Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice
Fagan, Anne M., Holtzman, David M., Munson, Gregory, Mathur, Tanya, Schneider, Danielle, Chang, Louis K., Getz, Godfrey S., Reardon, Catherine A., Lukens, John, Shah, Javeed A., LaDu, Mary Jo·1999·Journal of Biological Chemistry
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- Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neuronsGong, Jian-Sheng, Morita, Shin-ya, Kobayashi, Mariko, Handa, Tetsurou, Fujita, Shinobu C, Yanagisawa, Katsuhiko, Michikawa, Makoto · 2007 · Molecular Neurodegeneration
- Effects of Age on Gene Expression during Estrogen-Induced Synaptic Sprouting in the Female RatDavid J. Stone, Irina Rozovsky, Todd E. Morgan, Christopher P. Anderson, Lori M. Lopez, John Shick, Caleb E. Finch · 2000 · Experimental Neurology
- Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing ageIgbavboa, U., Eckert, G.P., Malo, T.M., Studniski, A.E., Johnson, L.N.A., Yamamoto, N., Kobayashi, M., Fujita, S.C., Appel, T.R., Müller, W.E. et al. · 2005 · Journal of the Neurological Sciences
- Metabolite transport across the mammalian and insect brain diffusion barriersAstrid Weiler, Anne Volkenhoff, Helen Hertenstein, Stefanie Schirmeier · 2017 · Neurobiology of Disease
- Brain cholesterol homeostasis and its association with neurodegenerative diseasesGao, Yi, Ye, Shiying, Tang, Yuehong, Tong, Wenjuan, Sun, Shaowei · 2023 · Neurochemistry International
- Liver X receptors, nervous system, and lipid metabolism.Gaia Cermenati, Elisabetta Brioschi, Federico Abbiati, Roberto Cosimo Melcangi, Donatella Caruso, Nico Mitro · 2013 · PubMed
- Astrocytes and the Warning Signs of Intracerebral Hemorrhagic StrokeAnnalisa Scimemi · 2018 · Neural Plasticity
- A role for lipoprotein lipase during synaptic remodeling in the adult mouse brainJean‐François Blain, Eric Paradis, Sophie B. Gaudreault, Danielle L. Champagne, Denis Richard, Judes Poirier · 2004 · Neurobiology of Disease
- α-Synuclein Regulates Neuronal Cholesterol EffluxJen-Hsiang T. Hsiao, Glenda Margaret Halliday, Woojin Kim · 2017 · Molecules
- A polymorphism in lipoprotein lipase affects the severity of Alzheimer's disease pathophysiologyJean‐François Blain, Nicole Aumont, Louise Théroux, Doris Dea, Judes Poirier · 2006 · European Journal of Neuroscience
- In situ AFM studies of astrocyte-secreted apolipoprotein E- and J-containing lipoproteinsJustin A. Legleiter, Ronald Bradley Demattos, David M. Holtzman, Tomasz Kowalewski · 2004 · Journal of Colloid and Interface Science
- Apolipoprotein E LDL receptor-binding domain-containing high-density lipoprotein: A nanovehicle to transport curcumin, an antioxidant and anti-amyloid bioflavonoidPanupon Khumsupan, Ricardo Ramírez, Darin Khumsupan, Vasanthy Narayanaswami · 2010 · Biochimica et Biophysica Acta (BBA) - Biomembranes
- Sterols in the central nervous systemMonique T Mulder · 2009 · Current Opinion in Clinical Nutrition & Metabolic Care
- Lipid efflux mechanisms, relation to disease and potential therapeutic aspectsDavid Castaño, Chutima Rattanasopa, Vera Filipa Monteiro-Cardoso, Maria Corlianò, Yiran Liu, A. Zhong, Mihaela Rusu, Elisa Anamaria Liehn, Roshni Rebecca Singaraja · 2020 · Advanced Drug Delivery Reviews
- Defining novel functions for cerebrospinal fluid in ALS pathophysiologyKoy Chong Ng Kee Kwong, Arpan R. Mehta, Maiken Nedergaard, Siddharthan Chandran · 2020 · Acta Neuropathologica Communications
- Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transportCarol A. Colton, Meggan Czapiga, Julie C. Snell, Olga N. Chernyshev, Michael Peter Vitek · 2001 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- The tocopherol transfer protein mediates vitamin E trafficking between cerebellar astrocytes and neuronsLynn M. Ulatowski, Mikel D. Ghelfi, Ryan West, J. Atkinson, Carrie J. Finno, Danny Manor · 2022 · Journal of Biological Chemistry
- Absence of ApoE Upregulates Murine Brain ApoD and ABCA1 Levels, But Does Not Affect Brain Sterol Levels, While Human ApoE3 and Human ApoE4 Upregulate Brain Cholesterol Precursor LevelsPaula J. Jansen, Dieter Lütjohann, Karin Thelen, Klaus von Bergmann, Fred VAN LEUVEN, Frans C. S. Ramaekers, Monique Monique · 2009 · Journal of Alzheimer s Disease
- Understanding the Exchange of Systemic HDL Particles Into the Brain and Vascular Cells Has Diagnostic and Therapeutic Implications for Neurodegenerative DiseasesJuno S. Van Valkenburgh, Cristiana Joy Meuret, Ashley E. Martinez, Vibha Kodancha, Victoria A. Solomon, Kai Chen, Hussein N. Yassine · 2021 · Frontiers in Physiology
- Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signalingFederica Gilardi, Barbara Viviani, Andrea Galmozzi, Mariaserena Boraso, Stefano Bartesaghi, A Torri, Donatella Caruso, Maurizio Crestani, Marina Marinovich, Emma De Fabiani · 2009 · Neuroscience
- Self-Assembly of HEK Cell-Secreted ApoE Particles Resembles ApoE Enrichment of Lipoproteins as a Ligand for the LDL Receptor-Related ProteinLaDu, Mary Jo, Stine,, W. Blaine, Narita, Masaaki, Getz, Godfrey S., Reardon, Catherine A., Bu, Guojun · 2006 · Biochemistry
- Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson DiseaseYue Yang, Christopher Dirk Keene, Elaine R. Peskind, Douglas R Galasko, Shu‐Ching Hu, Eiron Cudaback, Angela M. Wilson, Ge Li, Chang‐En Yu, Kathleen S. Montine et al. · 2015 · Journal of Neuropathology & Experimental Neurology
- Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteinsStrickland, Michael R., Rau, Michael J., Summers, Brock, Basore, Katherine, Wulf, John, Jiang, Hong, Chen, Yun, Ulrich, Jason D., Randolph, Gwendalyn J., Zhang, Rui et al. · 2024 · Neuron
- Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conferenceKloske, Courtney M., Belloy, Michael E., Blue, Elizabeth E., Bowman, Gregory R., Carrillo, Maria C., Chen, Xiaoying, Chiba‐Falek, Ornit, Davis, Albert A., Paolo, Gilbert Di, Garretti, Francesca et al. · 2024 · Alzheimer's & Dementia
- Optimized Negative Staining: a High-throughput Protocol for Examining Small and Asymmetric Protein Structure by Electron MicroscopyMatthew J. Rames, Yadong Yu, Gang Ren · 2014 · Journal of Visualized Experiments
- Astrocytes produce and secrete FGF-1, which promotes the production of apoE-HDL in a manner of autocrine actionJin‐ichi Ito, Yuko Nagayasu, Rui Lu, Alireza Kheirollah, Michi Hayashi, Shinji Yokoyama · 2005 · Journal of Lipid Research
- Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shiftLaDu, Mary Jo, Munson, Gregory W., Jungbauer, Lisa, Getz, Godfrey S., Reardon, Catherine A., Tai, Leon M., Yu, Chunjiang · 2012 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulationLevi, Ofir, Lütjohann, Dieter, Devir, Aliza, Von Bergmann, Klaus, Hartmann, Tobias, Michaelson, Daniel M. · 2005 · Journal of Neurochemistry
- APOE ε4 and lipid levels affect risk of recurrent nonlobar intracerebral hemorrhageMiriam R. Raffeld, Alessandro Biffi, Thomas W.K. Battey, Alison M. Ayres, Anand Viswanathan, Steven Mark Greenberg, Jonathan M. Rosand, Christopher D. Anderson · 2015 · Neurology
