Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works

Traumatic spinal cord injury

Ahuja, C. S., Wilson, J. R., Nori, S., Kotter, M. R. N., Druschel, C., Curt, A., & Fehlings, M. G. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.18 · Cited by 2,441 · see citing works

RNA delivery by extracellular vesicles in mammalian cells and its applications

O’Brien, K., Breyne, K., Ughetto, S., Laurent, L. C., & Breakefield, X. O. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0251-y · Cited by 1,811 · see citing works

New Technologies for Analysis of Extracellular Vesicles

Shao, H., Im, H., Castro, C. M., Breakefield, X. O., Weissleder, R., & Lee, H. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00534 · Cited by 1,672 · see citing works

Quantitative and stoichiometric analysis of the microRNA content of exosomes

Chevillet, J. R., Kang, Q., Ruf, I. K., Briggs, H., Vojtech, L. N., Hughes, S. M., Cheng, H. H., Arroyo, J. D., Meredith, E. K., Gallichotte, E. N., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408301111 · Cited by 1,105 · see citing works

Mesenchymal stem cell-derived extracellular vesicles: novel frontiers in regenerative medicine

Keshtkar, S., Azarpira, N., & Ghahremani, M. H. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0791-7 · Cited by 913 · see citing works

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 812 · see citing works

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

Fitzner, D., Schnaars, M., van Rossum, D., Krishnamoorthy, G., Dibaj, P., Bakhti, M., Regen, T., Hanisch, U.-K., & Simons, M. (2011) · Journal of Cell Science · doi:10.1242/jcs.074088 · Cited by 775 · see citing works

Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins

Fuhrmann, G., Serio, A., Mazo, M. M., Nair, R., & Stevens, M. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.11.029 · Cited by 746 · see citing works

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

Yang, Z., Shi, J., Xie, J., Wang, Y., Sun, J., Liu, T., Zhao, Y., Zhao, X., Wang, X., Ma, Y., et al. (2019) · Nature Biomedical Engineering · doi:10.1038/s41551-019-0485-1 · Cited by 744 · see citing works

Extracellular vesicles round off communication in the nervous system

Budnik, V., Ruiz-Cañada, C., & Wendler, F. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.29 · Cited by 712 · see citing works

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

Kooijmans, S. A. A., Stremersch, S., Braeckmans, K., de Smedt, S. C., Hendrix, A., Wood, M. J. A., Schiffelers, R. M., Raemdonck, K., & Vader, P. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.014 · Cited by 663 · see citing works

Spinal Cord Injury Scarring and Inflammation: Therapies Targeting Glial and Inflammatory Responses

Orr, M. B., & Gensel, J. C. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0631-6 · Cited by 584 · see citing works

Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain

Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578 · see citing works

Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies

Dehkordi, A. N., Mirahmadi, F., Chehelgerdi, M., & Dehkordi, S. R. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1212-2 · Cited by 547 · see citing works

3D Bioprinting for Organ Regeneration

Cui, H., Nowicki, M. A., Fisher, J. P., & Zhang, L. G. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201601118 · Cited by 542 · see citing works

Extracellular Vesicle-Mediated Transfer of Genetic Information between the Hematopoietic System and the Brain in Response to Inflammation

Ridder, K., Keller, S., Dams, M., Rupp, A.-K., Schlaudraff, J., Del Turco, D., Starmann, J., Macas, J., Karpova, D., Devraj, K., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001874 · Cited by 412 · see citing works

Extracellular vesicles: novel promising delivery systems for therapy of brain diseases.

Rufino-Ramos, D., Albuquerque, P. R., Carmona, V., Perfeito, R., Nobre, R. J., & Pereira de Almeida, L. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.001 · Cited by 395 · see citing works

Neuronal Exosomal miRNA-dependent Translational Regulation of Astroglial Glutamate Transporter GLT1

Morel, L., Regan, M., Higashimori, H., Ng, S. K., Esau, C., Vidensky, S., Rothstein, J., & Yang, Y. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.410944 · Cited by 390 · see citing works

Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents

Börger, V., Bremer, M., Ferrer-Tur, R., Gockeln, L., Stambouli, O., Becic, A., & Giebel, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071450 · Cited by 375 · see citing works

Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication

Lamichhane, T. N., Jeyaram, A., Patel, D. B., Parajuli, B., Livingston, N. K., Arumugasaamy, N., Schardt, J. S., & Jay, S. M. (2016) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-016-0457-4 · Cited by 371 · see citing works

The emerging role of exosomes in mental disorders

Saeedi, S., Israel, S. A., Nagy, C., & Turecki, G. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0459-9 · Cited by 367 · see citing works

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

de Jong, O. G., Kooijmans, S. A. A., Murphy, D. E., Jiang, L., Evers, M. J. W., Sluijter, J. P. G., Vader, P., & Schiffelers, R. M. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00109 · Cited by 358 · see citing works

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy

Rong, Y., Liu, W., Wang, J., Fan, J., Luo, Y., Li, L., Kong, F., Chen, J., Tang, P., & Cai, W. (2019) · Cell Death & Disease · doi:10.1038/s41419-019-1571-8 · Cited by 333 · see citing works

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

Hervera, A., Virgiliis, F. D., Palmisano, I., Zhou, L., Tantardini, E., Kong, G., Hutson, T. H., Danzi, M. C., Perry, R. B., Santos, C. X. C., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0039-x · Cited by 333 · see citing works

Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

Men, Y., Yelick, J., Jin, S., Tian, Y., Chiang, M. S. R., Higashimori, H., Brown, E., Jarvis, R., & Yang, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-11534-w · Cited by 331 · see citing works

Central Nervous System Regenerative Failure: Role of Oligodendrocytes, Astrocytes, and MicrogliaPreprint

Silver, J., Schwab, M. E., & Popovich, P. G. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020602 · Cited by 327 · see citing works

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

Kumar, A., Stoica, B. A., Loane, D. J., Yang, M., Abulwerdi, G. A., Khan, N., Kumar, A., Thom, S. R., & Faden, A. I. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0819-4 · Cited by 318 · see citing works

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

Prada, I., Gabrielli, M., Turola, E., Iorio, A., D’Arrigo, G., Parolisi, R., De Luca, M., Pacifici, M., Bastoni, M., Lombardi, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1803-x · Cited by 312 · see citing works

Extracellular Vesicles from Neural Stem Cells Transfer IFN-γ via Ifngr1 to Activate Stat1 Signaling in Target Cells

