Elevated Triglyceride Content Diminishes the Capacity of High Density Lipoprotein to Deliver Cholesteryl Esters via the Scavenger Receptor Class B Type I (SR-BI)

Greene, Diane J.; Skeggs, Josephine W.; Morton, Richard E.

doi:10.1074/jbc.m008725200

Cited by 133Cholesterol and Lipid MetabolismLipoproteins and Cardiovascular HealthLipid metabolism and disorders

Elevated Triglyceride Content Diminishes the Capacity of High Density Lipoprotein to Deliver Cholesteryl Esters via the Scavenger Receptor Class B Type I (SR-BI)

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Greene, Diane J., Skeggs, Josephine W., Morton, Richard E.·2001·Journal of Biological Chemistry

DOI 10.1074/jbc.m008725200

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Abstract

The selective uptake of high density lipoprotein (HDL) cholesteryl ester (CE) by the scavenger receptor class B type I (SR-BI) is well documented. However, the effect of altered HDL composition, such as occurs in hyperlipidemia, on this important process is not known. This study investigated the impact of variable CE and triglyceride (TG) content on selective uptake. CE selective uptake by Y1 and HepG2 cells was strongly affected by modification of either the CE or TG content of HDL. Importantly, TG, like CE, was selectively taken up by a dose-dependent, saturable process in these cells. As shown by ACTH up-regulation and receptor overexpression experiments, SR-BI mediated the selective uptake of both CE and TG. With in vitro modified HDLs of varying CE and TG composition, the selective uptake of CE and TG was dependent on the abundance of each lipid within the HDL particle. Furthermore, total selective uptake (CE + TG) remained constant, indicating that these lipids competed for cellular uptake. These data support a novel mechanism whereby SR-BI binds HDL and mediates the incorporation of a nonspecific portion of the HDL lipid core. In this way, TG directly affects the ability of HDL to donate CE to cells. Processes that raise the TG/CE ratio of HDL will impair the delivery of CE to cells via this receptor and may compromise the efficiency of sterol balancing pathways such as reverse cholesterol transport.

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Elevated TG and insulin resistance may both impair HDL function and predate the development of diabetes.
“In this regard, elevated TG and insulin resistance may both impair HDL function37-39 and predate the development of diabetes.40”
From Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?: New Insights From the Framingham Offspring Study (2016) · cites this paper as [38]
Experimental studies suggest that hypertriglyceridemic HDL may be dysfunctional.
“Experimental studies suggest that hypertriglyceridemic HDL may be dysfunctional, 55,56 that small, dense LDL particles may be more susceptible to oxidative modification, 57,58 and that an increased number of atherogenic particles may adversely influence CVD risk 59 ; however, no clinical outcome trials to date have determined whether normalization of particle composition or reduction of particle”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [55]

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Background
Accelerated Lipid Absorption in Mice Overexpressing Intestinal SR-BI
Biétrix, F., Yan, D., Nauze, M., Rolland, C., Bertrand‐Michel, J., Coméra, C., Schaak, S., Barbaras, R., Groen, A. K., Perret, B., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508868200 · Cited by 134 · see citing works
Scavenger Receptor Class B, Type I-mediated Uptake of Various Lipids into Cells
Thuahnai, S. T., Lund‐Katz, S., Williams, D. L., & Phillips, M. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106695200 · Cited by 129 · see citing works
HDL Biogenesis, Remodeling, and Catabolism
Zannis, V. I., Fotakis, P., Κούκος, Γ., Kardassis, D., Ehnholm, C., Jauhiainen, M., & Chroni, A. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-09665-0_2 · Cited by 113 · see citing works
“When it is bound to HDL, SR-BI mediates selective uptake of cholesteryl ester, triglycerides, phospholipids, and vitamin E from HDL to cells (Acton et al. 1996; Greene et al. 2001; Thuahnai et al. 2001; Stangl et al. 1999; Gu et al. 1998, 2000b; Urban et al. 2000).”
Background
Dyslipidemias in the Prevention of Cardiovascular Disease: Risks and Causality
Graham, I. M., Cooney, M. T., Bradley, D., Dudina, A. L., & Reiner, Ž. (2012) · Current Cardiology Reports · doi:10.1007/s11886-012-0313-7 · Cited by 109 · see citing works
“Furthermore, excess triglycerides in lipoproteins may result in abnormal transport [64, 65].”
