The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Targeted Inactivation of Gh/Tissue Transglutaminase II
Open accessAbstract
The novel G-protein, G(h)/tissue transglutaminase (TGase II), has both guanosine triphosphatase and Ca(2+)-activated transglutaminase activity and has been implicated in a number of processes including signal transduction, apoptosis, bone ossification, wound healing, and cell adhesion and spreading. To determine the role of G(h) in vivo, the Cre/loxP site-specific recombinase system was used to develop a mouse line in which its expression was ubiquitously inactivated. Despite the absence of G(h) expression and a lack of intracellular TGase activity that was not compensated by other TGases, the Tgm2(-/-) mice were viable, phenotypically normal, and were born with the expected Mendelian frequency. Absence of G(h) coupling to alpha(1)-adrenergic receptor signaling in Tgm2(-/-) mice was demonstrated by the lack of agonist-stimulated [alpha-(32)P]GTP photolabeling of a 74-kDa protein in liver membranes. Annexin-V positivity observed with dexamethasone-induced apoptosis was not different in Tgm2(-/-) thymocytes compared with Tgm2(+/+) thymocytes. However, with this treatment there was a highly significant decrease in the viability (propidium iodide negativity) of Tgm2(-/-) thymocytes. Primary fibroblasts isolated from Tgm2(-/-) mice also showed decreased adherence with culture. These results indicate that G(h) may be importantly involved in stabilizing apoptotic cells before clearance, and in responses such as wound healing that require fibroblast adhesion mediated by extracellular matrix cross-linking.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Schwenk, F., Baron, U., & Rajewsky, K. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.24.5080 · Cited by 1,289
Transglutaminases: multifunctional cross‐linking enzymes that stabilize tissues
Greenberg, C. S., Birckbichler, P. J., & Rice, R. H. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.15.1683845 · Cited by 985
Folk, J. E. (1980) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.49.070180.002505 · Cited by 835
Adrenergic and Muscarinic Receptors in the Human Heart
Brodde, O.-E., & Michel, M. C. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01425-x · Cited by 673
G h : a GTP-Binding Protein with Transglutaminase Activity and Receptor Signaling Function
Nakaoka, H., Perez, D. M., Baek, K. J., Das, T., Husain, A., Misono, K., Im, M.-J., & Graham, R. M. (1994) · Science · doi:10.1126/science.7911253 · Cited by 547
Self-citationTransglutaminases: Protein Cross-Linking Enzymes in Tissues and Body Fluids
Aeschlimann, D., & Paulsson, M. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1642451 · Cited by 499
Tissue Transglutaminase Is an Integrin-Binding Adhesion Coreceptor for Fibronectin
Akimov, S. S., Krylov, D., Fleischman, L. F., & Belkin, A. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.825 · Cited by 490
Platt, N., Suzuki, H., Kurihara, Y., Kodama, T., & Gordon, S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12456 · Cited by 428
Milano, C. A., Dolber, P. C., Rockman, H. A., Bond, R. A., Venable, M. E., Allen, L. F., & Lefkowitz, R. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.21.10109 · Cited by 371
[53] Manipulation of transgenes by site-specific recombination: Use of cre recombinase
Sauer, B. (1993) · Methods in Enzymology · doi:10.1016/0076-6879(93)25056-8 · Cited by 340
Cited by
Making sense of latent TGFβ activation
Annes, J. P., Munger, J. S., & Rifkin, D. B. (2003) · Journal of Cell Science · doi:10.1242/jcs.00229 · Cited by 1,628
Transglutaminases: crosslinking enzymes with pleiotropic functions
Lorand, L., & Graham, R. M. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1014 · Cited by 1,438
Self-citationTransglutaminases: Nature’s biological glues
GRIFFIN, M., CASADIO, R., & BERGAMINI, C. M. (2002) · Biochemical Journal · doi:10.1042/bj20021234 · Cited by 1,042
Transglutaminase 2 Undergoes a Large Conformational Change upon Activation
Pinkas, D. M., Strop, P., Brunger, A. T., & Khosla, C. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050327 · Cited by 450
Transglutaminase Regulation of Cell Function
Eckert, R. L., Kaartinen, M. T., Nurminskaya, M., Belkin, A. M., Colak, G., Johnson, G. V. W., & Mehta, K. (2014) · Physiological Reviews · doi:10.1152/physrev.00019.2013 · Cited by 419
Metadata
- Authors
- Nanda, N., Iismaa, S. E., Owens, W. A., Husain, A., Mackay, F., & Graham, R. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-01
- Volume
- 276
- Issue
- 23
- Pages
- 20673-20678
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1986366555
- Cited by
- 292
- References
- 36
- FWCI
- 13.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Targeted Inactivation of Gh/Tissue Transglutaminase II. https://app.cochat.ai/papers/10.1074/jbc.m010846200
- The paper
- Nanda, N., Iismaa, S. E., Owens, W. A., Husain, A., Mackay, F., & Graham, R. M. (2001). Targeted Inactivation of Gh/Tissue Transglutaminase II. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m010846200
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
