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A Bipartite Nuclear Localization Signal Is Required for p53 Nuclear Import Regulated by a Carboxyl-terminal Domain
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“Analyses of p53 nuclear import have identified three NLS sequences in its C-terminus. The dominant NLS I at amino-acids 305–322 conforms to a bipartite basic sequence. NLS II and III at residues 366–372 and 376–381, respectively, are weaker motifs with single stretches of basic amino acids.”
From Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding (2010) · cites this paper as [16]
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Cited by
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
Xu, J., Reumers, J., Couceiro, J. R., De Smet, F., Gallardo, R., Rudyak, S., Cornelis, A., Rozenski, J., Zwolinska, A., Marine, J.-C., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.546 · Cited by 543
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding
Marchenko, N. D., Hanel, W., Li, D., Becker, K., Reich, N., & Moll, U. M. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.173 · Cited by 123
Identification and Characterization of a Novel p300-mediated p53 Acetylation Site, Lysine 305
Wang, Y.-H., Tsay, Y.-G., Tan, B. C.-M., Lo, W.-Y., & Lee, S.-C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212574200 · Cited by 92
Kumar, G. R., Shum, L., & Glaunsinger, B. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05402-11 · Cited by 71
Metadata
- Authors
- Liang, S.-H., & Clarke, M. F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-11
- Volume
- 274
- Issue
- 46
- Pages
- 32699-32703
- ISSN
- 0021-9258
- Cited by
- 108
- References
- 1
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 7669 d)
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- CoChat. (2026). Citation check: A Bipartite Nuclear Localization Signal Is Required for p53 Nuclear Import Regulated by a Carboxyl-terminal Domain. https://app.cochat.ai/papers/10.1074/jbc.274.46.32699
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- Liang, S.-H., & Clarke, M. F. (1999). A Bipartite Nuclear Localization Signal Is Required for p53 Nuclear Import Regulated by a Carboxyl-terminal Domain. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.46.32699
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.