
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,627 · see citing works
Self-citation
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/40912 · Cited by 1,521 · see citing works
Mitochondrial control of apoptosis
Kroemer, G., Zamzami, N., & Susín, S. A. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)80014-x · Cited by 1,492 · see citing works
Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
Borchelt, D. R., Thinakaran, G., Eckman, C. B., Lee, M. K., Davenport, F., Ratovitsky, T., Prada, C.-M., Kim, G., Seekins, S., Yager, D., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80230-5 · Cited by 1,478 · see citing works
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,453 · see citing works
Aging, energy, and oxidative stress in neurodegenerative diseases
Beal, M. F. (1995) · Annals of Neurology · doi:10.1002/ana.410380304 · Cited by 1,434 · see citing works
Amyloid, the presenilins and Alzheimer’s disease
Hardy, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01030-2 · Cited by 1,370 · see citing works
Apoptosis is induced by beta-amyloid in cultured central nervous system neurons.
Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., & Cotman, C. W. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.7951 · Cited by 1,022 · see citing works
Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives
Mattson, M. P. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.1081 · Cited by 1,006 · see citing works
Self-citation
Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863 · see citing works
Self-citation
Redox Regulation of NF-kappa B Activation
Flohé, L., Brigelius‐Flohé, R., Saliou, C., Traber, M. G., & Packer, L. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00501-1 · Cited by 859 · see citing works
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
Mattson, M. P., Cheng, B., Culwell, A. R., Esch, F. S., Lieberburg, I. M., & Rydel, R. E. (1993) · Neuron · doi:10.1016/0896-6273(93)90315-i · Cited by 795 · see citing works
Self-citation
A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide
Mark, R. J., Lovell, M. A., Markesbery, W. R., Uchida, K., & Mattson, M. P. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68010255.x · Cited by 781 · see citing works
Self-citation
Cell Biology of the Amyloid beta-Protein Precursor and the Mechanism of Alzheimer's Disease
Selkoe, D. J. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.002105 · Cited by 748 · see citing works
Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
Kruman, I. I., Bruce‐Keller, A. J., Bredesen, D. E., Waeg, G., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05089.1997 · Cited by 719 · see citing works
Self-citation
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis
Cheng, B., Christakos, S., & Mattson, M. P. (1994) · Neuron · doi:10.1016/0896-6273(94)90159-7 · Cited by 660 · see citing works
Self-citation
Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.
Barger, S. W., Hörster, D., Furukawa, K., Goodman, Y., Krieglstein, J., & Mattson, M. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9328 · Cited by 625 · see citing works
Self-citation
Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., & Kaltschmidt, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2642 · Cited by 611 · see citing works
Immunohistochemical evidence for apoptosis in Alzheimer's disease.
Su, J., Anderson, A., Cummings, B. J., & Cotman, C. (1994) · NeuroReport · doi:10.1097/00001756-199412000-00031 · Cited by 607 · see citing works
Inhibition of NF‐kappaB/Rel induces apoptosis of murine B cells.
