Cited by 122Mitochondrial Function and PathologyDNA Repair MechanismsDNA and Nucleic Acid Chemistry

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Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

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Pohjoismäki, Jaakko L.O., Goffart, Steffi, Tyynismaa, Henna, Willcox, Smaranda, Ide, Tomomi, Kang, Dongchon, Suomalainen, Anu, Karhunen, Pekka J., Griffith, Jack D., Holt, Ian J., Jacobs, Howard T.·2009·Journal of Biological Chemistry

DOI 10.1074/jbc.m109.016600PMC PMC2755869

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Abstract

Analysis of human heart mitochondrial DNA (mtDNA) by electron microscopy and agarose gel electrophoresis revealed a complete absence of the -type replication intermediates seen abundantly in mtDNA from all other tissues. Instead only Y- and X-junctional forms were detected after restriction digestion. Uncut heart mtDNA was organized in tangled complexes of up to 20 or more genome equivalents, which could be resolved to genomic monomers, dimers, and linear fragments by treatment with the decatenating enzyme topoisomerase IV plus the cruciform-cutting T7 endonuclease I. Human and mouse brain also contained a population of such mtDNA forms, which were absent, however, from mouse, rabbit, or pig heart. Overexpression in transgenic mice of two proteins involved in mtDNA replication, namely human mitochondrial transcription factor A or the mouse Twinkle DNA helicase, generated abundant four-way junctions in mtDNA of heart, brain, and skeletal muscle. The organization of mtDNA of human heart as well as of mouse and human brain in complex junctional networks replicating via a presumed non- mechanism is unprecedented in mammals.

