Regulation of Apoptosis by Vitamin C

Free radicals in biology and medicine

Gutteridge, J. M. C. (1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90478-o · Cited by 17,178 · see citing works

A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V

Vermes, I., Haanen, C., Steffens-Nakken, H. M., & Reutellingsperger, C. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00072-i · Cited by 5,437 · see citing works

Ascorbate is an outstanding antioxidant in human blood plasma

Frei, B., England, L., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6377 · Cited by 1,870 · see citing works

Macrophage phagocytosis of aging neutrophils in inflammation. Programmed cell death in the neutrophil leads to its recognition by macrophages.

Savill, J. S., Wyllie, A. H., Henson, J. E., Walport, M. J., Henson, P. M., & Haslett, C. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113970 · Cited by 1,536 · see citing works

Triggering and modulation of apoptosis by oxidative stress

Chandra, J., Samali, A., & Orrenius, S. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00302-6 · Cited by 1,335 · see citing works

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

Ischiropoulos, H. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0755 · Cited by 1,024 · see citing works

Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis

Hampton, M. B., & Orrenius, S. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01068-5 · Cited by 663 · see citing works

Ascorbic acid: metabolism and functions of a multi-facetted molecule

Smirnoff, N. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)80070-9 · Cited by 619 · see citing works

Presence of hypochlorite-modified proteins in human atherosclerotic lesions.

Hazell, L. J., Arnold, L., Flowers, D., Waeg, G., Malle, E., & Stocker, R. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118576 · Cited by 592 · see citing works

Ascorbic acid: metabolism and functions of a multi-facetted molecule

Smirnoff, N. (2000) · Current Opinion in Plant Biology · doi:10.1016/s1369-5266(00)00069-8 · Cited by 584 · see citing works

Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant

Bowry, V. W., Ingold, K. U., & Stocker, R. (1992) · Biochemical Journal · doi:10.1042/bj2880341 · Cited by 511 · see citing works

Free radicals in biology and medicine

Rice-Evans, C. A. (1985) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(85)90074-x · Cited by 472 · see citing works

Control of apoptosis by the cellular ATP level

Richter, C., Schweizer, M., Cossarizza, A., & Franceschi, C. (1996) · FEBS Letters · doi:10.1016/0014-5793(95)01431-4 · Cited by 470 · see citing works

Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of oxidant to hypochlorite

Winterbourn, C. C. (1985) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(85)90120-5 · Cited by 463 · see citing works

Oxidation of Methionine in Proteins: Roles in Antioxidant Defense and Cellular Regulation

Levine, R. L., Moskovitz, J., & Stadtman, E. R. (2000) · IUBMB Life · doi:10.1080/713803735 · Cited by 446 · see citing works

Kinetics and Mechanisms of Hypochlorous Acid Reactions

Folkes, L. K., Candeias, L. P., & Wardman, P. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.0017 · Cited by 358 · see citing works

Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.

McKenzie, S. J., Baker, M. S., Buffinton, G. D., & Doe, W. F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118757 · Cited by 349 · see citing works

Involvement of Caspases in Neutrophil Apoptosis: Regulation by Reactive Oxygen Species

Fadeel, B., Åhlin, A., Henter, J., Orrenius, S., & Hampton, M. B. (1998) · Blood · doi:10.1182/blood.v92.12.4808 · Cited by 344 · see citing works

Vitamin C in health and disease.

Packer, L., & Fuchs, J. (1997) · Medical Entomology and Zoology · Cited by 339 · see citing works

Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate

Peskin, A. V., & Winterbourn, C. C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00506-2 · Cited by 338 · see citing works

Hypochlorous Acid Interactions with Thiols, Nucleotides, DNA, and Other Biological Substrates

Prütz, W. A. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0322 · Cited by 327 · see citing works

Living with a Killer: The Effects of Hypochlorous Acid on Mammalian Cells

Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2000) · IUBMB Life · doi:10.1080/713803731 · Cited by 315 · see citing works

Antioxidant protection against hypochlorous acid in human plasma.

