Protective ApoE variants support neuronal function by extracting peroxidated lipids

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

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The Amyloid-β Pathway in Alzheimer’s Disease

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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Rapid single-step induction of functional neurons from human pluripotent stem cells

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

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Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

Karch, C. M., & Goate, A. M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.006 · Cited by 1,357 · see citing works

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

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Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

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Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

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The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D

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Neurotoxicity of Alzheimer’s disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

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Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

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Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

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ApoE Cascade Hypothesis in the pathogenesis of Alzheimer’s disease and related dementias

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Self-generated theta oscillations in the hippocampus

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Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

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APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer’s disease pathology and brain diseases

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Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (−/−), and Human apoE Transgenic Mice

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Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors

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Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology

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Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

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ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

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Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease

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A Novel In Vitro Preparation: the Intact Hippocampal Formation

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The endosomal-lysosomal pathway is dysregulated by APOE4 expression in vivo

Nuriel, T., Peng, K. Y., Ashok, A., Dillman, A. A., Figueroa, H. Y., Apuzzo, J., Ambat, J., Levy, E., Cookson, M. R., Mathews, P. M., et al. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00702 · Cited by 140 · see citing works

Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism

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Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

Belaidi, A. A., Masaldan, S., Southon, A. G., Kalinowski, P., Acevedo, K. M., Appukuttan, A. T., Portbury, S. D., Lei, P., Agarwal, P., Leurgans, S. E., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01568-w · Cited by 121 · see citing works

Apolipoprotein E–low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner

Johnson, L. A., Olsen, R. H. J., Merkens, L. S., DeBarber, A. E., Steiner, R. D., Sullivan, P. M., Maeda, N., & Raber, J. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.016 · Cited by 105 · see citing works

The cell biology of APOE in the brain

Windham, I. A., & Cohen, S. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2023.09.004 · Cited by 103 · see citing works

Intersectin Regulates Dendritic Spine Development and Somatodendritic Endocytosis but Not Synaptic Vesicle Recycling in Hippocampal Neurons

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Decreased lipidated ApoE‐receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes

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Apolipoprotein E associated with reconstituted high‐density lipoprotein‐like particles is protected from aggregation

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Driving factors of neuronal ferroptosis

Jacquemyn, J., Ralhan, I., & Ioannou, M. S. (2024) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.01.010 · Cited by 69 · see citing works

Endosomal recycling reconciles the Alzheimer’s disease paradox

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ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism

Kawatani, K., Holm, M., Starling, S. C., Martens, Y. A., Zhao, J., Lü, W., Ren, Y., Li, Z., Jiang, P., Jiang, Y., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02372-w · Cited by 55 · see citing works

Autolysosomal exocytosis of lipids protect neurons from ferroptosis

Ralhan, I., Chang, J., Moulton, M. J., Goodman, L. D., Lee, N. Y. J., Plummer, G., Pasolli, H. A., Matthies, D., Bellen, H. J., & Ioannou, M. S. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202207130 · Cited by 42 · see citing works

A Neuron‐Glia Co‐culture System for Studying Intercellular Lipid Transport

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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins

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Single-Step PCR-Based Genetic Sex Determination of Rat Tissues and Cells

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The ABC's of Alzheimer risk gene ABCA7

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Rare missense mutations in ABCA7 might increase Alzheimer’s disease risk by plasma membrane exclusion

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A lentiviral system for efficient knockdown of proteins in neuronal cultures

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Triggering ferroptosis in neurodegenerative diseases

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APOE genotypes differentially remodel the astrocytic lipid droplet-associated proteome to shape lipid droplet dynamicsPreprint

Cuní‐López, C., Root, J. T., Hao, Y., Kowal, I., Blomberg, N., Ghirlando, R., Yang, L. G., Hertog, S. K.-D., Cookson, M., van der Kant, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.19.669163 · Cited by 7 · see citing works

Disrupted lipid homeostasis as a pathogenic mechanism in ABCA7 ‐associated Alzheimer's disease risk

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The functional neuronal lipotype is specified by activity and PS synthesis using dietary and lysosomal inputsPreprint

Lee, R. J., Rivas‐Serna, I. M., Theisen, E. K., Bibo, A., Hardy, E. B., Cheng, W., Zhou, Z., Chavez-Rios, J. S., Forward, J. C., Pham, T., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.26.754678

Protective ApoE variants support neuronal function by effluxing oxidized phospholipids

Ralhan, I., Do, A. D., Bae, J.-Y., Feringa, F. M., Cai, W., Chang, J., Chik, K., Lee, N. Y. J., Gerry, C. J., van der Kant, R., et al. (2026) · Neuron · doi:10.1016/j.neuron.2025.10.040 · Cited by 23 · see citing works

Protective ApoE variants eliminate toxic fats from neurons

Heffner, C. M., & Paolo, G. D. (2026) · Neuron · doi:10.1016/j.neuron.2026.01.010

Peroxidation protectors

Yates, D. M. (2026) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-01020-2

Apolipoprotein E and Apolipoprotein E receptor 2 signaling as drug targets in Alzheimer’s disease

Belaidi, A. A., Bush, A. I., & Ayton, S. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.086014 · Cited by 1 · see citing works

APOE Genotype Impacts Polyunsaturated Neutral Lipid Storage and Ferroptosis Vulnerability in Astrocytes

Richards, S. E. V., Yang, M., Deik, A. A., & Ricq, E. L. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04463-2 · Cited by 3 · see citing works