The DOI matches its Crossref record; 83 of the 85 references it cites were found in a registry or an index.
Secreted β-Amyloid Precursor Protein Counteracts the Proapoptotic Action of Mutant Presenilin-1 by Activation of NF-κB and Stabilization of Calcium Homeostasis
Open accessAbstract
Mutations in the presenilin-1 (PS-1) gene account for approximately 50% of the cases of autosomal dominant, early onset, inherited forms of Alzheimer's disease (AD). PS-1 is an integral membrane protein expressed in neurons and is localized primarily in the endoplasmic reticulum (ER). PS-1 mutations may promote neuronal degeneration by altering the processing of the beta-amyloid precursor protein (APP) and/or by engaging apoptotic pathways. Alternative processing of APP in AD may increase production of neurotoxic amyloid beta-peptide (Abeta) and reduce production of the neuroprotective alpha-secretase-derived form of APP (sAPPalpha). In differentiated PC12 cells expressing an AD-linked PS-1 mutation (L286V), sAPPalpha activated the transcription factor NF-kappaB and prevented apoptosis induced by Abeta. Treatment of cells with kappaB decoy DNA blocked the antiapoptotic action of sAPPalpha, demonstrating the requirement for NF-kappaB activation in the cytoprotective action of sAPPalpha. Cells expressing mutant PS-1 exhibited an aberrant pattern of NF-kappaB activity following exposure to Abeta, which was characterized by enhanced early activation of NF-kappaB followed by a prolonged depression of activity. Blockade of NF-kappaB activity in cells expressing mutant PS-1 by kappaB decoy DNA was associated with enhanced Abeta-induced increases of [Ca2+]i and mitochondrial dysfunction. Treatment of cells with sAPPalpha stabilized [Ca2+]i and mitochondrial function and suppressed oxidative stress by a mechanism involving activation of NF-kappaB. Blockade of ER calcium release prevented (and stimulation of ER calcium release by thapsigargin induced) apoptosis in cells expressing mutant PS-1, suggesting a pivotal role for ER calcium release in the proapoptotic action of mutant PS-1. Finally, a role for NF-kappaB in preventing apoptosis induced by ER calcium release was demonstrated by data showing that sAPPalpha prevents thapsigargin-induced apoptosis, an effect blocked by kappaB decoy DNA. We conclude that sAPPalpha stabilizes cellular calcium homeostasis and protects neural cells against the proapoptotic action of mutant PS-1 by a mechanism involving activation of NF-kappaB. The data further suggest that PS-1 mutations result in aberrant NF-kappaB regulation that may render neurons vulnerable to apoptosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“These analyses indicated significant Aβ42-mediated upregulation in the expression of a family of genes encoding the cytokines IL-1β, CEX-1, and TNF-α, COX-2, B94, and the proapoptotic Bax and Bik proteins (Guo et al., 1998; Metcalfe et al., 2004; Tarte et al., 2004).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
In the citing paper
“The amyloid plaque of AD shows Aβ40/Aβ42 enriched ratio (Guo et al., 1998; Selkoe and Kopan, 2003)”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
In the citing paper
“sAPPα promotes neuritogenesis and long-term survival of neurons in culture and protects brain cells against the toxicity of Aβ40 and Aβ42 peptides and excitotoxic and ischemic injury both in cell cultures and in vivo (Guo et al., 1998; Stein and Johnson, 2003).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
In the citing paper
“sAPPα also protect neural cells against the proapoptotic thapsigargin, an inhibitor of the endoplasmic reticulum Ca2+-ATPase, and the adverse effect of thapsigargin can be abolished in cells overexpressing antiapoptotic Bcl-2 (Guo et al., 1998).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
In the citing paper