Genetic Variation at the Scavenger Receptor Class B Type I Gene Locus Determines Plasma Lipoprotein Concentrations and Particle Size and Interacts with Type 2 Diabetes: The Framingham Study
Osgood, D. P., Corella, D., Demissie, S., Cupples, L. A., Wilson, P. W. F., Meigs, J. B., Schaefer, E. J., Coltell, Ó., & Ordovás, J. M. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021664 · Cited by 110 · see citing works
“effects of the SR-BI overexpression (51).”
Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and “selective” pathway connection
Azhar, S. (2003) · Frontiers in bioscience · doi:10.2741/1165 · Cited by 109 · see citing works
“According to this model, HDL docks with SR-BI, forming a hydrophobic channel in which neutral core lipids, CE and TG are translocated to the plasma membrane (250).”
BackgroundMethod
Role of Scavenger Receptors SR-BI and CD36 in Selective Sterol Uptake in the Small Intestine
Werder, M., Han, C., Wehrli, E., Bimmler, D., Schulthess, G., & Hauser, H. (2001) · Biochemistry · doi:10.1021/bi0109820 · Cited by 100 · see citing works
The Effects of Mutations in Helices 4 and 6 of ApoA-I on Scavenger Receptor Class B Type I (SR-BI)-mediated Cholesterol Efflux Suggest That Formation of a Productive Complex between Reconstituted High Density Lipoprotein and SR-BI Is Required for Efficient Lipid Transport
Liu, T., Krieger, M., Kan, H.-Y., & Zannis, V. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112103200 · Cited by 97 · see citing works
Is Isolated Low High-Density Lipoprotein Cholesterol a Cardiovascular Disease Risk Factor?: New Insights From the Framingham Offspring Study
Bartlett, J., Predazzi, I. M., Williams, S. M., Bush, W. S., Kim, Y., Havas, S., Toth, P. P., Fazio, S., & Miller, M. (2016) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.115.002436 · Cited by 96 · see citing works
“SBP 125 (34) 118 (20) 120 (38) 125 (53) 130 (38) 118 (18) 123 (30) 130 (19) 130 (36)”
Dysfunctional high-density lipoproteins in coronary heart disease: implications for diagnostics and therapy
Annema, W., & von Eckardstein, A. (2016) · Translational Research · doi:10.1016/j.trsl.2016.02.008 · Cited by 94 · see citing works
Scavenger Receptor BI Plays a Role in Facilitating Chylomicron Metabolism
Out, R., Kruijt, J. K., Rensen, P. C. N., Hildebrand, R. B., de Vos, P., Eck, M. V., & van Berkel, T. J. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401170200 · Cited by 90 · see citing works
HDL (High-Density Lipoprotein) Subclasses, Lipid Content, and Function Trajectories Across the Menopause Transition
Khoudary, S. R. E., Chen, X., Nasr, A., Billheimer, J. T., Brooks, M. M., McConnell, D. S., Orchard, T. J., Crawford, S. L., Matthews, K. A., & Rader, D. J. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315355 · Cited by 78 · see citing works
LDL and HDL enriched in triglyceride promote abnormal cholesterol transport
Skeggs, J. W., & Morton, R. E. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m100431-jlr200 · Cited by 73 · see citing works
“[ 3 H]cholesteryl ether and 125 I-tyramine-cellobiose-labeled HDL were prepared as previously described ( 24 ).”
BackgroundMethodInfluentialSelf-citation
Apolipoprotein A-II Modulates the Binding and Selective Lipid Uptake of Reconstituted High Density Lipoprotein by Scavenger Receptor BI
de Beer, M. C., Durbin, D. M., Cai, L., Mirocha, N., Jonas, A., Webb, N. R., de Beer, F. C., & van der Westhuyzen, D. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100228200 · Cited by 72 · see citing works
Endocytosis is not required for the selective lipid uptake mediated by murine SR-BI
Nieland, T. J. F., Ehrlich, M., Krieger, M., & Kirchhausen, T. L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.02.007 · Cited by 70 · see citing works
Torcetrapib Differentially Modulates the Biological Activities of HDL2 and HDL3 Particles in the Reverse Cholesterol Transport Pathway
Catalano, G., Julia, Z., Frisdal, É., Vedie, B., Fournier, N., Goff, W. L., Chapman, M. J., & Guérin, M. (2008) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179416 · Cited by 68 · see citing works
Intake of up to 3 Eggs per Day Is Associated with Changes in HDL Function and Increased Plasma Antioxidants in Healthy,Young Adults
DiMarco, D. M., Norris, G. H., Millar, C. L., Blesso, C. N., & Fernandez, M. L. (2017) · Journal of Nutrition · doi:10.3945/jn.116.241877 · Cited by 65 · see citing works
“A downside to this exchange is that HDLTG enrichment reduces its ability to take up cholesterol and interact with the hepatic transporters responsible for its uptake (16).”
