Cited by 855Enzyme Structure and FunctionDNA Repair MechanismsDNA and Nucleic Acid Chemistry

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DNA Polymerases: Structural Diversity and Common Mechanisms

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Steitz, Thomas A.·1999·Journal of Biological Chemistry

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Abstract

Possibly the earliest enzymatic activity to appear in evolution was that of the polynucleotide polymerases, the ability to replicate the genome accurately being a prerequisite for evolution itself. Thus, one might anticipate that the mechanism by which all polymerases work would be both simple and universal. Further, these enzymatic scribes must faithfully copy the sequences of the genome into daughter nucleic acid or the information contained within would be lost; thus some mechanism of assuring fidelity is required.

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Authors: Steitz, T. A.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Steitz, Thomas A.
ORCID: Steitz, Thomas A.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1999-06
Volume: 274
Issue: 25
Pages: 17395-17398
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.274.25.17395
OpenAlex: W2067371216
Cited by: 848
References: 30
Citations by year: 2026: 25 · 2025: 19 · 2024: 20 · 2023: 23 · 2022: 27 · 2021: 17 · 2020: 20 · 2019: 22 · 2018: 28 · 2017: 23 · 2016: 24 · 2015: 31 · 2014: 34 · 2013: 36 · 2012: 30
FWCI: 32.86
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7793 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: DNA polymerase, structural diversity, polymerase mechanism, DNA replication, replication fidelity, polynucleotide synthesis
MeSH terms: DNA, DNA-Directed DNA Polymerase, Escherichia coli, Metals, Models, Molecular, Templates, Genetic, Taq Polymerase, HIV Reverse Transcriptase

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DNA Polymerases: Structural Diversity and Common Mechanisms

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