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Conformational Reorganization of the Four-helix Bundle of Human Apolipoprotein E in Binding to Phospholipid
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This compact structure unfolds upon lipidation with unfolding of the four-helix bundle and ApoE adopting an extended conformation.
“However, this compact structure unfolds upon lipidation with unfolding of the four-helix bundle and ApoE adopting an extended conformation [54].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [54]
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Cites
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Three-Dimensional Structure of the LDL Receptor-Binding Domain of Human Apolipoprotein E
Wilson, C., Wardell, M. R., Weisgraber, K. H., Mahley, R. W., & Agard, D. A. (1991) · Science · doi:10.1126/science.2063194 · Cited by 678
The receptor-binding domain of human apolipoprotein E. Binding of apolipoprotein E fragments.
Innerarity, T. L., Friedlander, E. J., Rall, S. C., Weisgraber, K. H., & Mahley, R. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44180-9 · Cited by 276
Aggerbeck, L. P., Wetterau, J. R., Weisgraber, K. H., Wu, C. S., & Lindgren, F. T. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68779-4 · Cited by 229
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Research works printed but not linked: 34
- Mahley, 1988, Science, 240, 622, 10.1126/science.3283935 · DOI · Paper page
- Weisgraber, 1996, FASEB J., 10, 1485, 10.1096/fasebj.10.13.8940294 · DOI
- Mahley, 1999, Curr. Opin. Lipidol., 10, 207, 10.1097/00041433-199906000-00003 · DOI · Paper page
- Mahley, 1983, Biochim. Biophys. Acta, 737, 197, 10.1016/0304-4157(83)90001-1 · DOI
- Innerarity, 1979, J. Biol. Chem., 254, 4186, 10.1016/S0021-9258(18)50713-4 · DOI · Paper page
- Wetterau, 1988, J. Biol. Chem., 263, 6240, 10.1016/S0021-9258(18)68778-2 · DOI · Paper page
- Aggerbeck, 1988, J. Mol. Biol., 202, 179, 10.1016/0022-2836(88)90531-1 · DOI
- Breiter, 1991, Biochemistry, 30, 603, 10.1021/bi00217a002 · DOI
- Wang, 1997, J. Biol. Chem., 272, 17912, 10.1074/jbc.272.29.17912 · DOI
- Segrest, 1994, Adv. Protein Chem., 45, 303, 10.1016/S0065-3233(08)60643-9 · DOI
- Fisher, 1999, J. Lipid. Res., 40, 93, 10.1016/S0022-2275(20)33343-5 · DOI
- Mims, 1990, Biochemistry, 29, 6639, 10.1021/bi00480a013 · DOI
- De Pauw, 1995, Biochemistry, 34, 10953, 10.1021/bi00034a030 · DOI
- Raussens, 1998, J. Biol. Chem., 273, 25825, 10.1074/jbc.273.40.25825 · DOI
- Morrow, 1999, Protein Expression Purif., 16, 224, 10.1006/prep.1999.1069 · DOI
- Dong, 1996, J. Biol. Chem., 271, 19053, 10.1074/jbc.271.32.19053 · DOI · Paper page
- Dong, 1994, J. Biol. Chem., 269, 22358, 10.1016/S0021-9258(17)31797-0 · DOI · Paper page
- Lowry, 1951, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
- Sparks, 1992, J. Biol. Chem., 267, 25830, 10.1016/S0021-9258(18)35685-0 · DOI
- McLachlin, 1996, Protein Expression Purif., 7, 275, 10.1006/prep.1996.0039 · DOI
- Scheele, 1982, J. Biol. Chem., 257, 12277, 10.1016/S0021-9258(18)33711-6 · DOI
- Pownall, 1978, Biochemistry, 17, 1183, 10.1021/bi00600a008 · DOI
- Weers, 1999, J. Biol. Chem., 274, 21804, 10.1074/jbc.274.31.21804 · DOI
- Dong, 1998, J. Lipid. Res., 39, 1173, 10.1016/S0022-2275(20)32541-4 · DOI
- Forte, 1986, Methods Enzymol., 128, 442, 10.1016/0076-6879(86)28086-6 · DOI
- Matsumura, 1991, Methods Enzymol., 202, 336, 10.1016/0076-6879(91)02018-5 · DOI
- Weinstein, 1989, Am. J. Med., 86 Suppl. 4A, 27, 10.1016/0002-9343(89)90186-1 · DOI
- Gursky, 1996, Proc. Natl. Acad. Sci. U. S. A., 93, 2991, 10.1073/pnas.93.7.2991 · DOI
- Soulages, 1998, Biochemistry, 37, 10203, 10.1021/bi980622l · DOI
- Narayanaswami, 1996, J. Biol. Chem., 271, 26855, 10.1074/jbc.271.43.26855 · DOI
- Narayanaswami, 1999, Proc. Natl. Acad. Sci. U. S. A., 96, 4366, 10.1073/pnas.96.8.4366 · DOI