Wu, M., Lee, H., Bellas, R. E., Schauer, S. L., Arsura, M., Katz, D., Fitzgerald, M. J., Rothstein, T. L., Sherr, D. H., & Sonenshein, G. E. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00845.x · Cited by 587 · see citing works
Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death
Mark, R. J., Hensley, K., Butterfield, D. A., & Mattson, M. P. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-09-06239.1995 · Cited by 553 · see citing works
Self-citation
Alzheimer–associated presenilins 1 and 2 : Neuronal expression in brain and localization to intracellular membranes in mammalian cells
Kovacs, D. M., Fausett, H. J., Page, K. J., Kim, T., Moir, R. D., Merriam, D. E., Hollister, R. D., Hallmark, O. G., Mancini, R., Felsenstein, K. M., et al. (1996) · Nature Medicine · doi:10.1038/nm0296-224 · Cited by 551 · see citing works
Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system
Liou, H., & Baltimore, D. (1993) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(93)90014-h · Cited by 544 · see citing works
Evidence for Apoptotic Cell Death in Alzheimer's Disease
Smale, G., Nichols, N. R., Brady, D. R., Finch, C. E., & Horton, W. E. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1025 · Cited by 488 · see citing works
Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals
Guo, Q., Sopher, B. L., Furukawa, K., Pham, D. G., Robinson, N., Martin, G. M., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04212.1997 · Cited by 487 · see citing works
Self-citation
Neural apoptosis
Bredesen, D. E. (1995) · Annals of Neurology · doi:10.1002/ana.410380604 · Cited by 480 · see citing works
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
Clark, R. F., Hutton, M., Fuldner, M., Froelich, S., Karran, E., Talbot, C., Crook, R., Lendon, C., Prihar, G., He, C., et al. (1995) · Nature Genetics · doi:10.1038/ng1095-219 · Cited by 474 · see citing works
Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury
Goodman, Y., & Mattson, M. P. (1994) · Experimental Neurology · doi:10.1006/exnr.1994.1107 · Cited by 449 · see citing works
Self-citation
Participation of Presenilin 2 in Apoptosis: Enhanced Basal Activity Conferred by an Alzheimer Mutation
Wolozin, B. L., Iwasaki, K., Vito, P., Ganjei, J. K., Lacaná, E., Sunderland, T., Zhao, B., Kusiak, J. W., Wasco, W., & D'adamio, L. (1996) · Science · doi:10.1126/science.274.5293.1710 · Cited by 421 · see citing works
Increased Activity‐Regulating and Neuroprotective Efficacy of α‐Secretase‐Derived Secreted Amyloid Precursor Protein Conferred by a C‐Terminal Heparin‐Binding Domain
Furukawa, K., Sopher, B. L., Rydel, R. E., Begley, J. G., Pham, D. G., Martin, G. M., Fox, M., & Mattson, M. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67051882.x · Cited by 414 · see citing works
Self-citation
Inhibition of PC12 cell redox activity is a specific,early indicator of the mechanism of beta-amyloid-mediated celldeath.
Shearman, M. S., RAGAN, C. I., & Iversen, L. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1470 · Cited by 411 · see citing works
Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide
Yan, S. D., Yan, S. F., Chen, X., Fu, J., Chen, M., Kuppusamy, P., Smith, M. A., Perry, G., Godman, G. C., Nawroth, P., et al. (1995) · Nature Medicine · doi:10.1038/nm0795-693 · Cited by 406 · see citing works
Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF
Mattson, M. P., Tomaselli, K. J., & Rydel, R. E. (1993) · Brain Research · doi:10.1016/0006-8993(93)90295-x · Cited by 379 · see citing works
Self-citation
Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative
Gabuzda, D., Busciglio, J., Chen, L. B., Matsudaira, P., & Yankner, B. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36875-8 · Cited by 373 · see citing works
Protein Topology of Presenilin 1
Doan, A., Thinakaran, G., Borchelt, D., Slunt, H. H., Ratovitski, T., Podlisny, M. B., Selkoe, D. J., Seeger, M., Gandy, S., Price, D. L., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80232-9 · Cited by 371 · see citing works
Apoptosis mediated neurotoxicity induced by chronic application of β amyloid fragment 25–35
Forloni, G., Chiesa, R., Smiroldo, S., Verga, L., Salmona, M., Tagliavini, F., & Angeretti, N. (1993) · Neuroreport · doi:10.1097/00001756-199305000-00015 · Cited by 341 · see citing works
Alternative Cleavage of Alzheimer-Associated Presenilins During Apoptosis by a Caspase-3 Family Protease
Kim, T., Pettingell, W. H., Jung, Y., Kovacs, D. M., & Tanzi, R. E. (1997) · Science · doi:10.1126/science.277.5324.373 · Cited by 338 · see citing works
Alzheimerʼs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide
Guo, Q., Furukawa, K., Sopher, B. L., Pham, D. G., Xie, J., Robinson, N., Martin, G. M., & Mattson, M. P. (1996) · Neuroreport · doi:10.1097/00001756-199612200-00074 · Cited by 320 · see citing works
Self-citation
Internal Ca2+ mobilization is altered in fibroblasts from patients with Alzheimer disease.
