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Targeting phosphatases as the next generation of disease modifying therapeutics for Parkinson’s disease

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Neuronal hemoglobin in mitochondria is reduced by forming a complex with α-synuclein in aging monkey brains

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Nigral injection of a proteasomal inhibitor, lactacystin, induces widespread glial cell activation and shows various phenotypes of Parkinson’s disease in young and adult mouse

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Phosphorylation at serine 31 targets tyrosine hydroxylase to vesicles for transport along microtubules

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Revista Española de Geriatría y Gerontología

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Changes in Tyrosine Hydroxylase Activity and Dopamine Synthesis in the Nigrostriatal System of Mice in an Acute Model of Parkinson’s Disease as a Manifestation of Neurodegeneration and Neuroplasticity

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FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models

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Ceftriaxone attenuates acute cocaine‐evoked dopaminergic neurotransmission in the nucleus accumbens of the rat

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Estrogen‐related receptor gamma regulates dopaminergic neuronal phenotype by activating GSK 3β/ NFAT signaling in SH ‐ SY 5Y cells

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Phosphorylation Dependence and Stoichiometry of the Complex Formed by Tyrosine Hydroxylase and 14-3-3γ

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Impact of fatty acid-binding proteins and dopamine receptors on α-synucleinopathy

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The role of α-synuclein in neurodegeneration — An update

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Protein Phosphatase 2A is Involved in the Tyrosine Hydroxylase Phosphorylation Regulated by α-Synuclein

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Alpha-synuclein modulates the repair of genomic DNA double-strand breaks in a DNA-PKcs-regulated manner

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Intranasal Carnosine Mitigates α-Synuclein Pathology and Motor Dysfunction in the Thy1-aSyn Mouse Model of Parkinson’s Disease

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SMG1 Identified as a Regulator of Parkinson’s Disease-Associated alpha-Synuclein through siRNA Screening

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Leucine Carboxyl Methyltransferase Downregulation and Protein Phosphatase Methylesterase Upregulation Contribute Toward the Inhibition of Protein Phosphatase 2A by α-Synuclein

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Alpha-Synuclein Suppresses Retinoic Acid-Induced Neuronal Differentiation by Targeting the Glycogen Synthase Kinase-3β/β-Catenin Signaling Pathway

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A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease

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Could α-Synuclein Modulation of Insulin and Dopamine Identify a Novel Link Between Parkinson’s Disease and Diabetes as Well as Potential Therapies?

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Development of an enzyme-linked immunosorbent assay (ELISA) to measure the level of tyrosine hydroxylase protein in brain tissue from Parkinson's disease models

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Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control

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Disease‐specific neuropathological alterations of the locus coeruleus in Alzheimer's disease, Down syndrome, and Parkinson's disease

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Removal of proteinase K resistant αSyn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model

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Squamosamide derivative FLZ protected tyrosine hydroxylase function in a chronic MPTP/probenecid mouse model of Parkinson’s disease

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PINK1 suppresses alpha-synuclein-induced neuronal injury: a novel mechanism in protein phosphatase 2A activation

Yang, W., Wang, X., Liu, J., Duan, C., Gao, G., Lu, L., Yu, S., & Yang, H. (2017) · Oncotarget · doi:10.18632/oncotarget.21554 · Cited by 12 · see citing works

Parkinsonian GM2 synthase knockout mice lacking mature gangliosides develop urinary dysfunction and neurogenic bladder

Gil-Tommee, C., Vidal-Martínez, G., Reyes, C. A., Vargas‐Medrano, J., Herrera, G. V., Martin, S. M., Chaparro, S. A., & Perez, R. G. (2018) · Experimental Neurology · doi:10.1016/j.expneurol.2018.10.014 · Cited by 12 · see citing works

Mitochondrial Signaling and Neurodegeneration

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Sphingosine‐1‐phosphate receptor‐independent lung endothelial cell barrier disruption induced by FTY720 regioisomers

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Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy

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Synuclein and Parkinson’s Disease: An Update

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Regulation of α‐synuclein expression in down syndrome

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Trophoblast glycoprotein is a new candidate gene for Parkinson’s disease

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Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays

Lek, S., Vargas‐Medrano, J., Villanueva, E., Marcus, B. S., Godfrey, W. H., & Perez, R. G. (2017) · Journal of Visualized Experiments · doi:10.3791/55361 · Cited by 6 · see citing works

Don’t Take Away My P: Phosphatases as Therapeutic Targets in Huntington’s Disease

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Reduced TH expression and α-synuclein accumulation contribute towards nigrostriatal dysfunction in experimental hepatic encephalopathy

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Clavulanic acid inhibits methamphetamine locomotor sensitization in mice and normalizes methamphetamine-induced changes in glutaminase mRNA levels in the nucleus accumbens

Walters, T., Wiah, S., Shekarabi, A., Milton, M., Reddy, S., Zhao, P., Mokkarala, P., Potula, R., & Rawls, S. M. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114646 · Cited by 4 · see citing works

α-Synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells

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Protein Phosphatase 2A is Involved in the Tyrosine Hydroxylase Phosphorylation Regulated by α-Synuclein

Gao, H., Lan, X., Weiwei, Y., Wang, H., Zhu, Y., Dongmei, L., Yazhuo, Z., & Hui, Y. (2015) · Neurochemical Research · doi:10.1007/s11064-014-1477-x · Cited by 19 · see citing works

Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells

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α-Synuclein aggregation alters tyrosine hydroxylase phosphorylation and immunoreactivity: Lessons from viral transduction of knockout mice

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Enhanced Phosphatase Activity Attenuates α-Synucleinopathy in a Mouse Model

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