Hu, M., Louie, S., Cross, C., Motchnik, P. A., & Halliwell, B. B. (1993) · PubMed · Cited by 314 · see citing works

Myeloperoxidase

Klebanoff, S. J. (1999) · Proceedings of the Association of American Physicians · doi:10.1111/paa.1999.111.5.383 · Cited by 308 · see citing works

Myeloperoxidase

Winterbourn, C. C., Vissers, M. C. M., & Kettle, A. J. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200001000-00010 · Cited by 279 · see citing works

Redox Regulation of the Caspases during Apoptosisa

Hampton, M. B., Fadeel, B., & Orrenius, S. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09913.x · Cited by 274 · see citing works

Identification, localization, and role of fibronectin in cultured bovine endothelial cells.

Birdwell, C. R., Gospodarowicz, D., & Nicolson, G. L. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.7.3273 · Cited by 255 · see citing works

Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosis

Stridh, H., Kimland, M., Jones, D. P., Orrenius, S., & Hampton, M. B. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00630-9 · Cited by 251 · see citing works

Immunohistochemical evidence for the myeloperoxidase/H₂O₂/halide system in human atherosclerotic lesions: Colocalization of myeloperoxidase and hypochlorite‐modified proteins

Malle, E., Waeg, G., Schreiber, R., Gröne, E. F., Sattler, W., & Gröne, H. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01498.x · Cited by 245 · see citing works

Antioxidant Activity of Vitamin C in Iron-overloaded Human Plasma

Berger, T. M., Polidori, M. C., Dabbagh, A. J., Evans, P., Halliwell, B. B., Morrow, J. D., Roberts, L. J., & Frei, B. B. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15656 · Cited by 208 · see citing works

FUNCTION OF ASCORBIC ACID IN COLLAGEN METABOLISM

Barnes, M. J. (1975) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1975.tb29287.x · Cited by 166 · see citing works

ATP converts necrosis to apoptosis in oxidant-injured endothelial cells

Lelli, J. L., Becks, L. L., Dąbrowska, M., & Hinshaw, D. B. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00107-5 · Cited by 165 · see citing works

Conventional cell culture media do not adequately supply cells with antioxidants and thus facilitate peroxide-induced genotoxicity

Leist, M., RAAB, B., Maurer, S., Rösick, U., & Brigelius‐Flohé, R. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(96)00045-7 · Cited by 158 · see citing works

Mechanism of Dithiocarbamate Inhibition of Apoptosis: Thiol Oxidation by Dithiocarbamate Disulfides Directly Inhibits Processing of the Caspase-3 Proenzyme

Nobel, S., Burgess, D. H., Zhivotovsky, B., Burkitt, M. J., Orrenius, S., & Slater, A. F. G. (1997) · Chemical Research in Toxicology · doi:10.1021/tx970006a · Cited by 132 · see citing works

Oxidation of intracellular glutathione after exposure of human red blood cells to hypochlorous acid

Vissers, M. C. M., & Winterbourn, C. C. (1995) · Biochemical Journal · doi:10.1042/bj3070057 · Cited by 131 · see citing works

Interactions of Hypochlorous Acid with Pyrimidine Nucleotides, and Secondary Reactions of Chlorinated Pyrimidines with GSH, NADH, and Other Substrates

Prütz, W. A. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0440 · Cited by 121 · see citing works

The most unkindest cut of all: on the multiple roles of mammalian caspases*

Fadeel, B., Orrenius, S., & Zhivotovsky, B. (2000) · Leukemia · doi:10.1038/sj.leu.2401871 · Cited by 99 · see citing works

Ascorbic acid in lymphocytes: Cell preparation and liquid-chromatographic assay

Lee, W., Hamernyik, P., Hutchinson, M., Raisys, V. A., & Labbé, R. F. (1982) · Clinical Chemistry · doi:10.1093/clinchem/28.10.2165 · Cited by 97 · see citing works

Reactions of monochloramine with bromine, tribromide, hypobromous acid and hypobromite: formation of bromochloramines