Ito, E., Oka, K., Etcheberrigaray, R., Nelson, T. J., McPhie, D. L., Tofel-Grehl, B., Gibson, G. E., & Alkon, D. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.534 · Cited by 317 · see citing works
Expression of Presenilin 1 and 2 (PS1 and PS2) in Human and Murine Tissues
Lee, M. K., Slunt, H. H., Martin, L. J., Thinakaran, G., Kim, G. J., Gandy, S., Seeger, M., Koo, E. H., Price, D. L., & Sisodia, S. S. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07513.1996 · Cited by 286 · see citing works
Growth Factors Prevent Mitochondrial Dysfunction, Loss of Calcium Homeostasis, and Cell Injury, but Not ATP Depletion in Hippocampal Neurons Deprived of Glucose
Mattson, M. P., Zhang, Y., & Bose, S. C. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1066 · Cited by 265 · see citing works
Self-citation
Lymphocyte Apoptosis: Mediation by Increased Type 3 Inositol 1,4,5-Trisphosphate Receptor
Khan, A. A., Soloski, M. J., Sharp, A. H., Schilling, G., Sabatini, D. M., Li, S.-H., Ross, C. A., & Snyder, S. H. (1996) · Science · doi:10.1126/science.273.5274.503 · Cited by 259 · see citing works
Calcium‐Activated Neutral Proteinase (Calpain) System in Aging and Alzheimer's Diseasea
Nixon, R. A., Saito, K., Grynspan, F., Griffin, W. R., Katayama, S., Honda, T., Mohan, P. S., Shea, T. B., & Beermann, M. L. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb44402.x · Cited by 256 · see citing works
Calcium Ionophore Increases Amyloid .beta. Peptide Production by Cultured Cells
Querfurth, H. W., & Selkoe, D. J. (1994) · Biochemistry · doi:10.1021/bi00181a016 · Cited by 243 · see citing works
Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease
Xia, W., Zhang, J., Perez, R. G., Koo, E. H., & Selkoe, D. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8208 · Cited by 236 · see citing works
Ceramide Protects Hippocampal Neurons Against Excitotoxic and Oxidative Insults, and Amyloid β‐Peptide Toxicity
Goodman, Y., & Mattson, M. P. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.66020869.x · Cited by 231 · see citing works
Self-citation
The Alzheimer’s Disease-Associated Presenilins Are Differentially Phosphorylated Proteins Located Predominantly within the Endoplasmic Reticulum
Walter, J., Capell, A., Grünberg, J., Pesold, B., Schindzielorz, A., Prior, R., Podlisny, M. B., Fraser, P., George‐Hyslop, P. S., Selkoe, D. J., et al. (1996) · Molecular Medicine · doi:10.1007/bf03401652 · Cited by 225 · see citing works
Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease
Terai, K., Matsuo, A., & McGeer, P. L. (1996) · Brain Research · doi:10.1016/0006-8993(96)00310-1 · Cited by 215 · see citing works
Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein
Weidemann, A., Paliga, K., Dürrwang, U., Czech, C., Evin, G. M., Masters, C. L., & Beyreuther, K. T. (1997) · Nature Medicine · doi:10.1038/nm0397-328 · Cited by 211 · see citing works
Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites.
Cook, D. G., Sung, J. C., Golde, T. E., Felsenstein, K. M., Wójczyk, B. S., Tanzi, R. E., Trojanowski, J. Q., Lee, V. M., & Doms, R. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9223 · Cited by 202 · see citing works
Membrane Topology of the C. elegans SEL-12 Presenilin
Li, X., & Greenwald, I. (1996) · Neuron · doi:10.1016/s0896-6273(00)80231-7 · Cited by 199 · see citing works
Induction of neuroprotective κB-dependent transcription by secreted forms of the Alzheimer's β-amyloid precursor
Barger, S. W., & Mattson, M. P. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00036-8 · Cited by 195 · see citing works
Self-citation
Role of Calpain‐ and Interleukin‐1β Converting Enzyme‐Like Proteases in the β‐Amyloid‐Induced Death of Rat Hippocampal Neurons in Culture
Jordán, J., Galindo, M. F., & Miller, R. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68041612.x · Cited by 181 · see citing works
Light and Electron Microscopic Localization of Presenilin-1 in Primate Brain
Lah, J. J., Heilman, C. J., Nash, N. R., Rees, H. D., Yi, H., Counts, S. E., & Levey, A. I. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-06-01971.1997 · Cited by 168 · see citing works
Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+.
