Occurrence of a N-terminal proteolytic fragment of neurocan, not a C-terminal half, in a perineuronal net in the adult rat cerebrum
Abstract
Neurocan is a nervous tissue-unique chondroitin sulfate proteoglycan (CSPG) whose expression and proteolytic cleavage are developmentally regulated. In the adult rat brain, neurocan is completely cleaved into some proteoglycan fragments including the C-terminal half known as neurocan-C and a N-terminal fragment with a 130 kDa core glycoprotein (neurocan-130). We describe here the differential distribution of these two neurocan-derived CSPGs in the adult rat cerebrum and the occurrence of neurocan-130 as a new member of a perineuronal net-constituting molecule. At the light microscopic level, neurocan-130 exhibited pericellular localization around a subset of neurons in addition to diffuse distribution in the neuropil. In contrast, neurocan-C was distributed only diffusely in the neuropil. Double staining with anti-neurocan-130 and anti-synaptophysin antibodies suggested that neurocan-130 was localized in the vicinity of the synapses, but not at the synapses. Immunoelectron microscopy showed that neurocan-130 was mainly localized in the cytoplasm of glial cell processes, the so-called glial perineuronal net, encompassing the cell bodies of certain neurons. The presence of neurocan-130 in a limited number of glial cells may reflect some functional heterogeneity of the glia.
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All four lecticans are found in perineuronal nets.
“All four lecticans are found in PNNs (Carulli et al., 2006(Carulli et al., , 2010;;Hagihara et al., 1999;Matsui et al., 1998;Zimmermann and Dours-Zimmermann, 2008).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Matsui et al., 1998
Cites
Perineuronal nets — a specialized form of extracellular matrix in the adult nervous system
Celio, M. R., & Blümcke, I. (1994) · Brain Research Reviews · doi:10.1016/0165-0173(94)90006-x · Cited by 386 · see citing works
Immunocytochemical localization of serotonin1A receptors in the rat central nervous system
Kia, H. K., Miquel, M., Brisorgueil, M., Daval, G., Riad, M., Mestikawy, S. E., Hamon, M., & Verg�, D. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960205)365:2 · Cited by 378 · see citing works
Rauch, U., Karthikeyan, L., Maurel, P., Margolis, R. U., & Margolis, R. K. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41808-x · Cited by 333 · see citing works
Rauch, U., Gao, P., Janetzko, A., Flaccus, A., Hilgenberg, L., Tekotte, H., Margolis, R. K., & Margolis, R. U. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98755-7 · Cited by 267 · see citing works
Wilkin, G. P., Marriott, D. R., & Cholewinski, A. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90065-i · Cited by 255 · see citing works
Oohira, A., Matsui, F., Watanabe, E., Kushima, Y., & Maeda, N. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90210-0 · Cited by 174 · see citing works
Self-citationAquino, D. A., Margolis, R. U., & Margolis, R. K. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.3.1117 · Cited by 148 · see citing works
Maeda, N., Hamanaka, H., Oohira, A., & Noda, M. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00069-h · Cited by 134 · see citing works
Self-citationGuimaraes, A., Zaremba, S., & Hockfield, S. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-09-03014.1990 · Cited by 128 · see citing works
Aquino, D. A., Margolis, R. U., & Margolis, R. K. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.3.1130 · Cited by 126 · see citing works
Meyer‐Puttlitz, B., Milev, P., Junker, E., Zimmer, I., Margolis, R. U., & Margolis, R. K. (1995) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1995.65052327.x · Cited by 124 · see citing works
On the existence of a cartilage‐like proteoglycan and link proteins in the central nervous system
Asher, R. A., Scheibe, R. J., Keiser, H. D., & Bignami, A. (1995) · Glia · doi:10.1002/glia.440130406 · Cited by 100 · see citing works
Köppe, G., Brückner, G., Härtig, W., Delpech, B., & Bigl, V. (1997) · The Histochemical Journal · doi:10.1023/a:1026408716522 · Cited by 95 · see citing works
[6] Aggrecan-versican-neurocan family of proteoglycans
Margolis, R. U., & Margolis, R. K. (1994) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(94)45008-0 · Cited by 93 · see citing works
Bertolotto, A., Manzardo, E., & Guglielmone, R. (1996) · Cell and Tissue Research · doi:10.1007/s004410050538 · Cited by 80 · see citing works
MATSUI, F., Watanabe, E., & OOHIRA, A. (1994) · Neurochemistry International · doi:10.1016/0197-0186(94)90018-3 · Cited by 62 · see citing works