Background
The Role of Human and Mouse Hepatic Scavenger Receptor Class B Type I (SR-BI) in the Selective Uptake of Low-Density Lipoprotein−Cholesteryl Esters
Rhainds, D., Brodeur, M. R., Lapointe, J., Charpentier, D., Falstrault, L., & Brissette, L. (2003) · Biochemistry · doi:10.1021/bi026949a · Cited by 63 · see citing works
Specific Oxidized Phospholipids Inhibit Scavenger Receptor BI-mediated Selective Uptake of Cholesteryl Esters
Ashraf, M. Z., Kar, N. S., Chen, X., Choi, J., Salomon, R. G., Febbraio, M., & Podrez, E. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710474200 · Cited by 60 · see citing works
Spotlight on HDL-raising therapies: insights from the torcetrapib trials
Kontush, A., Guérin, M., & Chapman, M. J. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1191 · Cited by 59 · see citing works
“Consistent with this hypothesis, selective uptake of cholesteryl esters by hepatic cells is decreased with triglyceride-enriched HDL”
Background
Reconstituted Discoidal ApoE-Phospholipid Particles Are Ligands for the Scavenger Receptor BI
Li, X., Kan, H.-Y., Lavrentiadou, S. N., Krieger, M., & Zannis, V. I. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200658200 · Cited by 57 · see citing works
Hormonal regulation of adrenal microvillar channel formation
Azhar, S., Nomoto, A. M., & REAVEN, E. P. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30459-4 · Cited by 56 · see citing works
New insight on the molecular mechanisms of high-density lipoprotein cellular interactions
Martinez, L. O., Jacquet, S., Terc�, F., Collet, X., Perret, B., & Barbaras, R. (2004) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-004-4087-y · Cited by 54 · see citing works
Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice
Out, R., Hoekstra, M., de Jager, S. C. A., de Vos, P., van der Westhuyzen, D. R., Webb, N. R., Eck, M. V., Biessen, E. A. L., & van Berkel, T. J. C. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m400361-jlr200 · Cited by 52 · see citing works
“In addition to CE, SR-BI selectively takes up a variety of other molecules, such as lipoprotein-associated PL (8, 9), HDL-associated CE hydroxides (10), and triglycerides (TGs) (9, 11).”
Triglycerides are a predictive factor for arterial stiffness: a community-based 4.8-year prospective study
Wang, X.-N., Ye, P., Cao, R., Yang, X., Xiao, W., Zhang, Y., Bai, Y.-Y., & Wu, H.-M. (2016) · Lipids in Health and Disease · doi:10.1186/s12944-016-0266-8 · Cited by 59 · see citing works
“Indirectly, elevated TGs impairs the capacity of high density lipoprotein to deliver cholesteryl esters, which may promote atherosclerosis via the scavenger receptor class B Type I (SRBI) [23].”
Background
Reevaluation of the role of the multidrug-resistant P-glycoprotein in cellular cholesterol homeostasis
Goff, W. L., Settle, M., Greene, D. J., Morton, R. E., & Smith, J. D. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500255-jlr200 · Cited by 50 · see citing works
“LDL and HDL were isolated by sequential ultracentrifugation and radiolabeled in the presence of [(3)H]cholesteryl oleyl ether (COE), a nonhydrolyzable analog of CE, via cholesteryl ester transfer protein-mediated transfer from phospholipid/cholesterol liposomes, as described previously (11).”
