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An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia

Fan, Jianjia, Stukas, Sophie, Wong, Charmaine, Chan, Jennifer, May, Sharon, DeValle, Nicole, Hirsch-Reinshagen, Veronica, Wilkinson, Anna, Oda, Michael N., Wellington, Cheryl L.·2011·Journal of Lipid Research
DOI 10.1194/jlr.m014365
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  • Secreted ApoE is taken back up and transits through the recycling endosome pathway in multiple cell types, including astrocytes.

    “However, this interpretation is complicated by the fact that secreted ApoE is taken back up and transits through the recycling endosome pathway in multiple cell types, including astrocytes [32–36].”

    From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [32]

    The discussion section, “ApoA-I stimulates glial apoE recycling and lipidation in primary glia” (page unavailable), reports recycling of internalized apoE in several cell types and suggests that glia share this pathway. It specifically describes delivery to recycling endosomes in hepatocytes, but does not establish that apoE transits through recycling endosomes in astrocytes. (LLM, conf=0.82)

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Research works printed but not linked: 65

  1. Lund-Katz, 2010, High density lipoprotein structure-function and role in reverse cholesterol transport, Subcell. Biochem., 51, 183, 10.1007/978-90-481-8622-8_7 · DOI · Paper page
  2. Brooks-Wilson, 1999, Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency, Nat. Genet., 22, 336, 10.1038/11905 · DOI · Paper page
  3. Rust, 1999, Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1, Nat. Genet., 22, 352, 10.1038/11921 · DOI · Paper page
  4. Bodzioch, 1999, The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease, Nat. Genet., 22, 347, 10.1038/11914 · DOI · Paper page
  5. Hirsch-Reinshagen, 2004, Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain, J. Biol. Chem., 279, 41197, 10.1074/jbc.M407962200 · DOI · Paper page
  6. Wahrle, 2004, ABCA1 is required for normal CNS apoE levels and for lipidation of astrocyte-secreted apoE, J. Biol. Chem., 279, 40987, 10.1074/jbc.M407963200 · DOI · Paper page
  7. Fredrickson, 1961, Tangier disease: combined clinical staff conference at the National Institutes of Health, Ann. Intern. Med., 55, 1016, 10.7326/0003-4819-55-6-1016 · DOI
  8. Dietschy, 2001, Cholesterol metabolism in the brain, Curr. Opin. Lipidol., 12, 105, 10.1097/00041433-200104000-00003 · DOI · Paper page
  9. Fan, 2009, Greasing the wheels of Aβ clearance in Alzheimer's disease: the role of lipids and apolipoprotein E, Biofactors., 35, 239, 10.1002/biof.37 · DOI · Paper page
  10. Chattopadhyay, 2007, Lipid-protein interaction, regulation and dysfuntion of brain cholesterol, Biochem. Biophys. Res. Commun., 354, 627, 10.1016/j.bbrc.2007.01.032 · DOI
  11. Vanier, 2010, Neimann-Pick disease type C, Orphanet J. Rare Dis., 5, 16, 10.1186/1750-1172-5-16 · DOI · Paper page
  12. Ladu, 2000, Lipoproteins in the central nervous system, Ann. N. Y. Acad. Sci., 903, 167, 10.1111/j.1749-6632.2000.tb06365.x · DOI · Paper page
  13. Pitas, 1987, Lipoproteins and their receptors in the central nervous system, J. Biol. Chem., 262, 14352, 10.1016/S0021-9258(18)47945-8 · DOI · Paper page
  14. Saito, 1997, Marked increases in concentrations of apolipoproteins in the cerebrospinal fluid of poliovirus-infected macaques: relations between apolipoprotein concentrations and severity of brain injury, Biochem. J., 321, 145, 10.1042/bj3210145 · DOI
  15. Song, 1997, Cerebrospinal fluid apoE and apoA-I concentrations in early- and late-onset Alzheimer's disease, Neurosci. Lett., 231, 175, 10.1016/S0304-3940(97)00558-2 · DOI
  16. Demeester, 2000, Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease, J. Lipid Res., 41, 963, 10.1016/S0022-2275(20)32039-3 · DOI · Paper page
  17. Koch, 2001, Characterization of four lipoprotein classes in human cerebrospinal fluid, J. Lipid Res., 42, 1143, 10.1016/S0022-2275(20)31605-9 · DOI · Paper page
  18. Mahley, 2000, Apolipoprotein E: far more than a lipid transport protein, Annu. Rev. Genomics Hum. Genet., 1, 507, 10.1146/annurev.genom.1.1.507 · DOI · Paper page