Marín, M. C., Fernandez, A., Bick, R. J., Brisbay, S. M., Buja, L. M., Snuggs, M. B., McConkey, D. J., von Eschenbach, A. C., Keating, M. J., & McDonnell, T. J. (1996) · PubMed · Cited by 158 · see citing works
Evidence for a Six-transmembrane Domain Structure of Presenilin 1
Lehmann, S., Chiesa, R., & Harris, D. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.18.12047 · Cited by 150 · see citing works
Ca2+ and Reactive Oxygen Species in Staurosporine‐Induced Neuronal Apoptosis
Prehn, J. H. M., Jordán, J., Ghadge, G. D., Preis, E., Galindo, M. F., Roos, R. P., Krieglstein, J., & Miller, R. J. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.68041679.x · Cited by 126 · see citing works
Increased Apoptosis Arising from Increased Expression of the Alzheimer's Disease–associated Presenilin-2 Mutation (N141I)
Janicki, S. M., & Monteiro, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.2.485 · Cited by 118 · see citing works
Soluble derivatives of the β amyloid protein precursor in cerebrospinal fluid
Palmert, M. R., Usiak, M., Mayeux, R. P., Raskind, M. A., Tourtellotte, W. W., & Younkin, S. G. (1990) · Neurology · doi:10.1212/wnl.40.7.1028 · Cited by 106 · see citing works
Neuronal Localization of Presenilin-1 and Association with Amyloid Plaques and Neurofibrillary Tangles in Alzheimer’s Disease
Busciglio, J. A., Hartmann, H., Lorenzo, A., Wong, C. W., Baumann, K., Sommer, B., Staufenbiel, M., & Yankner, B. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-13-05101.1997 · Cited by 90 · see citing works
Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains
Elder, G. A., Tezapsidis, N., Carter, J. E., Shioi, J., Bouras, C., Li, H. ‐., Johnston, J. M., Efthimiopoulos, S., Friedrich, V. L., & Robakis, N. K. R. K. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960801)45:3 · Cited by 90 · see citing works
Thapsigargin-induced persistent intracellular calcium pool depletion and apoptosis in human hepatoma cells
Kaneko, Y., & Tsukamoto, A. (1994) · Cancer Letters · doi:10.1016/0304-3835(94)90253-4 · Cited by 85 · see citing works
Free Radicals, Calcium., and The Synaptic Plasticity-Cell Death Continuum: Emerging Roles of The Transcription Factor Nfκb
Mattson, M. P. (1998) · International review of neurobiology · doi:10.1016/s0074-7742(08)60609-1 · Cited by 69 · see citing works
Self-citation
Analysis of compound heterozygous mice reveals that the Trembler mutation can behave as a gain‐of‐function allele
Adlkofer, K., Naef, R., & Suter, U. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970915)49:6 · Cited by 59 · see citing works
Widespread neuronal expression of the presenilin-1 early-onset Alzheimer's disease gene in the murine brain.
Cribbs, D. H., Chen, L.-S., Bende, S. M., & LaFerla, F. M. (1996) · Europe PMC (PubMed Central) · Cited by 55 · see citing works
Presenilin-1-immunoreactive neurons are preserved in late-onset Alzheimer's disease.
