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Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration
Open accessAbstract
Macrophages and neutrophils are the pivotal immune phagocytes that enter the wound after tissue injury to remove the cell debris and invaded microorganisms, which presumably facilitate the regrowth of injured tissues. Taking advantage of the regeneration abilities of zebrafish and the newly generated leukocyte-specific zebrafish lines with labeling of both leukocyte lineages, we assessed the behaviors and functions of neutrophils and macrophages during tail fin regeneration. Live imaging showed that within 6 hours post amputation, the inflammatory stage, neutrophils were the primary cells scavenging apoptotic bodies and small cell debris, although they had limited phagocytic capacity and quickly underwent apoptosis. From 6 hours post amputation on, the resolution and regeneration stage, macrophages became the dominant scavengers, efficiently resolving inflammation and facilitating tissue remodeling and regrowth. Ablation of macrophages but not neutrophils severely impaired the inflammatory resolution and tissue regeneration, resulting in the formation of large vacuoles in the regenerated fins. In contrast, removal of neutrophils slightly accelerates the regrowth of injured fin. Our study documents the differing behaviors and functions of macrophages and neutrophils during tissue regeneration.
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“The zebrafish larval caudal fin regeneration model is a well-established system for studying the roles of the immune system in organ injury and regeneration [40]”
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Items 201–300 of 352
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Ifi30 Is Required for Sprouting Angiogenesis During Caudal Vein Plexus Formation in Zebrafish
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MethodHumoral immune parameters in serum of gilthead seabream (Sparus aurata L.) after induced skin injury
Ceballos‐Francisco, D., Guardiola, F. A., Cordero, H., Cuesta, A., & Esteban, M. Á. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.02.017 · Cited by 10
“Afterwards, macrophages became the dominant scavengers, efficiently resolving inflammation and giving rise to the regeneration stage [30].”
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“This is true of zebrafish tails (Li et al. 2012; Petrie et al. 2014) and axolotl limbs and heart (Godwin et al.”
BackgroundActivated PI3K delta syndrome 1 mutations cause neutrophilia in zebrafish larvae
Elworthy, S., Rutherford, H. A., Prajsnar, T. K., Hamilton, N., Vogt, K. L., Renshaw, S. A., & Condliffe, A. M. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049841 · Cited by 9
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Zebrafish: A Relevant Genetic Model for Human Primary Immunodeficiency (PID) Disorders?
Basheer, F., Sertori, R., Liongue, C., & Ward, A. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076468 · Cited by 10
High-throughput imaging of zebrafish embryos using a linear-CCD-based flow imaging system
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Real-time imaging reveals a role for macrophage protrusive motility in melanoma invasion
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The CXCR4-CXCL12 axis promotes T cell reconstitution via efficient hematopoietic immigration
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“To dissect the features of immune cells in the aging brains at single-cell resolution, we selected 12- and 26-month-old Tg(coro1a:GFP) zebrafish brains, in which the immunocytes were labeled by GFP signals (Li et al., 2012).”
MethodInfluentialParedes, L. C., Luz, R. B. D. S., Tozzi, O. N., de Carvalho, L. Â. S. J., Calado, S. L. D. M., Padovani, B. N., Morales, C., do Amaral, M. A., de Assis, H. C. S., Câmara, N. O. S., et al. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13026 · Cited by 9
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Osorio-Méndez, D., Miller, A. H., Begeman, I. J., Kurth, A., Hagle, R., Rolph, D., Dickson, A. L., Chen, C., Halloran, M. C., Poss, K. D., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2200342119 · Cited by 9
“At the early phase of appendage regeneration, infiltration of neutrophils and macrophages to injury sites is one key event for successful regeneration (62, 63).”
BackgroundSingh, S. K., Sethi, S., Aravamudhan, S., Krüger, M., & Grabher, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073998 · Cited by 9
“The use of zebrafish to study the ontogeny of leukocyte subsets [2], immune cell migration [3], regeneration [4,5], and host-pathogen interactions [6] has provided new insights towards the understanding of innate immunity in the developing vertebrate embryo.”