Gazda, M., & Margerum, D. W. (1994) · Inorganic Chemistry · doi:10.1021/ic00079a022 · Cited by 97 · see citing works

Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells

Vissers, M. C. M., Pullar, J. M., & Hampton, M. B. (1999) · Biochemical Journal · doi:10.1042/bj3440443 · Cited by 95 · see citing works

Glutathione Oxidation by Hypochlorous Acid in Endothelial Cells Produces Glutathione Sulfonamide as a Major Product but Not Glutathione Disulfide

Pullar, J. M., Vissers, M. C. M., & Winterbourn, C. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102088200 · Cited by 91 · see citing works

Relative reactivities ofN-chloramines and hypochlorous acid with human plasma constituents

Carr, A. C., Hawkins, C. L., Thomas, S. R., Stocker, R., & Frei, B. B. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00495-0 · Cited by 77 · see citing works

The uptake of ascorbic acid into human umbilical vein endothelial cells and its effect on oxidant insult

Alexandra, E. S., Ström, K., & Cotgreave, I. A. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)02024-1 · Cited by 64 · see citing works

Ascorbic Acid Inhibits Apoptosis Induced by X Irradiation in HL60 Myeloid Leukemia Cells

Witenberg, B., Kletter, Y., Kalir, H. H., Raviv, Z., Fenig, E., Nagler, A., Halperin, D., & Fabian, I. (1999) · Radiation Research · doi:10.2307/3580142 · Cited by 58 · see citing works

Reduced bactericidal activity in neutrophils from scorbutic animals and the effect of ascorbic acid on these target bacteria in vivo and in vitro

Goldschmidt, M. C. (1991) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/54.6.1214s · Cited by 56 · see citing works

Consecutive Halogen Transfer between Various Functional Groups Induced by Reaction of Hypohalous Acids: NADH Oxidation by Halogenated Amide Groups

Prütz, W. A. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1377 · Cited by 52 · see citing works

Initiation of Rapid, P53-Dependent Growth Arrest in Cultured Human Skin Fibroblasts by Reactive Chlorine Species

Vile, G. F., Rothwell, L. A., & Kettle, A. J. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1706 · Cited by 50 · see citing works

Hypochlorous Acid Activates the Tumor Suppressor Protein p53 in Cultured Human Skin Fibroblasts

Vile, G. F., Rothwell, L. A., & Kettle, A. J. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0881 · Cited by 46 · see citing works

Characterization of Hydrogen Peroxide-Induced Apoptosis in Mouse Primary Cultured Hepatocytes.

KANNO, S., Ishikawa, M., Takayanagi, M., Takayanagi, Y., & Sasaki, K. (2000) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.23.37 · Cited by 37 · see citing works

Changes in ascorbate levels on stimulation of human neutrophils

Winterbourn, C. C., & Vissers, M. C. M. (1983) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(83)90041-1 · Cited by 36 · see citing works

Inhibition of hypochlorous acid-mediated reactions by desferrioxamine. Implications for the mechanism of cellular injury by neutrophils

Vissers, M. C. M., & Fantone, J. C. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90098-4 · Cited by 28 · see citing works

The cytoprotective roles of ascorbate and glutathione against nitrogen dioxide toxicity in human endothelial cells

Tu, B. (1995) · Toxicology · doi:10.1016/0300-483x(94)02977-3 · Cited by 23 · see citing works

Myeloperoxidase-catalyzed chlorination of histamine by stimulated neutrophils

Thomas, E. L., Jefferson, M. M., Learn, D. B., King, C. C., & Dabbous, M. K. (2000) · Redox Report · doi:10.1179/135100000101535744 · Cited by 12 · see citing works

Bronchopulmonary dysplasia: the outcome.

Samuels, M. P., & Warner, J. O. (1987) · Archives of Disease in Childhood · doi:10.1136/adc.62.11.1099 · Cited by 9 · see citing works

The Roles of Vitamin C in Skin Health.

