KIBRA Regulates Hippo Signaling Activity via Interactions with Large Tumor Suppressor Kinases
Open accessAbstract
The Hippo pathway controls tissue growth and tumorigenesis by inhibiting cell proliferation and promoting apoptosis. Recent genetic studies in Drosophila identified Kibra as a novel regulator of Hippo signaling. Human KIBRA has been associated with memory performance and cell migration. However, it is unclear whether or how KIBRA is connected to the Hippo pathway in mammalian cells. Here, we show that KIBRA associates with and activates Lats (large tumor suppressor) 1 and 2 kinases by stimulating their phosphorylation on the hydrophobic motif. KIBRA overexpression stimulates the phosphorylation of Yes-associated protein (YAP), the Hippo pathway effector. Conversely, depletion of KIBRA by RNA interference reduces YAP phosphorylation. Furthermore, KIBRA stabilizes Lats2 by inhibiting its ubiquitination. We also found that KIBRA mRNA is induced by YAP overexpression in both murine and human cells, suggesting the evolutionary conservation of KIBRA as a transcriptional target of the Hippo signaling pathway. Thus, our study revealed a new connection between KIBRA and mammalian Hippo signaling.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
KIBRA can induce activation of LATS1/2 kinases and phosphorylation of the downstream effector YAP1 in the Hippo pathway.
“KIBRA can induce activation of LATS1/2 kinases and phosphorylation of the downstream effector YAP1 in the Hippo pathway (Xiao et al. 2011)”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Xiao et al. 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092 · see citing works
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498 · see citing works
Elucidation of a universal size-control mechanism in Drosophila and mammals
Dong, J., Feldmann, G., Huang, J., Wu, S., Zhang, N., Comerford, S. A., Gayyed, M. F., Anders, R. A., Maitra, A., & Pan, D. (2007) · Cell · doi:10.1016/j.cell.2007.07.019 · Cited by 2,370 · see citing works
Self-citationThe Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,274 · see citing works
Huang, J., Wu, S., Barrera, J. A., Matthews, K. A., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,870 · see citing works
YAP1 increases organ size and expands undifferentiated progenitor cells
Camargo, F. D., Gokhale, S., Johnnidis, J. B., Fu, D., Bell, G. W., Jaenisch, R., & Brummelkamp, T. R. (2007) · Current Biology · doi:10.1016/j.cub.2007.10.039 · Cited by 1,252 · see citing works
The Hippo–YAP pathway in organ size control and tumorigenesis: an updated versionPreprint
Zhao, B., Li, L., Lei, Q., & Guan, K. (2010) · Genes & Development · doi:10.1101/gad.1909210 · Cited by 1,140 · see citing works
Wu, S., Huang, J., Dong, J., & Pan, D. (2003) · Cell · doi:10.1016/s0092-8674(03)00549-x · Cited by 1,101 · see citing works
Self-citationThe Drosophila Mst Ortholog, hippo, Restricts Growth and Cell Proliferation and Promotes Apoptosis
Harvey, K. F., Pfleger, C. M., & Hariharan, I. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00557-9 · Cited by 983 · see citing works
Zhou, D., Conrad, C. H., Xia, F., Park, J.-S., Payer, B., Yin, Y., Lauwers, G. Y., Thasler, W. E., Lee, J. T., Avruch, J., et al. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.026 · Cited by 916 · see citing works
Zhang, N., Bai, H., David, K. K., Dong, J., Zheng, Y., Cai, J., Giovannini, M., Liu, P., Anders, R. A., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.06.015 · Cited by 804 · see citing works
Self-citationTumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP
Hao, Y., Chun, A., Cheung, K. J., Rashidi, B., & Yang, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709037200 · Cited by 780 · see citing works
Hamaratoǧlu, F., Willecke, M., Kango‐Singh, M., Nolo, R. M., Hyun, E., Tao, C., Jafar‐Nejad, H., & Halder, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1339 · Cited by 767 · see citing works
Tight Junctions and Cell Polarity
Shin, K., Fogg, V. C., & Margolis, B. L. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104219 · Cited by 745 · see citing works
Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver
Lu, L., Li, Y., Kim, S. M., Bossuyt, W., Liu, P., Qiu, Q., Wang, Y., Halder, G. A., Finegold, M. J., Lee, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911427107 · Cited by 721 · see citing works
The Salvador–Warts–Hippo pathway — an emerging tumour-suppressor network
Harvey, K., & Tapon, N. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2070 · Cited by 628 · see citing works
The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
Chan, E. H. Y., Nousiainen, M., Chalamalasetty, R. B., Schäfer, A., Nigg, E. A., & Silljé, H. H. W. (2005) · Oncogene · doi:10.1038/sj.onc.1208445 · Cited by 584 · see citing works
Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression
Song, H., Mak, K. K., Topol, L. Z., Yun, K., Hu, J., Garrett, L. J., Chen, Y., Park, O., Chang, J., Simpson, R. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911409107 · Cited by 583 · see citing works
Self-citationControl of Cell Proliferation and Apoptosis by Mob as Tumor Suppressor, Mats
Lai, Z.-C., Wei, X., Shimizu, T., Ramos, E., Rohrbaugh, M., Nikolaidis, N., Ho, L., & Li, Y. (2005) · Cell · doi:10.1016/j.cell.2004.12.036 · Cited by 570 · see citing works
