DNA Polymerases: Structural Diversity and Common Mechanisms

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Structure of a Covalently Trapped Catalytic Complex of HIV-1 Reverse Transcriptase: Implications for Drug Resistance

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Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

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A general two-metal-ion mechanism for catalytic RNA

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

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Structural basis for the 3′‐5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

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Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP

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STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP

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An attempt to unify the structure of polymerases

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FUNCTION AND STRUCTURE RELATIONSHIPS IN DNA POLYMERASES

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UV-induced DNA damage and repair: a review

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DNA Replication Fidelity

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Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance

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DNA Replication Fidelity

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Eukaryotic DNA Polymerases

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Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde

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Role of Magnesium in Genomic Stability

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Crystal Structure of a Y-Family DNA Polymerase in Action

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STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY

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CELLULAR DNA REPLICASES: Components and Dynamics at the Replication Fork

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The Structure and Function of Telomerase Reverse Transcriptase

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ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

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Cancer in xeroderma pigmentosum and related disorders of DNA repair

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DNA Polymerase γ, The Mitochondrial Replicase

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Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes

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Directed evolution of polymerase function by compartmentalized self-replication

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Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

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Structure of a Transcribing T7 RNA Polymerase Initiation Complex

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OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

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Structure of the Catalytic Core of S. cerevisiae DNA Polymerase η

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The Structural Mechanism of Translocation and Helicase Activity in T7 RNA Polymerase

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Evolution of foot-and-mouth disease virus

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DNA Polymerase Fidelity: Kinetics, Structure, and Checkpoints

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The Oligoadenylate Synthetase Family: An Ancient Protein Family with Multiple Antiviral Activities

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Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing

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Structures of Mismatch Replication Errors Observed in a DNA Polymerase

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Structure and Mechanism of DNA Polymerase β

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RNA Polymerase: Structural Similarities Between Bacterial RNA Polymerase and Eukaryotic RNA Polymerase II

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Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis

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Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations

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Magnesium-Induced Assembly of a Complete DNA Polymerase Catalytic Complex

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Rev1 Employs a Novel Mechanism of DNA Synthesis Using a Protein Template

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Terminal deoxynucleotidyl transferase: The story of a misguided DNA polymerase

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Evolution of DNA Polymerase Families: Evidences for Multiple Gene Exchange Between Cellular and Viral Proteins

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Simplified Normal Mode Analysis of Conformational Transitions in DNA-dependent Polymerases: the Elastic Network Model

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The Palm Subdomain-based Active Site is Internally Permuted in Viral RNA-dependent RNA Polymerases of an Ancient Lineage

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Nucleoside 5′-triphosphates: self-association, acid–base, and metal ion-binding properties in solution

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Structure of BeF3−-Modified Response Regulator PleD: Implications for Diguanylate Cyclase Activation, Catalysis, and Feedback Inhibition

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Human DNA Polymerase κ Encircles DNA: Implications for Mismatch Extension and Lesion Bypass

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Structure of Foot-and-Mouth Disease Virus RNA-dependent RNA Polymerase and Its Complex with a Template-Primer RNA

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Structure of the Tetrahymena Ribozyme

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Toxicity of Nucleoside Analogues Used to Treat AIDS and the Selectivity of the Mitochondrial DNA Polymerase

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Eukaryotic DNA polymerases, a growing family

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Telomerase Mechanism of Telomere Synthesis

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Structural basis for the dual coding potential of 8‐oxoguanosine by a high‐fidelity DNA polymerase

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Unlocking the Sugar “Steric Gate” of DNA Polymerases

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Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase η

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Using electrostatic potentials to predict DNA-binding sites on DNA-binding proteins

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Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA

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Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase

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Arginine Methylation Regulates DNA Polymerase β

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Crystal Structure of a DinB Lesion Bypass DNA Polymerase Catalytic Fragment Reveals a Classic Polymerase Catalytic Domain

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Non-nucleoside Analogue Inhibitors Bind to an Allosteric Site on HCV NS5B Polymerase

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Comparative architecture of transposase and integrase complexes.