Pullar, J., Carr, A., & Vissers, M. (2017) · Nutrients · doi:10.3390/nu9080866 · Cited by 756 · see citing works

Mammalian Heme Peroxidases: From Molecular Mechanisms to Health Implications

Davies, M. J., Hawkins, C. L., Pattison, D. I., & Rees, M. D. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1927 · Cited by 556 · see citing works

Hypochlorous Acid, a Macrophage Product, Induces Endothelial Apoptosis and Tissue Factor Expression

Sugiyama, S., Kugiyama, K., Aikawa, M., Nakamura, S., Ogawa, H., & Libby, P. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000131784.50633.4f · Cited by 413 · see citing works

Myeloperoxidase-derived oxidation: Mechanisms of biological damage and its prevention

Davies, M. J. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-006fr · Cited by 412 · see citing works

Legume nodule senescence: roles for redox and hormone signalling in the orchestration of the natural aging process

Puppo, A., Groten, K., Bastián, F., Carzaniga, R., Soussi, M., Lucas, M. M., de Felipe, M. R., Harrison, J., Vanacker, H., & Foyer, C. H. (2004) · New Phytologist · doi:10.1111/j.1469-8137.2004.01285.x · Cited by 346 · see citing works

Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?

Whiteman, M., Cheung, N. S., Zhu, Y. Z., Chu, S. H., Siau, J. L., Wong, B., Armstrong, J. S., & Moore, P. K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.11.110 · Cited by 333 · see citing works

The Role of Myeloperoxidase in Biomolecule Modification, Chronic Inflammation, and Disease

Davies, M. J., & Hawkins, C. L. (2020) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8030 · Cited by 332 · see citing works

Potential carcinogenic hazards of non-regulated disinfection by-products: Haloquinones, halo-cyclopentene and cyclohexene derivatives, N-halamines, halonitriles, and heterocyclic amines

Bull, R. J., Reckhow, D. A., Li, X., Humpage, A. R., Joll, C. A., & Hrudey, S. E. (2011) · Toxicology · doi:10.1016/j.tox.2011.05.004 · Cited by 255 · see citing works

Reactions and reactivity of myeloperoxidase-derived oxidants: Differential biological effects of hypochlorous and hypothiocyanous acids

Pattison, D. I., Davies, M. J., & Hawkins, C. L. (2012) · Free Radical Research · doi:10.3109/10715762.2012.667566 · Cited by 175 · see citing works

Hypochlorous acid induces apoptosis of cultured cortical neurons through activation of calpains and rupture of lysosomes

Yap, Y. W., Whiteman, M., Bay, B., Li, Y., Sheu, F., Qi, R. Z., Tan, C. H., & Cheung, N. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03996.x · Cited by 161 · see citing works

Ceruloplasmin Is an Endogenous Inhibitor of Myeloperoxidase

Chapman, A., Mocatta, T. J., Shiva, S., Seidel, A., Chen, B., Khalilova, I. S., Paumann-Page, M., Jameson, G. N. L., Winterbourn, C. C., & Kettle, A. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.418970 · Cited by 153 · see citing works

Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate

Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.11.023 · Cited by 125 · see citing works

Hypochlorous acid-mediated mitochondrial dysfunction and apoptosis in human hepatoma HepG2 and human fetal liver cells: role of mitochondrial permeability transition

Whiteman, M., Rose, P. E., Siau, J. L., Cheung, N. S., Tan, G. S., Halliwell, B. B., & Armstrong, J. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.02.030 · Cited by 121 · see citing works

Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

Rayner, B. S., Love, D. T., & Hawkins, C. L. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.004 · Cited by 114 · see citing works

Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1α

Vissers, M. C. M., & Wilkie-Grantham, R. P. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0806541 · Cited by 110 · see citing works

Vitamin C Inactivates the Proteasome Inhibitor PS-341 in Human Cancer Cells

Zou, W., Yue, P., Lin, N., He, M., Zhou, Z., Lonial, S., Khuri, F. R., Wang, B., & Sun, S. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0503 · Cited by 107 · see citing works