BackgroundOrgan and Appendage Regeneration in the Axolotl
Farkas, J. E., Erler, P., Freitas, P. D., Sweeney, A. E., & Monaghan, J. R. (2016) · Springer eBooks · doi:10.1007/978-3-319-27583-3_7 · Cited by 8
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“It has been suggested that neutrophils are not required for fin regeneration [51], with their sustained presence inhibitory to the repair process [52].”
BackgroundRoles of Ca2+ activity in injury-induced migration of microglia in zebrafish in vivo
Du, T., Zhou, X., Zhang, R. D. Y., & Du, X.-F. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101340 · Cited by 9
“The Tg(coro1a:GCaMP5)ion15d line was generated by using the same promoter as the Tg(coro1a:eGFP) line which was previously described [23].”
MethodVascular endothelial growth factor c regulates hematopoietic stem cell fate in the dorsal aorta
Schiavo, R. K., & Tamplin, O. J. (2021) · Development · doi:10.1242/dev.199498 · Cited by 7
Pro-regenerative Dialogue Between Macrophages and Mesenchymal Stem/Stromal Cells in Osteoarthritis
Bohaud, C., Contreras-López, R. A., Cruz, J. D. L., Terraza‐Aguirre, C., Wei, M., Djouad, F., & Jørgensen, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.718938 · Cited by 8
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“M2-type macrophages are also involved in zebrafish cardiac and fin regeneration, where they accumulate near the injury by 1 dpl and do not express Tnfα (Lai et al., 2017; L. Li et al., 2012).”
BackgroundBurgos-Ruiz, A. M., Geng, F., Pujol, G., Sanabria, E., Brethouwer, T., Almuedo‐Castillo, M., Ruiz‐Herrera, A., Tena, J. J., & Bogdanović, O. (2025) · Molecular Systems Biology · doi:10.1038/s44320-025-00157-7 · Cited by 9
“S3 and Dataset EV2), and hematopoietic immune cells (expressed markers: rac2 , coro1a , grap2 and others) (Deng et al, 2011; Li et al, 2012; Ma et al, 2001) (Appendix Fig.”
Safian, D., Wiegertjes, G. F., & Pollux, B. J. A. (2021) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2021.613157 · Cited by 6
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“Zebrafish of the Casper line and Coro1a:EGFP [42] were obtained from the China Zebrafish Resource Center (Wuhan, China).”
Rutherford, H. A., Candeias, D., Duncan, C. J. A., Renshaw, S. A., & Hamilton, N. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2321496121 · Cited by 7
Paredes, A. D., Benavidez, D., Cheng, J., Mangos, S., Patil, R. V., Donoghue, M. J., Benedetti, E., & Bartholomew, A. M. (2019) · Photobiomodulation Photomedicine and Laser Surgery · doi:10.1089/photob.2018.4494 · Cited by 6
“27,44 However, the time postinjury is important in considering the average macrophage migration behavior.”
From the Basis of Epimorphic Regeneration to Enhanced Regenerative Therapies
Laplace-Builhe, B., Bahraoui, S., Jørgensen, C., & Djouad, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.605120 · Cited by 7
Ying, C., Fang, X., Wang, H., Yang, Y., Xu, P., Liu, K., & Yin, G. (2022) · Journal of Fish Biology · doi:10.1111/jfb.15027 · Cited by 6
leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts
Shin, K., Begeman, I. J., Cao, J., & Kang, J. (2022) · Developmental Dynamics · doi:10.1002/dvdy.556 · Cited by 6
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“RNA analysis in zebrafish demonstrates a similar trend to IL-1 β with a sharp increase at 2 hpi and a return to control levels at 24 hpi [34].”
