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Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver
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Global- and hepatocyte-specific loss of MARCHF6 in mice results in elevated abundance of G6PD.
“In line with this heightened NADPH demand, global- and hepatocyte-specific loss of MARCHF6 in mice resulted in elevated abundance of G6PD, the rate-limiting enzyme in the NADPH-producing pentose-phosphate pathway, and an SREBP1-sensitive gene [58,59].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [58]
G6PD is the rate-limiting enzyme in the NADPH-producing pentose-phosphate pathway and an SREBP1-sensitive gene.
“In line with this heightened NADPH demand, global- and hepatocyte-specific loss of MARCHF6 in mice resulted in elevated abundance of G6PD, the rate-limiting enzyme in the NADPH-producing pentose-phosphate pathway, and an SREBP1-sensitive gene [58,59].”
From Loss of the E3 ubiquitin ligase MARCHF6 alters hepatic lipid metabolism and drives spontaneous hepatosteatosis (2026) · cites this paper as [58]
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Metadata
- Authors
- Shimomura, I., Shimano, H., Korn, B. S., Bashmakov, Y., & Horton, J. D.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-12
- Volume
- 273
- Issue
- 52
- Pages
- 35299-35306
- ISSN
- 0021-9258
- Cited by
- 333
- References
- 0
- Language
- en
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