Cossetti, C., Iraci, N., Mercer, T. R., Leonardi, T., Alpi, E., Drago, D., Alfaro‐Cervelló, C., Saini, H. K., Davis, M. P. A., Schaeffer, J., et al. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.08.020 · Cited by 301 · see citing works

US County-Level Trends in Mortality Rates for Major Causes of Death, 1980-2014

Dwyer‐Lindgren, L., Bertozzi-Villa, A., Stubbs, R. W., Morozoff, C., Kutz, M., Huynh, C. K., Barber, R. M., Shackelford, K. A., Mackenbach, J. P., van Lenthe, F. J., et al. (2016) · JAMA · doi:10.1001/jama.2016.13645 · Cited by 291 · see citing works

Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

Dickens, A. M., Tovar-y-Romo, L. B., Yoo, S.-W., Trout, A. L., Bae, M., Kanmogne, M., Megra, B., Williams, D. W., Witwer, K. W., Gacias, M., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aai7696 · Cited by 285 · see citing works

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

Webb, R. L., Kaiser, E. E., Scoville, S. L., Thompson, T. A., Fatima, S., Pandya, C., Sriram, K., Swetenburg, R. L., Vaibhav, K., Arbab, A. S., et al. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0599-2 · Cited by 284 · see citing works

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

Jiang, D., Gong, F., Ge, X., Lv, C., Huang, C., Feng, S., Zhou, Z., Rong, Y., Wang, J., Ji, C., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00665-8 · Cited by 282 · see citing works

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis

Jarmalavičiūtė, A., Tunaitis, V., Pivoraitė, U., Venalis, A., & Pivoriūnas, A. (2015) · Cytotherapy · doi:10.1016/j.jcyt.2014.07.013 · Cited by 260 · see citing works

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

Katari, V., Ghosh, S. K., Mullick, M., Manivasagam, G., & Sen, D. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03039-1 · Cited by 254 · see citing works

Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell‐derived extracellular vesicles

Patel, D. B., Gray, K. M., Santharam, Y., Lamichhane, T. N., Stroka, K. M., & Jay, S. M. (2017) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10065 · Cited by 252 · see citing works

Spinal Cord Injury Causes Brain Inflammation Associated with Cognitive and Affective Changes: Role of Cell Cycle Pathways

Wu, J., Zhao, Z., Sabirzhanov, B. E., Stoica, B. A., Kumar, A., Luo, T., Skovira, J. W., & Faden, A. I. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5110-13.2014 · Cited by 246 · see citing works

Increased Microglial Exosomal miR-124-3p Alleviates Neurodegeneration and Improves Cognitive Outcome after rmTBI

Ge, X., Guo, M., Hu, T., Li, W., Huang, S., Yin, Z., Li, Y., Chen, F., Zhu, L., Kang, C., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2019.11.017 · Cited by 242 · see citing works

Exosome‐mediated inflammasome signaling after central nervous system injury

de Rivero Vaccari, J. P., Brand, F., Adamczak, S., Lee, S. W., Perez‐Barcena, J., Wang, M. Y., Bullock, M. R., Dietrich, W. D., & Keane, R. W. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13036 · Cited by 240 · see citing works

Human Neural Stem Cell Extracellular Vesicles Improve Recovery in a Porcine Model of Ischemic Stroke

Webb, R. L., Kaiser, E. E., Jurgielewicz, B. J., Spellicy, S. E., Scoville, S. L., Thompson, T. A., Swetenburg, R. L., Hess, D. C., West, F. D., & Stice, S. L. (2018) · Stroke · doi:10.1161/strokeaha.117.020353 · Cited by 219 · see citing works

Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

Holm, M. M., Kaiser, J., & Schwab, M. E. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.03.006 · Cited by 207 · see citing works

In vivo evidence for the contribution of peripheral circulating inflammatory exosomes to neuroinflammation

Li, J. J., Wang, B., Kodali, M. C., Chen, C., Kim, E., Patters, B. J., Lan, L.-B., Kumar, S., Wang, X., Yue, J., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1038-8 · Cited by 202 · see citing works

Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles

O’Loughlin, A. J., Mäger, I., de Jong, O. G., Varela, M. A., Schiffelers, R. M., Andaloussi, S. E., Wood, M. J. A., & Vader, P. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.021 · Cited by 200 · see citing works

MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway

Yang, Y., Ye, Y., Kong, C., Su, X., Zhang, X., Bai, W., & He, X. (2019) · Neurochemical Research · doi:10.1007/s11064-018-02714-z · Cited by 199 · see citing works

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Lombardi, M., Parolisi, R., Scaroni, F., Bonfanti, E., Gualerzi, A., Gabrielli, M., de Rosbo, N. K., Uccelli, A., Giussani, P., Viani, P., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02049-1 · Cited by 188 · see citing works

ATP Modifies the Proteome of Extracellular Vesicles Released by Microglia and Influences Their Action on Astrocytes

Drago, F., Lombardi, M., Prada, I., Gabrielli, M., Joshi, P., Cojoc, D., Franck, J., Fournier, I., Vizioli, J., & Verderio, C. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00910 · Cited by 185 · see citing works

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

Chaudhuri, A. D., Dastgheyb, R. M., Yoo, S.-W., Trout, A., Talbot Jr, C. C., Hao, H., Witwer, K. W., & Haughey, N. J. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0369-4 · Cited by 184 · see citing works

Improvement of neuronal cell survival by astrocyte‐derived exosomes under hypoxic and ischemic conditions depends on prion protein

Guitart, K., Loers, G., Buck, F., Bork, U., Schachner, M., & KLEENE, R. B. (2016) · Glia · doi:10.1002/glia.22963 · Cited by 184 · see citing works

Enhanced Loading of Functional miRNA Cargo via pH Gradient Modification of Extracellular Vesicles

Jeyaram, A., Lamichhane, T. N., Wang, S., Zou, L., Dahal, E., Kronstadt, S. M., Levy, D. H., Parajuli, B., Knudsen-Palmer, D. R., Chao, W., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.12.007 · Cited by 184 · see citing works

Exosomes Derived From miR-133b-Modified Mesenchymal Stem Cells Promote Recovery After Spinal Cord Injury

Li, D., Zhang, P., Yao, X., Li, H., Shen, H., Li, X., Wu, J., & Lu, X. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00845 · Cited by 182 · see citing works

New windows into the brain: Central nervous system-derived extracellular vesicles in blood

Shi, M., Sheng, L., Stewart, T., Zabetian, C. P., & Zhang, J. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.005 · Cited by 181 · see citing works