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The double-strand-break repair model for recombination
Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437
Replication of animal mitochondrial DNA
Clayton, D. A. (1982) · Cell · doi:10.1016/0092-8674(82)90049-6 · Cited by 1,243
Mitochondrial transcription factor A regulates mtDNA copy number in mammals
Ekstrand, M. I. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh109 · Cited by 919
RuvAB Acts at Arrested Replication Forks
Seigneur, M., Bidnenko, V., Ehrlich, S. D., & Michel, B. (1998) · Cell · doi:10.1016/s0092-8674(00)81772-9 · Cited by 538
THE STRUCTURE AND REPLICATION OF KINETOPLAST DNA
Shapiro, T. A., & Englund, P. T. (1995) · Annual Review of Microbiology · doi:10.1146/annurev.mi.49.100195.001001 · Cited by 461
Coupled Leading- and Lagging-Strand Synthesis of Mammalian Mitochondrial DNA
Holt, I. J., Lorimer, H. E., & Jacobs, H. T. (2000) · Cell · doi:10.1016/s0092-8674(00)80688-1 · Cited by 418
Recombinational DNA repair and human disease
Thompson, L. H., & Schild, D. (2002) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/s0027-5107(02)00224-5 · Cited by 417
Recombinational repair and restart of damaged replication forks
McGlynn, P., & Lloyd, R. G. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm951 · Cited by 397
Inheritance and recombination of mitochondrial genomes in plants, fungi and animals
Barr, C. M., Neiman, M., & TAYLOR, D. R. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2005.01492.x · Cited by 386
Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age
Miller, F. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gng060 · Cited by 332
Circular Dimer and Catenate Forms of Mitochondrial DNA in Human Leukaemic Leucocytes
Clayton, D. A., & Vinograd, J. R. (1967) · Nature · doi:10.1038/216652a0 · Cited by 328
Multiple pathways process stalled replication forks
Michel, B., Grompone, G., Florès, M.-J., & Bidnenko, V. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401586101 · Cited by 322
Pathways for mitotic homologous recombination in mammalian cells
Helleday, T. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.013 · Cited by 314
Rescue of arrested replication forks by homologous recombination
Michel, B., Flores, M. J., Viguera, E., Grompone, G., Seigneur, M., & Bidnenko, V. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111008798 · Cited by 292
Biased Incorporation of Ribonucleotides on the Mitochondrial L-Strand Accounts for Apparent Strand-Asymmetric DNA Replication
Yang, M., Bowmaker, M., Reyes, A., Vergani, L., Angeli, P., Gringeri, E., Jacobs, H. T., & Holt, I. J. (2002) · Cell · doi:10.1016/s0092-8674(02)01075-9 · Cited by 275
Overexpression of Mitochondrial Transcription Factor A Ameliorates Mitochondrial Deficiencies and Cardiac Failure After Myocardial Infarction
Ikeuchi, M., Matsusaka, H., Kang, D., Matsushima, S., Ide, T., Kubota, T., Fujiwara, T., Hamasaki, N., Takeshita, A., Sunagawa, K., et al. (2005) · Circulation · doi:10.1161/circulationaha.104.524835 · Cited by 273
Mammalian Mitochondria Possess Homologous DNA Recombination Activity
Thyagarajan, B., Padua, R. A., & Campbell, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27536 · Cited by 269
Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand
Yasukawa, T., Reyes, A., Cluett, T. J., Yang, M., Bowmaker, M., Jacobs, H. T., & Holt, I. J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601392 · Cited by 251
Twinkle helicase is essential for mtDNA maintenance and regulates mtDNA copy number
Tyynismaa, H., Sembongi, H., Bokori-Brown, M., Granycome, C., Ashley, N., Poulton, J., Jalanko, A., Spelbrink, J. N., Holt, I. J., & Suomalainen, A. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh342 · Cited by 250
Unique mitochondrial genome architecture in unicellular relatives of animals
Burger, G., Forget, L., Zhu, Y. J., Gray, M. W., & Lang, B. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0336115100 · Cited by 225
Mammalian Mitochondrial DNA Replicates Bidirectionally from an Initiation Zone
Bowmaker, M., Yang, M., Yasukawa, T., Reyes, A., Jacobs, H. T., Huberman, J. A., & Holt, I. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308028200 · Cited by 218
Replication of Mitochondrial DNA. Circular Replicative Intermediates in Mouse L Cells
Robberson, D. L., Kasamatsu, H., & Vinograd, J. R. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.3.737 · Cited by 213
Recombination proteins and rescue of arrested replication forks
Michel, B., Boubakri, H., Baharoglu, Z., Masson, M. L., & Lestini, R. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.016 · Cited by 211
The histone‐like protein HU binds specifically to DNA recombination and repair intermediates
Kamashev, D., & Rouvière-Yaniv, J. (2000) · EMBO Journal · doi:10.1093/emboj/19.23.6527 · Cited by 201
RECOMBINATION AND RECOMBINATION-DEPENDENT DNA REPLICATION IN BACTERIOPHAGE T4
Mosig, G. (1998) · Annual Review of Genetics · doi:10.1146/annurev.genet.32.1.379 · Cited by 196
Structural Analysis of Mitochondrial DNA Molecules from Fungi and Plants Using Moving Pictures and Pulsed-field Gel Electrophoresis