“Furthermore, NPD1 biosynthesis is enhanced by the neurotrophic peptide sAPPα, a 612-amino acid fragment derived from α-secretase-mediated cleavage of βAPP (Guo et al., 1998; Selkoe and Kopan, 2003).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Guo et al., 1998
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., et al. (1995) · Nature · doi:10.1038/375754a0 · Cited by 4,051
An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death
Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047
Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599
Suppression of TNF-α-Induced Apoptosis by NF-κB
Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., & Verma, I. M. (1996) · Science · doi:10.1126/science.274.5288.787 · Cited by 2,581
Oxidative stress hypothesis in Alzheimer’s disease
Markesbery, W. R. (1997) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(96)00629-6 · Cited by 2,383
Hydrogen peroxide mediates amyloid β protein toxicity
Behl, C. (1994) · Cell · doi:10.1016/0092-8674(94)90131-7 · Cited by 2,074
Differential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/386855a0 · Cited by 1,763
Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,633
Self-citationDifferential activation of transcription factors induced by Ca2+ response amplitude and duration
Dolmetsch, R. E., Lewis, R. S., Goodnow, C. C., & Healy, J. I. (1997) · Nature · doi:10.1038/40912 · Cited by 1,521
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C.-M., Pérez‐Tur, J., Hutton, M., Buée, L., Harigaya, Y., Yager, D., et al. (1996) · Nature · doi:10.1038/383710a0 · Cited by 1,486
Flagged first, then by citations
2 of the 85 references couldn’t be matched to a known paper.
Research works printed but not linked: 4
- Cribbs, 1996, Am. J. Pathol., 148, 1797
- Murphy, 1996, Am. J. Pathol., 149, 1839
- Giannakopoulos, 1997, Am. J. Pathol., 150, 429
- Marin, 1996, Oncogene, 12, 2259
Cited by
Sorted by citations
Control of apoptosis by Rel/NF-κB transcription factors
Barkett, M., & Gilmore, T. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203238 · Cited by 1,202
Korte, S. M., Koolhaas, J. M., Wingfield, J. C., & McEwen, B. S. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.08.009 · Cited by 1,097
Calcium dyshomeostasis and intracellular signalling in alzheimer's disease
LaFerla, F. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn960 · Cited by 988
NF-κB in neuronal plasticity and neurodegenerative disorders
Mattson, M. P., & Camandola, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11916 · Cited by 877
Self-citationLukiw, W. J. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25420 · Cited by 897
Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the α-secretase ADAM 10
Kojro, E., Gimpl, G., Lammich, S., März, W., & Fahrenholz, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.081612998 · Cited by 804
To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis
Kucharczak, J., Simmons, M. J., Fan, Y., & Gélinas, C. (2003) · Oncogene · doi:10.1038/sj.onc.1207230 · Cited by 773
Not just amyloid: physiological functions of the amyloid precursor protein family
Müller, U. C., Deller, T., & Korte, M. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.29 · Cited by 634
Roles for NF-κB in nerve cell survival, plasticity, and disease
Mattson, M. P., & Meffert, M. K. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401837 · Cited by 612
Self-citationGuo, Q., Fu, W., Sopher, B. L., Miller, M. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Nature Medicine · doi:10.1038/4789 · Cited by 489
Self-citationNew Insights into the Role of Nuclear Factor-κB in Cell Growth Regulation
Chen, F., Castranova, V., & Shi, X. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)61708-7 · Cited by 472
Roles of Nuclear Factor κB in Neuronal Survival and Plasticity
Mattson, M. P., Culmsee, C., Yu, Z., & Camandola, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740443.x · Cited by 449
Self-citationNeuronal and glial calcium signaling in Alzheimer’s disease
Mattson, M. P., & Chan, S. L. (2003) · Cell Calcium · doi:10.1016/s0143-4160(03)00128-3 · Cited by 459