Giannakopoulos, P., Bouras, C., Kövari, E., Shioi, J., Tezapsidis, N., Hof, P. R., & Robakis, N. K. (1997) · Europe PMC (PubMed Central) · Cited by 53 · see citing works
Decreased Inositol (1,4,5)-Trisphosphate Receptor Levels in Alzheimer's Disease Cerebral Cortex: Selectivity of Changes and Possible Correlation to Pathological Severity
Haug, L. S., Østvold, A. C., Cowburn, R. F., Garlind, A., Winblad, B. G., Bogdanovich, N. K., & Walaas, S. I. (1996) · Neurodegeneration · doi:10.1006/neur.1996.0024 · Cited by 53 · see citing works
β-Amyloid polypeptide increases calcium-uptake in PC12 cells: a possible mechanism for its cellular toxicity in Alzheimer's disease
Fukuyama, R., Wadhwani, K. C., Galdzicki, Z., Rapoport, S. I., & Ehrenstein, G. (1994) · Brain Research · doi:10.1016/0006-8993(94)91505-9 · Cited by 46 · see citing works
Effects of intraventricular transplantation of NGF-secreting cells on cholinergic basal forebrain neurons after partial immunolesion
Ro�ner, S., Yu, J., Pizzo, D. P., Werrbach‐Perez, K., Schliebs, R., Bigl, V., & Perez-Polo, J. R. (1996) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19960701)45:1 · Cited by 41 · see citing works
Antibodies to presenilin proteins detect neurofibrillary tangles in Alzheimer's disease.
Murphy, G. M., Forno, L. S., Ellis, W. G., Nochlin, D., Levy‐Lahad, E., Poorkaj, P., Bird, T. D., Jiang, Z., & Cordell, B. (1996) · Europe PMC (PubMed Central) · Cited by 40 · see citing works
Sequence-specific interaction of α β-anomeric doublestranded DNA with the p50 subunit of NFxB: application to the decoy approach
Tanaka, H., Vickart, P., Bertrand, J., Rayner, B., Morvan, F., Imbach, J., Paulin, D., & Malvy, C. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.15.3069 · Cited by 30 · see citing works
Nerve Growth Factor-independent Reduction in Choline Acetyltransferase Activity in PC12 Cells Expressing Mutant Presenilin-1
Pedersen, W. A., Guo, Q., Hartman, B. K., & Mattson, M. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22397 · Cited by 23 · see citing works
Self-citation
Bifunctional fusion between nerve growth factor and a transferrin receptor antibody
McGrath, J. P., Cao, X., Schutz, A. J., Lynch, P., Ebendal, T., Coloma, M. J., Morrison, S. L., & Putney, S. D. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970115)47:2 · Cited by 20 · see citing works
Alteration of acylphosphatase levels in familial Alzheimer's disease fibroblasts with presenilin gene mutations
Liguri, G., Cecchi, C., Latorraca, S., Pieri, A., Sorbi, S., Degl’Innocenti, D., & Ramponi, G. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)12696-3 · Cited by 19 · see citing works
Amyloid βprotein precursors with kunitz-type inhibitor domains and acetyl-cholinesterase in cerebrospinal fluid from patients with dementia of the Alzheimer type
Urakami, K., Takahashi, K., Saito, H., Okada, A., Nakamura, S., Tanaka, S., Kitaguchi, N., Tokushima, Y., & Yamamoto, S. (2009) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1992.tb04057.x · Cited by 14 · see citing works
Chapter 6 Contribution of Mitochondrial Alterations to Brain Aging
Benzi, G., & Moretti, A. (1997) · Advances in cell aging and gerontology · doi:10.1016/s1566-3124(08)60056-5 · Cited by 11 · see citing works

Flagged first, then by citations

2 of the 85 references couldn’t be matched to a known paper.