- Differential effects of apoE4 and activation of ABCA1 on brain and plasma lipoproteinsBoehm-Cagan, Anat, Bar, Roni, Harats, Dror, Shaish, Aviv, Levkovitz, Hana, Bielicki, John K., Johansson, Jan O., Michaelson, Daniel M. · 2016 · PLOS ONE
- The Modulating Effect of Mechanical Changes in Lipid Bilayers Caused by ApoE-Containing Lipoproteins on Aβ Induced Membrane DisruptionJustin A. Legleiter, John Denis Fryer, David M. Holtzman, Tomasz Kowalewski · 2011 · ACS Chemical Neuroscience
- A Novel Perspective on the ApoM-S1P Axis, Highlighting the Metabolism of ApoM and Its Role in Liver Fibrosis and NeuroinflammationStefan Hajny, Christina Christoffersen · 2017 · International Journal of Molecular Sciences
- The influence of APOEε4 on the pTau interactome in sporadic Alzheimer’s diseaseManon Thierry, Jackeline Ponce, Mitchell Martá-Ariza, Manor Askenazi, Arline Faustin, Dominique Leitner, Geoffrey Pires, Evgeny Kanshin, Eleanor Drummond, Beatrix M. Ueberheide et al. · 2024 · Acta Neuropathologica
- An acidic fibroblast growth factor-like factor secreted into the brain cell culture medium upregulates apoE synthesis, HDL secretion and cholesterol metabolism in rat astrocytesSachiko Ueno, Jin‐ichi Ito, Yuko Nagayasu, Toshi A. Furukawa, Shinji Yokoyama · 2002 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Neurological aspects of SARS-CoV-2 infection: lipoproteins and exosomes as Trojan horsesSin Man Lam, Xun Huang, Guanghou Shui · 2022 · Trends in Endocrinology and Metabolism
- Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 alleleEden Rebecca Padayachee, Henrik Zetterberg, Erik Portelius, Jan Borén, José Luís Molinuevo, Nancy C. Andreasen, Risto Cukalevski, Sara Snogerup Linse, Kaj Blennow, Ulf Andréasson · 2016 · Brain Research
- High-density lipoprotein-related cholesterol metabolism in Alzheimer's diseasePedrini, Steve, Chatterjee, Pratishtha, Hone, Eugene, Martins, Ralph N. · 2021 · Journal of Neurochemistry
- Identification of a Chrysanthemic Ester as an Apolipoprotein E Inducer in AstrocytesJianjia Fan, Shahab Zareyan, Wenchen Zhao, Yoko Shimizu, Tom A. Pfeifer, Jun‐Hyung Tak, Murray B. Isman, Bernard G. Van den Hoven, Mark E. Duggan, Michael W. Wood et al. · 2016 · PLoS ONE
- Protective ApoE variants support neuronal function by effluxing oxidized phospholipidsRalhan, Isha, Do, Alison D., Bae, Ju-Young, Feringa, Femke M., Cai, Wendy, Chang, Jinlan, Chik, Kennedi, Lee, Nathanael Y.J., Gerry, Christopher J., van der Kant, Rik et al. · 2026 · Neuron
- The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brainFelix Oestereich, Noosha Yousefpour, Ethan Yang, Jasmine Phénix, Zari Saadati Nezhad, Albert Nitu, Antonio Vázquez Cobá, Alfredo Ribeiro‐da‐Silva, Pierre Chaurand, Lisa Marie Munter · 2022 · Journal of Lipid Research
- Fatty acid sensing in the brain: The role of glial-neuronal metabolic crosstalk and horizontal lipid fluxNicholas R W Cleland, Kimberley D. Bruce · 2022 · Biochimie
- ApoE and cholesterol in schizophrenia and bipolar disorder: comparison of grey and white matter and relation with APOE genotypeFidel Vila‐Rodriguez · 2010 · Journal of Psychiatry and Neuroscience
- An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from gliaFan, Jianjia, Stukas, Sophie, Wong, Charmaine, Chan, Jennifer, May, Sharon, DeValle, Nicole, Hirsch-Reinshagen, Veronica, Wilkinson, Anna, Oda, Michael N., Wellington, Cheryl L. · 2011 · Journal of Lipid Research