BackgroundRecent advances in heart regeneration
Xiong, J., & Chang, N. (2013) · Birth Defects Research Part C Embryo Today Reviews · doi:10.1002/bdrc.21039 · Cited by 6
Kif15 regulates Coro1a+ cell migration and phagocytosis in zebrafish after spinal cord injury
Dong, Z., Zhuo, R., Wang, Q., Sun, Y., Zhou, Z., Wu, R., Liu, Y., & Liu, M. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113874 · Cited by 5
Effects of pyrazosulfuron-ethyl on caudal fin regeneration in zebrafish larvae
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Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration
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de Lima, F. M. R., Abrahão, I., Pentagna, N., & Carneiro, K. (2022) · Developmental Dynamics · doi:10.1002/dvdy.543 · Cited by 7
“Conversely, the depletion of another PAC subset (neutrophils) correlates with an increase in regeneration speed.(133) Notably, while tumor necrosis factor alpha (TNF-α) produced during inflammation acts as a potent endothelial cell activator, it exerts minimal effects on PACs.”
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Functional Regeneration and Remyelination in the Zebrafish Optic Nerve
Zou, S., Wu, Y., Huang, Y., Tian, C., Ge, S., & Hu, B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801732-6.00002-1 · Cited by 5
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“To demonstrate the utility of the Zirmi image analysis pipeline, our experimental results, based on wounding severity and oxidative stress, provided additional detail to previous studies defining early wound macrophage recruitment [7,15,16,19].”
MethodInfluentialSimkin, J., Dawson, L., Simkin, M., & Muneoka, K. (2019) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2019.100026 · Cited by 5
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In-silico engineering of RNA nanoplatforms to promote the diabetic wound healing
Beheshtizadeh, N., Salimi, A., Golmohammadi, M., Ansari, J. M., & Azami, M. (2023) · BMC Chemistry · doi:10.1186/s13065-023-00969-4 · Cited by 5
“Apoptosis in immune cells may be the key to ending inflammation and kicking off healing since macrophages are the major phagocytes that help resolve inflammation and promote tissue regeneration [70].”
BackgroundPolydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types
Pessina, A., Vincenzo, M. D., Maradonna, F., Marchegiani, F., Olivieri, F., Randazzo, B., Gioacchini, G., & Carnevali, O. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18031116 · Cited by 5
“Six hours after tissue damage, macrophages replace neutrophils and they remain abundant until final tissue repair [18].”
BackgroundSynthesis of 7-azaindoles and their pro-angiogenic and anti-inflammatory activities
Tan, Z., Yang, W., Zou, L., Luo, Z., Lu, Z., Zeng, W., & Liu, J. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118446 · Cited by 4
Zebrafish as a multimodal platforms for anti-inflammatory phytomedicine discovery and translation
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“Neutrophil migration peaks at ~4 h post-amputation, followed by macrophage recruitment and dominance in wound repair from ~6 h onward (Xie et al., 2020; Li et al., 2012).”
Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1
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An accurate and sensitive method for neurotoxicity assessment of emerging contaminants in zebrafish
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Johnston, H. J., Gillies, S. L. J., Verdon, R., Stone, V., Henry, T. B., Tran, L., Tucker, C. S., Rossi, A. G., & Tyler, C. R. (2025) · F1000Research · doi:10.12688/f1000research.128851.2 · Cited by 4
Galanin-Mediated Inflammatory Responses in Zebrafish Spinal Cord Regeneration
Okitsu-Sakurayama, S., Kasica, N., Potoczna, M., Szczepanek, J. D., Wa̧sowicz, K., & Podlasz, P. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05228-2 · Cited by 4
“The role of neutrophils in tissue regeneration is still controversial [11, 12, 44, 45].”
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Xu, M., Su, J., Yue, Z., Yu, Y., Zhao, X., & Xie, X. (2022) · Russian Journal of Developmental Biology · doi:10.1134/s1062360422030055 · Cited by 4
“In transgenic zebrafish model, Li et al. (2012) utilized the Tg(coro1a:eGFP;lyz:Dsred) double transgenic lines to assay the functions of neutrophils in the larva tail fin regeneration and found that the regeneration speed of the fin is slightly faster in the neutrophil-deficient runx1w84x,…”
BackgroundMethodInfluentialCurcumin-Encapsulated Nanomicelles Promote Tissue Regeneration in Zebrafish Eleutheroembryo
Narra, S. S., Gence, L., Youssouf, L., Couprie, J., Giraud, P., Diotel, N., & d’Hellencourt, C. L. (2023) · Zebrafish · doi:10.1089/zeb.2023.0007 · Cited by 4
“43 Macro-phages also promote fin regeneration by downregulating ROS levels at the site of injury.”