Chlorine transfer between glycine, taurine, and histamine: reaction rates and impact on cellular reactivity

Peskin, A. V., Midwinter, R. G., Harwood, D. T., & Winterbourn, C. C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.08.010 · Cited by 90 · see citing works

Carotenoid derived aldehydes-induced oxidative stress causes apoptotic cell death in human retinal pigment epithelial cells

Kalariya, N. M., Ramana, K. V., Sk, S., & van Kuijk, F. J. G. M. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.09.010 · Cited by 91 · see citing works

Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

Lloyd, M. M., van Reyk, D. M., Davies, M. J., & Hawkins, C. L. (2008) · Biochemical Journal · doi:10.1042/bj20080468 · Cited by 79 · see citing works

Essential Cellular Regulatory Elements of Oxidative Stress in Early and Late Phases of Apoptosis in the Central Nervous System

Chong, Z. Z., Kang, J., & Maiese, K. (2004) · Antioxidants and Redox Signaling · doi:10.1089/152308604322899341 · Cited by 78 · see citing works

The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways

Whiteman, M., Chu, S. H., Siau, J. L., Rose, P. E., Sabapathy, K., Schantz, J., Cheung, N. S., Spencer, J. P. E., & Armstrong, J. S. (2006) · Cellular Signalling · doi:10.1016/j.cellsig.2006.08.019 · Cited by 72 · see citing works

Vitamins and respiratory disease: antioxidant micronutrients in pulmonary health and disease

Kelly, F. J. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005457 · Cited by 72 · see citing works

Histamine chloramine reactivity with thiol compounds, ascorbate, and methionine and with intracellular glutathione

Peskin, A. V., & Winterbourn, C. C. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00502-1 · Cited by 59 · see citing works

Cellular Oxidative Processes in Relation to Renal Disease

WARDLE, E. N. (2005) · American Journal of Nephrology · doi:10.1159/000083477 · Cited by 60 · see citing works

Protective Effects of Vitamin C on Cisplatin-Induced Renal Damage: A Light and Electron Microscopic Study

Tarladaçalişir, Y. T., Kanter, M., & Uygun, M. (2008) · Renal Failure · doi:10.1080/08860220701742070 · Cited by 57 · see citing works

Involvement of the yeast metacaspase Yca1 in Δ-programmed cell death

Bettiga, M., Calzari, L., Orlandi, I., Alberghina, L., & Vai, M. (2004) · FEMS Yeast Research · doi:10.1016/j.femsyr.2004.07.005 · Cited by 55 · see citing works

Vitamin C Protects Against Hypochlorous Acid–Induced Glutathione Depletion and DNA Base and Protein Damage in Human Vascular Smooth Muscle Cells

Jenner, A. M., Ruiz, J. E., Dunster, C., Halliwell, B. B., Mann, G. E., & Siow, R. C. M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013785.03265.5c · Cited by 55 · see citing works

Hypothiocyanous acid is a potent inhibitor of apoptosis and caspase 3 activation in endothelial cells

Bozonet, S. M., Scott-Thomas, A., Nagy, P., & Vissers, M. C. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.06.028 · Cited by 53 · see citing works

Mechanical Ventilation Antioxidant Trial

Howe, K. P., Clochesy, J. M., Goldstein, L. S., & Owen, H. (2015) · American Journal of Critical Care · doi:10.4037/ajcc2015335 · Cited by 52 · see citing works

Involvement of protein radical, protein aggregation, and effects on NO metabolism in the hypochlorite-mediated oxidation of mitochondrial cytochrome c

Chen, Y.-R., Chen, C.-L., Liu, X., Li, H., Zweier, J. L., & Mason, R. P. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.07.013 · Cited by 51 · see citing works

Hypochlorous acid-induced heme oxygenase-1 gene expression promotes human endothelial cell survival

Wei, Y., Liu, X., Peyton, K. J., Wang, H., Johnson, F. K., Johnson, R. A., & Durante, W. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00536.2008 · Cited by 51 · see citing works

