The Stress-inducted Proteins RTP801 and RTP801L Are Negative Regulators of the Mammalian Target of Rapamycin Pathway

Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action

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Upstream and downstream of mTOR

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TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

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Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

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Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

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PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase

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Hypoxia regulates TSC1/2–mTOR signaling and tumor suppression through REDD1-mediated 14–3–3 shuttling

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

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The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development

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Pathogenesis of depression: Insights from human and rodent studies

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The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

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Signalling to translation: How signal transduction pathways control the protein synthetic machinery

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Hypoxia-inducible Factor 1α Is Regulated by the Mammalian Target of Rapamycin (mTOR) via an mTOR Signaling Motif

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Autophagy and Cell Death

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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

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Akt-dependent and -independent mechanisms of mTOR regulation in cancer

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Identification of the circadian transcriptome in adult mouse skeletal muscle

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Nutrient Sensing, Metabolism, and Cell Growth Control

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Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling

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Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

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Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase

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Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps

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REDD1 is essential for stress-induced synaptic loss and depressive behavior

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Plzf Regulates Germline Progenitor Self-Renewal by Opposing mTORC1

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Bnip3 Mediates the Hypoxia-induced Inhibition on Mammalian Target of Rapamycin by Interacting with Rheb

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ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

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Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease

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Inhibition of mTOR Signaling in Parkinson’s Disease Prevents l -DOPA–Induced Dyskinesia

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Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

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Dexamethasone Represses Signaling through the Mammalian Target of Rapamycin in Muscle Cells by Enhancing Expression of REDD1

Wang, H., Kubica, N., Ellisen, L. W., Jefferson, L. S., & Kimball, S. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m610023200 · Cited by 262

Amino Acid Signaling in TOR Activation

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Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

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RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

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Hypoxia Inhibits Protein Synthesis through a 4E-BP1 and Elongation Factor 2 Kinase Pathway Controlled by mTOR and Uncoupled in Breast Cancer Cells

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Neuronal intrinsic barriers for axon regeneration in the adult CNS

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A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity

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Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals

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Genome-wide screen of promoter methylation identifies novel markers in melanomaPreprint

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RTP801 Is Elevated in Parkinson Brain Substantia Nigral Neurons and Mediates Death in Cellular Models of Parkinson's Disease by a Mechanism Involving Mammalian Target of Rapamycin Inactivation

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Human Muscle Gene Expression following Resistance Exercise and Blood Flow Restriction

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ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

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Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

Lee, M. N., Ha, S. H., Kim, J. J., Koh, A., Lee, C. S., Kim, J. H., Jeon, H., Kim, D., Suh, P., & Ryu, S. H. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00165-09 · Cited by 196

An overview on genus garcinia: phytochemical and therapeutical aspects

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Eukaryotic initiation factor 4E-binding protein 1 (4E-BP1): a master regulator of mRNA translation involved in tumorigenesis

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Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways

Tang, G., Yue, Z., Tallóczy, Z., Hagemann, T. L., Cho, W., Messing, A., Sulzer, D., & Goldman, J. E. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn042 · Cited by 176

AMP‐activated protein kinase and cancer

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Mammalian Target of Rapamycin: Hitting the Bull′s‐Eye for Neurological Disorders

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DNA Damage Inducible Transcript 4 Gene: The Switch of the Metabolism as Potential Target in Cancer

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The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy

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Growth Control Under Stress: mTOR Regulation through the REDD1-TSC Pathway

Ellisen, L. W. (2005) · Cell Cycle · doi:10.4161/cc.4.11.2139 · Cited by 131

The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1

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Control of Translation Initiation through Integration of Signals Generated by Hormones, Nutrients, and Exercise*

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Signaling regulations of neuronal regenerative ability

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Silver nanoparticles induce tight junction disruption and astrocyte neurotoxicity in a rat blood–brain barrier primary triple coculture model

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Activating transcription factor 4 and CCAAT/enhancer-binding protein-β negatively regulate the mammalian target of rapamycin via Redd1 expression in response to oxidative and endoplasmic reticulum stress

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Interplay Between pVHL and mTORC1 Pathways in Clear-Cell Renal Cell Carcinoma

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Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals

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Hypoxia-Induced Energy Stress Inhibits the mTOR Pathway by Activating an AMPK/REDD1 Signaling Axis in Head and Neck Squamous Cell Carcinoma

Schneider, A., Younis, R. H., & Gutkind, J. S. (2008) · Neoplasia · doi:10.1593/neo.08586 · Cited by 107

Phosphoinositide 3-kinases as drug targets in cancer

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Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells

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Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence

Kolesnichenko, M., Hong, L., Liao, R., Vogt, P. K., & Sun, P. (2012) · Cell Cycle · doi:10.4161/cc.20683 · Cited by 123

Glucocorticoids Modulate the mTOR Pathway in the Hippocampus: Differential Effects Depending on Stress History

Polman, J. A. E., Hunter, R. G., Speksnijder, N., van den Oever, J. M. E., Korobko, O. B., McEwen, B. S., de Kloet, E. R., & Datson, N. A. (2012) · Endocrinology · doi:10.1210/en.2012-1255 · Cited by 104

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

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Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis

Drummond, M. J., Miyazaki, M., Dreyer, H. C., Pennings, B., Dhanani, S., Volpi, E., Esser, K. A., & Rasmussen, B. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90842.2008 · Cited by 100

Rapid Turnover of the mTOR Complex 1 (mTORC1) Repressor REDD1 and Activation of mTORC1 Signaling following Inhibition of Protein Synthesis

Kimball, S. R., Do, A. N. D., Kutzler, L., Cavener, D. R., & Jefferson, L. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706643200 · Cited by 106

Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4

Knowles, L. M., Chen, Y., Osterman, A. L., & Smith, J. W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803384200 · Cited by 100

Glucocorticoid elevation of dexamethasone-induced gene 2 (Dig2/RTP801/REDD1) protein mediates autophagy in lymphocytes

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Short-Term Calorie Restriction in Male Mice Feminizes Gene Expression and Alters Key Regulators of Conserved Aging Regulatory Pathways

Estep, P. W., Warner, J. B., & Bulyk, M. L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005242 · Cited by 91

Early Relapse in ALL Is Identified by Time to Leukemia in NOD/SCID Mice and Is Characterized by a Gene Signature Involving Survival Pathways

Meyer, L. H., Eckhoff, S. M., Queudeville, M., Kraus, J. M., Giordan, M., Stursberg, J., Zangrando, A., Vendramini, E., Möricke, A., Zimmermann, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2010.11.014 · Cited by 93

The mTOR Signaling Pathway in the Brain: Focus on Epilepsy and Epileptogenesis

Russo, E., Citraro, R., Constanti, A., & Sarro, G. D. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8314-5 · Cited by 91

Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exercising human muscle

Moberg, M., Apró, W., & Blomstrand, E. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00353.2011 · Cited by 93

Transcriptome Analysis of Wnt3a-Treated Triple-Negative Breast Cancer Cells

Maubant, S., Tesson, B. M., Maire, V., Ye, M., Rigaill, G. J., Gentien, D., Cruzalegui, F. H., Tucker, G. C., Roman‐Roman, S., & Dubois, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122333 · Cited by 85

Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells

Nishioka, C., Ikezoe, T., Yang, J., Koeffler, H. P., & Yokoyama, A. (2008) · Leukemia · doi:10.1038/leu.2008.243 · Cited by 86

Regulated in DNA damage and development 1 (REDD1) promotes cell survival during serum deprivation by sustaining repression of signaling through the mechanistic target of rapamycin in complex 1 (mTORC1)

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Evaluation of the siRNA PF-04523655 versus Ranibizumab for the Treatment of Neovascular Age-related Macular Degeneration (MONET Study)

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Cell-Type-Dependent Regulation of mTORC1 by REDD1 and the Tumor Suppressors TSC1/TSC2 and LKB1 in Response to Hypoxia

Wolff, N. C., Vega-Rubín-de-Celis, S., Xie, X., Castrillón, D. H., Kabbani, W., & Brugarolas, J. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01393-10 · Cited by 86

Timosaponin AIII Is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress

King, F. W., Fong, S., Griffin, C. A., Shoemaker, M., Staub, R., Zhang, Y., Cohen, I. V., & Shtivelman, E. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007283 · Cited by 83

Structural Analysis and Functional Implications of the Negative mTORC1 Regulator REDD1,

Vega-Rubín-de-Celis, S., Abdallah, Z., Kinch, L. N., Grishin, N. V., Brugarolas, J., & Zhang, X. (2010) · Biochemistry · doi:10.1021/bi902135e · Cited by 81

REDD1 Is a Major Target of Testosterone Action in Preventing Dexamethasone-Induced Muscle Loss

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Growth inhibition of colon cancer cells by polyisoprenylated benzophenones is associated with induction of the endoplasmic reticulum response

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Motexafin Gadolinium and Zinc Induce Oxidative Stress Responses and Apoptosis in B-Cell Lymphoma Lines

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Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice

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Skeletal Muscle Disuse Atrophy and the Rehabilitative Role of Protein in Recovery from Musculoskeletal Injury

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