Activated human astrocyte‐derived extracellular vesicles modulate neuronal uptake, differentiation and firing

You, Y., Borgmann, K., Edara, V. V., Stacy, S., Ghorpade, A., & Ikezu, T. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1706801 · Cited by 176 · see citing works

Brain-derived microparticles induce systemic coagulation in a murine model of traumatic brain injury

Tian, Y., Salsbery, B., Wang, M., Yuan, H., Yang, J., Zhao, Z., Wu, X., Zhang, Y., Konkle, B. A., Thiagarajan, P., et al. (2015) · Blood · doi:10.1182/blood-2014-09-598805 · Cited by 171 · see citing works

Cognitive function after spinal cord injury

Sachdeva, R., Gao, F., Chan, C. C. H., & Krassioukov, A. V. (2018) · Neurology · doi:10.1212/wnl.0000000000006244 · Cited by 170 · see citing works

Extracellular Vesicle-Mediated Cell–Cell Communication in the Nervous System: Focus on Neurological Diseases

Bavisotto, C. C., Scalia, F., Marino, A., Carlisi, D., Bucchieri, F., de Macario, E. C., Macario, A. J. L., Cappello, F., & Campanella, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020434 · Cited by 166 · see citing works

Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis

Zhong, D., Cao, Y. B., Li, C., Li, M., Rong, Z., Jiang, L., Guo, Z., Lü, H., & Hu, J. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370219895491 · Cited by 158 · see citing works

Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases

D’Anca, M., Fenoglio, C., Serpente, M., Arosio, B., Cesari, M., Scarpini, E. A., & Galimberti, D. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00232 · Cited by 156 · see citing works

Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system

Patel, D. B., Luthers, C. R., Lerman, M. J., Fisher, J. P., & Jay, S. M. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.024 · Cited by 152 · see citing works

Immunomodulatory Functions of Mesenchymal Stem Cells in Tissue Engineering

Li, H., Shen, S. H., Fu, H., Wang, Z., Li, X., Sui, X., Yuan, M., Liu, S., Wang, G., & Guo, Q. (2019) · Stem Cells International · doi:10.1155/2019/9671206 · Cited by 151 · see citing works

Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers

Ramirez, S. H., Andrews, A. M., Paul, D., & Pachter, J. S. (2018) · Fluids and Barriers of the CNS · doi:10.1186/s12987-018-0104-7 · Cited by 139 · see citing works

Exosomes Derived From Schwann Cells Ameliorate Peripheral Neuropathy in Type 2 Diabetic Mice

Wang, L., Chopp, M., Szalad, A., Lu, X., Zhang, Y., Wang, X., Cepparulo, P., Lü, M., Li, C., & Zhang, Z. G. (2020) · Diabetes · doi:10.2337/db19-0432 · Cited by 137 · see citing works

Extracellular vesicles are independent metabolic units with asparaginase activity

Iraci, N., Gaude, E., Leonardi, T., Costa, A. S. H., Cossetti, C., Peruzzotti-Jametti, L., Bernstock, J. D., Saini, H. K., Gelati, M., Vescovi, A. L., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2422 · Cited by 134 · see citing works

Stimulus‐dependent modifications in astrocyte‐derived extracellular vesicle cargo regulate neuronal excitability

Chaudhuri, A. D., Dastgheyb, R. M., Devine, L. R., Bi, H., Cole, R. N., & Haughey, N. J. (2019) · Glia · doi:10.1002/glia.23708 · Cited by 130 · see citing works

Neonatal Subventricular Zone Neural Stem Cells Release Extracellular Vesicles that Act as a Microglial Morphogen

Morton, M. C., Neckles, V. N., Seluzicki, C. M., Holmberg, J. C., & Feliciano, D. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.03.037 · Cited by 128 · see citing works

Autophagy in Neurotrauma: Good, Bad, or Dysregulated

Wu, J., & Lipinski, M. M. (2019) · Cells · doi:10.3390/cells8070693 · Cited by 125 · see citing works

Traumatic Brain Injury-Induced Acute Lung Injury: Evidence for Activation and Inhibition of a Neural-Respiratory-Inflammasome Axis

Kerr, N. A., Vaccari, J. P. D. R., Abbassi, S., Kaur, H., Zambrano, R. A. P., WU, S. M., Dietrich, W. D., & Keane, R. W. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2017.5430 · Cited by 116 · see citing works

Emerging Roles of miRNAs in Brain Development and Perinatal Brain Injury

Cho, K. H. T., Xu, B., Blenkiron, C., & Fraser, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00227 · Cited by 114 · see citing works

Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment

Patel, D. B., Santoro, M., Born, L. J., Fisher, J. P., & Jay, S. M. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.09.001 · Cited by 113 · see citing works

Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases

Ciregia, F., Urbani, A., & Palmisano, G. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00276 · Cited by 110 · see citing works

Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction

Yu, Z., Shi, M. Y., Stewart, T., Fernagut, P., Huang, Y. X. R., Tian, C., Dehay, B., Atik, A., Yang, D., Giorgi, F. D., et al. (2020) · Brain · doi:10.1093/brain/awaa110 · Cited by 108 · see citing works

Isolated spinal cord contusion in rats induces chronic brain neuroinflammation, neurodegeneration, and cognitive impairment

Wu, J., Stoica, B. A., Luo, T., Sabirzhanov, B. E., Zhao, Z., Guanciale, K., Nayar, S. K., Foss, C. A., Pomper, M. G., & Faden, A. I. (2014) · Cell Cycle · doi:10.4161/cc.29420 · Cited by 106 · see citing works

Low active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery

Sutaria, D. S., Jiang, J., Elgamal, O. A., Pomeroy, S. M., Badawi, M. A., Zhu, X., Pavlovicz, R. E., Azevedo‐Pouly, A. C. P., Chalmers, J. J., Li, C., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1333882 · Cited by 104 · see citing works

Spinal cord injury alters microRNA and CD81+ exosome levels in plasma extracellular nanoparticles with neuroinflammatory potential

Khan, N., Cao, T., He, J., Ritzel, R. M., Li, Y., Henry, R. J., Colson, C., Stoica, B. A., Faden, A. I., & Wu, J. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.007 · Cited by 104 · see citing works

Exosome-shuttled miR-92b-3p from ischemic preconditioned astrocytes protects neurons against oxygen and glucose deprivation

Xu, L., Cao, H., Xie, Y., Zhang, Y., Du, M., Xu, X., Ye, R., & Liu, X. (2019) · Brain Research · doi:10.1016/j.brainres.2019.04.009 · Cited by 102 · see citing works

Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain

Baulch, J. E., Acharya, M. M., Allen, B. D., Ru, N., Chmielewski, N. N., Martirosian, V., Giedzinski, E., Syage, A. R., Park, A. L., Benke, S. N., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1521668113 · Cited by 100 · see citing works

Neuronal RARβ Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration

Goncalves, M. B. C. V., Malmqvist, T., Clarke, E. E., Hubens, C. J., Grist, J., Hobbs, C., Trigo, D., Risling, M., Angéria, M., Damberg, P., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1339-15.2015 · Cited by 98 · see citing works

Focus on Extracellular Vesicles: Therapeutic Potential of Stem Cell-Derived Extracellular Vesicles

Zhang, B., Yeo, R. W. Y., Tan, K. H., & Lim, S. K. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020174 · Cited by 96 · see citing works

High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesicles

Longatti, A., Schindler, C., Collinson, A., Jenkinson, L., Matthews, C., FitzPatrick, L., Blundy, M., Minter, R., Vaughan, T. J., Shaw, M., et al. (2018) · Nanoscale · doi:10.1039/c8nr03970d · Cited by 96 · see citing works

Stem cell paracrine effect and delivery strategies for spinal cord injury regeneration

Veneruso, V., Rossi, F., Villella, A., Bena, A., Forloni, G., & Veglianese, P. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.02.038 · Cited by 91 · see citing works

Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders

Galieva, L. R., James, V. H., Mukhamedshina, Y. O., & Rizvanov, A. A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00163 · Cited by 88 · see citing works

von Willebrand factor enhances microvesicle-induced vascular leakage and coagulopathy in mice with traumatic brain injury

Wu, Y., Liu, W., Zhou, Y., Hilton, T., Zhao, Z., Liu, W., Wang, M., Yeon, J., Houck, K., Thiagarajan, P., et al. (2018) · Blood · doi:10.1182/blood-2018-03-841932 · Cited by 87 · see citing works

Exosomes from MiR-21-5p-Increased Neurons Play a Role in Neuroprotection by Suppressing Rab11a-Mediated Neuronal Autophagy In Vitro After Traumatic Brain Injury

Li, D., Huang, S., Zhu, J.-L., Hu, T., Han, Z., Zhang, S.-S., Zhao, J., Chen, F.-L., & Lei, P. (2019) · Medical Science Monitor · doi:10.12659/msm.915727 · Cited by 86 · see citing works

Insulin-like growth factor-1 enhances neuroprotective effects of neural stem cell exosomes after spinal cord injury via an miR-219a-2-3p/YY1 mechanism

Ma, K., Xu, H., Zhang, J., Zhao, F., Liang, H., Sun, H., Li, P., Zhang, S., Wang, R., & Chen, X. (2019) · Aging · doi:10.18632/aging.102568 · Cited by 86 · see citing works

Multi-Dimensional Mapping of Brain-Derived Extracellular Vesicle MicroRNA Biomarker for Traumatic Brain Injury Diagnostics

Ko, J., Hemphill, M. A., Yang, Z., Beard, K., Sewell, E., Shallcross, J. A., Schweizer, M., Sandsmark, D. K., Diaz-Arrastia, R. R., Kim, J., et al. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6220 · Cited by 82 · see citing works

MiR-219a-5p Enriched Extracellular Vesicles Induce OPC Differentiation and EAE Improvement More Efficiently Than Liposomes and Polymeric Nanoparticles

Osorio-Querejeta, I., Carregal‐Romero, S., Ayerdi-Izquierdo, A., Mäger, I., Nash, L. A., Wood, M. J. A., Egimendia, A., Betanzos, M., Alberro, A., Iparraguirre, L., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020186 · Cited by 82 · see citing works

Facts and Figures at a Glance

(2007) · Journal of Spinal Cord Medicine · doi:10.1080/10790268.2007.11753944 · Cited by 79 · see citing works

Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age

Willis, C. M., Nicaise, A. M., Bongarzone, E. R., Givogri, M., Reiter, C. R., Heintz, O., Jellison, E. R., Sutter, P. A., TeHennepe, G., Ananda, G., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-57663-x · Cited by 76 · see citing works

Exacerbation of Acute Traumatic Brain Injury by Circulating Extracellular Vesicles

Hazelton, I., Yates, A. G., Dale, A., Roodselaar, J., Akbar, N., Ruitenberg, M. J., Anthony, D. C., & Couch, Y. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2017.5049 · Cited by 75 · see citing works

Neural stem cell small extracellular vesicle-based delivery of 14-3-3t reduces apoptosis and neuroinflammation following traumatic spinal cord injury by enhancing autophagy by targeting Beclin-1

Rong, Y., Liu, W., Lv, C., Wang, J., Luo, Y., Jiang, D., Li, L., Zhou, Z. Y., Zhou, W., Li, Q., et al. (2019) · Aging · doi:10.18632/aging.102283 · Cited by 75 · see citing works

Traumatic brain injury increases plasma astrocyte‐derived exosome levels of neurotoxic complement proteins

Goetzl, E. J., Yaffe, K. S., Peltz, C. B., Ledreux, A., Gorgens, K. A., Davidson, B. S., Granholm, A., Mustapić, M., Kapogiannis, D., Tweedie, D., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902842r · Cited by 74 · see citing works

Assessment of Depression in a Rodent Model of Spinal Cord Injury

Luedtke, K., Bouchard, S. M., Woller, S. A., Funk, M. K., Aceves, M., & Hook, M. A. (2014) · Journal of Neurotrauma · doi:10.1089/neu.2013.3204 · Cited by 72 · see citing works

Depression and Quality of Life in Patients within the First 6 Months after the Spinal Cord Injury

Shin, J. C., Goo, H. R., Yu, S., Kim, D., & Yoon, S. Y. (2012) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2012.36.1.119 · Cited by 72 · see citing works

Extracellular Vesicles Mediate Neuroprotection and Functional Recovery after Traumatic Brain Injury

Sun, M. K., Passaro, A. P., Latchoumane, C.-F. V., Spellicy, S. E., Bowler, M., Goeden, M., Martin, W. J., Holmes, P. V., Stice, S. L., & Karumbaiah, L. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2019.6443 · Cited by 72 · see citing works

Extracellular Vesicles: New Endogenous Shuttles for miRNAs in Cancer Diagnosis and Therapy?