Research works printed but not linked: 8

Loo, D. T., Copani, A., Pike, C. J., Whittemore, E. R., Walencewicz, A. J., and Cotman, C. W. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 7951-7955
Clark, R. F., Hutton, M., Fuldner, R., Froelich, S., Karran, E., Talbot, C., Crook, R., Lendon, C., Prihar, G., He, C., Korenblat, K., Martinez, A., Wragg, M., Busfield, F., Behrens, M. J., Myers, A., Norton, J., Morris, J., Mehta, N., Pearson, C., Lincoln, S., Baker, M., Duff, K., Zehr, C., Perez-Tur, J., Houlden, H., Ruiz, A., Ossa, J., Lopera, F., Arcos, M., Madrigal, L., Collinge, J., Humphreys, C., Ashworth, A., Sarner, S., Fox, N., Harvey, R., Kennedy, A., Roques, P., Cline, R. T., Phillips, C. A., Venter, J. C., Forsell, L., Axelman, K., Lilius, L., Johnston, J., Cowburn, R., Vitanen, M., Winblad, B., Kosik, K., Haltia, M., Poyhonen, M., Dickson, D., Mann, D., Neary, D., Snowden, J., Lantos, P., Lannfelt, L., Rossor, M., Roberts, G. W., Adams, M. D., Hardy, J., and Goate, A. (1995) Nat. Genet. 11, 219 -222
Cook, D. B., Sung, J. C., Golde, T. E., Felsenstein, K. M., Wojczyk, B. S., Tanzi, R. E., Trojanowski, J. Q., Lee, V. M. Y., and Doms, R. W. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9223-9228
Barger, S. W., Horster, D., Furukawa, K., Goodman, Y., Krieglstein, J., and Mattson, M. P. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9328 -9332
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., and Kaltschmidt, C. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2642-2647
Shearman, M. S., Ragan, C. I., and Iversen, L. L. (1994) Proc. Natl. Acad. Sci.
Ito, E., Oka, K., Etcheberrigaray, R., Nelson, T. J., McPhie, D. L., Tofel-Grehl, B., Gibson, G. E., and Alkon, D. L. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 534 -538
Xia, W., Zhang, J., Perez, R., Koo, E. H., and Selkoe, D. J. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 8208 -8213

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The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease
Korte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097 · see citing works
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Self-citation
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Cheng, G., Yu, Z., Zhou, D., & Mattson, M. P. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7920 · Cited by 81 · see citing works
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Yu, Z., Zhou, D., Cheng, G., & Mattson, M. P. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:15:1:31 · Cited by 77 · see citing works
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Bisaglia, M., Venezia, V., Piccioli, P., Stanzione, S., Porcile, C., Russo, C., Mancini, F. R., Milanese, C., & Schettini, G. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00136-x · Cited by 71 · see citing works
Stimulus-Dependent Activation of NF-kappaB Specifies Apoptosis
Kaltschmidt, B., Heinrich, M., & Kaltschmidt, C. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:3:299 · Cited by 70 · see citing works
Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations
Guo, Q., Fu, W., Holtsberg, F. W., Steiner, S. M., & Mattson, M. P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990601)56:5 · Cited by 69 · see citing works
Self-citation
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Huang, X., Chen, Y., Zhang, H., Ma, Q., Zhang, Y., & Xu, H. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.10.007 · Cited by 68 · see citing works
The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor κB in neurons
Camandola, S., Poli, G., & Mattson, M. P. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00234-5 · Cited by 68 · see citing works
Self-citation
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Milhavet, O., Martindale, J. L., Camandola, S., Chan, S. L., Gary, D. S., Cheng, A., Holbrook, N. J., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01165.x · Cited by 66 · see citing works
Self-citation
Presenilin mutations and calcium signaling defects in the nervous and immune systems
Mattson, M. P., Chan, S. L., & Camandola, S. (2001) · BioEssays · doi:10.1002/bies.1103 · Cited by 66 · see citing works
Self-citation
Potential role of NF‐κB in adult neural stem cells: the underrated steersman?
Widera, D., Mikenberg, I., Kaltschmidt, B., & Kaltschmidt, C. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.017 · Cited by 65 · see citing works
Overexpression of atypical PKC in PC12 cells enhances NGF-responsiveness and survival through an NF-κB dependent pathway
Wooten, M. W., Seibenhener, M. L., Zhou, G., Vandenplas, M. L., & Tan, T. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400548 · Cited by 64 · see citing works
Magnesium Modulates Amyloid-β Protein Precursor Trafficking and Processing
Yu, J. H., Sun, M., Chen, Z., Lu, J., Liu, Y., Zhou, L., Xu, X., Fan, D., & Chui, D. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091444 · Cited by 61 · see citing works
Temporal Relations Among Amyloid β-Peptide-Induced Free-Radical Oxidative Stress, Neuronal Toxicity, and Neuronal Defensive Responses
Yatin, S. M., Aksenova, M. V., Aksenov, M. Y., Markesbery, W. R., Aulick, T., & Butterfield, D. A. (1998) · Journal of Molecular Neuroscience · doi:10.1385/jmn:11:3:183 · Cited by 61 · see citing works
ER-stress in Alzheimer's disease: turning the scale?