The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila
Pantalacci, S., Tapon, N., & Léopold, P. (2003) · Nature Cell Biology · doi:10.1038/ncb1051 · Cited by 552 · see citing works
Yu, J., Zheng, Y., Dong, J., Klusza, S., Deng, W.-M., & Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.012 · Cited by 496 · see citing works
Self-citationThe Hippo–YAP pathway: new connections between regulation of organ size and cancer
Zhao, B., Lei, Q., & Guan, K. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.10.001 · Cited by 456 · see citing works
Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
John, M. A. R. S., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M. L., Brownstein, D. G., Parlow, A. F., McGrath, J. M., & Xu, T. (1999) · Nature Genetics · doi:10.1038/5965 · Cited by 440 · see citing works
Zeng, Q., & Hong, W. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.02.011 · Cited by 436 · see citing works
In vivo regulation of Yorkie phosphorylation and localization
Oh, H., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.015255 · Cited by 404 · see citing works
Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network
Genevet, A., Wehr, M. C., Brain, R., Thompson, B. J., & Tapon, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.011 · Cited by 402 · see citing works
Common Kibra Alleles Are Associated with Human Memory Performance
Papassotiropoulos, A., Stephan, D. A., Huentelman, M. J., Hoerndli, F. J., Craig, D. W., Pearson, J. V., Huynh, K.-D., Brunner, F., Corneveaux, J. J., Osborne, D., et al. (2006) · Science · doi:10.1126/science.1129837 · Cited by 402 · see citing works
Saucedo, L. J., & Edgar, B. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2221 · Cited by 363 · see citing works
Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms
Grzeschik, N. A., Parsons, L. M., Allott, M. L., Harvey, K. F., & Richardson, H. E. (2010) · Current Biology · doi:10.1016/j.cub.2010.01.055 · Cited by 341 · see citing works
From Cell Structure to Transcription: Hippo Forges a New Path
Edgar, B. A. (2006) · Cell · doi:10.1016/j.cell.2006.01.005 · Cited by 331 · see citing works
Chen, L., Zheng, Y., Yin, F., Yu, J., Huang, J., Hong, Y., Wu, S., & Pan, D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004279107 · Cited by 320 · see citing works
The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila
Baumgartner, R., Poernbacher, I., Buser, N., Hafen, E., & Stocker, H. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.013 · Cited by 320 · see citing works
Crumbs Regulates Salvador/Warts/Hippo Signaling in Drosophila via the FERM-Domain Protein Expanded
Robinson, B. S., Huang, J., Hong, Y., & Moberg, K. H. (2010) · Current Biology · doi:10.1016/j.cub.2010.03.019 · Cited by 312 · see citing works
Takahashi, Y., Miyoshi, Y., Takahata, C., Irahara, N., Taguchi, T., Tamaki, Y., & Noguchi, S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-1773 · Cited by 280 · see citing works
The Fat and Warts signaling pathways: new insights into their regulation,mechanism and conservation
Reddy, B. V. V. G., & Irvine, K. D. (2008) · Development · doi:10.1242/dev.020974 · Cited by 187 · see citing works
Characterization of KIBRA, a novel WW domain-containing protein
Kremerskothen, J., Plaas, C., Büther, K., Finger, I., Veltel, S., Matanis, T., Liedtke, T., & Barnekow, A. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02945-5 · Cited by 157 · see citing works
KIBRA Modulates Directional Migration of Podocytes
Duning, K., Schurek, E.-M., Diaeresis]ter, M. S., Bayer, M. E., Reinhardt, H.-C., Schwab, A., Schaefer, L., Benzing, T. R., Schermer, B., Saleem, M. A., et al. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007080916 · Cited by 121 · see citing works
Regulation of organ size: Insights from the Drosophila Hippo signaling pathway
Kango-Singh, M., & Singh, A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.21996 · Cited by 117 · see citing works
Evidence for an association between KIBRA and late-onset Alzheimer's disease
Corneveaux, J. J., Liang, W. S., Reiman, E. M., Webster, J., Myers, A., Zismann, V., Joshipura, K. D., Pearson, J. V., Hu‐Lince, D., Craig, D. W., et al. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.07.014 · Cited by 112 · see citing works
Margolis, B. L., & Borg, J. (2005) · Journal of Cell Science · doi:10.1242/jcs.02597 · Cited by 112 · see citing works
Rossé, C., Formstecher, É., Boeckeler, K., Zhao, Y., Kremerskothen, J., White, M., Camonis, J., & Parker, P. J. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000235 · Cited by 112 · see citing works
KIBRA gene variants are associated with episodic memory in healthy elderly
Schaper, K., Kölsch, H., Popp, J., Wagner, M., & Jessen, F. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.001 · Cited by 109 · see citing works
Towards prediction of cognate complexes between the WW domain and proline‐rich ligands
Einbond, A., & Sudol, M. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00263-3 · Cited by 106 · see citing works
KIBRA is a novel substrate for protein kinase Cζ
Büther, K., Plaas, C., Barnekow, A., & Kremerskothen, J. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.107 · Cited by 103 · see citing works
KIBRA: a new gateway to learning and memory?