Self-citationChen, C.-H., Zhou, W., Liu, S., Deng, Y., Cai, F., Tone, M., Tone, Y., Tong, Y., & Song, W. (2012) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000149 · Cited by 433
Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival
Bhakar, A. L., Tannis, L.-L., Zeindler, C., Russo, M. P., Jobin, C., Park, D. S., MacPherson, S., & Barker, P. A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08466.2002 · Cited by 310
Chan, S. L., Mayne, M. B., Holden, C. P., Geiger, J. D., & Mattson, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000040200 · Cited by 314
Self-citationNeurodegenerative disorders and ischemic brain diseases
Mattson, M. P., Duan, W., Pedersen, W. A., & Culmsee, C. (2001) · APOPTOSIS · doi:10.1023/a:1009676112184 · Cited by 307
Self-citationInhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis
Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., & Kaltschmidt, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9409 · Cited by 281
Baghdiguian, S., Martin, M., Richard, I., Pons, F., Astier, C., Bourg, N., Hay, R. T., Chemaly, R., Halaby, G., Loiselet, J., et al. (1999) · Nature Medicine · doi:10.1038/8385 · Cited by 277
Larson, J., LYNCH, G. S., Games, D., & Seubert, P. A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01698-4 · Cited by 291
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease
Reddy, P. H. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.042 · Cited by 266
NF-κB in the Survival and Plasticity of Neurons
Mattson, M. P. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6961-x · Cited by 254
Self-citationOmega-3 fatty acids, pro-inflammatory signaling and neuroprotection
Bazan, N. G. (2007) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e32802b7030 · Cited by 252
Nerve Growth Factor-Dependent Activation of NF-κB Contributes to Survival of Sympathetic Neurons
Maggirwar, S. B., Sarmiere, P. D., Dewhurst, S., & Freeman, R. S. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10356.1998 · Cited by 225
Yu, Z., Zhou, D., Bruce‐Keller, A. J., Kindy, M. S., & Mattson, M. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08856.1999 · Cited by 248
Self-citationCalcium dysregulation in Alzheimer's disease
Bojarski, Ł., Herms, J. W., & Kuźnicki, J. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.10.002 · Cited by 207
NF-κB functions in the nervous system: From development to disease
Mémet, S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.09.003 · Cited by 203
Guo, Q., Sebastian, L., Sopher, B. L., Miller, M. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721019.x · Cited by 197
Self-citationA molecular mechanism of aluminium-induced Alzheimer's disease?
Exley, C. (1999) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(99)00125-7 · Cited by 184
Dysregulation of Cellular Calcium Homeostasis in Alzheimer's Disease: Bad Genes and Bad Habits
Mattson, M. P., & Chan, S. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:205 · Cited by 181
Self-citationMattson, M. P., Zhu, H., Yu, J., & Kindy, M. S. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01358.2000 · Cited by 172
Self-citationNeuroplasticity in Alzheimer's disease
Teter, B., & Ashford, J. W. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10441 · Cited by 170
Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities
Yu, J., Chang, R. C., & Tan, L. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.07.009 · Cited by 169
Begley, J. G., Duan, W., Chan, S. L., Duff, K., & Mattson, M. P. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0721030.x · Cited by 158
Self-citationPresenilins and Alzheimer’s disease: biological functions and pathogenic mechanisms
Czech, C., Tremp, G. L., & Pradier, L. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00033-7 · Cited by 160
Ray, B., & Lahiri, D. K. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.012 · Cited by 150
Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148