Self-citationPyramidal cells ensheathed by perineuronal nets in human motor and somatosensory cortex
Hausen, D., Brückner, G., Drlicek, M., Härtig, W., Brauer, K., & Bigl, V. (1996) · NeuroReport · doi:10.1097/00001756-199607290-00006 · Cited by 59 · see citing works
Co-localization of hyaluronic acid and chondroitin sulfate proteoglycan in rat cerebral cortex
Bignami, A., Asher, R., & Perides, G. (1992) · Brain Research · doi:10.1016/0006-8993(92)90759-3 · Cited by 55 · see citing works
Wintergerst, E. S., Faissner, A., & Celio, M. R. (1996) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(96)00011-1 · Cited by 46 · see citing works
Brückner, G., Delpech, B., DELPECH, A., & Girard, N. (1990) · PubMed · Cited by 20 · see citing works
Fuxé, K., Tinner, B., Chadi, G., Härfstrand, A., & Agnati, L. F. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90348-4 · Cited by 20 · see citing works
Ultrastructural Characterization of Prolactin-Like Immunoreactivity in Rat Medial Basal Hypothalamus
Nishizuka, M., Shivers, B. D., Léránth, C., & Pfaff, D. W. (2008) · Neuroendocrinology · doi:10.1159/000125346 · Cited by 16 · see citing works
Self-citationMeyer-Puttlitz (1996) · doi:10.1002/(sici)1096-9861(19960226)366:1
Flagged first, then by citations
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Sorted by citations
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679 · see citing works
Proteoglycans in the Developing Brain: New Conceptual Insights for Old Proteins
Bandtlow, C. E., & Zimmermann, D. R. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1267 · Cited by 632 · see citing works
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575 · see citing works
Sandy, J. D., Westling, J., Kenagy, R. D., Iruela‐Arispe, M. L., Verscharen, C., Rodrı́guez-Manzaneque, J. C., Zimmermann, D. R., Lemire, J. M., Fischer, J. W., Wight, T. N., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009737200 · Cited by 454 · see citing works
Extracellular matrix and perineuronal nets in CNS repair
Kwok, J. C. F., Dick, G., Wang, D., & Fawcett, J. W. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20974 · Cited by 395 · see citing works
The perineuronal net and the control of CNS plasticity
Wang, D., & Fawcett, J. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1375-y · Cited by 373 · see citing works
Composition of Perineuronal Net Extracellular Matrix in Rat Brain
Deepa, S. S., Carulli, D., Galtrey, C., Rhodes, K., Fukuda, J., Mikami, T., Sugahara, K., & Fawcett, J. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600544200 · Cited by 367 · see citing works
Carulli, D., Rhodes, K. E., Brown, D. J., Bonnert, T. P., Pollack, S. J., Oliver, K., Strata, P., & Fawcett, J. W. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20822 · Cited by 341 · see citing works
Chondroitin sulphate proteoglycans: preventing plasticity or protecting the CNS?
Rhodes, K. E., & Fawcett, J. W. (2003) · Journal of Anatomy · doi:10.1111/j.1469-7580.2004.00261.x · Cited by 296 · see citing works
Galtrey, C. M., Kwok, J. C. F., Carulli, D., Rhodes, K. E., & Fawcett, J. W. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06108.x · Cited by 203 · see citing works
Extracellular matrix components associated with remodeling processes in brain
Rauch, U. (2004) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/s00018-004-4043-x · Cited by 205 · see citing works
Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works
Miyata, S., & Kitagawa, H. (2017) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2017.06.010 · Cited by 171 · see citing works
Molecular Interactions of Neural Chondroitin Sulfate Proteoglycans in the Brain Development
Oohira, A., Matsui, F., Tokita, Y., Yamauchi, S., & Aono, S. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1598 · Cited by 161 · see citing works
Self-citationYe, Q., & Miao, Q.-L. (2013) · Matrix Biology · doi:10.1016/j.matbio.2013.04.001 · Cited by 146 · see citing works
Haas, C. A., Rauch, U., Thon, N., Merten, T., & Deller, T. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-09953.1999 · Cited by 151 · see citing works
Geissler, M., Gottschling, C., Aguado, A., Rauch, U., Wetzel, C. H., Hatt, H., & Faissner, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3275-12.2013 · Cited by 140 · see citing works
Vo, T., Carulli, D., Ehlert, E., Kwok, J. C. F., Dick, G., Mecollari, V., Moloney, E. B., Neufeld, G., de Winter, F., Fawcett, J. W., et al. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.04.009 · Cited by 138 · see citing works
How does chondroitinase promote functional recovery in the damaged CNS?