Santos, M. D. F., Carneiro, W. F., Virote, B. D. C. R., da Silva, K. C. D., Castro, T. F. D., Coli, A., Murgas, L. D. S., Ferrante, M., Gavilanes, M. L., & Carvalho, E. E. N. (2023) · Oriental Pharmacy and Experimental Medicine · doi:10.1007/s13596-023-00722-1 · Cited by 4
“This finding might be associated with the anti-inflammatory activity identified in the extracts since reduced neutrophil migration leads to accelerated epidermal healing, as measured by wound closure, indicating these cells may inhibit the regeneration stage (Li et al. 2012; He et al. 2020).”
Elf1 Deficiency Impairs Macrophage Development in Zebrafish Model Organism
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“After 10 h post-amputation, fewer than half the number of macrophages were observed in fi ltrating the injury site compared to controls (Figure 5A,B).”
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Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish
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Loss of Shp1 impairs myeloid cell function and causes lethal inflammation in zebrafish larvae
Allers, M., Bakker, P. A., Hoeksma, J., Spaink, H. P., & den Hertog, J. (2023) · Disease Models & Mechanisms · doi:10.1242/dmm.049715 · Cited by 4
“This is surprising, given a previous report that showed that ablation of macrophages severely impaired regeneration (Li et al., 2012).”
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Vascular Lamb1 guides the migration of retinal microglial precursors via Itga6-Rac1 signaling
Zhan, D., Xu, L., Mu, W., Jin, B., Feng, Z. W., Liu, S., Wu, C., Luo, L., & Li, L. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116544 · Cited by 3
Ruden, D. M. (2026) · Cells · doi:10.3390/cells15111030 · Cited by 3
Zavitri, N. G., Syahbaniati, A. P., Putri, R. M., Dwivany, F. M., Wibowo, I., Pramudita, D., & Indarto, A. (2025) · Materials Advances · doi:10.1039/d5ma00775e · Cited by 3
Gene expression patterns associated with caudal fin shape in the cichlid Lamprologus tigripictilis
Ahi, E. P., Richter, F. M., & Sefc, K. M. (2022) · Hydrobiologia · doi:10.1007/s10750-022-05068-4 · Cited by 3
“Among the latter, myc, irf8, and foxd3 were already indicated in fin regeneration studies of other teleost fish (Christen et al., 2010; Li et al., 2012; Kang et al., 2015; Hasegawa et al., 2017; Huang & Chen, 2017).”
BackgroundZhao, L., Wang, L., Wang, Y.-C., Liu, A., Xiao, Q.-W., Hu, M., Sun, M.-Z., Hao, H.-Y., Gao, Q., Zhao, X. J., et al. (2024) · Cell Biology and Toxicology · doi:10.1007/s10565-024-09882-5 · Cited by 3
“In addition to their important functions in innate immunity, macrophages and neutrophils contribute to wound healing and tissue regeneration (Li et al. 2012).”
Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Li, S., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07392-8 · Cited by 3
“In contrast, in Tg(coro1a:GFP) embryos, GFP-labeled cells marked immature T cells [26].”
InfluentialCFTR regulates embryonic T lymphopoiesis via Wnt signaling in zebrafish
Lin, Z., Luo, M., Zhou, B., Liu, Y., & Sun, H. (2021) · Immunology Letters · doi:10.1016/j.imlet.2021.04.010 · Cited by 3
Functional Verification of Novel ELMO1 Variants by Live Imaging in Zebrafish
Xue, R., Wang, Y., Wang, T., Lyu, M., Mo, G., Fan, X., Li, J., Yen, K., Yu, S., Liu, Q., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.723804 · Cited by 3
“, 2017), Tg(lyz:DsRed) (Li et al., 2012), Tg(lck:DsRedx), which is short for Tg(lck:LoxP-DsRedx-LoxP-GFP) (Tian et al.”
