Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1
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Neurons can transfer miR-124a in exosomes to astrocytes to regulate expression of astroglial glutamate transporters.
“neurons can transfer miR-124a in exosomes to astrocytes to regulate the expression of astroglial glutamate transporters, which is important for the maintenance of extracellular glutamate levels47.”
From Neurons secrete miR-132-containing exosomes to regulate brain vascular integrity (2017) · cites this paper as [47]
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Exosomes are released by cultured cortical neurones
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“Because astrocytes are known to release various signals tomodulate synaptic/neuronal functions (49, 50) and survival (51, 52), it is likely that astroglial exosomes may also play a modulatory role in synaptic functions.”
BackgroundMicroRNA expression in the adult mouse central nervous system
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MicroRNAs change the games in central nervous system pharmacology
Marangon, D., Raffaele, S., Fumagalli, M., & Lecca, D. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.06.019 · Cited by 22 · see citing works
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- Authors
- Morel, L., Regan, M., Higashimori, H., Ng, S. K., Esau, C., Vidensky, S., Rothstein, J., & Yang, Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 288
- Issue
- 10
- Pages
- 7105-7116
- ISSN
- 0021-9258
- Cited by
- 390
- References
- 6
- Language
- en
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