Crespo, D., Asher, R. A., Lin, R., Rhodes, K. E., & Fawcett, J. W. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.05.001 · Cited by 138 · see citing works
Neurocan: a brain chondroitin sulfate proteoglycan
Rauch, U., Feng, K., & Zhou, X.-H. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000822 · Cited by 136 · see citing works
Oohashi, T., Edamatsu, M., Bekku, Y., & Carulli, D. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.09.010 · Cited by 131 · see citing works
Wiera, G., & Mozrzymas, J. W. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00427 · Cited by 117 · see citing works
The Nonreceptor Tyrosine Kinase Fer Mediates Cross-Talk between N-Cadherin and β1-Integrins
Arregui, C. O., Pathre, P., Lilien, J. E., & Balsamo, J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.6.1263 · Cited by 120 · see citing works
Metalloprotease‐induced ectodomain shedding of neural cell adhesion molecule (NCAM)
Hinkle, C. L., Diestel, S., Lieberman, J. A., & Maness, P. F. (2006) · Journal of Neurobiology · doi:10.1002/neu.20257 · Cited by 119 · see citing works
Li, H., Leung, T.-C., Hoffman, S., Balsamo, J., & Lilien, J. E. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.6.1275 · Cited by 111 · see citing works
Yuan, W., Matthews, R. T., Sandy, J. D., & Gottschall, P. E. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00347-0 · Cited by 109 · see citing works
Inatani, M., & Tanihara, H. (2002) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00009-5 · Cited by 105 · see citing works
Distribution of pyramidal cells associated with perineuronal nets in the neocortex of rat
Alpár, A., Gärtner, U., Härtig, W., & Brückner, G. (2006) · Brain Research · doi:10.1016/j.brainres.2006.08.069 · Cited by 93 · see citing works
The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development
Mencio, C. P., Hussein, R. K., Yu, P., & Geller, H. M. (2020) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155420959147 · Cited by 68 · see citing works
Howell, M. D., & Gottschall, P. E. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.034 · Cited by 66 · see citing works
Morphology of perineuronal nets in tenascin-R and parvalbumin single and double knockout mice
Haunsø, A., Ibrahim, M., Bartsch, U., Letiembre, M., Celio, M. R., & Menoud, P.-A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02173-9 · Cited by 61 · see citing works
Proteoglycans and injury of the central nervous system
Matsui, F., & Oohira, A. (2004) · Congenital Anomalies · doi:10.1111/j.1741-4520.2004.00038.x · Cited by 64 · see citing works
Self-citationBeggah, A., Dours-Zimmermann, M. T., Barras, F. M., Brosius, A., Zimmermann, D., & Zurn, A. D. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.005 · Cited by 61 · see citing works
Okamoto, M., Sakiyama, J., Mori, S., Kurazono, S., Usui, S., Hasegawa, M., & Oohira, A. (2003) · Experimental Neurology · doi:10.1016/s0014-4886(03)00251-6 · Cited by 60 · see citing works
Self-citationBlosa, M., Sonntag, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., Rübsamen, R., Arendt, T., & Morawski, M. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.10.003 · Cited by 59 · see citing works
Klein, J., Le, M., & Zaia, J. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000766 · Cited by 57 · see citing works
Inatani, M., Tanihara, H., Oohira, A., Honjo, M., Kido, N., & Honda, Y. (2000) · PubMed · Cited by 53 · see citing works