Oxidative Stress, Perturbed Calcium Homeostasis, and Immune Dysfunction in Alzheimer's Disease
Mattson, M. P. (2002) · Journal of NeuroVirology · doi:10.1080/13550280290100978 · Cited by 143
Self-citationApoptosis by Par-4 in cancer and neurodegenerative diseases
El-Guendy, N., & Rangnekar, V. M. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(02)00016-2 · Cited by 132
NF-κB transcription factors: critical regulators of hematopoiesis and neuronal survival
Denk, A., Wirth, T., & Baumann, B. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00009-5 · Cited by 129
Alzheimer’s disease due to loss of function: A new synthesis of the available data
Kepp, K. P. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.06.004 · Cited by 123
Guo, Q., Sebastian, L., Sopher, B. L., Miller, M. W., Glazner, G. W., Ware, C. B., Martin, G. M., & Mattson, M. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4125 · Cited by 124
Self-citationCheema, Z. F., Wade, S. B., Sata, M., Walsh, K., Sohrabji, F., & Miranda, R. C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01754.1999 · Cited by 158
Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease
Camandola, S., & Mattson, M. P. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.10.005 · Cited by 128
Self-citationKojro, E., Postina, R., Buro, C., Meiringer, C., Gehrig‐Burger, K., & Fahrenholz, F. (2006) · The FASEB Journal · doi:10.1096/fj.05-4812fje · Cited by 118
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα
Mockett, B. G., Richter, M., Abraham, W. C., & Müller, U. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00030 · Cited by 127
Cyclooxygenase-2 is a neuronal target gene of NF-κB
Kaltschmidt, B., Linker, R. A., Deng, J., & Kaltschmidt, C. (2002) · BMC Molecular Biology · doi:10.1186/1471-2199-3-16 · Cited by 115
APP Receptor? To Be or Not To Be
Deyts, C., Thinakaran, G., & Parent, A. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.01.005 · Cited by 121
Mattson, M. P., & Pedersen, W. A. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00082-3 · Cited by 108
Self-citationYogev‐Falach, M., Amit, T., Bar‐Am, O., Weinstock, M., & Youdim, M. B. H. (2002) · The FASEB Journal · doi:10.1096/fj.02-0198fje · Cited by 104
Fu, W., Lu, C., & Mattson, M. P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-24-10710.2002 · Cited by 105
Self-citationLang, H., Schulte, B. A., Zhou, D., Smythe, N. M., Spicer, S. S., & Schmiedt, R. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2488-05.2006 · Cited by 101
Mattson, M. P., Guo, Z. H., & Geiger, J. D. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0730532.x · Cited by 96
Self-citationHabib, A., Sawmiller, D. R., & Tan, J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23823 · Cited by 95
Guan, P.-P., Cao, L., & Wang, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115900 · Cited by 99
Apoptotic and Anti‐Apoptotic Synaptic Signaling Mechanisms
Mattson, M. P. (2000) · Brain Pathology · doi:10.1111/j.1750-3639.2000.tb00264.x · Cited by 94
Self-citationHirakura, Y., Lin, M.-C., & Kagan, B. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991201)58:5 · Cited by 25
Role of amyloid beta in lipid homeostasis
Grösgen, S., Grimm, M. O. W., Frieß, P., & Hartmann, T. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.05.002 · Cited by 90
APP as a Protective Factor in Acute Neuronal Insults
Hefter, D., & Draguhn, A. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00022 · Cited by 97
Molecular basis of Alzheimer's disease
Drouet, B., Pinçon‐Raymond, M., Chambaz, J., & Pillot, T. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050035 · Cited by 96
Neuropathology of synuclein aggregates
Duda, J. E., Lee, V. M. ‐., & Trojanowski, J. Q. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000715)61:2 · Cited by 263
Self-citationRoles of amyloid precursor protein family members in neuroprotection, stress signaling and aging