  19. Bertram, 2010, The genetics of Alzheimer disease: back to the future, Neuron., 68, 270, 10.1016/j.neuron.2010.10.013 · DOI · Paper page
  20. Corder, 1993, Gene dose of apolipoprotein E type 4 and the risk of Alzheimer's disease in late onset families, Science., 261, 921, 10.1126/science.8346443 · DOI · Paper page
  21. Corder, 1994, Protective effect of apolipoprotein E type 2 for late onset Alzheimer disease, Nat. Genet., 7, 180, 10.1038/ng0694-180 · DOI · Paper page
  22. Wahrle, 2005, Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease, J. Biol. Chem., 280, 43236, 10.1074/jbc.M508780200 · DOI · Paper page
  23. Rothblat, 2010, High-density lipoprotein heterogeneity and function in reverse cholesterol transport, Curr. Opin. Lipidol., 21, 229, 10.1097/MOL.0b013e328338472d · DOI
  24. Cavigiolio, 2008, The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses, Biochemistry., 47, 4770, 10.1021/bi7023354 · DOI
  25. Brunham, 2006, Intestinal ABCA1 directly contributes to HDL biogenesis in vivo, J. Clin. Invest., 116, 1052, 10.1172/JCI27352 · DOI · Paper page
  26. Asztalos, 2007, Role of LCAT in HDL remodeling: investigation of LCAT deficiency states, J. Lipid Res., 48, 592, 10.1194/jlr.M600403-JLR200 · DOI
  27. Acton, 1996, Identification of scavenger receptor SR-BI as a high density lipoprotein receptor, Science., 271, 518, 10.1126/science.271.5248.518 · DOI · Paper page
  28. McNeish, 2000, High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1, Proc. Natl. Acad. Sci. U SA., 97, 4245, 10.1073/pnas.97.8.4245 · DOI
  29. Ryan, 2003, Optimized bacterial expression of human apolipoprotein A-I, Protein Expr. Purif., 27, 98, 10.1016/S1046-5928(02)00568-5 · DOI
  30. Fazio, 1999, Recycling of apolipoprotein E in mouse liver, J. Biol. Chem., 274, 8247, 10.1074/jbc.274.12.8247 · DOI
  31. Fazio, 2000, The cell biology and physiologic relevance of ApoE recycling, Trends Cardiovasc. Med., 10, 23, 10.1016/S1050-1738(00)00033-5 · DOI
  32. Swift, 2001, A recycling pathway for resecretion of internalized apolipoprotien E in liver cells, J. Biol. Chem., 276, 22965, 10.1074/jbc.M100172200 · DOI
  33. Braun, 2006, Intracellular trafficing of recycling apolipoprotein E in Chinese hamster ovary cells, J. Lipid Res., 47, 1176, 10.1194/jlr.M500503-JLR200 · DOI · Paper page
  34. Heeren, 2003, Recycling of apolipoprotein E is associated with cholesterol efflux and high density lipoprotein internalization, J. Biol. Chem., 278, 14370, 10.1074/jbc.M209006200 · DOI · Paper page
  35. Heeren, 2006, Apolipoprotein E recycling implications for dyslipidemia and atherosclerosis, Arterioscler. Thromb. Vasc. Biol., 26, 442, 10.1161/01.ATV.0000201282.64751.47 · DOI · Paper page
  36. Hasty, 2005, The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I, J. Lipid Res., 46, 1433, 10.1194/jlr.M400418-JLR200 · DOI
  37. Farkas, 2003, The recycling of apolipoprotein E in primary cultures of mouse hepatocytes, J. Biol. Chem., 278, 9412, 10.1074/jbc.M208026200 · DOI
  38. Bencharif, 2010, Effect of apoA-I on cholesterol release and apoE secretion in human mature adipocytes, Lipids Health Dis., 9, 75, 10.1186/1476-511X-9-75 · DOI
  39. Dory, 1991, Regulation of apolipoprotein E secretion by high density lipoprotein 3 in mouse macrophages, J. Lipid Res., 32, 783, 10.1016/S0022-2275(20)42030-9 · DOI
  40. Dory, 1989, Synthesis and secretion of apoE in thioglycolate-elicited mouse peritoneal macrophages: effect of cholesterol efflux, J. Lipid Res., 30, 809, 10.1016/S0022-2275(20)38303-6 · DOI
  41. Rellin, 2008, Recycling of apolipoprotein E is not associated with cholesterol efflux in neuronal cells, Biochim. Biophys. Acta., 1781, 232, 10.1016/j.bbalip.2008.02.001 · DOI
  42. Kockx, 2004, Apolipoprotein A-I-stimulated apolipoprotein E secretion from human macrophages is independent of cholesterol efflux, J. Biol. Chem., 279, 25966, 10.1074/jbc.M401177200 · DOI · Paper page
  43. Catte, 2006, Novel changes in discoidal high density lipoprotein morphology: a molecular dynamics study, Biophys. J., 90, 4345, 10.1529/biophysj.105.071456 · DOI
  44. Zhang, 2011, Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy, J. Lipid Res., 52, 175, 10.1194/jlr.D010959 · DOI