BackgroundMethodInfluentialAdvancements in a Zebrafish Model for Toxicity Assessment of Nanomaterials
Lee, S. L. J., & Lin, S. (2022) · Springer eBooks · doi:10.1007/978-981-16-9116-4_5 · Cited by 4
Zhang, X., Yang, Y., Wei, Y., Zhao, Q., & Lou, X. (2022) · Development · doi:10.1242/dev.200919 · Cited by 3
Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S. A., Mani, S., Bharathi, S., Mandal, K., Kuram, N. A., Vuppaladadium, S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.20.445069 · Cited by 3
Tnfrsf10 Signaling is Required to Maintain the Stem Cell Niche in the Zebrafish Lateral LinePreprint
Fan, C., Yuan, X., Wang, J., Pei, W., Zheng, H., Zhang, X., & Burgess, S. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.18.649014 · Cited by 3
Liu, L., Hu, W., Kerman, F. D., & Spaink, H. P. (2025) · International Journal of Biological Sciences · doi:10.7150/ijbs.101055 · Cited by 2
Neutrophils from Protection to Pathogenesis in Tuberculosis
Beig, H., & Singh, A. (2025) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.5c00096 · Cited by 2
Mitra, S., Devi, S., Lee, M., Sahu, A., Jui, J., Kriukov, E., Baranov, P. Y., & Goldman, D. J. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2535044123 · Cited by 2
“S3 G ) (56).”
Liu, T., Wu, L., Mishra, S. K., Fang, Q., & Wang, H. (2026) · Science Advances · doi:10.1126/sciadv.aee7124 · Cited by 2
“We then crossed Tg(coro1a:EGFP) ( 33 ) with Tg(gsdf:mCherry) ( 34 ), generated double transgenic zebrafish Tg(coro1a:EGFP;gsdf:mCherry) , and examined how the previously undescribed immune subtype fits in the traditional Sertoli cells, as shown by gsdf + cells.”
Johnston, H. J., Gillies, S. L. J., Verdon, R., Stone, V., Henry, T. B., Tran, L., Tucker, C. S., Rossi, A. G., & Tyler, C. R. (2023) · F1000Research · doi:10.12688/f1000research.128851.1 · Cited by 2
Lin, G., Wang, Y., Pham, T. G., & Wen, Z. (2025) · Development · doi:10.1242/dev.204410 · Cited by 2
Chen, W., Wu, J., She, P., Li, J., Lan, Y., Hu, X., Huangfu, Y. F., Wu, C., Jin, D., Xie, P., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61680-7 · Cited by 2
“TofurtherdeterminewhethertheT lymphocyte defect in atf7ip − / − mutants was caused by a cell-autonomous effect, we generated a tol2 transposon construct to drive atf7ip expression by the coro1a promoter during early T cell migrationanddifferentiation 44,45 (Fig.1l).”
Alibardi, L. (2022) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2022.151940 · Cited by 2
Zou, D., Qin, J., Hu, W., Wei, Z., Zhan, Y., He, Y., Zhao, C., & Li, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810551 · Cited by 2
“The same phenomenon was also found in Tg(coro1a:DsRed;mpeg1:GFP) double transgenic lines [37] (Figure S2A).”
BackgroundMethodDUSP2 Deletion Inhibits Macrophage Migration by Inhibiting ERK Activation in Zebrafish
Li, Y., Wang, X., Shi, L., Wang, Z., Zhao, Z.-A., Ge, S., & Hu, B. (2023) · Fishes · doi:10.3390/fishes8060310 · Cited by 2
“After tail fin injury, neutrophils and macrophages migrated to the injury site at different velocities [24].”