Vitamin C Attenuates Isoflurane-Induced Caspase-3 Activation and Cognitive Impairment

Cheng, B., Zhang, Y., Wang, A., Dong, Y., & Xie, Z. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8959-3 · Cited by 48 · see citing works

Extracellular Oxidation by Taurine Chloramine Activates ERK via the Epidermal Growth Factor Receptor

Midwinter, R. G., Peskin, A. V., Vissers, M. C. M., & Winterbourn, C. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402070200 · Cited by 47 · see citing works

Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, M. J., & Hawkins, C. L. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.10.007 · Cited by 45 · see citing works

Macrophage antioxidant protection within atherosclerotic plaques

Steven, P. G. (2009) · Frontiers in bioscience · doi:10.2741/3305 · Cited by 42 · see citing works

The Effect of Ascorbic Acid and Garlic Administration on Lead-Induced Neural Damage in Rat Offspring's Hippocampus.

Sadeghi, A., Ebrahimzadeh‐Bideskan, A., Alipour, F., Fazel, A., & Haghir, H. (2013) · Europe PMC (PubMed Central) · Cited by 40 · see citing works

Chlorine transfer between glycine, taurine, and histamine: reaction rates and impact on cellular reactivity

Peskin, A. V., Midwinter, R. G., Harwood, D. T., & Winterbourn, C. C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.006 · Cited by 41 · see citing works

Oxidation of 2-Cys Peroxiredoxins in Human Endothelial Cells by Hydrogen Peroxide, Hypochlorous Acid, and Chloramines

Stacey, M. M., Vissers, M. C. M., & Winterbourn, C. C. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4348 · Cited by 39 · see citing works

Vitamin C attenuates the cytotoxic effects of Porphyromonas gingivalis on human gingival fibroblasts

Staudte, H., Güntsch, A., Völpel, A., & Sigusch, B. W. (2009) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2009.11.009 · Cited by 38 · see citing works

Role of Thiocyanate, Bromide and Hypobromous Acid in Hydrogen Peroxide-induced Apoptosis

Wagner, B. A., Reszka, K. J., McCormick, M. L., Britigan, B. E., Evig, C. B., & Burns, C. P. (2003) · Free Radical Research · doi:10.1080/10715760310001643302 · Cited by 35 · see citing works

Oxidative Damage to Proteins

Davies, M. J. (2012) · Wiley eBooks · doi:10.1002/9781119953678.rad045 · Cited by 34 · see citing works

Hydrogen peroxide-induced apoptosis of HL-60 human leukemia cells is mediated by the oxidants hypochlorous acid and chloramines

Wagner, B. A., Britigan, B. E., Reszka, K. J., McCormick, M. L., & Burns, C. P. (2002) · Archives of Biochemistry and Biophysics · doi:10.1016/s0003-9861(02)00053-x · Cited by 32 · see citing works

Poly(ADP-Ribose) Polymerase Inhibition Improves Endothelial Dysfunction Induced by Hypochlorite

Radovits, T., Zotkina, J., Lin, L.-N., Bömicke, T., Arif, R., Gerő, D., Horvath, E. M., Karck, M., Szabó, C., & Szabo, G. B. (2007) · Experimental Biology and Medicine · doi:10.3181/0701-rm-16 · Cited by 29 · see citing works

Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage

Carroll, L., Pattison, D. I., Fu, S., Schiesser, C. H., Davies, M. J., & Hawkins, C. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.029 · Cited by 26 · see citing works

Selective macrophage ascorbate deficiency suppresses early atherosclerosis

Babaev, V. R., Whitesell, R. R., Li, L., Linton, M. F., Fazio, S., & May, J. M. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.10.702 · Cited by 21 · see citing works

Over-expression of l-galactono-γ-lactone dehydrogenase increases vitamin C, total phenolics and antioxidant activity in lettuce through bio-fortification

Guo, X., Liu, R. H., Fu, X., Sun, X., & Tang, K. (2013) · Plant Cell Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-013-0318-y · Cited by 20 · see citing works