MethodSelf-citation
Impairment of the Ability of HDL From Patients With Metabolic Syndrome but Without Diabetes Mellitus to Activate eNOS
Denimal, D., Monier, S., Brindisi, M., Petit, J., Bouillet, B., Nguyen, A., Demizieux, L., Simoneau, I., de Barros, J.-P. P., Vergès, B. L., et al. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.309287 · Cited by 49 · see citing works
Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
Salazar, J. J., Olivar, L. C., Ramos, E., Chávez-Castillo, M., Rojas, J., & Bermúdez, V. (2015) · Cholesterol · doi:10.1155/2015/296417 · Cited by 48 · see citing works
“ABCA-1: ATP-binding cassette transporter A-1 Apo A-I: Apolipoprotein A-I CAD: Coronary artery disease CE: Cholesteryl ester CETP: Cholesteryl ester transfer protein CVD: Cardiovascular disease CVR: Cardiovascular risk DM2: Type 2 diabetes mellitus FC: Free cholesterol HDL: High-Density Lipoprotein IDL: Intermediate-De…”
BackgroundInfluential
Triglyceride-to-HDL cholesterol ratio
Yunke, Z., Lü, G., & Zhenyue, C. (2013) · Herz · doi:10.1007/s00059-013-3788-0 · Cited by 45 · see citing works
Revealing the Role of High-Density Lipoprotein in Colorectal Cancer
Zeljković, A., Vekić, J., Mihajlović, M., Gojković, T., Vladimirov, S. S., Zeljković, D., Spasojević‐Kalimanovska, V., & Trifunović, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073352 · Cited by 43 · see citing works
“In addition, triglycerideenriched HDL particles have impaired function within the RCT process [36].”
Background
Functionality of postprandial larger HDL2 particles is enhanced following CETP inhibition therapy
Bellanger, N., Julia, Z., Villard, E. F., Khoury, P. E., Duchêne, E., Chapman, M. J., Fournier, N., Goff, W. L., & Guérin, M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.12.027 · Cited by 39 · see citing works
Elevated CETP Activity Improves Plasma Cholesterol Efflux Capacity From Human Macrophages in Women
Villard, E. F., Khoury, P. E., Duchêne, E., Bonnefont‐Rousselot, D., Clément, K., Bruckert, É., Bittar, R., Goff, W. L., & Guérin, M. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.252841 · Cited by 39 · see citing works
Expression of Human Hepatic Lipase in the Rabbit Model Preferentially Enhances the Clearance of Triglyceride-Enriched Versus Native High-Density Lipoprotein Apolipoprotein A-I
Rashid, S., Trinh, D. K. Y., Uffelman, K. D., Cohn, J. S., Rader, D. J., & Lewis, G. F. (2003) · Circulation · doi:10.1161/01.cir.0000070947.64595.47 · Cited by 40 · see citing works
Efficacy and Safety of Adding Omega-3 Fatty Acids in Statin-treated Patients with Residual Hypertriglyceridemia: ROMANTIC (Rosuvastatin-OMAcor iN residual hyperTrIglyCeridemia), a Randomized, Double-blind, and Placebo-controlled Trial
Kim, C. H., Han, K. A., Yu, J., Lee, S. H., Jeon, H. K., Kim, S. H., Kim, S. Y., Han, K. H., Won, K., Kim, D.-B., et al. (2018) · Clinical Therapeutics · doi:10.1016/j.clinthera.2017.11.007 · Cited by 36 · see citing works
Long-Term Alcohol Consumption Caused a Significant Decrease in Serum High-Density Lipoprotein (HDL)-Cholesterol and Apolipoprotein A-I with the Atherogenic Changes of HDL in Middle-Aged Korean Women
Cho, K., Nam, H.-S., Kang, D.-J., Park, M.-H., & Kim, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158623 · Cited by 34 · see citing works
“In addition, elevated TG content in HDL diminished the capacity of CE delivery via scavenger receptor class B type I (SR-BI) [28].”
Background
Impaired capacity of acute-phase high density lipoprotein particles to deliver cholesteryl ester to the human HUH-7 hepatoma cell line
Artl, A., Marsche, G., Pussinen, P. J., Knipping, G., Sattler, W., & Malle, E. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00132-7 · Cited by 33 · see citing works
ABO Genotype, ‘Blood-Type’ Diet and Cardiometabolic Risk Factors
Wang, J., García‐Bailo, B., Nielsen, D. E., & El‐Sohemy, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084749 · Cited by 32 · see citing works
“High levels of TG are known to both impede the scavenging capacity of HDL [52,53] and promote the formation of small, dense LDL particles, which are more easily oxidized and thus”
Background
Mechanisms of HDL deficiency in mice overexpressing human apoA-II
Julve, J., Escolá‐Gil, J. C., Ribas, V., González‐Sastre, F., Ordóñez‐Llanos, J., Sánchez‐Quesada, J. L., & Blanco‐Vaca, F. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200081-jlr200 · Cited by 32 · see citing works
“It is worthy to note that HDL composition affects selective cholesteryl ester uptake because triglyceride and cholesteryl esters compete for SR-BI-mediated cellular uptake ( 31 ).”