Martellucci, S., Orefice, N. S., Angelucci, A., Luce, A., Caraglia, M., & Zappavigna, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186486 · Cited by 72 · see citing works

None of us is the same as all of us: resolving the heterogeneity of extracellular vesicles using single-vesicle, nanoscale characterization with resonance enhanced atomic force microscope infrared spectroscopy (AFM-IR)

Kim, S. Y., Khanal, D., Tharkar, P., Kalionis, B., & Chrzanowski, W. (2018) · Nanoscale Horizons · doi:10.1039/c8nh00048d · Cited by 68 · see citing works

Human Lung Cell Pyroptosis Following Traumatic Brain Injury

Kerr, N. A., Vaccari, J. P. D. R., Umland, O., Bullock, M. R., Conner, G. E., Dietrich, W. D., & Keane, R. W. (2019) · Cells · doi:10.3390/cells8010069 · Cited by 61 · see citing works

Systemic Immune Response to Traumatic CNS Injuries—Are Extracellular Vesicles the Missing Link?

Yates, A. G., Anthony, D. C., Ruitenberg, M. J., & Couch, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02723 · Cited by 60 · see citing works

Subventricular zone-derived extracellular vesicles promote functional recovery in rat model of spinal cord injury by inhibition of NLRP3 inflammasome complex formation

Mohammed, I., Ijaz, S., Mokhtari, T., Gholaminejhad, M., Mahdavipour, M., Jameie, B., Akbari, M., & Hassanzadeh, G. (2020) · Metabolic Brain Disease · doi:10.1007/s11011-020-00563-w · Cited by 58 · see citing works

Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation

Couch, Y., Akbar, N., Roodselaar, J., Evans, M. C., Gardiner, C., Sargent, I. L., Romero, I. A., Bristow, A., Buchan, A. M., Haughey, N. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09710-3 · Cited by 54 · see citing works

Functional equivalence of stem cell and stem cell-derived extracellular vesicle transplantation to repair the irradiated brain

Smith, S. M., Giedzinski, E., Angulo, M. C., Lui, T., Lu, C., Park, A. L., Tang, S. S., Martirosian, V., Ru, N., Chmielewski, N. N., et al. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0227 · Cited by 52 · see citing works

Engineering three-dimensional microenvironments towards in vitro disease models of the central nervous system

Yildirimer, L., Zhang, Q., Kuang, S., Cheung, J. C., Chu, K. A., He, Y., Yang, M., & Zhao, X. (2019) · Biofabrication · doi:10.1088/1758-5090/ab17aa · Cited by 52 · see citing works

Ethanol Exposure Increases miR‐140 in Extracellular Vesicles: Implications for Fetal Neural Stem Cell Proliferation and Maturation

Tseng, A. M., Chung, D. D., Pinson, M. R., Salem, N. A., Eaves, S. E., & Miranda, R. C. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14066 · Cited by 52 · see citing works

Using Mesenchymal Stromal Cells in Islet Transplantation

Arzouni, A. A., Vargas, A. E., Nardi, N. B., King, A., & Jones, P. M. (2018) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0033 · Cited by 50 · see citing works

Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells

Goncalves, M. B. C. V., Wu, Y., Clarke, E. E., Grist, J., Hobbs, C., Trigo, D., Jack, J., & Corcoran, J. P. T. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2922-18.2019 · Cited by 48 · see citing works

Glutaminase-containing microvesicles from HIV-1-infected macrophages and immune-activated microglia induce neurotoxicity

Wu, B., Huang, Y., Braun, A. L., Tong, Z., Zhao, R., Li, Y., Liu, F., & Zheng, J. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0058-z · Cited by 45 · see citing works

Identification of serum exosomal microRNAs in acute spinal cord injured rats

Ding, S., Chen, J., Wang, S., Duan, F., Chen, Y., Shi, Y., Hu, J., & Lü, H. (2019) · Experimental Biology and Medicine · doi:10.1177/1535370219872759 · Cited by 44 · see citing works

Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy

Goetzl, E. J., Ledreux, A., Granholm, A., Elahi, F. M., Goetzl, L. M., Hiramoto, J. S., & Kapogiannis, D. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00452 · Cited by 42 · see citing works

Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury

Yasui, H., Donahue, D. L., Walsh, M. M., Castellino, F., & Ploplis, V. A. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00429.2015 · Cited by 41 · see citing works

Human Neural Stem Cell Transplantation Provides Long-Term Restoration of Neuronal Plasticity in the Irradiated Hippocampus

Acharya, M. M., Rosi, S., Jopson, T. D., & Limoli, C. L. (2015) · Cell Transplantation · doi:10.3727/096368914x684600 · Cited by 40 · see citing works

CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system

Pomper, N., Liu, Y., Hoye, M. L., Dougherty, J. D., & Miller, T. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-61307-5 · Cited by 39 · see citing works

Retinoic acid synthesis by NG2 expressing cells promotes a permissive environment for axonal outgrowth

Goncalves, M. B. C. V., Wu, Y., Trigo, D., Clarke, E. E., Malmqvist, T., Grist, J., Hobbs, C., Carlstedt, T. P., & Corcoran, J. P. T. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.12.016 · Cited by 38 · see citing works

Stem Cell Extracellular Vesicles and their Potential to Contribute to the Repair of Damaged CNS Cells

Branscome, H., Paul, S., Khatkar, P., Kim, Y., Barclay, R. A., Pinto, D. O., Yin, D., Zhou, W., Liotta, L. A., El‐Hage, N., et al. (2019) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-019-09865-y · Cited by 37 · see citing works

Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair

Branscome, H., Paul, S., Yin, D., El‐Hage, N., Agbottah, E. T., Zadeh, M. A., Liotta, L. A., & Kashanchi, F. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00455 · Cited by 37 · see citing works

A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration

Sekine, Y., Lindborg, J. A., & Strittmatter, S. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009896 · Cited by 36 · see citing works

Neuronal activity triggers uptake of hematopoietic extracellular vesicles in vivo

Kur, I., Prouvot, P.-H., Fu, T., Fan, W., Müller-Braun, F., Das, A., Das, S., Deller, T., Roeper, J., Stroh, A., et al. (2019) · bioRxiv · doi:10.1371/journal.pbio.3000643 · Cited by 31 · see citing works

Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions

Chew, S. Y., Nguyen, L. H., Ong, W., Wang, K., Wang, M., & Nižetić, D. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266922 · Cited by 27 · see citing works

Serum exosomal microRNA transcriptome profiling in subacute spinal cord injured rats

