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Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift
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Aβ has also been reported to associate with ApoE specifically, in contrast to ApoJ containing lipoprotein for instance, in human CSF.
“Aβ has also been reported to associate with ApoE specifically, in contrast to ApoJ containing lipoprotein for instance, in human CSF [83, 84].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [84]
Results §3.2 reports that endogenous Aβ in the human CSF sample was associated with apoE-containing lipoproteins, and identifies a portion in an apoE/Aβ complex. The paper does not report a comparison with ApoJ-containing lipoproteins, so the claimed contrast is unsupported. (LLM, conf=0.87)
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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schiossmacher, M., Whaley, J., Swindlehurst, C., et al. (1992) · Nature · doi:10.1038/359325a0 · Cited by 1,731
The role of apolipoprotein E in Alzheimer's disease
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Isoform-specific binding of apolipoprotein E to beta-amyloid.
LaDu, M. J., Falduto, M. T., Manelli, A. M., Reardon, C. A., Getz, G. S., & Frail, D. E. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31529-6 · Cited by 540
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Nascent astrocyte particles differ from lipoproteins in CSF
LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G., Reardon, C. A., Van Eldik, L. J., & Holtzman, D. M. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70052070.x · Cited by 285 · cited 10×
“In the current study, the use of density gradient ultracentrifugation also resulted in >90% of the endogenous Aβ eluting as free protein (data not shown), a pattern consistent with previous studies showing the loss of actual apolipoproteins from CSF and astrocyte conditioned media [30].”
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Mulder, M., & Terwel, D. (1998) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000022429 · Cited by 40
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Metadata
- Authors
- LaDu, M. J., Munson, G. W., Jungbauer, L., Getz, G. S., Reardon, C. A., Tai, L. M., & Yu, C.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 1821
- Issue
- 2
- Pages
- 295-302
- ISSN
- 1388-1981
- PMC
- PMC3273043
- Cited by
- 30
- References
- 12
- Language
- en
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