Translation of the Alzheimer Amyloid Precursor Protein mRNA Is Up-regulated by Interleukin-1 through 5′-Untranslated Region Sequences

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

Goate, A., Chartier-Harlin, M.-C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L., et al. (1991) · Nature · doi:10.1038/349704a0 · Cited by 4,659

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619

Biologic basis for interleukin-1 in disease.

Dinarello, C. (1996) · Blood · doi:10.1182/blood.v87.6.2095.bloodjournal8762095 · Cited by 4,344

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Scheuner, D., Eckman, C., Jensen, M., Song, X., Citron, M., Suzuki, N., Bird, T. D., Hardy, J., Hutton, M., Kukull, W., et al. (1996) · Nature Medicine · doi:10.1038/nm0896-864 · Cited by 2,599

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Games, D., Adams, D., Alessandrini, R., Barbour, R., Borthelette, P., Blackwell, C., Carr, T., Clemens, J., Donaldson, T., Gillespie, F., et al. (1995) · Nature · doi:10.1038/373523a0 · Cited by 2,516

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012

On Finding All Suboptimal Foldings of an RNA Molecule

Zuker, M. (1989) · Science · doi:10.1126/science.2468181 · Cited by 1,998

Amyloid β-peptide is produced by cultured cells during normal metabolism

Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., et al. (1992) · Nature · doi:10.1038/359322a0 · Cited by 1,921

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A. Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., & Selkoe, D. J. (1992) · Nature · doi:10.1038/360672a0 · Cited by 1,757

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611

Occurrence of neuropathological changes and dementia of Alzheimer’s disease in Down’s syndrome

Wisniewski, K. E., Wisniewski, H. M., & Wen, G. Y. (1985) · Annals of Neurology · doi:10.1002/ana.410170310 · Cited by 1,159

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 900

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathwayPreprint

Gingras, A., Kennedy, S. G., O'Leary, M., Sonenberg, N., & Hay, N. (1998) · Genes & Development · doi:10.1101/gad.12.4.502 · Cited by 885

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

Ma, J., Yee, A., Brewer, H. B., Das, S., & Potter, H. (1994) · Nature · doi:10.1038/372092a0 · Cited by 871

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847

Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

Khoury, J. E., Hickman, S. E., Thomas, C. A., Cao, L., Silverstein, S. C., & Loike, J. D. (1996) · Nature · doi:10.1038/382716a0 · Cited by 727

β-Amyloid-mediated vasoactivity and vascular endothelial damage

Thomas, T., Thomas, G., McLendon, C., Sutton, T., & Mullan, M. (1996) · Nature · doi:10.1038/380168a0 · Cited by 703

The Amyloid Precursor Protein of Alzheimer's Disease in the Reduction of Copper(II) to Copper(I)

Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., Masters, C. L., & Beyreuther, K. T. (1996) · Science · doi:10.1126/science.271.5254.1406 · Cited by 680

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., DONNELLY, R. J., Jacobsen, J. S., Vitek, M. P., & Gajdusek, D. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7606 · Cited by 597

Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

Selkoe, D. J., Podlisny, M. B., Joachim, C. L., Vickers, E., Lee, G. S., Fritz, L. C., & Oltersdorf, T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7341 · Cited by 579

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

Busciglio, J., Gabuzda, D. H., Matsudaira, P., & Yankner, B. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.2092 · Cited by 569

Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.

Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas‐Kramarski, R., JAFFE, E. A., Gandy, S., & Greengard, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10075 · Cited by 563

Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers.

Tokunaga, K., Nakamura, Y., Sakata, K., Fujimori, K., Ohkubo, M., Sawada, K., & Sakiyama, S. (1987) · PubMed · Cited by 537

Untitled work

(1997) · doi:10.1073/pnas.94.4.1550 · Cited by 535

Ameboid microglia as effectors of inflammation in the central nervous system

Giulian, D. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180123 · Cited by 482

Nonsteroidal anti-inflammatory drugs in Alzheimer's disease

Rich, J. B., Rasmusson, D. X., Folstein, M. F., Carson, K. A., Kawas, C., & Brandt, J. (1995) · Neurology · doi:10.1212/wnl.45.1.51 · Cited by 446

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

(1994) · PubMed Central · Cited by 441

βA4 amyloid protein deposition in brain after head trauma

Roberts, G., Gentleman, S., Lynch, A., & Graham, D. I. (1991) · The Lancet · doi:10.1016/0140-6736(91)92724-g · Cited by 440

Formation of β-amyloid protein deposits in brains of transgenic mice

Quon, D. H., Wang, Y., Catalano, R., Scardina, J. M., Murakami, K., & Cordell, B. (1991) · Nature · doi:10.1038/352239a0 · Cited by 405

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

Sanan, D. A., Weisgraber, K. H., Russell, S. J., Mahley, R. W., Huang, D., Saunders, A., Schmechel, D., Wisniewski, T., Frangione, B., & Roses, A. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117407 · Cited by 404

Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage

Siman, R. G., Card, J. P., Nelson, R. B., & Davis, L. G. (1989) · Neuron · doi:10.1016/0896-6273(89)90252-3 · Cited by 344

Apolipoprotein E is a kinetic but not a thermodynamic inhibitor of amyloid formation: implications for the pathogenesis and treatment of Alzheimer disease

Evans, K. C., Berger, E. P., Cho, C. G., Weisgraber, K. H., & Lansbury, P. T. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.763 · Cited by 333

Structural relationship between an iron-regulated RNA-binding protein (IRE-BP) and aconitase: Functional implications

Rouault, T. A., Stout, C. D., Kaptain, S., Harford, J. B., & Klausner, R. D. (1991) · Cell · doi:10.1016/0092-8674(91)90312-m · Cited by 296

Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease?

Andersen, K., Launer, L. J., Ott, A., Hoes, A. W., Breteler, M. M. B., & Albert Hofman, D. (1995) · Neurology · doi:10.1212/wnl.45.8.1441 · Cited by 284

In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

Sheng, J. G., Ito, K., Skinner, R. D., Mrak, R. E., Rovnaghi, C. R., van Eldik, L. J., & Griffin, W. S. T. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00104-2 · Cited by 269

Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1.

Rogers, J. T., Bridges, K. R., Durmowicz, G. P., Glass, J., Auron, P. E., & Munro, H. N. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77341-9 · Cited by 260

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1

Forloni, G., Demicheli, F., Giorgi, S., Bendotti, C., & Angeretti, N. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90202-m · Cited by 257

Ferritin Synthesis in Inflammation: I. PATHOGENESIS OF IMPAIRED IRON RELEASE

Konijn, A. M., & Hershko, C. (1977) · British Journal of Haematology · doi:10.1111/j.1365-2141.1977.tb08806.x · Cited by 247

Sequence homology between human .alpha.1-antichymotrypsin, .alpha.1-antitrypsin, and antithrombin III

Chandra, T., Stackhouse, R., Kidd, V. J., Robson, K., & Woo, S. L. C. (1983) · Biochemistry · doi:10.1021/bi00291a001 · Cited by 198

In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease.

Cohen, M. L., Golde, T. E., Usiak, M., Younkin, L. H., & Younkin, S. G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1227 · Cited by 186

Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury

Nieto‐Sampedro, M., & Berman, M. A. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490170303 · Cited by 177

Expression of the Alzheimer amyloid-promoting factor antichymotrypsin is induced in human astrocytes by IL-1

Das, S., & Potter, H. (1995) · Neuron · doi:10.1016/0896-6273(95)90300-3 · Cited by 167

Differences in the Regulation of Iron Regulatory Protein-1 (IRP-1) by Extra- and Intracellular Oxidative Stress

Pantopoulos, K., Mueller, S., Atzberger, A., Ansorge, W. J., Stremmel, W., & Hentze, M. W. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.15.9802 · Cited by 163

Thyroid Hormone Modulates the Interaction between Iron Regulatory Proteins and the Ferritin mRNA Iron-responsive Element

Leedman, P. J., Stein, A. R., Chin, W. W., & Rogers, J. T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.12017 · Cited by 154

Ferritin translation by interleukin-6: the role of sequences upstream of the start codons of the heavy and light subunit genes

Rogers, J. (1996) · Blood · doi:10.1182/blood.v87.6.2525.bloodjournal8762525 · Cited by 154

Phosphorylation and Activation of both Iron Regulatory Proteins 1 and 2 in HL-60 Cells

Schalinske, K. L., & Eisenstein, R. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.12.7168 · Cited by 125

Regulation of β-amyloid precursor protein isoform mRNAs by transforming growth factor-β1 and interleukin-1β in astrocytes

Gray, C. W., & Patel, A. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90037-p · Cited by 117

Nucleolin and Heterogeneous Nuclear Ribonucleoprotein C Proteins Specifically Interact with the 3′-Untranslated Region of Amyloid Protein Precursor mRNA

Zaidi, S. H. E., & Malter, J. S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17292 · Cited by 110

Relative Increase in Alzheimer's Disease of Soluble Forms of Cerebral Aβ Amyloid Protein Precursor Containing the Kunitz Protease Inhibitory Domain

Moir, R. D., Lynch, T., Bush, A. I., Whyte, S., Henry, A., Portbury, S. D., Multhaup, G., Small, D. H., Tanzi, R. E., Beyreuther, K. T., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.9.5013 · Cited by 103

Interleukin-1: a gene expression system regulated at multiple levels.