Self-citationHaunsø, A., Celio, M. R., Margolis, R. K., & Menoud, P.-A. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01596-6 · Cited by 52 · see citing works
Proteolysis: a key post-translational modification regulating proteoglycans
Mead, T. J., Bhutada, S., Martin, D. R., & Apte, S. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00215.2022 · Cited by 49 · see citing works
Yamagata, M., & Sanes, J. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1976-05.2005 · Cited by 47 · see citing works
Expression of aggrecan components in perineuronal nets in the mouse cerebral cortex
Ueno, H., Fujii, K., Suemitsu, S., Murakami, S., Kitamura, N., Wani, K., Aoki, S., Okamoto, M., Ishihara, T., & Takao, K. (2018) · IBRO Reports · doi:10.1016/j.ibror.2018.01.002 · Cited by 47 · see citing works
Blanchard, V., Chevalier, F., Imberty, A., Leeflang, B. R., Basappa, B., Sugahara, K., & Kamerling, J. P. (2007) · Biochemistry · doi:10.1021/bi061971f · Cited by 40 · see citing works
Vitellaro‐Zuccarello, L., Bosisio, P., Mazzetti, S., Monti, C., & Biasi, S. D. (2006) · Cell and Tissue Research · doi:10.1007/s00441-006-0289-y · Cited by 38 · see citing works
Kurazono, S., Okamoto, M., Sakiyama, J., Mori, S., Nakata, Y., Fukuoka, J., Amano, S., Oohira, A., & Matsui, H. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02128-x · Cited by 36 · see citing works
Self-citationNeurocan contributes to the molecular heterogeneity of the perinodal ECM
Bekku, Y., & Oohashi, T. (2010) · Archivum histologicum japonicum · doi:10.1679/aohc.73.95 · Cited by 34 · see citing works
Friauf, E. (2000) · Audiology and Neurotology · doi:10.1159/000013889 · Cited by 33 · see citing works
Yabuno, K., Morise, J., Kizuka, Y., Hashii, N., Kawasaki, N., Takahashi, S., Miyata, S., Izumikawa, T., Kitagawa, H., Takematsu, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144560 · Cited by 33 · see citing works
Distinct roles for hyaluronan in neural stem cell niches and perineuronal nets
Su, W., Matsumoto, S. G., Sorg, B. A., & Sherman, L. S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.022 · Cited by 32 · see citing works
Morita, S., Oohira, A., & Miyata, S. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.01.041 · Cited by 31 · see citing works
Self-citationDACS, novel matrix structure composed of chondroitin sulfate proteoglycan in the brain
Hayashi, N., Tatsumi, K., Okuda, H., Yoshikawa, M., Ishizaka, S., Miyata, S., Manabe, T., & Wanaka, A. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.040 · Cited by 30 · see citing works
Sugitani, K., Egorova, D., Mizumoto, S., Nishio, S., Yamada, S., Kitagawa, H., Oshima, K., Nadano, D., Matsuda, T., & Miyata, S. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129804 · Cited by 28 · see citing works
Inatani, M., Tanihara, H., Oohira, A., Honjo, M., & Honda, Y. (1999) · PubMed · Cited by 28 · see citing works
Self-citationPerineuronal net, CSPG receptor and their regulation of neural plasticity.
Miao, Q., Ye, Q., & Zhang, X.-H. (2014) · PubMed · Cited by 27 · see citing works
Talts, U., Kuhn, U., Roos, G., & Rauch, U. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4987 · Cited by 22 · see citing works
Lee, H., Leamey, C. A., & Sawatari, A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003020 · Cited by 21 · see citing works
Okamoto, M., Sakiyama, J., Kurazono, S., Mori, S., Nakata, Y., Nakaya, N., & Oohira, A. (2001) · Cell and Tissue Research · doi:10.1007/s004410100441 · Cited by 21 · see citing works
Self-citationProteoglycans in Perineuronal Nets.