- Soulages, 1995, Proc. Natl. Acad. Sci. U. S. A., 92, 5650, 10.1073/pnas.92.12.5650 · DOI
- Zhang, 1993, Biochemistry, 32, 3942, 10.1021/bi00066a014 · DOI
- Segelke, 2000, Protein Sci., 9, 886, 10.1110/ps.9.5.886 · DOI
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Sorted by citations
Apolipoprotein E structure: insights into function
Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.06.008 · Cited by 583
Apolipoprotein E isoforms and lipoprotein metabolism
Phillips, M. C. (2014) · IUBMB Life · doi:10.1002/iub.1314 · Cited by 328
Apolipoprotein E4 Forms a Molten Globule
Morrow, J. A., Hatters, D. M., Lu, B., Höchtl, P., Oberg, K. A., Rupp, B., & Weisgraber, K. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204898200 · Cited by 204
Ji, Z.-S., Miranda, R. D., Newhouse, Y. M., Weisgraber, K. H., Huang, Y., & Mahley, R. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112109200 · Cited by 177
Apolipoprotein E and cholesterol in aging and disease in the brain
de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164
New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E
Libeu, C. P., Lund-Katz, S., Phillips, M. C., Wehrli, S., Hernáiz, M. J., Capila, I., Linhardt, R. J., Raffaı̈, R. L., Newhouse, Y. M., Zhou, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104746200 · Cited by 113
Lipid Binding-induced Conformational Change in Human Apolipoprotein E
Saito, H., Dhanasekaran, P., Baldwin, F., Weisgraber, K. H., Lund-Katz, S., & Phillips, M. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106337200 · Cited by 113
Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils
Hatters, D. M., Zhong, N., Rutenber, E., & Weisgraber, K. H. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.06.080 · Cited by 105
Two-step Mechanism of Binding of Apolipoprotein E to Heparin
Futamura, M., Dhanasekaran, P., Handa, T., Phillips, M. C., Lund-Katz, S., & Saito, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411719200 · Cited by 91
Characterization of the Heparin Binding Sites in Human Apolipoprotein E
Saito, H., Dhanasekaran, P., Nguyen, D., Baldwin, F., Weisgraber, K. H., Wehrli, S., Phillips, M. C., & Lund-Katz, S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213207200 · Cited by 90
Minagawa, H., Gong, J., Jung, C., Watanabe, A., Lund‐Katz, S., Phillips, M. C., Saito, H., & Michikawa, M. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22073 · Cited by 90
Lipid Association-induced N- and C-terminal Domain Reorganization in Human Apolipoprotein E3
Narayanaswami, V., Szeto, S. S. W., & Ryan, R. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102953200 · Cited by 59
Effects of polymorphism on the microenvironment of the LDL receptor-binding region of human apoE
Lund-Katz, S., Wehrli, S., Zaiou, M., Newhouse, Y., Weisgraber, K. H., & Phillips, M. C. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31612-6 · Cited by 40
Self-citationKloske, C. M., Belloy, M. E., Blue, E. E., Bowman, G. R., Carrillo, M. C., Chen, X., Chiba‐Falek, O., Davis, A. A., Paolo, G. D., Garretti, F., et al. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13877 · Cited by 33
Clément-Collin, V., Barbier, A., Dergunov, A. D., Visvikis, A., Siest, G., Desmadril, M., Takahashi, M., & Aggerbeck, L. P. (2006) · Biophysical Chemistry · doi:10.1016/j.bpc.2005.07.009 · Cited by 32
Pollard, R. D., Fulp, B., Sorci-Thomas, M. G., & Thomas, M. J. (2016) · Biochemistry · doi:10.1021/acs.biochem.6b00347 · Cited by 19
Strickland, M. R., & Holtzman, D. M. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00970-0
Metadata
- Authors
- Lu, B., Morrow, J. A., & Weisgraber, K. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2000-07
- Volume
- 275
- Issue
- 27
- Pages
- 20775-20781
- ISSN
- 0021-9258
- Cited by
- 89
- References
- 4
- Language
- en
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