Endres, K., & Reinhardt, S. (2013) · Europe PMC (PubMed Central) · Cited by 54 · see citing works
The NF-κB Signaling Pathway Is Not Required for Fas Ligand Gene Induction but Mediates Protection from Activation-induced Cell Death
Rivera-Walsh, I., Cvijic, M. E., Xiao, G., & Sun, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000444200 · Cited by 55 · see citing works
Distinct destructive signal pathways of neuronal death in Alzheimer's disease
Shen, Y., He, P., Zhong, Z., McAllister, C. E., & Lindholm, K. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.002 · Cited by 53 · see citing works
Formononetin Protects Neurons Against Hypoxia-Induced Cytotoxicity Through Upregulation of ADAM10 and sAβPPα
Sun, M., Zhou, T., Zhou, L., Chen, Q., Yu, Y., Yang, H., Zhong, K., Zhang, X., Xu, F., Cai, S., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110506 · Cited by 52 · see citing works
Neuronal survival activity of S100ββ is enhanced by calcineurin inhibitors and requires activation of NF‐κB
Alexanian, A. R., & Bamburg, J. R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1611 · Cited by 52 · see citing works
Cellular delivery of a double-stranded oligonucleotide
Fisher, L., Soomets, U., Toro, V. C., Chilton, L., Jiang, Y., Langel, Ü., & Iverfeldt, K. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302291 · Cited by 50 · see citing works
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Eggert, S., Kins, S., Endres, K., & Brigadski, T. (2022) · Biological Chemistry · doi:10.1515/hsz-2021-0330 · Cited by 46 · see citing works
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Cohen, H., Kozlovsky, N., Matar, M. A., Zohar, J., & Kaplan, Z. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.118 · Cited by 49 · see citing works
Dysregulation of calcium in Alzheimer's disease
Brzyska, M., & Elbaum, D. (2003) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2003-1465 · Cited by 49 · see citing works
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Ezquerra, M., Pardo, C. C., Blesa, R., Gelpí, J. L., Ballesta, F., & Oliva, R. (1999) · Neurology · doi:10.1212/wnl.52.3.566 · Cited by 48 · see citing works
Kainic acid-induced activation of nuclear factor-κB in rat hippocampus
Matsuoka, Y., Kitamura, Y., Okazaki, M., Terai, K., & Taniguchi, T. (1999) · Experimental Brain Research · doi:10.1007/s002210050616 · Cited by 48 · see citing works
Presenilin-1 regulates the neuronal threshold to excitotoxicity both physiologically and pathologically
Grilli, M., Diodato, E., Lozza, G., Brusa, R., Casarini, M. J., Uberti, D. L., Rozmahel, R. F., Westaway, D. A., George‐Hyslop, P. S., Memo, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12822 · Cited by 47 · see citing works
Selective and biphasic effect of the membrane lipid peroxidation product 4‐hydroxy‐2,3‐nonenal on N‐methyl‐ d ‐aspartate channels
Lu, C., Chan, S. L., Haughey, N. J., Lee, W., & Mattson, M. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00431.x · Cited by 45 · see citing works
Self-citation
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Self-citation
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Calabrese, E. J. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440801981973 · Cited by 44 · see citing works
Statins and the Squalene Synthase Inhibitor Zaragozic Acid Stimulate the Non-Amyloidogenic Pathway of Amyloid-β Protein Precursor Processing by Suppression of Cholesterol Synthesis
Kojro, E., Füger, P., Prinzen, C., Kanarek, A. M., Rat, D., Endres, K., Fahrenholz, F., & Postina, R. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091621 · Cited by 45 · see citing works
Age-related differences in NFκB translocation and Bcl-2/Bax ratio caused by TNFα and Abeta42 promote survival in middle-age neurons and death in old neurons
Patel, J. R., & Brewer, G. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.007 · Cited by 42 · see citing works
Protein kinase C iota protects neural cells against apoptosis induced by amyloid β-peptide
Xie, J., Guo, Q., Zhu, H., Wooten, M. W., & Mattson, M. P. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00187-x · Cited by 42 · see citing works