Schneider, A. (2010) · Frontiers in Aging Neuroscience · doi:10.3389/neuro.24.004.2010 · Cited by 96 · see citing works
Notch2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cells
Lee, K. M., Yasuda, H., Hollingsworth, M. A., & Ouellette, M. M. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700298 · Cited by 88 · see citing works
Association of KIBRA and memory
Bates, T. C., Price, J. F., Harris, S. E., Marioni, R. E., Fowkes, F. G. R., Stewart, M. C. W., Murray, G. D., Whalley, L. J., Starr, J. M., & Deary, I. J. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.050 · Cited by 75 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- Lu, L., Li, Y., Kim, S. M., Bossuyt, W., Liu, P., Qiu, Q., Wang, Y., Halder, G., Finegold, M. J., Lee, J. S., and Johnson, R. L. (2010) Proc. Natl. Acad. Sci.
- Song, H., Mak, K. K., Topol, L., Yun, K., Hu, J., Garrett, L., Chen, Y., Park, O., Chang, J., Simpson, R. M., Wang, C. Y., Gao, B., Jiang, J., and Yang, Y. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 1431-1436
- Papassotiropoulos, A., Stephan, D. A., Huentelman, M. J., Hoerndli, F. J., Craig, D. W., Pearson, J. V., Huynh, K. D., Brunner, F., Corneveaux, J., Osborne, D., Wollmer, M. A., Aerni, A., Coluccia, D., Ha ¨nggi, J., Monda- dori, C. R., Buchmann, A., Reiman, E. M., Caselli, R. J., Henke, K., and de Quervain, D. J. (2006) Science 314, 475-478
- Corneveaux, J. J., Liang, W. S., Reiman, E. M., Webster, J. A., Myers, A. J., Zismann, V. L., Joshipura, K. D., Pearson, J. V., Hu-Lince, D., Craig, D. W., Coon, K. D., Dunckley, T., Bandy, D., Lee, W., Chen, K., Beach, T. G., Mastroeni, D., Grover, A., Ravid, R., Sando, S. B., Aasly, J. O., Heun, R., Jessen, F., Ko ¨lsch, H., Rogers, J., Hutton, M. L., Melquist, S., Petersen, R. C., Alexander, G. E., Caselli, R. J., Papassotiropoulos, A., Stephan, D. A., and Huentelman, M. J. (2010) Neurobiol. Aging 31, 901-909
- Ling, C., Zheng, Y., Yin, F., Yu, J., Huang, J., Hong, Y., Wu, S., and Pan, D. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 10532-10537
Cited by
Sorted by citations
The Biology of YAP/TAZ: Hippo Signaling and Beyond
Piccolo, S., Dupont, S., & Cordenonsi, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00005.2014 · Cited by 1,797 · see citing works
Yin, F., Yu, J., Zheng, Y., Chen, Q., Zhang, N., & Pan, D. (2013) · Cell · doi:10.1016/j.cell.2013.08.025 · Cited by 506 · see citing works
YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
Stein, C., Bardet, A. F., Roma, G., Bergling, S., Clay, I., Ruchti, A., Agarinis, C., Schmelzle, T., Bouwmeester, T., Schübeler, D., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005465 · Cited by 414 · see citing works
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway
Furth, N., & Aylon, Y. (2017) · Cell Death and Differentiation · doi:10.1038/cdd.2017.99 · Cited by 262 · see citing works
KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
Song, L., Tang, S. H., Han, X., Jiang, Z., Dong, L., Liu, C., Liang, X., Dong, J., Qiu, C., Wang, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09720-x · Cited by 246 · see citing works
Self-citationAngiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor
Paramasivam, M., Sarkeshik, A., Yates, J. R., Fernandes, M. J., & McCollum, D. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-04-0300 · Cited by 211 · see citing works
The Hippo signaling pathway in development and regeneration
Zhong, Z., Jiao, Z., & Yu, F. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113926 · Cited by 204 · see citing works
PTPN14 interacts with and negatively regulates the oncogenic function of YAP
Liu, X., Yang, N., Figel, S. A., Wilson, K. E., Morrison, C. D., Gelman, I. H., & Zhang, J. (2013) · Oncogene · doi:10.1038/onc.2012.147 · Cited by 196 · see citing works
Rewiring cell polarity signaling in cancer
Halaoui, R., & McCaffrey, L. M. (2014) · Oncogene · doi:10.1038/onc.2014.59 · Cited by 176 · see citing works
The Hippo pathway and apico–basal cell polarity