Kögel, D., Deller, T., & Behl, C. (2011) · Experimental Brain Research · doi:10.1007/s00221-011-2932-4 · Cited by 97
Calsenilin Enhances Apoptosis by Altering Endoplasmic Reticulum Calcium Signaling
Lilliehöök, C., Chan, S. L., Choi, E., Zaidi, N. F., Wasco, W., Mattson, M. P., & Buxbaum, J. D. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2001.1096 · Cited by 86
Self-citationNurmi, A., Vartiainen, N. E., Pihlaja, R., Goldsteins, G., Yrjänheikki, J., & Koıstınaho, J. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02756.x · Cited by 85
Cheng, G., Yu, Z., Zhou, D., & Mattson, M. P. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7920 · Cited by 81
Self-citationNeuroprotective Role for the p50 Subunit of NF-κB in an Experimental Model of Huntington's Disease
Yu, Z., Zhou, D., Cheng, G., & Mattson, M. P. (2000) · Journal of Molecular Neuroscience · doi:10.1385/jmn:15:1:31 · Cited by 77
Self-citationBisaglia, M., Venezia, V., Piccioli, P., Stanzione, S., Porcile, C., Russo, C., Mancini, F. R., Milanese, C., & Schettini, G. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(01)00136-x · Cited by 71
Stimulus-Dependent Activation of NF-kappaB Specifies Apoptosis
Kaltschmidt, B., Heinrich, M., & Kaltschmidt, C. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:3:299 · Cited by 70
Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations
Guo, Q., Fu, W., Holtsberg, F. W., Steiner, S. M., & Mattson, M. P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990601)56:5 · Cited by 69
Self-citationHuang, X., Chen, Y., Zhang, H., Ma, Q., Zhang, Y., & Xu, H. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.10.007 · Cited by 68
Camandola, S., Poli, G., & Mattson, M. P. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00234-5 · Cited by 68
Self-citationInvolvement of Gadd153 in the pathogenic action of presenilin‐1 mutations
Milhavet, O., Martindale, J. L., Camandola, S., Chan, S. L., Gary, D. S., Cheng, A., Holbrook, N. J., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01165.x · Cited by 68
Self-citationPresenilin mutations and calcium signaling defects in the nervous and immune systems
Mattson, M. P., Chan, S. L., & Camandola, S. (2001) · BioEssays · doi:10.1002/bies.1103 · Cited by 67
Self-citationPotential role of NF‐κB in adult neural stem cells: the underrated steersman?
Widera, D., Mikenberg, I., Kaltschmidt, B., & Kaltschmidt, C. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.017 · Cited by 65
Wooten, M. W., Seibenhener, M. L., Zhou, G., Vandenplas, M. L., & Tan, T. (1999) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400548 · Cited by 64
Magnesium Modulates Amyloid-β Protein Precursor Trafficking and Processing
Yu, J. H., Sun, M., Chen, Z., Lu, J., Liu, Y., Zhou, L., Xu, X., Fan, D., & Chui, D. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091444 · Cited by 61
Yatin, S. M., Aksenova, M. V., Aksenov, M. Y., Markesbery, W. R., Aulick, T., & Butterfield, D. A. (1998) · Journal of Molecular Neuroscience · doi:10.1385/jmn:11:3:183 · Cited by 62
ER-stress in Alzheimer's disease: turning the scale?
Endres, K., & Reinhardt, S. (2013) · Europe PMC (PubMed Central) · Cited by 54
Rivera-Walsh, I., Cvijic, M. E., Xiao, G., & Sun, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m000444200 · Cited by 55
Distinct destructive signal pathways of neuronal death in Alzheimer's disease
Shen, Y., He, P., Zhong, Z., McAllister, C. E., & Lindholm, K. (2006) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.10.002 · Cited by 53
Sun, M., Zhou, T., Zhou, L., Chen, Q., Yu, Y., Yang, H., Zhong, K., Zhang, X., Xu, F., Cai, S., et al. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110506 · Cited by 52
Alexanian, A. R., & Bamburg, J. R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1611 · Cited by 52
Cellular delivery of a double-stranded oligonucleotide
Fisher, L., Soomets, U., Toro, V. C., Chilton, L., Jiang, Y., Langel, Ü., & Iverfeldt, K. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302291 · Cited by 51