Auron, P. E., & Webb, A. C. (1995) · PubMed · Cited by 94

Iron Levels Modulate α‐Secretase Cleavage of Amyloid Precursor Protein

Bodovitz, S., Falduto, M. T., Frail, D. E., & Klein, W. L. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.64010307.x · Cited by 86

NSAIDS inhibit the IL-1β-induced IL-6 release from human post-mortem astrocytes: the involvement of prostaglandin E2

Blom, M. A. A., van Twillert, M. G. H., de Vries, S. C., Engels, F., Finch, C. E., Veerhuis, R., & Eikelenboom, P. (1997) · Brain Research · doi:10.1016/s0006-8993(97)01204-3 · Cited by 79

Differential APP gene expression in rat cerebral cortex, meninges, and primary astroglial, microglial and neuronal cultures

LeBlanc, A. C., Chen, H. Y., AUTILIO‐GAMBETTI, L., & Gambetti, P. L. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80861-v · Cited by 76

Dysregulation of gene expression in mouse trisomy 16, an animal model of Down syndrome.

Holtzman, D. M., Bayney, R. M., Li, Y. W., Khosrovi, H., Berger, C. N., Epstein, C. J., & Mobley, W. C. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05094.x · Cited by 68

Alternative polyadenylation of the amyloid protein precursor mRNA regulates translation.

de Sauvage, F. J., Kruys, V., Marinx, O., Huez, G. A., & Octave, J. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05382.x · Cited by 57

Translational enhancement of H-ferritin mRNA by interleukin-1β acts through 5′ leader sequences distinct from the iron responsive element

Rogers, J. T., Andriotakis, J., Lacroix, L., Durmowicz, G. P., Kasschau, K., & Bridges, K. R. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.13.2678 · Cited by 55

The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2.

Nostrand, W. E. V., Farrow, J. S., Wagner, S. L., Bhasin, R., Goldgaber, D., Cotman, C. W., & Cunningham, D. D. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10302 · Cited by 52

A specific structural interaction of Alzheimer's peptide Aβ1–42 with α1-antichymotrypsin

Janciauskiene, S. M., Eriksson, S., & Wright, H. T. (1996) · Nature Structural & Molecular Biology · doi:10.1038/nsb0896-668 · Cited by 51

HB-GAM is a cytokine present in Alzheimerʼs and Downʼs syndrome lesions

Wısnıewskı, T., Lalowski, M. M., Baumann, M., Rauvala, H., Raulo, E., Nolo, R. M., & Frangione, B. (1996) · Neuroreport · doi:10.1097/00001756-199601310-00068 · Cited by 43

Quantification of APP and APLP2 mRNA in APOE genotyped Alzheimer's disease brains

Johnston, J. A., Norgren, S., Ravid, R., Wasco, W., Winblad, B. G., Lannfelt, L., & Cowburn, R. F. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00161-1 · Cited by 28

IL-1β and TNFα, but not IL-6, induce α1- antichymotrypsin expression in the human astrocytoma cell line U373 MG

Machein, U., Lieb, K., Hüll, M., & Fiebich, B. L. (1995) · Neuroreport · doi:10.1097/00001756-199511270-00004 · Cited by 27

A comprehensive study of the spatiotemporal pattern of β-amyloid precursor protein mRNA and protein in the rat brain: lack of modulation by exogenously applied nerve growth factor

Neve, R. L., Valletta, J. S., Li, Y., Ventosa-Michelman, M., Holtzman, D. M., & Mobley, W. C. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00007-1 · Cited by 19

A new quantitative solution hybridisation-RNase protection assay for APP and APLP2 mRNA

Johnston, J. A., Norgren, S., Annerén, G., Cowburn, R. F., & Lannfelt, L. (1996) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00160-x · Cited by 13

Inflammation and Alzheimer’s disease

Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

Lee, J. W., Lee, Y. K., Yuk, D. Y., Choi, D. Y., Ban, S. B., Oh, K. W., & Hong, J. T. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-37 · Cited by 772

History and progress of hypotheses and clinical trials for Alzheimer’s disease

Liu, P.-P., Xie, Y., Meng, X.-Y., & Kang, J.-S. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0063-8 · Cited by 723

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

Chin-Chan, M., Navarro-Yepes, J., & Quintanilla‐Vega, B. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00124 · Cited by 746

Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.

Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., DONNELLY, R. J., Jacobsen, J. S., Vitek, M. P., & Gajdusek, D. C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7606 · Cited by 597

Expression of amyloid precursor protein mRNAs in endothelial, neuronal and glial cells: modulation by interleukin-1

Forloni, G., Demicheli, F., Giorgi, S., Bendotti, C., & Angeretti, N. (1992) · Molecular Brain Research · doi:10.1016/0169-328x(92)90202-m · Cited by 257

THE EFFECT OF IL-1 ON β AMYLOID PRECURSOR PROTEIN GENE EXPRESSION IN RAT BRAIN

Yube, S. (1997)

Interleukin-1 stimulates the beta-amyloid precursor protein promoter

DONNELLY, R. J., Friedhoff, A. J., Beer, B., Blume, A. J., & Vitek, M. P. (1990) · Cellular and Molecular Neurobiology · doi:10.1007/bf00712843 · Cited by 94

Focusing on IL1-promotion of β-amyloid precursor protein synthesis as an early event in Alzheimer's disease

Blume, A. J., & Vitek, M. P. (1989) · Neurobiology of Aging · doi:10.1016/0197-4580(89)90077-8 · Cited by 36