Ascorbic acid in lymphocytes: Cell preparation and liquid-chromatographic assay
Abstract
Measurements of ascorbic acid concentration in leukocytes by "high-performance" liquid chromatography (HPLC) provides better nutritional assessment, leading to better management, particularly of presymptomatic and critically ill patients. This procedure includes a simple, reproducible cell-separation technique that requires no more than 2 mL of whole blood. Cell populations are separable with greater than 95% purity and greater than 99% viability. Ascorbic acid is assayed by HPLC. The vitamin can be reproducibly quantified in concentrations as low as 0.1 microgram/mL of cell extract. The chromatographic procedure is very rapid, analysis being completed within 15 min after specimen preparation. The assay is suitable also for urine and protein-free filtrates of plasma and of other biological materials. Reference intervals for plasma, mononuclear leukocytes, and polymorphonuclear leukocytes were established. A preliminary clinical evaluation revealed that hospital patients were at a greater risk of ascorbic acid deficiency than expected.
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While plasma and serum levels of vitamin C reflect dietary intake, efficacy is better determined by its retention in cells, such as leukocytes, which more accurately reflect tissue vitamin C concentrations.
“While the plasma and serum levels of vitamin C reflect dietary intake, efficacy is better determined by its retention in cells, such as leukocytes, which more accurately reflect tissue vitamin C concentrations [40,41].”
From Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults (2025) · cites this paper as [40]
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Improving outcome of haematopoietic stem cell transplantation
van Gorkom, G. N. Y. (2022) · doi:10.26481/dis.20220616gg
- Authors
- Lee, W., Hamernyik, P., Hutchinson, M., Raisys, V. A., & Labbé, R. F.
- Venue
- Clinical Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 1982-10-01
- Volume
- 28
- Issue
- 10
- Pages
- 2165-2169
- ISSN
- 0009-9147 (ISSN-L)
- 1530-8561
- OpenAlex
- W2286937251
- Cited by
- 97
- References
- 6
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 4 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Clinical Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Vitamin C and Antioxidants Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Keywords
- vitamin C, lymphocytes, leukocytes, cell isolation, HPLC assay, nutritional assessment, scurvy, mononuclear leukocytes, polymorphonuclear leukocytes, critically ill patients
- MeSH terms
- Ascorbic Acid, Cell Separation, Chromatography, High Pressure Liquid, Humans, Leukocytes, Monocytes, Neutrophils, Phenylhydrazines, Reference Values
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