Matsui, F., Nishizuka, M., & Oohira, A. (1999) · ACTA HISTOCHEMICA ET CYTOCHEMICA · doi:10.1267/ahc.32.141 · Cited by 19 · see citing works
Self-citationGrycz, K., Głowacka, A., Ji, B., Krzywdzińska, K., Charzyńska, A., Czarkowska‐Bauch, J., Gajewska‐Woźniak, O., & Skup, M. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114098 · Cited by 14 · see citing works
Matsuyama, A., Kalargyrou, A. A., Smith, A. J., Ali, R. R., & Pearson, R. A. (2022) · Scientific Reports · doi:10.1038/s41598-022-11204-w · Cited by 15 · see citing works
Amontree, M., Nelson, M., Stefansson, L., Pak, D. T. S., Maguire-Zeiss, K., Turner, R., & Conant, K. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16031 · Cited by 13 · see citing works
Inoue, M., Kato, K., Matsuhashi, H., Kizuka, Y., Kawasaki, T., & Oka, S. (2007) · Brain Research · doi:10.1016/j.brainres.2007.05.012 · Cited by 13 · see citing works
Tisay, K. T., John, J. A. S., & Key, B. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10107 · Cited by 8 · see citing works
Zooming in on the (Peri)synaptic Extracellular Matrix
Александровна, К. С., Zanacchi, F. C., Diaspro, A., & Dityatev, A. E. (2014) · Neuromethods · doi:10.1007/978-1-4614-9179-8_10 · Cited by 8 · see citing works
Otsuka, M. Y., Essel, L. B., Sinha, A., Nickerson, G., Mejia, S. M., Edge, A., Matthews, R. T., & Bouyain, S. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108525 · Cited by 7 · see citing works
Chondroitin Sulfate Proteoglycans in the Brain
Aono, S., & Oohira, A. (2006) · Advances in pharmacology · doi:10.1016/s1054-3589(05)53015-1 · Cited by 6 · see citing works
Self-citationMultiple Species and Functions of Proteoglycans in the Central Nervous System
Oohira, A. (2007) · Elsevier eBooks · doi:10.1016/b978-044451967-2/00095-7 · Cited by 6 · see citing works
Self-citationGilbert, K. F., Amontree, M., Deasy, S., Ma, J., & Conant, K. E. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16570 · Cited by 5 · see citing works
Regulation of CNS Plasticity Through the Extracellular Matrix
Warren, P. M., Dickens, S., Gigout, S., Fawcett, J. W., & Kwok, J. C. F. (2018) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190635374.013.11 · Cited by 5 · see citing works
Natori, T., & Nagai, K. (2008) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-008-9262-5 · Cited by 3 · see citing works
Emerging Therapeutic Role of Chondroitinase (ChABC) in Neurological Disorders and Cancer
Kolathur, K. K., Kumar, A., Biswas, A., Bojja, S. L., & Subrahmanyam, V. M. (2022) · Current Drug Therapy · doi:10.2174/1574885517666220331151619 · Cited by 3 · see citing works
Immunolocalization of laminin-α1-like antigens around synapses in mouse cerebellar perineuronal nets
Yagi, T., Terada, N., Baba, T., & Ohno, S. (2003) · The Histochemical Journal · doi:10.1023/a:1026044517888 · Cited by 2 · see citing works
Proteoglycans of the Central Nervous System
Gupta, G. (2012) · Springer eBooks · doi:10.1007/978-3-7091-1065-2_38 · Cited by 1 · see citing works
Studies on Semaphorin 3A in the Neuromuscular
Heutink, P. D. P., Hol, D. E., Pasterkamp, D. R. J., Fonds, V. L., Bv, L., Tri, C., Vo, T., Bossers, B. D. K., & Vo, T. T. (2011) · Data Archiving and Networked Services (DANS) · Cited by 1 · see citing works
Structural features of free and covalently bound glycans
Blanchard, V. (2006) · Utrecht University Repository (Utrecht University)
Review Neurocan: a brain chondroitin sulfate proteoglycan
Rauch, U., & Feng, K. (2001)
Douceau, S. (2020) · theses.fr (ABES) · doi:10.70675/6f1007f2z8468z4365zb07dz7d863bf32cd5
Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R
Br�ckner, G., Grosche, J., Schmidt, S., H�rtig, W., Margolis, R. U., Delpech, B., Seidenbecher, C. I., Czaniera, R., & Schachner, M. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001225)428:4
- Authors
- Matsui, F., Nishizuka, M., Yasuda, Y., Aono, S., Watanabe, E., & Oohira, A.
- Affiliations
- Institute for Developmental Research (JP)
- Juntendo University (JP)
- National Institute for Basic Biology (JP)
- Corresponding author
- Matsui, Fumiko
- ORCID
- Watanabe, Eiji
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1998-04
- Volume
- 790
- Issue
- 1-2
- Pages
- 45-51
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2001796760
- Cited by
- 78
- References
- 23
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 4 · 2020: 3 · 2018: 4 · 2017: 1 · 2015: 3 · 2014: 2 · 2013: 3 · 2012: 4
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neurocan, proteolytic cleavage, chondroitin sulfate proteoglycans, perineuronal nets, cerebrum, synaptophysin, glial cells, adult rat brain
- MeSH terms
- Age Factors, Animals, Brain Chemistry, Cerebral Cortex, Hippocampus, Nerve Tissue Proteins, Neuroglia, Neurons, Peptide Fragments, Chondroitin Sulfate Proteoglycans, Rabbits, Microscopy, Immunoelectron, Synaptophysin, Neostriatum, Rats, Sprague-Dawley, Neuropil, Lectins, C-Type, Rats, Neurocan
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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