Ding, S., Chen, Y., Chen, J., Wang, S., Duan, F., Shi, Y., Hu, J., & Lü, H. (2019) · Genomics · doi:10.1016/j.ygeno.2019.12.003 · Cited by 23 · see citing works

Immune response following traumatic spinal cord injury: Pathophysiology and therapies

Sterner, R. C., & Sterner, R. M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1084101 · Cited by 246 · see citing works

Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

Liu, C., Hu, F., Jiao, G., Guo, Y., Zhou, P., Zhang, Y., Zhang, Z., Yi, J., You, Y., Li, Z., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01273-4 · Cited by 225 · see citing works

LncRNA-encoded peptides in cancer

Zhang, Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01591-0 · Cited by 129 · see citing works

Engineered extracellular vesicles for delivery of siRNA promoting targeted repair of traumatic spinal cord injury

Rong, Y., Wang, Z., Tang, P., Wang, J., Ji, C., Chang, J., Zhu, Y., Wu, Y., Bai, J., Liu, W., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.11.011 · Cited by 114 · see citing works

Targeted Delivery of RGD-CD146+CD271+ Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Promotes Blood–Spinal Cord Barrier Repair after Spinal Cord Injury

Xie, Y., Sun, Y. X., Liu, Y., Zhao, J., Liu, Q., Xu, J., Qin, Y., He, R., Yuan, F., Wu, T., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c04423 · Cited by 112 · see citing works

Spinal cord injury-induced cognitive impairment: a narrative review

Ibarra, A., Alcantar-Garibay, O., & Abraham, D. I. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.339475 · Cited by 84 · see citing works

Extracellular Vesicles of Mesenchymal Stem Cells: Therapeutic Properties Discovered with Extraordinary Success

Racchetti, G., & Meldolesi, J. (2021) · Biomedicines · doi:10.3390/biomedicines9060667 · Cited by 68 · see citing works

Microglia-Derived Exosomal microRNA-151-3p Enhances Functional Healing After Spinal Cord Injury by Attenuating Neuronal Apoptosis via Regulating the p53/p21/CDK1 Signaling Pathway

Li, C., Qin, T., Liu, Y., Wen, H., Zhao, J., Luo, Z., Peng, W., Lü, H., Duan, C., Cao, Y. B., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.783017 · Cited by 62 · see citing works

Recent advances in nanomaterials for the treatment of spinal cord injury

Gong, W., Zhang, T., Che, M., Wang, Y., He, C., Liu, L., Lv, Z., Xiao, C., Wang, H., & Zhang, S. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100524 · Cited by 59 · see citing works

Transplantation of Neural Stem Cells Loaded in an IGF‐1 Bioactive Supramolecular Nanofiber Hydrogel for the Effective Treatment of Spinal Cord Injury

Song, P., Han, T., Wu, Z., Fang, H., Liu, Y., Wang, Y., Wang, X., & Shen, C. (2024) · Advanced Science · doi:10.1002/advs.202306577 · Cited by 58 · see citing works

Extracellular vesicles: biological mechanisms and emerging therapeutic opportunities in neurodegenerative diseases

Wang, L., Zhang, X., Yang, Z., Wang, B., Gong, H., Zhang, K., Lin, Y., & Sun, M. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00453-6 · Cited by 55 · see citing works

Local delivery of EGFR+NSCs-derived exosomes promotes neural regeneration post spinal cord injury via miR-34a-5p/HDAC6 pathway

Qin, T., Li, C., Xu, Y., Qin, Y., Jin, Y., He, R., Luo, Z., Zhao, J., Duan, C., Lü, H., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.11.013 · Cited by 49 · see citing works

Rat Bone Mesenchymal Stem Cell‐Derived Exosomes Loaded with miR‐494 Promoting Neurofilament Regeneration and Behavioral Function Recovery after Spinal Cord Injury

Huang, W., Lin, M., Yang, C., Wang, F.-M., Zhang, M., Gao, J., & Yu, X. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/1634917 · Cited by 49 · see citing works

A swift expanding trend of extracellular vesicles in spinal cord injury research: a bibliometric analysis

Zhiguo, F., Ji, W., Chen, S., Guoyou, Z., Chen, K., Hui, Q., Xu, W., & Zhai, X. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02051-6 · Cited by 45 · see citing works

A tannic acid doped hydrogel with small extracellular vesicles derived from mesenchymal stem cells promotes spinal cord repair by regulating reactive oxygen species microenvironment

Liu, Z., Guo, S., Dong, L., Wu, P., Li, K., Li, X., Li, X., Qian, H., & Fu, Q. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100425 · Cited by 44 · see citing works

Schwann Cell-Derived Exosomal Vesicles: A Promising Therapy for the Injured Spinal Cord

Ghosh, M., & Pearse, D. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417317 · Cited by 43 · see citing works

Cellular nanovesicles for therapeutic immunomodulation: A perspective on engineering strategies and new advances

Zhang, E., Phan, P., & Zhao, Z. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.08.020 · Cited by 42 · see citing works

Extracellular vesicle therapy in neurological disorders

Putthanbut, N., Lee, J.-Y., & Borlongan, C. V. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01075-w · Cited by 44 · see citing works

Intranasal Delivery of Brain‐Derived Neurotrophic Factor (BDNF)‐Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys

Huang, Z., Li, J., Wo, J., Li, C., Wu, Z., Deng, X., Liang, Y., Li, F., Chen, B., Jia, B., et al. (2025) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70066 · Cited by 44 · see citing works

3D printing of functional bioengineered constructs for neural regeneration: a review

Zhu, H., Yao, C., Wei, B.-Y., Xu, C., Huang, X., Liu, Y., He, J., Zhang, J., & Li, D. (2023) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/ace56c · Cited by 38 · see citing works

Unraveling the Emerging Niche Role of Extracellular Vesicles (EVs) in Traumatic Brain Injury (TBI)

Ashique, S., Pal, R., Sharma, H., Mishra, N., & Garg, A. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273288155240201065041 · Cited by 36 · see citing works

Biodegradable bilayer hydrogel membranes loaded with bazedoxifene attenuate blood–spinal cord barrier disruption via the NF-κB pathway after acute spinal cord injury

Wang, X., Baokun, Z., Chen, Z., Qiang, S., Yang, E., Jianguang, X., & Xiaofeng, L. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.01.056 · Cited by 34 · see citing works

Exosomes combined with biomaterials in the treatment of spinal cord injury

Zhang, X., Jiang, W., Lu, Y., Mao, T., Gu, Y., Ju, D., & Dong, C. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1077825 · Cited by 32 · see citing works