Genevet, A., & Tapon, N. (2011) · Biochemical Journal · doi:10.1042/bj20110217 · Cited by 167 · see citing works
The Hippo pathway in normal development and cancer
Maugeri‐Saccà, M., & Maria, R. D. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.12.011 · Cited by 165 · see citing works
Zhang, L., Yang, S., Chen, X., Stauffer, S., Yu, F., Lele, S. M., Fu, K., Datta, K., Palermo, N. Y., Chen, Y., et al. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00102-15 · Cited by 162 · see citing works
Self-citationCellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network
Sun, S., & Irvine, K. D. (2016) · Trends in Cell Biology · doi:10.1016/j.tcb.2016.05.003 · Cited by 135 · see citing works
Stephens, R., Lim, K., Portela, M., Kvansakul, M., Humbert, P. O., & Richardson, H. E. (2018) · Journal of Molecular Biology · doi:10.1016/j.jmb.2018.01.011 · Cited by 132 · see citing works
Defining the Protein–Protein Interaction Network of the Human Hippo Pathway
Wang, W., Li, X., Huang, J., Feng, L., Dolinta, K., & Chen, J. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.030049 · Cited by 132 · see citing works
Integrating developmental signals: a Hippo in the (path)way
Mauviel, A., Nallet-Staub, F., & Varelas, X. (2011) · Oncogene · doi:10.1038/onc.2011.363 · Cited by 129 · see citing works
KIBRA exhibits MST-independent functional regulation of the Hippo signaling pathway in mammals
Moleirinho, S., Chang, N., Sims, A. H., Tilston-Lünel, A., Angus, L., Steele, A., Boswell, V., Barnett, S. C., Ormandy, C. J., Faratian, D., et al. (2012) · Oncogene · doi:10.1038/onc.2012.196 · Cited by 128 · see citing works
Yang, S., Zhang, L., Liu, M., Chong, R., Ding, S., Chen, Y., & Dong, J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-2049 · Cited by 126 · see citing works
Self-citationThe Angiomotins – From discovery to function
Moleirinho, S., Guerrant, W., & Kissil, J. L. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.02.006 · Cited by 112 · see citing works
WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
Qi, S., Zhu, Y., Liu, X., Li, P., Wang, Y., Zeng, Y. J., Yu, A., Wang, Y., Sha, Z., Zhong, Z., et al. (2022) · Molecular Cell · doi:10.1016/j.molcel.2022.03.027 · Cited by 115 · see citing works
Zyxin-Siah2–Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways
Ma, B., Cheng, H., Gao, R., Mu, C., Chen, L., Wu, S., Chen, Q., & Zhu, Y. (2016) · Nature Communications · doi:10.1038/ncomms11123 · Cited by 111 · see citing works
Multiphase coalescence mediates Hippo pathway activation
Wang, L., Choi, K., Su, T., Li, B., Wu, X., Zhang, R., Driskill, J. H., Li, H., Lei, H., Guo, P., et al. (2022) · Cell · doi:10.1016/j.cell.2022.09.036 · Cited by 110 · see citing works
Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling
Hergovich, A. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-32 · Cited by 108 · see citing works
The mammalian Hippo pathway: regulation and function of YAP1 and TAZ
Kodaka, M., & Hata, Y. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1742-9 · Cited by 108 · see citing works
Yang, S., Zhang, L., Purohit, V., Shukla, S. K., Chen, X., Yu, F., Fu, K., Chen, Y., Solheim, J. C., Singh, P. K., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5935 · Cited by 106 · see citing works
Self-citationCoordinating developmental signaling: novel roles for the Hippo pathway
Varelas, X., & Wrana, J. L. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.10.002 · Cited by 103 · see citing works
Drosophila Pez Acts in Hippo Signaling to Restrict Intestinal Stem Cell Proliferation
Poernbacher, I., Baumgartner, R., Marada, S., Edwards, K. A., & Stocker, H. (2012) · Current Biology · doi:10.1016/j.cub.2012.01.019 · Cited by 99 · see citing works
Orr, B., & Compton, D. A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00164 · Cited by 99 · see citing works
Hippo‐YAP signaling pathway: A new paradigm for cancer therapy
Ma, Y., Yang, Y., Wang, F., Wei, Q., & Qin, H. (2014) · International Journal of Cancer · doi:10.1002/ijc.29073 · Cited by 99 · see citing works