Bendich, A. J. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0048 · Cited by 191
The DNA replication priming protein, PriA, is required for homologous recombination and double-strand break repair
Kogoma, T., Cadwell, G. W., Barnard, K. G., & Asai, T. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.5.1258-1264.1996 · Cited by 180
Recombination associated with replication of malarial mitochondrial DNA.
Preiser, P. R., Wilson, R. J., Moore, P. W., McCready, S. J., Hajibagheri, M. A. N., Blight, K. J., Strath, M., & Williamson, D. H. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00401.x · Cited by 180
A Bidirectional Origin of Replication Maps to the Major Noncoding Region of Human Mitochondrial DNA
Yasukawa, T., Yang, M., Jacobs, H. T., & Holt, I. J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.05.002 · Cited by 173
Differential Suppression of priA2::kan Phenotypes in Escherichia coli K-12 by Mutations in priA, lexA, and dnaC
Sandler, S. J., Samra, H. S., & Clark, A. J. (1996) · Genetics · doi:10.1093/genetics/143.1.5 · Cited by 173
Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells
Pohjoismäki, J., Wanrooij, S., Hyvärinen, A. K., Goffart, S., Holt, I. J., Spelbrink, J. N., & Jacobs, H. T. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl703 · Cited by 168
Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication
Crews, S. T., Ojala, D., Posakony, J. W., Nishiguchi, J., & Attardi, G. M. (1979) · Nature · doi:10.1038/277192a0 · Cited by 167
Rolling circle replication of DNA in yeast mitochondria.
Maleszka, R., Skelly, P. J., & Clark-Walker, G. D. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04962.x · Cited by 164
Replicative bypass repair of ultraviolet damage to DNA of mammalian cells: caffeine sensitive and caffeine resistant mechanisms
Fujiwara, Y., & Tatsumi, M. (1976) · Mutation Research · doi:10.1016/0027-5107(76)90058-0 · Cited by 142
Most Chloroplast DNA of Maize Seedlings in Linear Molecules with Defined Ends and Branched Forms
Oldenburg, D. J., & Bendich, A. J. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.11.020 · Cited by 141
Replication of Mitochondrial DNA in Mouse L Cells and Their Thymidine Kinase - Derivatives: Displacement Replication on a Covalently-Closed Circular Template
Robberson, D. L., & Clayton, D. A. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.12.3810 · Cited by 137
The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA
Hyvärinen, A. K., Pohjoismäki, J., Reyes, A., Wanrooij, S., Yasukawa, T., Karhunen, P. J., Spelbrink, J. N., Holt, I. J., & Jacobs, H. T. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm676 · Cited by 132
Mitochondrial plasmids of neurospora: Integration into mitochondrial DNA and evidence for reverse transcription in mitochondria
Akins, R. A., Kelley, R. L., & Lambowitz, A. M. (1986) · Cell · doi:10.1016/0092-8674(86)90615-x · Cited by 132
Functions of the High Mobility Group Protein, Abf2p, in Mitochondrial DNA Segregation, Recombination and Copy Number in Saccharomyces cerevisiae
Zelenaya-Troitskaya, O., Newman, S. M., Okamoto, K., Perlman, P. S., & Butow, R. A. (1998) · Genetics · doi:10.1093/genetics/148.4.1763 · Cited by 131
Mitochondrial DNA from the liverwort Marchantia polymorpha : circularly permuted linear molecules, head-to-tail concatemers, and a 5′ protein 1 1Edited by N.-M. Chua
Oldenburg, D. J., & Bendich, A. J. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4783 · Cited by 123
Electron-microscopic visualization of deletion mutations.
Davis, R. W., & Davidson, N. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.60.1.243 · Cited by 119
Size and Structure of Replicating Mitochondrial DNA in Cultured Tobacco Cells.
Oldenburg, D., & Bendich, A. J. (1996) · The Plant Cell · doi:10.1105/tpc.8.3.447 · Cited by 115
Phage T4-like intermediates of DNA replication and recombination in the mitochondria of the higher plant Chenopodium album (L.)
Backert, S., & Börner, T. (2000) · Current Genetics · doi:10.1007/s002940050532 · Cited by 113
Late‐onset mitochondrial DNA depletion: DNA copy number, multiple deletions, and compensation
Barthélémy, C., de Baulny, H. O., Diaz, J., Cheval, M. A., Frachon, P., Romero, N. B., Goutières, F., Fardeau, M., & Lombès, A. (2001) · Annals of Neurology · doi:10.1002/ana.1002 · Cited by 109
The evolution of mitochondrial DNA
Saccone, C. (1994) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(94)90073-6 · Cited by 106
The high mobility group protein Abf2p influences the level of yeast mitochondrial DNA recombination intermediates in vivo
MacAlpine, D. M., Perlman, P. S., & Butow, R. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6739 · Cited by 106
Heterologous mitochondrial DNA recombination in human cells
D’Aurelio, M., Gajewski, C. D., Lin, M. T. S., Mauck, W. M., Shao, L. Z., Lenaz, G., Moraes, C. T., & Manfredi, G. (2004) · Human Molecular Genetics · doi:10.1093/hmg/ddh326 · Cited by 106
Replication fork regression in repetitive DNAs
Fouché, N., Özgür, S., Roy, D., & Griffith, J. D. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl757 · Cited by 103
Repression of mutagenesis by Rad51D-mediated homologous recombination