BackgroundSingle-cell RNA-seq reveals endoimmune cells in zebrafishPreprint
Shi, Y., Qian, P., Sheng, J., Zhang, X., Wang, X., Jingxiang, Z., Wei, G., Liu, X., Xie, G., & Liu, D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.31.892240 · Cited by 2
“Transgenic zebrafish lines, Tg(kdrl:EGFP), Tg(kdrl:ras-mCherry) and Tg(coro1a:EGFP) were used as described in previous work [14, 16, 17].”
MethodInflammation modulates regeneration in the acute or chronically damaged zebrafish retinaPreprint
Iribarne, M., & Hyde, D. R. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.06.463331 · Cited by 2
Jablonka‐Shariff, A., Broberg, C., & Snyder‐Warwick, A. K. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1535323 · Cited by 1
“Previous work has uncovered several epigenetic and transcriptional effectors implicated in regulating synaptic protein dynamics in health and disease (Li et al., 2012), and during NMJ remodeling after nerve injury (Guzman et al., 2023).”
Mathematical and Numerical Methods for Understanding Immune Cell Motion During Wound Healing
Lupi, G., Park, S. A., Ambroz, M., Özbilgiç, R., Chi, M. N., Lutfalla, G., & Mikula, K. (2025) · Mathematical Modelling of Natural Phenomena · doi:10.1051/mmnp/2025030 · Cited by 1
In vivo screen reveals specific roles of Hippo pathway components in development and regeneration
Riley, S. E., Nosková, M., Xia, S., Cunningham, R., Cholewa-Waclaw, J., Feng, Y., & Hansen, C. G. (2025) · Life Science Alliance · doi:10.26508/lsa.202503296 · Cited by 1
“…Crispants may have a defect in the switch from M1-like to M2-like macrophages, suggesting that the defect in regeneration might be a result of an extended pro-inflammatory environment in the tail fin, including a lack of the pro-regenerative M2-like macrophages (105, 106, 107, 111, 112, 113, 118).”
Zhao, S., Li, S., Zhang, C., Tang, Z., Zhang, A., Huang, C., Cheng, K., Yu, T., Yan, Y., & Wen, Z. (2026) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2026.02.017 · Cited by 1
O’Connor, O. L., Knutshaug, S. S., Varshney, S., Siriyappagouder, P., & Olsvik, P. A. (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120029 · Cited by 1
Cheng, X., Li, L., Fang, S., Yu, L., Liu, C., Jiao, Y., Yang, F., Lin, L., Zhao, L., & Su, Y. (2026) · Communications Biology · doi:10.1038/s42003-026-10137-8 · Cited by 1
The mitochondrial protein Cox17 negatively regulates antibacterial and antiviral defense in teleosts
Shi, J., Lou, Q., Jing, Y., Li, L., Zhang, Y.-A., Su, J., Yin, Z., & Liu, J.-X. (2026) · Water Biology and Security · doi:10.1016/j.watbs.2026.100640 · Cited by 1
Metz, M., Jørgensen, L. V. G., & Jutfelt, F. (2026) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2026.111452 · Cited by 1
Metadata
- Authors
- Li, L., Yan, B., Shi, Y.-Q., Zhang, W.-Q., & Wen, Z.-L.
- Affiliations
- Southwest University (CN)
- Hong Kong University of Science and Technology (HK)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2012-07
- Volume
- 287
- Issue
- 30
- Pages
- 25353-25360
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3408142
- OpenAlex
- W1980758898
- Cited by
- 353
- References
- 49
- Citations by year
- 2026: 26 · 2025: 24 · 2024: 23 · 2023: 21 · 2022: 41 · 2021: 34 · 2020: 22 · 2019: 36 · 2018: 19 · 2017: 24 · 2016: 23 · 2015: 19 · 2014: 25 · 2013: 13 · 2012: 3
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- macrophages, neutrophils, tail fin regeneration, zebrafish, wound healing, phagocytosis, inflammation resolution, tissue remodeling, macrophage depletion, live imaging
- MeSH terms
- Animals, Macrophages, Neutrophils, Regeneration, Tail, Zebrafish, Animal Fins
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