Wilson, K. E., Li, Y.-W., Yang, N., Shen, H., Orillion, A. R., & Zhang, J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.534701 · Cited by 92 · see citing works
WWP1 E3 Ligase Targets LATS1 for Ubiquitin-Mediated Degradation in Breast Cancer Cells
Yeung, B., Ho, K. C., & Yang, X. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061027 · Cited by 90 · see citing works
Frassanito, M. A., Desantis, V., Marzo, L. D., Craparotta, I., Beltrame, L., Marchini, S., Annese, T., Visino, F., Arciuli, M., Saltarella, I., et al. (2018) · The Journal of Pathology · doi:10.1002/path.5187 · Cited by 89 · see citing works
NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation
Salah, Z., Cohen, S., Itzhaki, E., & Aqeilan, R. I. (2013) · Cell Cycle · doi:10.4161/cc.26672 · Cited by 89 · see citing works
The Hippo Signaling Pathway in Cancer: A Cell Cycle Perspective
Xiao, Y., & Dong, J. (2021) · Cancers · doi:10.3390/cancers13246214 · Cited by 84 · see citing works
Self-citationMokhtari, R. B., Ashayeri, N., Baghaie, L., Sambi, M., Satari, K., Baluch, N., Bosykh, D. A., Szewczuk, M. R., & Chakraborty, S. (2023) · Cancers · doi:10.3390/cancers15133468 · Cited by 88 · see citing works
Zhang, X., Liu, X., Luo, J., Xiao, W. L., Ye, X., Chen, M., Li, Y., & Zhang, G.-J. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.67 · Cited by 81 · see citing works
Mammalian Hippo signalling: a kinase network regulated by protein–protein interactions
Hergovich, A. (2012) · Biochemical Society Transactions · doi:10.1042/bst20110619 · Cited by 82 · see citing works
WW domain interactions regulate the Hippo tumor suppressor pathway
Salah, Z., & Aqeilan, R. I. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.53 · Cited by 76 · see citing works
Han, Q., Lin, X., Zhang, X., Jiang, G., Zhang, Y., Miao, Y., Rong, X., Zheng, X., Han, Y., Han, X., et al. (2017) · The Journal of Pathology · doi:10.1002/path.4919 · Cited by 76 · see citing works
KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase Mζ
Vogt-Eisele, A. K., Krüger, C., Duning, K., Weber, D., Spoelgen, R., Pitzer, C., Plaas, C., Eisenhardt, G., Meyer, A., Vogt, G., et al. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12480 · Cited by 71 · see citing works
Hippo signaling: A hub of growth control, tumor suppression and pluripotency maintenance
Yin, M.-X., & Zhang, L. (2011) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2011.09.009 · Cited by 69 · see citing works
Evolutionary and Molecular Facts Link the WWC Protein Family to Hippo Signaling
Wennmann, D. O., Schmitz, J., Wehr, M. C., Krahn, M. P., Koschmal, N., Gromnitza, S., Schulze, U., Weide, T., Chekuri, A. K., Skryabin, B. V., et al. (2014) · Molecular Biology and Evolution · doi:10.1093/molbev/msu115 · Cited by 69 · see citing works
Liu, Y., Lu, J., Zhang, Z., Zhu, L., Dong, S., Guo, G., Li, R., Yang, N., Yu, K., Zhong, Y., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.396 · Cited by 69 · see citing works
mRNA Expression in Papillary and Anaplastic Thyroid Carcinoma: Molecular Anatomy of a Killing Switch
Hébrant, A., Dom, G., Dewaele, M., Andry, G., Trésallet, C., Leteurtre, E., Dumont, J. E., & Maenhaut, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037807 · Cited by 67 · see citing works
Hippo pathway and breast cancer stem cells
Maugeri‐Saccà, M., & Maria, R. D. (2015) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2015.12.004 · Cited by 68 · see citing works
Song, H., Pu, J., Wang, L., Wu, L., Xiao, J., Liu, Q., Chen, J., Zhang, M., Liu, Y., Ni, M., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1060386 · Cited by 66 · see citing works
NEDD4 controls intestinal stem cell homeostasis by regulating the Hippo signalling pathway
Bae, S. J., Kim, M., Kim, S.-H., Kwon, Y. E., Lee, J.-H., Kim, J., Chung, C. H., Lee, W., & Seol, J. H. (2015) · Nature Communications · doi:10.1038/ncomms7314 · Cited by 66 · see citing works
Hippo signaling in mammalian stem cells