Ascorbate does not protect macrophages against apoptosis induced by oxidised low density lipoprotein

Harris, L. K., Mann, G. E., Ruiz, E., Mushtaq, S., & Leake, D. S. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.07.019 · Cited by 20 · see citing works

Vitamin C Modulation of Cisplatin-Induced Cytogenotoxicity in Bone Marrow, Spermatogonia and its Transmission in the Male Germline of Swiss Mice

Misra, S., & Choudhury, R. C. (2006) · Journal of Chemotherapy · doi:10.1179/joc.2006.18.2.182 · Cited by 19 · see citing works

The Antioxidant Milieu at Asthmatic Respiratory Tract Surfaces: Commentary on the article by Schock et al. on page 375

Cross, C. E. (2003) · Pediatric Research · doi:10.1203/01.pdr.0000049510.15555.30 · Cited by 18 · see citing works

The Effect of Ascorbic Acid and Garlic Administration on Lead-Induced Apoptosis in Rat Offspring's Eye Retina

Khordad, E., Fazel, A., & Ebrahimzadeh‐Bideskan, A. (1996) · Europe PMC (PubMed Central) · doi:10.6091/ibj.1229.2013 · Cited by 18 · see citing works

Therapeutic Potential of Combined Therapy of Vitamin A and Vitamin C in the Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats

Navidhamidi, M., Nazari, A., Dehghan, S., Ebrahimpour, A., Nasrnezhad, R., & Pourabdolhossein, F. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02755-0 · Cited by 17 · see citing works

Vitamin C Exacerbates Hydrogen Peroxide Induced Apoptosis and Concomitant PGE2Release in Amnion Epithelial and Mesenchymal Cells, and in Intact Amnion

Kumar, D., Moore, R. M., Khwad, M. E., Silver, R. J., & Moore, J. J. (2004) · Placenta · doi:10.1016/j.placenta.2003.12.005 · Cited by 17 · see citing works

Vascular dysfunction induced by hypochlorite is improved by the selective phosphodiesterase-5-inhibitor vardenafil

Radovits, T., Arif, R., Bömicke, T., Korkmaz, S., Barnucz, E., Karck, M., Merkely, B. P., & Szabo, G. B. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.04.012 · Cited by 16 · see citing works

L-ascorbic acid and the evolution of multicellular eukaryotes

Edgar, J. A. (2019) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2019.06.001 · Cited by 11 · see citing works

Detection of apoptosis by caspase-3 activation in tracheal aspirate neutrophils from premature infants: relationship with NF-κB activation

Cheah, F., Hampton, M. B., Darlow, B. A., Winterbourn, C. C., & Vissers, M. C. M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0904520 · Cited by 11 · see citing works

Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation

Ki, M., Lee, H.-R., Park, J., Hong, I., Han, S., You, S., Lee, E.-M., Kim, A.-Y., Lee, S., & Jeong, K. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.04.008 · Cited by 8 · see citing works

The effects of vitamin C and menthone on acyclovir induced DNA damage in rat spermatozoa: An experimental study.

Toghiani, S., Roodbari, N. H., Dashti, G., & Rouzbehani, S. (2018) · Europe PMC (PubMed Central) · Cited by 7 · see citing works

Naturally Occurring Antioxidants

Ronzio, R. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-323-43044-9.00097-2 · Cited by 6 · see citing works

Respiratory burst activity and viability of bovine blood and milk neutrophils during different stages of lactation and mastitis

Mehrzad, J. (2002) · Ghent University Academic Bibliography (Ghent University) · Cited by 6 · see citing works

Effects of Letrozole Treatment and Vitamin C Supplementation on Morphology, Endoplasmic Reticulum Stress, Programmed Cell Death, and Oxidative Stress in the Small Intestine of Adult Male Rats

Pilutin, A., Rzeszotek, S., Wilk, A., Klimaszewska, K., Łukasiewicz, J., Mafuta, R. L., Nagendran, T., Ndambara, R., & Wiszniewska, B. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46030127 · Cited by 5 · see citing works