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HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism

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The origin of DNA genomes and DNA replication proteins

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Prokaryotic DNA polymerase I: evolution, structure, and “base flipping” mechanism for nucleotide selection

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Rational Design and Synthesis of Novel Dimeric Diketoacid-Containing Inhibitors of HIV-1 Integrase: Implication for Binding to Two Metal Ions on the Active Site of Integrase

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The human DINB1 gene encodes the DNA polymerase Polθ

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DNA Polymerase λ, a Novel DNA Repair Enzyme in Human Cells

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Crystal Structure of the 2′-Specific and Double-Stranded RNA-Activated Interferon-Induced Antiviral Protein 2′-5′-Oligoadenylate Synthetase

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Fidelity and Processivity of Saccharomyces cerevisiae DNA Polymerase η

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Crystal structure of a DinB family error-prone DNA polymerase from Sulfolobus solfataricus.

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Capture of a third Mg 2+ is essential for catalyzing DNA synthesis

Gao, Y., & Yang, W. (2016) · Science · doi:10.1126/science.aad9633 · Cited by 178

A general strategy for expanding polymerase function by droplet microfluidics

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Fidelity of DNA replication—a matter of proofreading

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Drug Targets and Molecular Mechanisms of Drug Resistance in Chronic Hepatitis B

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Motors, Switches, and Contacts in the Replisome

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Structural Insights into the Origins of DNA Polymerase Fidelity

Beard, W. A., & Wilson, S. H. (2003) · Structure · doi:10.1016/s0969-2126(03)00051-0 · Cited by 157

Structural and Functional Comparisons of Nucleotide Pyrophosphatase/Phosphodiesterase and Alkaline Phosphatase: Implications for Mechanism and Evolution,

Zalatan, J. G., Fenn, T. D., Brünger, A. T., & Herschlag, D. (2006) · Biochemistry · doi:10.1021/bi060847t · Cited by 164

DNA Replicases from a Bacterial Perspective

McHenry, C. S. (2011) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-061208-091655 · Cited by 162

Structure of the RNA Polymerase Domain of E. coli Primase

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The kinetic and chemical mechanism of high-fidelity DNA polymerases

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The 3′→5′ exonuclease of DNA polymerase δ can substitute for the 5′ flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability

Jin, Y. H., Obert, R., Burgers, P., Kunkel, T. A., Resnick, M. A., & Gordenin, D. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091095198 · Cited by 158

RNA Polymerase Active Center: The Molecular Engine of Transcription

Nudler, E. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.052705.164655 · Cited by 168

Design Principles of Regulatory Networks: Searching for the Molecular Algorithms of the Cell

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Crystal Structures of Active and Inactive Conformations of a Caliciviral RNA-dependent RNA Polymerase

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Alkaline Phosphatase Mono- and Diesterase Reactions: Comparative Transition State Analysis

Zalatan, J. G., & Herschlag, D. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056528r · Cited by 153

Crystal structure of mammalian poly(A) polymerase in complex with an analog of ATP

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Crystal Structure and Deletion Analysis Show that the Accessory Subunit of Mammalian DNA Polymerase γ, PolγB, Functions as a Homodimer

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Structural basis for the suppression of skin cancers by DNA polymerase η

Silverstein, T. D., Johnson, R. E., Jain, R., Prakash, L., Prakash, S., & Aggarwal, A. K. (2010) · Nature · doi:10.1038/nature09104 · Cited by 149

Computer Simulation of the Chemical Catalysis of DNA Polymerases: Discriminating between Alternative Nucleotide Insertion Mechanisms for T7 DNA Polymerase

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DNA Polymerases as Therapeutic Targets

Berdis, A. J. (2008) · Biochemistry · doi:10.1021/bi801179f · Cited by 146

Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors

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Structural design of a eukaryotic DNA repair polymerase: DNA polymerase β

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Control of Hepatitis C: A Medicinal Chemistry Perspective

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RNA polymerase: the vehicle of transcription

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Crystallographic snapshots of a replicative DNA polymerase encountering an abasic site

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A Structural Solution for the DNA Polymerase λ-Dependent Repair of DNA Gaps with Minimal Homology

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Poliovirus RNA-dependent RNA Polymerase (3Dpol)

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Roles of DNA Polymerases in Replication, Repair, and Recombination in Eukaryotes

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A Water-Mediated and Substrate-Assisted Catalytic Mechanism forSulfolobus solfataricusDNA Polymerase IV

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Human DNA Polymerase ι Incorporates dCTP Opposite Template G via a G.C+ Hoogsteen Base Pair

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Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)

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Network of Dynamically Important Residues in the Open/Closed Transition in Polymerases Is Strongly Conserved

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