- Inhibition of ACAT as a Therapeutic Target for Alzheimer's Disease Is Independent of ApoE4 LipidationValencia-Olvera, Ana C., Balu, Deebika, Faulk, Naomi, Amiridis, Aspasia, Wang, Yueting, Pham, Christine, Avila-Munoz, Eva, York, Jason M., Thatcher, Gregory R.J., LaDu, Mary Jo · 2023 · Neurotherapeutics
- Circadian Regulation of Apolipoproteins in the Brain: Implications in Lipid Metabolism and DiseaseC. Lee, Charlotte Ellzabeth Murrell, Alexander Chu, Xiaoyue Pan · 2023 · International Journal of Molecular Sciences
- Apolipoprotein Aβ: Black Sheep in a Good FamilyAnatol Kontush · 2004 · Brain Pathology
- Apolipoprotein A-I induces translocation of protein kinase Cα to a cytosolic lipid-protein particle in astrocytesJin‐ichi Ito, Hao Li, Yuko Nagayasu, Alireza Kheirollah, Shinji Yokoyama · 2004 · Journal of Lipid Research
- Lipoproteins produced by ApoE–/– astrocytes infected with adenovirus expressing human ApoEDacheng Peng, Ching Song, Catherine A. Reardon, Shutsung Liao, Godfrey S. Getz · 2003 · Journal of Neurochemistry
- Current insights into apolipoprotein E and the immune response in Alzheimer's diseaseLin, Peter Bor‐Chian, Holtzman, David M. · 2024 · Immunological Reviews
- Stage-Specific Association of Apolipoprotein A-I and E in Developing Mouse Retina真吾 車田, Akishi Onishi, Hiroo Imai, Kumiko Ishii, Toshihide Kobayashi, Satoshi B. Sato · 2007 · Investigative Ophthalmology & Visual Science
- Study of Exosomes Shed New Light on Physiology of AmyloidogenesisGuillaume van Niel · 2016 · Cellular and Molecular Neurobiology
- Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; Implications for prevention of stroke and ADDaniel Famer, Lars‐Olof Wahlund, Milita Crisby · 2010 · Biochemical and Biophysical Research Communications
- APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer’s Disease and Cardiovascular DiseaseЧан Лю, Juan Liu, Yanyang Wang, Shang-Fu Xu, Li-Mei Yu · 2025 · Molecular Neurobiology
- A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3Ana Carolina Valencia‐Olvera, Deebika Balu, Shreya Bellur, Thomas P. McNally, Yaseen Saleh, Don Pham, Shivesh Ghura, Jason M. York, Jan O. Johansson, Mary Jo LaDu et al. · 2023 · Alzheimer s Research & Therapy
- Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitroShivesh Ghura, Leon M. Tai, Ming Zhao, Nicole Collins, Chun‐Tao Che, Katherine M. Warpeha, Mary Jo LaDu · 2016 · Scientific Reports
- HDL and Endothelial FunctionYufei Wu, Yangkai Xu, Jie Chen, Mingming Zhao, Kerry‐Anne Rye · 2022 · Advances in experimental medicine and biology
- Apolipoprotein E polymorphism and the risk of intracranial aneurysms in a Chinese populationHao Liu, Ping Mao, Changhou Xie, Wanfu Xie, Maode Wang, Haitao Jiang · 2016 · BMC Neurology
- Roles of glia cells in cholesterol homeostasis in the brainJin‐ichi Ito, Shinji Yokoyama · 2003 · Advances in molecular and cell biology
- Role of A β Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s DiseaseDavid M. Holtzman, Berislav V. Zloković · 2007 · Springer eBooks
- Neuroimmunometabolism: how metabolism orchestrates immune response in healthy and diseased brainAnil Kumar Rana, Babita Bhatt, Chitralekha Gusain, Suryanarayan Biswal, Debashree Das, Mohit Kumar · 2025 · American Journal of Physiology-Endocrinology and Metabolism
- Apolipoprotein E Gene Polymorphism and the Risk of Intracerebral Hemorrhage in the Chinese PopulationRongjun Zhang, Xiaofeng Wang, Jianxin Liu, Shuzhen Yang, Zongchun Tang, LI Shuan-de, Yabin Peng, Hongbin Zhang, Xingkui Yang, Yongchun Zhou et al. · 2011 · Genetic Testing and Molecular Biomarkers