Background
Serum Triglyceride Levels and Cardiovascular Disease Events in Koreans
Kim, E. H., Lee, J. B., Kim, S., Jo, M., Hwang, J. Y., Bae, S. J., Jung, C. H., Lee, W. J., Park, J., Park, G., et al. (2015) · Cardiology · doi:10.1159/000380941 · Cited by 30 · see citing works
Normal HDL Cholesterol Efflux and Anti-Inflammatory Capacities in Type 2 Diabetes Despite Lipidomic Abnormalities
Denimal, D., Benanaya, S., Monier, S., Simoneau, I., de Barros, J.-P. P., Goff, W. L., Bouillet, B., Vergès, B. L., & Duvillard, L. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac339 · Cited by 28 · see citing works
Comment on: Triglyceride-to-HDL cholesterol ratio: Predictive value for CHD severity and new-onset heart failure
İşçen, S., & Zhenyue, C. (2013) · Herz · doi:10.1007/s00059-013-3840-0 · Cited by 28 · see citing works
Polyphenols can Potentially Prevent Atherosclerosis and Cardiovascular Disease by Modulating Macrophage Cholesterol Metabolism
Ito, F. (2020) · Current Molecular Pharmacology · doi:10.2174/1874467213666200320153410 · Cited by 27 · see citing works
Effect of DanQi Pill on PPARα, lipid disorders and arachidonic acid pathway in rat model of coronary heart disease
Chang, H., Wang, Q., Shi, T., Huo, K., Li, C., Zhang, Q., Wang, G., Wang, Y., Tang, B., Wang, W., et al. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1083-3 · Cited by 27 · see citing works
“The cholesterol kit (COD-PAP Method), triglyceride kit (GPO-PAP Method), direct HDL kit and direct LDL kit were purchased from BiosinaTechnologies Inc. Evaluation of mRNA expressions of molecules involved in lipid metabolism by polymerase chain reaction (PCR) Expressions of LPL and CD36 in heart tissues were determine…”
BackgroundInfluential
A specific plasma lipid signature associated with high triglycerides and low HDL cholesterol identifies residual CAD risk in patients with chronic coronary syndrome
Giorgi, N. D., Michelucci, E., Smit, J. M., Scholte, A. J. H. A., Mahdiui, M. E., Knuuti, J. M., Buechel, R. R., Teresińska, A., Pizzi, M. N., Roque, A., et al. (2021) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2021.11.013 · Cited by 26 · see citing works
High Density Lipoprotein: Assembly, Structure, Cargo, and Functions
Murphy, A. J. (2013) · ISRN Physiology · doi:10.1155/2013/186365 · Cited by 26 · see citing works
“Therefore, SR-B1 has the ability to facilitate selective uptake CE and other lipids from both HDL and LDL into the cell, and either uptake or donate unesterified cholesterol [124, 136–142].”
Background
Postprandial lipemia enhances the capacity of large HDL2 particles to mediate free cholesterol efflux via SR-BI and ABCG1 pathways in type IIB hyperlipidemia
Julia, Z., Duchêne, E., Fournier, N., Bellanger, N., Chapman, M. J., Goff, W. L., & Guérin, M. (2010) · Journal of Lipid Research · doi:10.1194/jlr.p009746 · Cited by 26 · see citing works
Determinants of HDL Cholesterol Efflux Capacity after Virgin Olive Oil Ingestion: Interrelationships with Fluidity of HDL Monolayer
Fernández‐Castillejo, S., Rubió, L., Hernáez, Á., Catalán, Ú., Pedret, A., Valls, R. M., Mosele, J. I., Covas, M., Remaley, A. T., Castañer, O., et al. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700445 · Cited by 25 · see citing works
“[52] In summary, by using a model as VOO consumption in which improvements in HDL characteristics and functionality have been reported,[10,17–24] we looked for the major determinants of the CEC.”