Self-citation
Creatine enhances survival of glutamate‐treated neuronal/glial cells, modulates Ras/NF‐κB signaling, and increases the generation of reactive oxygen species
Juravleva, E., Barbakadze, T., Mikeladze, D., & Kekelidze, T. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20291 · Cited by 41 · see citing works
Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus
Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-376 · Cited by 39 · see citing works
Nuclear Factor-κB Activated by Capacitative Ca2+ Entry Enhances Muscarinic Receptor-mediated Soluble Amyloid Precursor Protein (sAPPα) Release in SH-SY5Y Cells
Choi, S., Kim, J. H., Roh, E.-J., Ko, M.-J., Jung, J., & Kim, H. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601018200 · Cited by 39 · see citing works
Execution of BMP-4-induced apoptosis by p53-dependent ER dysfunction in myeloma and B-cell hybridoma cells
Fukuda, N., Saitoh, M., Kobayashi, N., & Miyazono, K. (2006) · Oncogene · doi:10.1038/sj.onc.1209393 · Cited by 38 · see citing works
NF-κB activated by ER calcium release inhibits Aβ-mediated expression of CHOP protein: Enhancement by AD-linked mutant presenilin 1
Schapansky, J., Olson, K. L., der Ploeg, R. V., & Glazner, G. W. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.04.009 · Cited by 35 · see citing works

Mutant Presenilin-1 Induces Apoptosis and Downregulates Akt/PKB
Weihl, C. C., Ghadge, G. D., Kennedy, S. G., Hay, N., Miller, R. J., & Roos, R. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05360.1999 · Cited by 137 · see citing works
Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals
Guo, Q., Sopher, B. L., Furukawa, K., Pham, D. G., Robinson, N., Martin, G. M., & Mattson, M. P. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-11-04212.1997 · Cited by 487 · see citing works
Self-citation
Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: Reduced oxidative stress and preserved mitochondrial function
Guo, Q., Christakos, S., Robinson, N., & Mattson, M. P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.3227 · Cited by 220 · see citing works
Self-citation
P3–402: Pathogenic mutations of presenilins enhance pro–apoptotic activity by reducing mitochondrial Bcl–2
Nishimura, M., Wang, H., Nakaya, Y., Du, Z., Yamane, T., Shirane, M., Kudo, T., Takeda, M., & Nakayama, K. I. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1673
Presenilins, the Endoplasmic Reticulum, and Neuronal Apoptosis in Alzheimer's Disease
Mattson, M. P., Guo, Q., Furukawa, K., & Pedersen, W. A. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70010001.x · Cited by 246 · see citing works
Self-citation

Authors: Guo, Q., Robinson, N., & Mattson, M. P.
Affiliations: University of Kentucky (US)
Corresponding author: Mattson, Mark P.
ORCID: Guo, Qing
Mattson, Mark P.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-05
Volume: 273
Issue: 20
Pages: 12341-12351
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.20.12341
OpenAlex: W2055585878
Cited by: 196
References: 85
Citations by year: 2026: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 5
FWCI: 13.93
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8191 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ag014554-07, 5r01ns035253-03, NS35253, AG05144, AG14554)
National Institute on Aging (P50AG005144, AG14554, AG-05144)
National Institute of Neurological Disorders and Stroke (NS 35253)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: presenilin 1, amyloid precursor protein, sAPPα, NF-κB, apoptosis, Alzheimer's disease, calcium homeostasis, endoplasmic reticulum calcium release, thapsigargin, mitochondrial dysfunction, oxidative stress, amyloid-beta, PC12 cells
MeSH terms: Animals, Calcium, Homeostasis, Humans, Membrane Proteins, Mutation, Amyloid beta-Peptides, NF-kappa B, Amyloid beta-Protein Precursor, PC12 Cells, Apoptosis, Rats, Presenilin-1

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Secreted β-Amyloid Precursor Protein Counteracts the Proapoptotic Action of Mutant Presenilin-1 by Activation of NF-κB and Stabilization of Calcium Homeostasis

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