Hinz, J. M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl020 · Cited by 100
Lack of age-related increase of mitochondrial DNA amount in brain, skeletal muscle and human heart
Frahm, T., Mohamed, S. A., Bruse, P., Gemünd, C., Oehmichen, M., & Meißner, C. (2005) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2005.06.008 · Cited by 100
Prominent mitochondrial DNA recombination intermediates in human heart muscle
Kajander, O. A., Karhunen, P. J., Holt, I. J., & Jacobs, H. T. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve233 · Cited by 100
Behaviour of a population of partially duplicated mitochondrial DNA molecules in cell culture: segregation, maintenance and recombination dependent upon nuclear background
Holt, I. J. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.8.1251 · Cited by 99
Escherichia coli Strains Lacking Protein HU Are UV Sensitive due to a Role for HU in Homologous Recombination
Li, S., & Waters, R. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.15.3750-3756.1998 · Cited by 98
Late‐onset mitochondrial DNA depletion: DNA copy number, multiple deletions, and compensation
Barthélémy, C., de Baulny, H. O., Diaz, J., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1002.abs · Cited by 91
Maintenance of Human Rearranged Mitochondrial DNAs in Long-Term Cultured Transmitochondrial Cell Lines
Tang, Y., Manfredi, G., Hirano, M., & Schon, E. A. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.7.2349 · Cited by 91
Bidirectional Replication Initiates at Sites Throughout the Mitochondrial Genome of Birds
Reyes, A., Yang, M., Bowmaker, M., & Holt, I. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411916200 · Cited by 82
Occurrence of Complex Mitochondrial DNA in Normal Tissues
Clayton, D. A., Smith, C. A., JORDAN, J. M., Teplitz, M., & Vinograd, J. R. (1968) · Nature · doi:10.1038/220976a0 · Cited by 77
Intramitochondrial Location and Dynamics of Crithidia fasciculata Kinetoplast Minicircle Replication Intermediates
Drew, M. E., & Englund, P. T. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.4.735 · Cited by 76
Recombination of mitochondrial DNA in skeletal muscle of individuals with multiple mitochondrial DNA heteroplasmy
Zsurka, G., Kraytsberg, Y., Kudina, T. A., Kornblum, C., Elger, C. E., Khrapko, K., & Kunz, W. S. (2005) · Nature Genetics · doi:10.1038/ng1606 · Cited by 66
Rolling-Circle Replication of Mitochondrial DNA in the Higher Plant Chenopodium album (L.)
Backert, S., Dörfel, P., Lurz, R., & Börner, T. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6285 · Cited by 66
Replicating molecules of circular mitochondrial DNA.
Kirschner, R. H., Wolstenholme, D. R., & Gross, N. J. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.60.4.1466 · Cited by 65
Single‐stranded DNA binding protein and DNA helicase of bacteriophage T7 mediate homologous DNA strand exchange.
Kong, D., & Richardson, C. C. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00552.x · Cited by 64
An Arabidopsis homologue of bacterial RecA that complements an E. coli recA deletion is targeted to plant mitochondria
Khazi, F. R., Edmondson, A. C., & Nielsen, B. L. (2003) · Molecular Genetics and Genomics · doi:10.1007/s00438-003-0859-6 · Cited by 60
Moving pictures and pulsed-field gel electrophoresis show only linear mitochondrial DNA molecules from yeasts with linear-mapping and circular-mapping mitochondrial genomes
Jacobs, M. A., Payne, S. R., & Bendich, A. J. (1996) · Current Genetics · doi:10.1007/s002940050093 · Cited by 56
Role of the histone-like proteins OsmZ and HU m homologous recombination
Dri, A., Moreau, P. L., & Rouvière‐Yaniv, J. (1992) · Gene · doi:10.1016/0378-1119(92)90003-8 · Cited by 51
Binding of Human Mitochondrial Transcription Factor A, an HMG Box Protein, to a Four-Way DNA Junction
Ohno, T., Umeda, S., Hamasaki, N., & Kang, D. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2656 · Cited by 51
Analysis of Schizosaccharomyces pombe mitochondrial DNA replication by two dimensional gel electrophoresis
Han, Z., & Stachow, C. (1994) · Chromosoma · doi:10.1007/bf00368008 · Cited by 49
DNA Recombination-Initiation Plays a Role in the Extremely Biased Inheritance of Yeast [rho−] Mitochondrial DNA That Contains the Replication Origin ori5
Ling, F., Hori, A., & Shibata, T. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00770-06 · Cited by 49
Recombinational DNA repair: the ignored repair systems
Smith, K. C. (2004) · BioEssays · doi:10.1002/bies.20109 · Cited by 39
Size and Structure of Replicating Mitochondrial DNA in Cultured Tobacco Cells
Oldenburg, D. J., & Bendich, A. J. (1996) · The Plant Cell · doi:10.2307/3870324 · Cited by 39
[24] Electron microscopic visualization of DNA and DNA-protein complexes as adjunct to biochemical studies
Thresher, R., & Griffith, J. D. (1992) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(92)11026-f · Cited by 38
Involvement of mitochondrial-targeted RecA in the repair of mitochondrial DNA in the moss, Physcomitrella patens
Odahara, M., Inouye, T., Fujita, T., Hasebe, M., & Sekine, Y. (2007) · Genes & Genetic Systems · doi:10.1266/ggs.82.43 · Cited by 26