BackgroundInfluential
Arterial Stiffness Determinants for Primary Cardiovascular Prevention among Healthy Participants
Vallée, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11092512 · Cited by 26 · see citing works
“Furthermore, elevated triglyceride levels can promote atherosclerosis through the scavenger receptor class B Type 1 (SR-BI) by impairing the capacity of high-density lipoprotein to deliver cholesteryl esters [58].”
Background
Early Signs of Atherogenic Features in the HDL Lipidomes of Normolipidemic Patients Newly Diagnosed with Type 2 Diabetes
Kostara, C. E., Ferrannini, E., Bairaktari, E. T., Papathanasiou, A. I., Elisaf, M., & Tsimihodimos, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228835 · Cited by 22 · see citing works
“the RCT, these particles negatively influence other important metabolic pathways involved in heart disease, including a reduced capacity for lecithin; less cholesterol acyltransferase (LCAT) to convert free cholesterol to cholesterol esters; and a diminished capacity to deliver cholesterol esters to hepatic cells via…”
Background
Protein Mediators of Sterol Transport Across Intestinal Brush Border Membrane
Brown, J. M., & Yu, L. (2010) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-90-481-8622-8_12 · Cited by 22 · see citing works
“Additionally, SR-BI can also promote selective uptake of free sterols, phospholipids, triglycerides, and cholesteryl ethers (Stangl et al., 1999, Urban et al., 2000, Greene et al., 2001).”
Background
Metabolic disorders and inflammation are associated with familial combined hyperlipemia
Díaz-Ruiz, M., Martínez-Triguero, M. L., López‐Ruiz, A., la Cruz, F. F.-D., Bañuls, C., & Hernández‐Mijares, A. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.09.009 · Cited by 18 · see citing works
Triglycerides: How Much Credit Do They Deserve?
Kohli, P., & Cannon, C. P. (2012) · Medical Clinics of North America · doi:10.1016/j.mcna.2011.11.006 · Cited by 17 · see citing works
Triglyceride enrichment of HDL does not alter HDL-selective cholesteryl ester clearance in rabbits
Rashid, S., Uffelman, K. D., Barrett, P. H. R., Vicini, P., Adeli, K., & Lewis, G. F. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31688-6 · Cited by 16 · see citing works
Scavenger Receptor Class B, Type I: A Promising Immunotherapy Target
Fioravanti, J., Medina‐Echeverz, J., & Berraondo, P. (2011) · Immunotherapy · doi:10.2217/imt.10.104 · Cited by 15 · see citing works
Feedback Inhibition of Human Scavenger Receptor Class B Type I Gene Expression by Glucocorticoid in Adrenal and Ovarian Cells
Mavridou, S., Venihaki, M., Rassouli, O., Tsatsanis, C., & Kardassis, D. (2010) · Endocrinology · doi:10.1210/en.2009-1302 · Cited by 15 · see citing works
Cardiovascular risk profile in burn survivors
Leung, B., Younger, J. F., Stockton, K. A., Müller, M. J., & Paratz, J. D. (2017) · Burns · doi:10.1016/j.burns.2017.07.010 · Cited by 14 · see citing works
Pedoman Tatalaksana Dislipidemia PERKI 2013
Erwinanto, E., Santoso, A., Putranto, J. N., Tedjasukmana, P., Suryawan, R., Rifqi, S., & Kasiman, S. (2015) · Indonesian Journal of Cardiology · doi:10.30701/ijc.v34i4.385 · Cited by 14 · see citing works
Improved plasma cholesterol efflux capacity from human macrophages in patients with hyperalphalipoproteinemia
Khoury, P. E., Plengpanich, W., Frisdal, É., Goff, W. L., Khovidhunkit, W., & Guérin, M. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.02.032 · Cited by 12 · see citing works
Enterocyte Fatty Acid Handling Proteins and Chylomicron Formation
Cifarelli, V., & Abumrad, N. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00048-7 · Cited by 13 · see citing works
Triglyceride and Cardiovascular Disease
Kim, M. (2013) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2013.2.1.1 · Cited by 11 · see citing works
Reduced Reverse Cholesterol Transport Efficacy in Healthy Men with Undesirable Postprandial Triglyceride Response
Motte, A., Gall, J., Salem, J., Dasque, E., Lebot, M., Frisdal, É., Galier, S., Villard, E. F., Bouaziz-Amar, É., Lacorte, J., et al. (2020) · Biomolecules · doi:10.3390/biom10050810 · Cited by 11 · see citing works
“Those observations are entirely consistent with earlier studies showing that the CETP-mediated reduction in the CE/TG ratio in HDL particles due to a TG enrichment, as observed in subjects from GHigh as compared to GLow or during postprandial lipemia (Table 3) is associated with a significant decrease in the SR-BI-med…”
Result
Early time‐restricted feeding improves high‐density lipoprotein amount and function in nonhuman primates, without effects on body composition
Kavanagh, K., Bashore, A. C., Davis, M. A., Jorgensen, M. J., McLouth, C. J., Beavers, D. P., & Parks, J. S. (2022) · Obesity · doi:10.1002/oby.23564 · Cited by 9 · see citing works
“Our study points to a clear shift toward larger HDL particle size, which can result from more TG content, and TG is known to interfere with CEC function [35].”
