The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Estrogen Receptor β-Selective Transcriptional Activity and Recruitment of Coregulators by Phytoestrogens
Open accessAbstract
Estrogens used in hormone replacement therapy regimens may increase the risk of developing breast cancer. Paradoxically, high consumption of plant-derived phytoestrogens, particularly soybean isoflavones, is associated with a low incidence of breast cancer. To explore the molecular basis for these potential different clinical outcomes, we investigated whether soybean isoflavones elicit distinct transcriptional actions from estrogens. Our results demonstrate that the estrogen 17beta-estradiol effectively triggers the transcriptional activation and repression pathways with both estrogen receptors (ERs) ERalpha and ERbeta. In contrast, soybean isoflavones (genistein, daidzein, and biochanin A) are ERbeta-selective agonists of transcriptional repression and activation at physiological levels. The molecular mechanism for ERbeta selectivity by isoflavones involves their capacity to create an activation function-2 surface of ERbeta that has a greater affinity for coregulators than ERalpha. Phytoestrogens may act as natural selective estrogen receptor modulators that elicit distinct clinical effects from estrogens used for hormone replacement by selectively recruiting coregulatory proteins to ERbeta that trigger transcriptional pathways.
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Cited by
Soy and Health Update: Evaluation of the Clinical and Epidemiologic Literature
Messina, M. (2016) · Nutrients · doi:10.3390/nu8120754 · Cited by 537
Shanle, E. K., & Xu, W. (2011) · Chemical Research in Toxicology · doi:10.1021/tx100231n · Cited by 522
Estimated Asian adult soy protein and isoflavone intakes
Messina, M., Nagata, C., & Wu, A. H. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5501_1 · Cited by 435
Adolescent and adult soy intake and risk of breast cancer in Asian-Americans
Wu, A. H. (2002) · Carcinogenesis · doi:10.1093/carcin/23.9.1491 · Cited by 406
Environmental pollutants and breast cancer: Epidemiologic studies
Brody, J. G., Moysich, K. B., Humblet, O., Attfield, K. R., Beehler, G. P., & Rudel, R. A. (2007) · Cancer · doi:10.1002/cncr.22655 · Cited by 375
Metadata
- Authors
- An, J., Tzagarakis-Foster, C., Scharschmidt, T. C., Lomri, N., & Leitman, D. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 276
- Issue
- 21
- Pages
- 17808-17814
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2091256192
- Cited by
- 323
- References
- 63
- FWCI
- 13.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- An, J., Tzagarakis-Foster, C., Scharschmidt, T. C., Lomri, N., & Leitman, D. C. (2001). Estrogen Receptor β-Selective Transcriptional Activity and Recruitment of Coregulators by Phytoestrogens. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m100953200
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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