Tremblay, A., & Camargo, F. D. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.08.001 · Cited by 64 · see citing works
KIBRA: In the brain and beyond
Zhang, L., Yang, S., Wennmann, D. O., Chen, Y., Kremerskothen, J., & Dong, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.02.023 · Cited by 64 · see citing works
Self-citationThe expanding family of FERM proteins
Moleirinho, S., Tilston-Lünel, A., Angus, L., Gunn‐Moore, F. J., & Reynolds, P. A. (2013) · Biochemical Journal · doi:10.1042/bj20121642 · Cited by 64 · see citing works
KIBRA Protein Phosphorylation Is Regulated by Mitotic Kinase Aurora and Protein Phosphatase 1
Xiao, L., Chen, Y., Ji, M. H., Volle, D. J., Lewis, R. E., Tsai, M.-Y., & Dong, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.246850 · Cited by 61 · see citing works
Self-citationZhou, J., Zeng, Y., Cui, L., Chen, X., Stauffer, S., Wang, Z., Yu, F., Lele, S. M., Talmon, G. A., Black, A. R., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800621115 · Cited by 61 · see citing works
Self-citationRegulators of mammalian Hippo pathway in cancer
Liu, A. M., Wong, K., Jiang, X., Qiao, Y., & Luk, J. M. (2012) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2012.05.006 · Cited by 58 · see citing works
Morgan, J. T., Murphy, C. J., & Russell, P. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.06.012 · Cited by 56 · see citing works
YAP/TAZ in Bone and Cartilage Biology
Zarka, M., Haÿ, E., & Cohen-Solal, M. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.788773 · Cited by 54 · see citing works
Ajuba Phosphorylation by CDK1 Promotes Cell Proliferation and Tumorigenesis
Chen, X., Stauffer, S., Chen, Y., & Dong, J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.722751 · Cited by 54 · see citing works
Self-citationKnight, J. F., Sung, V. Y. C., Kuzmin, E., Couzens, A. L., de Verteuil, D. A., Ratcliffe, C. D. H., Coelho, P. P., Johnson, R. M., Samavarchi‐Tehrani, P., Gruosso, T., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.095 · Cited by 54 · see citing works
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells
Mao, X., Li, P., Wang, Y., Liang, Z., Liu, J., Li, J., Jiang, Y., Bao, G., Li, L., Zhu, B., et al. (2017) · Cell Death and Disease · doi:10.1038/cddis.2016.478 · Cited by 52 · see citing works
Zhang, L., Iyer, J., Chowdhury, A., Ji, M. H., Xiao, L., Yang, S., Chen, Y., Tsai, M.-Y., & Dong, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.385518 · Cited by 51 · see citing works
Self-citationZhou, P.-J., Xue, W., Peng, J., Wang, Y., Wei, L., Yang, Z., Zhu, H. H., Fang, Y., & Gao, W. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0609-y · Cited by 51 · see citing works
Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity
Lin, Z., Yang, Z., Xie, R., Ji, Z., Guan, K., & Zhang, M. (2019) · eLife · doi:10.7554/elife.49439 · Cited by 50 · see citing works
Targeting the Hippo pathway in heart repair
Meng, F., Xie, B., & Martin, J. F. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab291 · Cited by 49 · see citing works
Yang, S., Ji, M. H., Zhang, L., Chen, Y., Wennmann, D. O., Kremerskothen, J., & Dong, J. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.012 · Cited by 51 · see citing works
Self-citationGrieve, S., Hao, Y., & Yang, X. (2011) · Oncogene · doi:10.1038/onc.2011.318 · Cited by 49 · see citing works
Hermann, A., Wennmann, D. O., Gromnitza, S., Edeling, M., Marck, V. V., Sudol, M., Schaefer, L., Duning, K., Weide, T., Pavenstädt, H. J., et al. (2017) · Hepatology · doi:10.1002/hep.29647 · Cited by 48 · see citing works
Two Hippo signaling modules orchestrate liver size and tumorigenesis
Qi, S., Zhong, Z., Zhu, Y., Wang, Y., Ma, M., Wang, Y., Liu, X., Jin, R., Jiao, Z., Zhu, R., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022112126 · Cited by 47 · see citing works
Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis
Emami, S. S., Zhang, D., & Yang, X. (2020) · Cancers · doi:10.3390/cancers12092438 · Cited by 46 · see citing works