Background
Modification of CETP function by changing its substrate preference: a new paradigm for CETP drug design
Morton, R. E., & Izem, L. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m056333 · Cited by 10 · see citing works
Self-citation
The beneficial effects of HDL-C on atherosclerosis: rationale and clinical results
Santos‐Gallego, C. G., Torres, F., & Badimón, J. J. (2011) · Clinical Lipidology · doi:10.2217/clp.10.90 · Cited by 10 · see citing works
Associations of Abdominal and Cardiovascular Adipose Tissue Depots With HDL Metrics in Midlife Women: the SWAN Study
Nasr, A., Matthews, K. A., Janssen, İ., Brooks, M. M., Barinas‐Mitchell, E., Orchard, T. J., Billheimer, J. T., Wang, N. C., McConnell, D. S., Rader, D. J., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac148 · Cited by 8 · see citing works
Metabolismus und Funktion der Lipoproteine hoher Dichte (HDL)
Jomard, A., & Osto, E. (2019) · Praxis · doi:10.1024/1661-8157/a003241 · Cited by 8 · see citing works
CD36 and Intestinal Fatty Acid Absorption
Nassir, F., & Abumrad, N. A. (2009) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152209788009823 · Cited by 8 · see citing works
Adrenocorticotrophic hormone retarded metabolism of low‐density lipoprotein in rats
Xu, N., Hurtig, M., Ekström, U., & Nilsson‐Ehle, P. (2004) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510410005730 · Cited by 8 · see citing works
Belgian expert opinion: how to reduce the residual risk in atherogenic dyslipidaemic patients: place of fibrates
Ducobu, J., Scheen, A. J., Gaal, L. V., Velkeniers, B., & Hermans, M. P. (2008) · Acta Cardiologica · doi:10.2143/ac.63.2.2029534 · Cited by 8 · see citing works
High-density lipoprotein: what is the best way to measure its antiatherogenic potential?
Remaley, A. T., & Warnick, G. R. (2008) · Expert Opinion on Medical Diagnostics · doi:10.1517/17530059.2.7.773 · Cited by 8 · see citing works
Intravascular hemolysis triggers NAFLD characterized by a deregulation of lipid metabolism and lipophagy blockade
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Scavenger receptor class B type I and high density lipoprotein metabolism
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Authors: Greene, D. J., Skeggs, J. W., & Morton, R. E.
Affiliations: Cleveland Clinic (US)
Corresponding author: Morton, Richard E.
ORCID: Morton, Richard E.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2001-02
Volume: 276
Issue: 7
Pages: 4804-4811
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m008725200
OpenAlex: W2053088392
Cited by: 133
References: 52
Citations by year: 2025: 3 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 12 · 2012: 8
FWCI: 7.54
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 7191 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL060934, HL60934)
Topics: Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: high-density lipoprotein, scavenger receptor class B type I, cholesteryl ester uptake, triglyceride content, HDL lipid composition, selective uptake, reverse cholesterol transport, sterol balance, hyperlipidemia, receptor overexpression
MeSH terms: Animals, Biological Transport, Cell Line, Cholesterol Esters, Humans, Lipoproteins, HDL, Membrane Proteins, Receptors, Immunologic, Substrate Specificity, Transfection, Triglycerides, Receptors, Lipoprotein, CD36 Antigens, COS Cells, Receptors, Scavenger, Scavenger Receptors, Class B

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Elevated Triglyceride Content Diminishes the Capacity of High Density Lipoprotein to Deliver Cholesteryl Esters via the Scavenger Receptor Class B Type I (SR-BI)

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