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Authors: Pohjoismäki, J. L. O., Goffart, S., Tyynismaa, H., Willcox, S., Ide, T., Kang, D., Suomalainen, A., Karhunen, P. J., Griffith, J. D., Holt, I. J., & Jacobs, H. T.
Affiliations: Tampere University Hospital (FI)
University of Helsinki (FI)
University of North Carolina at Chapel Hill (US)
Kyushu University (JP)
University of Tampere (FI)
MRC Mitochondrial Biology Unit (GB)
Corresponding author: Jacobs, Howard T.
ORCID: Pohjoismäki, Jaakko L.O.
Goffart, Steffi
Tyynismaa, Henna
Willcox, Smaranda
Kang, Dongchon
Suomalainen, Anu
Karhunen, Pekka J.
Griffith, Jack D.
Holt, Ian J.
Jacobs, Howard T.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2009-08
Volume: 284
Issue: 32
Pages: 21446-21457
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.m109.016600
PMC: PMC2755869
OpenAlex: W2014114000
Cited by: 122
References: 70
Citations by year: 2026: 1 · 2025: 1 · 2024: 9 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 8 · 2019: 10 · 2018: 10 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 10
FWCI: 3.89
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 4089 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
UNC Libraries
Funders: Foundation for Cardiovascular Research
European Commission
Academy of Finland
Suomen Kulttuurirahasto
Sydäntutkimussäätiö
Tays
National Institutes of Health
Medical Research Council
National Institute of General Medical Sciences (GM-31819, R01GM031819)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Keywords: mitochondrial DNA, heart, four-way junction, replication fork, topoisomerase IV, T7 endonuclease I, TFAM, Twinkle helicase, mitochondrial DNA replication, brain, skeletal muscle, species differences
MeSH terms: Adult, Aged, Animals, Brain, Child, Preschool, DNA, Mitochondrial, Female, Heart, Humans, Male, Mice, Transgenic, Middle Aged, Nucleic Acid Conformation, Rabbits, Species Specificity, Swine, Tissue Distribution, Mice

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Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks

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