Tian, Y., Bachman, J. F., & Lai, Z.-C. (2014) · Protein & Cell · doi:10.1007/s13238-014-0122-4 · Cited by 46 · see citing works
Targeting the Hippo pathway: Clinical implications and therapeutics
Ye, S., & Eisinger‐Mathason, T. S. K. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.025 · Cited by 45 · see citing works
Chen, N., Uddin, B., Voit, R., & Schiebel, E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515605113 · Cited by 44 · see citing works
Stauffer, S., Zeng, Y., Zhou, J., Chen, X., Chen, Y., & Dong, J. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.001 · Cited by 43 · see citing works
Self-citationMukund, A. X., Tycko, J., Allen, S. J., Robinson, S. A., Andrews, C. J., Sinha, J., Ludwig, C., Spees, K. K., Bassik, M. C., & Bintu, L. (2023) · Cell Systems · doi:10.1016/j.cels.2023.07.001 · Cited by 40 · see citing works
WWC Proteins: Important Regulators of Hippo Signaling in Cancer
Höffken, V., Hermann, A., Pavenstädt, H. J., & Kremerskothen, J. (2021) · Cancers · doi:10.3390/cancers13020306 · Cited by 41 · see citing works
Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression
Ji, M. H., Yang, S., Chen, Y., Xiao, L., Zhang, L., & Dong, J. (2012) · Biochemical Journal · doi:10.1042/bj20120751 · Cited by 38 · see citing works
Self-citationThe Tumor Suppressor BAP1 Regulates the Hippo Pathway in Pancreatic Ductal Adenocarcinoma
Lee, H.-J., Pham, T., Chang, M. T., Barnes, D., Cai, A. G., Noubade, R., Tótpál, K., Chen, X., Tran, C., Hagenbeek, T. J., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-1704 · Cited by 38 · see citing works
The Role of the Hippo Pathway in Melanocytes and Melanoma
Kim, J. E., Finlay, G. J., & Baguley, B. C. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00123 · Cited by 38 · see citing works
Zeng, Y., Stauffer, S., Zhou, J., Chen, X., Chen, Y., & Dong, J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.796284 · Cited by 35 · see citing works
Self-citationYAP ping about and not forgetting TAZ
Callus, B. A., Finch‐Edmondson, M., Fletcher, S., & Wilton, S. D. (2018) · FEBS Letters · doi:10.1002/1873-3468.13318 · Cited by 35 · see citing works
The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer
Lee, H. Y., Son, S. W., Moeng, S., Choi, S. Y., & Park, J. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020627 · Cited by 35 · see citing works
Yuan, T., Annamalai, K., Naik, S., Lupše, B., Geravandi, S., Pal, A., Dobrowolski, A., Ghawali, J., Ruhlandt, M., Gorrepati, K. D. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25145-x · Cited by 35 · see citing works
CDK1 phosphorylation of TAZ in mitosis inhibits its oncogenic activity
Zhang, L., Chen, X., Stauffer, S., Yang, S., Chen, Y., & Dong, J. (2015) · Oncotarget · doi:10.18632/oncotarget.5189 · Cited by 33 · see citing works
Self-citationKIBRA promotes prostate cancer cell proliferation and motility
Stauffer, S., Chen, X., Zhang, L., Chen, Y., & Dong, J. (2016) · FEBS Journal · doi:10.1111/febs.13718 · Cited by 32 · see citing works
Self-citationDeng, L., Jiang, L., Lin, X., Tseng, K., Lu, Z., & Wang, X. (2017) · Oncology Letters · doi:10.3892/ol.2017.5597 · Cited by 32 · see citing works
The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
Wilson, K. E., Yang, N., Mussell, A. L., & Zhang, J. (2016) · Genes · doi:10.3390/genes7060023 · Cited by 32 · see citing works
Yang, S., Zhang, L., Chen, X., Chen, Y., & Dong, J. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.624411 · Cited by 31 · see citing works
Self-citationZhang, Y., Yan, S., Chen, J., Gan, C., Chen, D., Li, Y., Wen, J., Kremerskothen, J., Chen, S., Zhang, J., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13281 · Cited by 31 · see citing works
WWC3 Inhibits Glioma Cell Proliferation Through Suppressing the Wnt/β-Catenin Signaling Pathway
Wang, Y., Jiang, M., Yao, Y., & Cai, Z. (2017) · DNA and Cell Biology · doi:10.1089/dna.2017.3931 · Cited by 30 · see citing works
Schelleckes, K., Schmitz, B., Ciarimboli, G., Lenders, M., Pavenstädt, H. J., Herrmann, E., Brand, S., & Brand, E. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0415-6 · Cited by 31 · see citing works