Eggert, S., Kins, S., Endres, K., & Brigadski, T. (2022) · Biological Chemistry · doi:10.1515/hsz-2021-0330 · Cited by 46
Cohen, H., Kozlovsky, N., Matar, M. A., Zohar, J., & Kaplan, Z. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.118 · Cited by 49
Dysregulation of calcium in Alzheimer's disease
Brzyska, M., & Elbaum, D. (2003) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2003-1465 · Cited by 49
A presenilin 1 mutation (Ser169Pro) associated with early-onset AD and myoclonic seizures
Ezquerra, M., Pardo, C. C., Blesa, R., Gelpí, J. L., Ballesta, F., & Oliva, R. (1999) · Neurology · doi:10.1212/wnl.52.3.566 · Cited by 48
Kainic acid-induced activation of nuclear factor-κB in rat hippocampus
Matsuoka, Y., Kitamura, Y., Okazaki, M., Terai, K., & Taniguchi, T. (1999) · Experimental Brain Research · doi:10.1007/s002210050616 · Cited by 48
Grilli, M., Diodato, E., Lozza, G., Brusa, R., Casarini, M. J., Uberti, D. L., Rozmahel, R. F., Westaway, D. A., George‐Hyslop, P. S., Memo, M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12822 · Cited by 48
Lu, C., Chan, S. L., Haughey, N. J., Lee, W., & Mattson, M. P. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00431.x · Cited by 45
Self-citationChan, S. L., Furukawa, K., & Mattson, M. P. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:167 · Cited by 45
Self-citationPharmacological Enhancement of Neuronal Survival
Calabrese, E. J. (2008) · Critical Reviews in Toxicology · doi:10.1080/10408440801981973 · Cited by 44
Kojro, E., Füger, P., Prinzen, C., Kanarek, A. M., Rat, D., Endres, K., Fahrenholz, F., & Postina, R. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091621 · Cited by 49
Patel, J. R., & Brewer, G. J. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.007 · Cited by 42
Protein kinase C iota protects neural cells against apoptosis induced by amyloid β-peptide
Xie, J., Guo, Q., Zhu, H., Wooten, M. W., & Mattson, M. P. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00187-x · Cited by 43
Self-citationJuravleva, E., Barbakadze, T., Mikeladze, D., & Kekelidze, T. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20291 · Cited by 41
Ryan, M. M., Morris, G. P., Mockett, B. G., Bourne, K., Abraham, W. C., Tate, W. P., & Williams, J. M. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-376 · Cited by 44
Choi, S., Kim, J. H., Roh, E.-J., Ko, M.-J., Jung, J., & Kim, H. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601018200 · Cited by 40
Fukuda, N., Saitoh, M., Kobayashi, N., & Miyazono, K. (2006) · Oncogene · doi:10.1038/sj.onc.1209393 · Cited by 38
Schapansky, J., Olson, K. L., der Ploeg, R. V., & Glazner, G. W. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.04.009 · Cited by 35
Metadata
- Authors
- Guo, Q., Robinson, N., & Mattson, M. P.
- Affiliations
- University of Kentucky (US)
- Corresponding author
- Mattson, Mark P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 273
- Issue
- 20
- Pages
- 12341-12351
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2055585878
- Cited by
- 196
- References
- 85
- Citations by year
- 2026: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 1 · 2013: 5 · 2012: 5
- FWCI
- 13.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ag014554-07, 5r01ns035253-03, NS35253, AG05144, AG14554)
- National Institute on Aging (P50AG005144, AG14554, AG-05144)
- National Institute of Neurological Disorders and Stroke (NS 35253)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- presenilin 1, amyloid precursor protein, sAPPα, NF-κB, apoptosis, Alzheimer's disease, calcium homeostasis, endoplasmic reticulum calcium release, thapsigargin, mitochondrial dysfunction, oxidative stress, amyloid-beta, PC12 cells
- MeSH terms
- Animals, Calcium, Homeostasis, Humans, Membrane Proteins, Mutation, Amyloid beta-Peptides, NF-kappa B, Amyloid beta-Protein Precursor, PC12 Cells, Apoptosis, Rats, Presenilin-1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