- Lipolysis-Stimulated Lipoprotein Receptor Acts as Sensor to Regulate ApoE Release in AstrocytesAméziane Herzine, Ghita Sekkat, Sandra Kaminski, Gaetano Calcagno, Sandrine Boschi‐Müller, Héla Safi, Catherine Corbier, Sophie Visvikis‐Siest, Thomas Claudepierre, Frances T. Yen · 2022 · International Journal of Molecular Sciences
- Nitric oxide counteracts the hyperoxia-induced proliferation and proinflammatory responses of mouse astrocytesChristie J. Bruno, Todd M. Greco, Harry Ischiropoulos · 2011 · Free Radical Biology and Medicine
- Bioactive TGF‐β can associate with lipoproteins and is enriched in those containing apolipoprotein E3Ina C. Tesseur, Hui Zhang, Walter J. Brecht, Jacob E. Corn, Jian‐Sheng Gong, Katsuhiko Yanagisawa, Makoto Michikawa, Karl Heinrich Weisgraber, Yadong Huang, Tony Wyss‐Coray · 2009 · Journal of Neurochemistry
- Could Lipoprotein Lipase Play a Role in Alzheimer's Disease?Jean‐François Blain, Judes Poirier · 2004 · The Scientific World JOURNAL
- Age-related changes in regiospecific expression of Lipolysis Stimulated Receptor (LSR) in mice brainAseel El Hajj, Frances T. Yen, Thierry Oster, Catherine Malaplate, Lynn Gregory, Catherine Corbier, Marie‐Claire Lanhers, Thomas Claudepierre · 2019 · PLoS ONE
- Targeted Suppression of Lipoprotein Receptor LSR in Astrocytes Leads to Olfactory and Memory Deficits in MiceEl Hajj, Aseel, Herzine, Ameziane, Calcagno, Gaetano, Désor, Frédéric, Djelti, Fathia, Bombail, Vincent, Denis, Isabelle, Oster, Thierry, Malaplate, Catherine, Vigier, Maxime et al. · 2022 · International Journal of Molecular Sciences
- Lipid peroxidation and Alzheimer’s disease: Key role of Amyloid-βAnatol Kontush · 2006 · Oléagineux Corps gras Lipides
- LCAT deficiency does not impair amyloid metabolism in APP/PS1 miceStukas, Sophie, Freeman, Lita, Lee, Michael, Wilkinson, Anna, Ossoli, Alice, Vaisman, Boris, Demosky, Stephen, Chan, Jeniffer, Hirsch-Reinshagen, Veronica, Remaley, Alan T. et al. · 2014 · Journal of Lipid Research
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- Sphingosine kinase-dependent regulation of pro-resolving lipid mediators in Alzheimer's diseaseMaria Ayub, Hee Kyung Jin, Jae‐sung Bae · 2022 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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- Cholesterol—A Janus-Faced Molecule in the Central Nervous SystemW. Gibson Wood, Urule Igbavboa, Gunter Peter Eckert, Wernér E.G. Müller · 2007 · Springer eBooks
- ApoE isoform-specific differences in behavior and cognition associated with subchronic MPTP exposureEileen Ruth S. Torres, Sydney Weber Boutros, Charles K. Meshul, Jacob Raber · 2020 · Learning & Memory
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- Inflammation in Alzheimer's Disease: Cross-talk between Lipids and Innate Immune Cells of the BrainLoewendorf Ai, Csete Me · 2015
- Genetic Risk Factors: Their Function and Comorbidities in Alzheimer′s DiseaseMikko O. Hiltunen, Lars Bertram, Aleister J. Saunders · 2011 · International Journal of Alzheimer s Disease
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- Influence of genetic variability and external regulating factors on amyloid-beta peptide aggregationEllen Hubin · 2014
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- Cholesterol Disturbances in Inherited Neurodegenerative DiseasesAino Mutka · 2009