The Regulation of the Hippo Pathway by Intercellular Junction Proteins
Ahmad, U. S., Uttagomol, J., & Wan, H. (2022) · Life · doi:10.3390/life12111792 · Cited by 29 · see citing works
Yoshihama, Y., Chida, K., & Ohno, S. (2012) · Communicative & Integrative Biology · doi:10.4161/cib.18849 · Cited by 29 · see citing works
Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis
Azad, T., Rezaei, R., Surendran, A., Singaravelu, R., Boulton, S., Dave, J., Bell, J. C., & Ilkow, C. S. (2020) · Cancers · doi:10.3390/cancers12082042 · Cited by 28 · see citing works
G protein-coupled receptors: bridging the gap from the extracellular signals to the Hippo pathway
Zhou, X., Wang, Z., Huang, W., & Lei, Q. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu108 · Cited by 28 · see citing works
Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4
Aerne, B. L., Gailite, I., Sims, D., & Tapon, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131113 · Cited by 28 · see citing works
Wasinski, B. D., Sohail, A., Bonfil, R. D., Kim, S., Saliganan, A. D., Polin, L., Bouhamdan, M., Kim, H.-R. C., Prunotto, M., & Fridman, R. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-59028-w · Cited by 27 · see citing works
Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer
Nguyen, T., & Kugler, J. (2018) · Cancers · doi:10.3390/cancers10040121 · Cited by 24 · see citing works
Moleirinho, S., Calum, P., Tilston-Lünel, A., Higginson, J. R., Angus, L., Antkowiak, M. K., Barnett, S. C., Prystowsky, M. B., Reynolds, P. A., & Gunn‐Moore, F. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060028 · Cited by 26 · see citing works
Mechanical Properties of Glioblastoma: Perspectives for YAP/TAZ Signaling Pathway and Beyond
Pontes, B., & Mendes, F. A. (2023) · Diseases · doi:10.3390/diseases11020086 · Cited by 26 · see citing works
Transcriptomic and Epigenetic Analysis of Breast Cancer Stem Cells
Li, G., Wang, D., Ma, W., An, K., Liu, Z. Z., Wang, X., Yang, C., Du, F., Han, X., Chang, S., et al. (2018) · Epigenomics · doi:10.2217/epi-2018-0008 · Cited by 24 · see citing works
Stauffer, S., Zeng, Y., Santos, M., Zhou, J., Chen, Y., & Dong, J. (2019) · Journal of Cell Science · doi:10.1242/jcs.236000 · Cited by 24 · see citing works
Self-citationMendoza, M. L., Quigley, L. D., Dunham, T. L., & Volk, L. J. (2022) · iScience · doi:10.1016/j.isci.2022.105623 · Cited by 20 · see citing works
- Authors
- Xiao, L., Chen, Y., Ji, M., & Dong, J.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Ji, Ming
- Dong, Jixin
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 286
- Issue
- 10
- Pages
- 7788-7796
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3048666
- OpenAlex
- W2000662094
- Cited by
- 190
- References
- 47
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 13 · 2021: 14 · 2020: 12 · 2019: 11 · 2018: 14 · 2017: 17 · 2016: 11 · 2015: 14 · 2014: 13 · 2013: 19 · 2012: 11
- FWCI
- 7.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health and Human Services
- University of Nebraska Medical Center
- Johns Hopkins University
- Nebraska Department of Health and Human Services
- National Institutes of Health
- National Center for Research Resources (5P20-RR018759-07, P20RR018759)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- KIBRA, Hippo signaling pathway, LATS1, LATS2, YAP, YAP phosphorylation, hydrophobic motif, kinase activation, ubiquitination, protein stability, transcriptional regulation, cell proliferation, apoptosis, tissue growth, carcinogenesis
- MeSH terms
- YAP-Signaling Proteins, Animals, Carrier Proteins, Drosophila melanogaster, Humans, Phosphoproteins, Phosphorylation, Proteins, Transcription Factors, Signal Transduction, Protein Serine-Threonine Kinases, Amino Acid Motifs, Tumor Suppressor Proteins, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Mice, Ubiquitination, HEK293 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