  45. Ladu, 2006, Self-assembly of HEK cell-secreted apoE particles resembes apoE enrichment of lipoproteins as a ligand for the LDL receptor-related protein, Biochemistry., 45, 381, 10.1021/bi051765s · DOI · Paper page
  46. Rensen, 1997, Particle size determines the specificity of apolipoprotein E-containing triglyceride-rich emulsions for the LDL receptor versus hepatic remnant receptor in vivo, J. Lipid Res., 38, 1070, 10.1016/S0022-2275(20)37190-X · DOI
  47. Farkas, 2004, The recycling of apolipoprotein E and its amino-terminal 22 kDa fragment: evidence for multiple redundant pathways, J. Lipid Res., 45, 1546, 10.1194/jlr.M400104-JLR200 · DOI · Paper page
  48. Heeren, 2001, Recycling of apolipoprotein E and lipoprotein lipase through endosomeal compartments in vivo, J. Biol. Chem., 276, 42333, 10.1074/jbc.M107461200 · DOI · Paper page
  49. Takahashi, 1999, Cholesterol efflux to apolipoprotein A1 involves endocytosis and resecretion in a calcium-dependent pathway, Proc. Natl. Acad. Sci. U SA., 96, 11358, 10.1073/pnas.96.20.11358 · DOI
  50. Neufeld, 2004, The ABCA1 transporter modulates late endocytic trafficking, J. Biol. Chem., 279, 15571, 10.1074/jbc.M314160200 · DOI
  51. Denis, 2008, ATP-binding cassett A1-mediated lipidation of apoA-I occurs at the plasma membrane and not in the endocytic compartment, J. Biol. Chem., 283, 16178, 10.1074/jbc.M709597200 · DOI
  52. Lefterov, 2010, Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1E9 mice, J. Biol. Chem., 285, 36945, 10.1074/jbc.M110.127738 · DOI
  53. Lewis, 2010, Overexpression of human apolipoprotein A-I preserves cognitive function and attenuates neuroinflammation and cerebral amyloid angiopathy in a mouse model of Alzheimer's disease, J. Biol. Chem., 285, 36958, 10.1074/jbc.M110.127829 · DOI
  54. Heeren, 2004, Impaired recycling of apolipoprotein E4 is associated with intracellular cholesterol accumulation, J. Biol. Chem., 279, 55483, 10.1074/jbc.M409324200 · DOI · Paper page
  55. Zhong, 2009, Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function, J. Biol. Chem., 284, 27273, 10.1074/jbc.M109.014464 · DOI
  56. Hatters, 2005, Modulation of apolipoprotein E structure by domain interaction, J. Biol. Chem., 280, 34288, 10.1074/jbc.M506044200 · DOI · Paper page
  57. Dong, 1994, Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms, J. Biol. Chem., 269, 22358, 10.1016/S0021-9258(17)31797-0 · DOI · Paper page
  58. Chen, 2010, ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling, Proc. Natl. Acad. Sci. U SA., 107, 12011, 10.1073/pnas.0914984107 · DOI · Paper page
  59. Bertrand, 1995, Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer dsiease, Brain Res. Mol. Brain Res., 33, 174, 10.1016/0169-328X(95)00097-C · DOI · Paper page
  60. Beffert, 1999, Apolipoprotein E and beta-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent, Brain Res., 843, 87, 10.1016/S0006-8993(99)01894-6 · DOI · Paper page
  61. Poirier, 2005, Apolipoprotein E, cholesterol transport and synthesis in sporadic Alzheimer's disease, Neurobiol. Aging., 26, 355, 10.1016/j.neurobiolaging.2004.09.003 · DOI
  62. Glockner, 2002, Genotype-related differences of hippocampal apolipoprotein E levels only in early stages of neuropathological changes in Alzheimer's disease, Neuroscience., 114, 1103, 10.1016/S0306-4522(02)00178-1 · DOI
  63. Fryer, 2005, Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model, J. Neurosci., 25, 2803, 10.1523/JNEUROSCI.5170-04.2005 · DOI · Paper page
  64. Sullivan, 2004, Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice, Neuroscience., 124, 725, 10.1016/j.neuroscience.2003.10.011 · DOI · Paper page
  65. Fukumoto, 2003, Age but not diagnosis is the main predictor of plasma amyloid β-protein levels, Arch. Neurol., 60, 958, 10.1001/archneur.60.7.958 · DOI

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Metadata

Authors
Fan, J., Stukas, S., Wong, C., Chan, J., May, S., DeValle, N., Hirsch-Reinshagen, V., Wilkinson, A., Oda, M. N., & Wellington, C. L.
Venue
Journal of Lipid Research
Publisher
Elsevier BV
Published
2011-09
Volume
52
Issue
9
Pages
1605-1616
ISSN
0022-2275
DOI
10.1194/jlr.m014365
Cited by
21
References
20
Language
en
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