L-Threoascorbic acid treatment promotes S. aureus-infected primary human endothelial cells survival and function, as well as intracellular bacterial killing, and immunomodulates the release of IL-1β and soluble ICAM-1

Dahou, S., Smahi, M. C.-E., Nouari, W., Dahmani, Z., Benmansour, S., Ysmail-Dahlouk, L., Miliani, M., Yebdri, F., Fakir, N., Laoufi, M. Y., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107476 · Cited by 5 · see citing works

Vitamin C protects against lysophosphatidylcholine-induced expression of monocyte chemoattractant protein-1 in cultured human umbilical vein endothelial cells.

Pan, J. P., Cheng, T., Chou, S.-C., & Lai, S. T. (2003) · PubMed · Cited by 5 · see citing works

IN VITRO ANTIBACTERIAL, ANTIOXIDANT AND HEPATOPROTECTIVE EFFECT OF CURCUMIN-ZINC OXIDE NANO-PARTICLES IN COMBINATION

Hussein, M. A. (2015) · International Journal of Pharma and Bio Sciences · Cited by 3 · see citing works

Naturally Occurring Antioxidants

Ronzio, R. A. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-2333-5.00108-5 · Cited by 3 · see citing works

This student paper was written as an assignment in the graduate course Free Radicals in Biology and Medicine

Buettner, G. R., Oberley, L. W., Spitz, D. R., & Domann, F. E. (2003)

A model of complex plaque formation: 7,8-Dihydroneopterin protects human monocyte-derived macrophages from oxidised low density lipoprotein-induced death

Amit, Z. (2008) · UC Research Repository (University of Canterbury) · doi:10.26021/6317

Klora Maruz Kalan A549 Hücre Hattında Çeşitli Antioksidanların Etkileri

Sezigen, S., & Sarper, M. (2019) · Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi · doi:10.22312/sdusbed.577977

Vitamin C as a Cancer Chemopreventive Agent

Higdon, J. V., & Frei, B. B. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-767-3_32

Between Deficiency and Excess: The Dual Role of Selected Dietary Supplements in Immune Health

Skrzypska, N., Głowacka-Kamińska, W., Wróblewska, J., Wojtczak, O., Zagaja, K. K., Tarczykowski, J., Stupnicki, S., Karminska, M., & Czernikiewicz, K. (2026) · Cureus · doi:10.7759/cureus.104014

The Role of Reactive Chlorine Species in Bacterial Killing by Neutrophils

Coker, M. S. A. (2011) · Otago University Research Archive (University of Otago)

Induction of apoptosis by cooperative action of vitamins C and E.

Satoh, K., Ida, Y., Hosaka, M., Arakawa, H., Maeda, M., Ishihara, M., Kunii, S., Kanda, Y., Toguchi, M., & Sakagami, H. (1998) · PubMed · Cited by 25 · see citing works

Inhibition by vitamin C of apoptosis induced by N‐nitrosamines in HepG2 and HL‐60 cells

Arranz, N., Haza, A. I., García, A., Delgado, M. E., Rafter, J. J., & Morales, P. (2008) · Journal of Applied Toxicology · doi:10.1002/jat.1340 · Cited by 9 · see citing works

Vitamin C Protects Against Hypochlorous Acid–Induced Glutathione Depletion and DNA Base and Protein Damage in Human Vascular Smooth Muscle Cells

Jenner, A. M., Ruiz, J. E., Dunster, C., Halliwell, B. B., Mann, G. E., & Siow, R. C. M. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013785.03265.5c · Cited by 55 · see citing works

An experiment on inhibitive affection of vitamin C on the apoptosis of vascular endothelial cell induced by mannitol

Kai-yu, P. (2006) · Journal of Pediatric Pharmacy · Cited by 1 · see citing works

Energy metabolism of the kidney: segmental differences may determine xenobiotic actions

Ruegg, C. E., & Mandel, L. J. (1990) · Toxicology Letters · doi:10.1016/0378-4274(90)90090-9 · Cited by 2 · see citing works