Role of Stem Cell-Derived Exosomes and microRNAs in Spinal Cord Injury

Hwang, J., Jang, S., Kim, C., Lee, S., & Jeong, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241813849 · Cited by 32 · see citing works

Exosomes secreted from sonic hedgehog-modified bone mesenchymal stem cells facilitate the repair of rat spinal cord injuries

Jia, Y., Lu, T., Chen, Q., Pu, X., Ji, L., Yang, J., & Luo, C. (2021) · Acta Neurochirurgica · doi:10.1007/s00701-021-04829-9 · Cited by 32 · see citing works

The Potential Role of Inflammation in Modulating Endogenous Hippocampal Neurogenesis After Spinal Cord Injury

Sefiani, A., & Geoffroy, C. G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.682259 · Cited by 26 · see citing works

Ginsenoside Rg1 Regulates Immune Microenvironment and Neurological Recovery After Spinal Cord Injury Through MYCBP2 Delivery via Neuronal Cell‐Derived Extracellular Vesicles

Rong, Y., Wang, J., Hu, T., Shi, Z., Lang, C., Liu, W., Cai, W., Sun, Y., Zhang, F., & Zhang, W. (2024) · Advanced Science · doi:10.1002/advs.202402114 · Cited by 30 · see citing works

Potential of different cells-derived exosomal microRNA cargos for treating spinal cord injury

Pan, D., Liu, W., Zhu, S., Fan, B., Yu, N., Ning, G., & Feng, S. (2021) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2021.09.008 · Cited by 30 · see citing works

An injectable decellularized extracellular matrix hydrogel with cortical neuron-derived exosomes enhances tissue repair following traumatic spinal cord injury

Wang, G., Li, Q., Liu, S., Mo, L., Liu, B., Zhao, T., Liu, B., & Chen, Z. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101250 · Cited by 28 · see citing works

Advances in molecular therapies for targeting pathophysiology in spinal cord injury

Kim, H. N., McCrea, M. R., & Li, S. (2023) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2023.2194532 · Cited by 30 · see citing works

Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions

Choi, H. K., Chen, M., Goldston, L. L., & Lee, K.-B. (2024) · Nano Convergence · doi:10.1186/s40580-024-00426-5 · Cited by 26 · see citing works

Exosomes as promising bioactive materials in the treatment of spinal cord injury

Li, Y., Luo, W., Meng, C., Shi, K., Gu, R., & Cui, S. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03952-5 · Cited by 26 · see citing works

Hydrogel-encapsulated extracellular vesicles for the regeneration of spinal cord injury

Nazerian, Y., Nazerian, A., Mohamadi-Jahani, F., Sodeifi, P., Jafarian, M., & Javadi, S. A. H. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1309172 · Cited by 25 · see citing works

Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain

Li, Y., Khan, N., Ritzel, R. M., Lei, Z., Allen, S., Faden, A. I., & Wu, J. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02881-z · Cited by 24 · see citing works

Neuron-Derived Exosomes Promote the Recovery of Spinal Cord Injury by Modulating Nerve Cells in the Cellular Microenvironment of the Lesion Area

Xu, Y., Zhu, Z.-H., Xu, X., Sun, H., Zheng, H.-M., Zhang, J., Wang, H., Fang, J.-W., Liu, Y., Huang, L., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03341-8 · Cited by 22 · see citing works

Interorgan communication in neurogenic heterotopic ossification: the role of brain-derived extracellular vesicles

Lu, W., Yan, J., Wang, C., Qin, W., Han, X., Qin, Z., Wei, Y., Xu, H., Gao, J., Gao, C., et al. (2024) · Bone Research · doi:10.1038/s41413-023-00310-8 · Cited by 23 · see citing works

Decellularized tissue matrices hydrogels functionalized with extracellular vesicles promote macrophage reprogramming and neural stem cell differentiation for spinal cord injury repair

Deng, M., Xie, P., Xue, H., Chen, Q., Zhou, Y., Ming, J., Ma, Y., Liu, J., & Huang, H. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03152-0 · Cited by 24 · see citing works

The Role of Exosomes and Exosomal Noncoding RNAs From Different Cell Sources in Spinal Cord Injury

Yang, Z., Rao, J., Lin, F., Liang, Z., Xu, X., Lin, Y., Chen, X., Wang, C., & Chen, C. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.882306 · Cited by 23 · see citing works

Small extracellular vesicles derived from mesenchymal stem cell facilitate functional recovery in spinal cord injury by activating neural stem cells via the ERK1/2 pathway

Hu, X., Liu, Z., Zhou, X., Jin, Q., Xu, W., Zhai, X., Fu, Q., & Qian, H. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.954597 · Cited by 23 · see citing works

Inflammatory stimulation of astrocytes affects the expression of miRNA-22-3p within NSCs-EVs regulating remyelination by targeting KDM3A

Han, T., Song, P., Wu, Z., Wang, C., Liu, Y., Wang, Y., Li, K., & Shen, C. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03284-w · Cited by 23 · see citing works

Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord Injury

Han, T., Song, P., Wu, Z., Liu, Y., Ying, W., & Shen, C. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10560-y · Cited by 23 · see citing works

Neurovascular Unit-Derived Extracellular Vesicles: From Their Physiopathological Roles to Their Clinical Applications in Acute Brain Injuries

Reymond, S., Vujić, T., & Sanchez, J. (2022) · Biomedicines · doi:10.3390/biomedicines10092147 · Cited by 18 · see citing works

Smart micro/nanorobots for drug delivery in the brain

Shi, D., Wang, X., Deng, Y., Zhou, H., Wang, Y., Chu, P. K.-H., & Li, J. (2025) · Progress in Materials Science · doi:10.1016/j.pmatsci.2025.101533 · Cited by 17 · see citing works

Yin-Yang: two sides of extracellular vesicles in inflammatory diseases

Zeng, B., Li, Y., Khan, N., Su, A., Yang, Y., Mi, P., Jiang, B., Liang, Y., & Duan, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02779-9 · Cited by 17 · see citing works

Extracellular vesicles from human umbilical cord mesenchymal stem cells reduce lipopolysaccharide-induced spinal cord injury neuronal apoptosis by mediating miR-29b-3p/PTEN

Xiao, X., Li, W., Xu, Z., Sun, Z., Ye, H., Wu, Y., Zhang, Y., Xie, L., Jiang, D., Jia, R., et al. (2022) · Connective Tissue Research · doi:10.1080/03008207.2022.2060826 · Cited by 17 · see citing works

Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury

Wang, H.-D., Wei, Z.-J., Li, J.-J., & Feng, S.-Q. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.324823 · Cited by 16 · see citing works

Spinal cord injury disrupts plasma extracellular vesicles cargoes leading to neuroinflammation in the brain and neurological dysfunction in aged male mice

Lei, Z., Krishnamachary, B., Khan, N., Ji, Y., Li, Y., Li, H., Brunner, K., Faden, A. I., Jones, J. W., & Wu, J. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.005 · Cited by 15 · see citing works

Regenerative Potential of Injured Spinal Cord in the Light of Epigenetic Regulation and Modulation

Gupta, S., Dutta, S., & Hui, S. P. (2023) · Cells · doi:10.3390/cells12131694 · Cited by 15 · see citing works

Pre-treated mesenchymal stem cell-derived exosomes: A new perspective for accelerating spinal cord injury repair

Liao, Z., Zeng, J., Lin, A., Zou, Y., & Zhou, Z. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177349 · Cited by 17 · see citing works

Characterization of Marine Organism Extracellular Matrix-Anchored Extracellular Vesicles and Their Biological Effect on the Alleviation of Pro-Inflammatory Cytokines

Jo, S., Kim, S.-H., Kim, C. S., & Park, S. (2021) · Marine Drugs · doi:10.3390/md19110592 · Cited by 15 · see citing works

Nanomaterials as therapeutic agents to modulate astrocyte-mediated inflammation in spinal cord injury

Luo, W., Li, Y., Xiang, C., Aizawa, T., Niu, R., Wang, Y., Zhao, J., Liu, Z., Li, C., Liu, W., et al. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100888 · Cited by 15 · see citing works

Brain region changes following a spinal cord injury

Wu, Z., Feng, K., Huang, J., Ye, X., Yang, R., Huang, Q., & Jiang, Q. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105696 · Cited by 14 · see citing works

Mesenchymal stem cell-derived exosomes as a new drug carrier for the treatment of spinal cord injury: A review

Cheng, L., You, C.-Q., Cheng, P., Ren, J.-J., Guo, K., & Liu, T. (2024) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2024.03.009 · Cited by 14 · see citing works

Therapeutic potential of extracellular vesicles in neurodegenerative disorders

Roudi, S., Rädler, J., & Andaloussi, S. E. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-323-85555-6.00017-5 · Cited by 14 · see citing works

The role of small extracellular vesicles and microRNA as their cargo in the spinal cord injury pathophysiology and therapy

Sintakova, K., & Romanyuk, N. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1400413 · Cited by 13 · see citing works

Extracellular Vesicles in the Pathogenesis, Treatment, and Diagnosis of Spinal Cord Injury: A Mini-Review

Wang, Y., Xu, H., Wang, J., Yi, H., & Song, Y. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220330005937 · Cited by 14 · see citing works

Extracellular vesicle-mediated spinal cord-brain crosstalk induces hippocampal neurogenesis impairment and cognitive deficits post-spinal cord injury

Qin, T., Qin, Y., Jin, Y., Liang, X., Sun, Y. X., Liu, B., Lü, H., Li, C., Hu, J., & Jiang, L. (2025) · Theranostics · doi:10.7150/thno.110560 · Cited by 13 · see citing works

How Advanced Are Exosomes as Cell-Free Therapeutics for Spinal Cord Injury?

Wu, Y., Wang, Y., Zhou, J., Tang, Z., Huang, L., & Liu, S. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s536652 · Cited by 11 · see citing works

Acid-sensing ion channel-1 contributes to the failure of myelin sheath regeneration following spinal cord injury by transcellular delivery of PGE2

Wu, Z., Han, T., Dong, Y., Wang, Y., Fang, H., Liu, Y., Song, P., & Shen, C. (2024) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00672-9 · Cited by 11 · see citing works

Extracellular Vesicles: Therapeutic Potential in Central Nervous System Trauma by Regulating Cell Death

Chen, Y., Zhang, H., Hu, X., Cai, W., Jiang, L., Wang, Y., Wu, Y., Wang, X., Ni, W., & Zhou, K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03501-w · Cited by 11 · see citing works

Exosome-based regenerative rehabilitation: A novel ice breaker for neurological disorders

Wang, Y., Cheng, J., Liu, Y., Wang, Y.-P., Yang, Q., & Zhou, N. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115920 · Cited by 11 · see citing works

Enzyme-immobilized nanoclay hydrogel simultaneously reduces inflammation and scar deposition to treat spinal cord injury

Wu, T., Li, Y., Wu, Z., Wang, Z., Li, Y., Jian, K., He, C., Zhang, C., Shi, L., & Dai, J. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149642 · Cited by 10 · see citing works

Epidermal Neural Crest Stem Cell Conditioned Medium Enhances Spinal Cord Injury Recovery via PI3K/AKT-Mediated Neuronal Apoptosis Suppression

Ma, Z., Liu, T., Liu, L., Pei, Y., Wang, T., Wang, Z., Guan, Y., Zhang, X., Zhang, Y., & Chen, X. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04207-8 · Cited by 10 · see citing works

Exosomes Derived from Tanshinone IIA-Pretreated Umbilical Cord Mesenchymal Stem Cells Repair Traumatic Spinal Cord Injury by miR-223–5p/USP8/NLRP3 Axis

Shen, G., Liu, M., Wang, J., Qi, Z., Cao, Y., Jin, Z., Chen, S., Wan, B., & Gu, J. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c09766 · Cited by 10 · see citing works

Nanoparticle and Gene Therapy Strategies for Site‐Specific Pain Management: A Review

Nagaraj, K. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500356 · Cited by 10 · see citing works

Efficacy of Interventions to Improve Cognitive Function in Adults with Spinal Cord Injury: A Systematic Review

Li, Y., Hu, Y., Pozzato, I., Arora, M., Schoffl, J., McBain, C., Middleton, J. W., & Craig, A. R. (2024) · Journal of Neurotrauma · doi:10.1089/neu.2024.0032 · Cited by 8 · see citing works

Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury

Liu, Y., Luo, Z., Xie, Y., Sun, Y., Yuan, F.-F., Jiang, L.-Y., Lu, H.-B., & Hu, J.-Z. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01434-4 · Cited by 9 · see citing works

Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury

Hörauf, J.-A., Schindler, C. R., Schaible, I., Wang, M., Weber, B., Saman, A. E., Pallas, C., Widera, M., Marzi, İ., Henrich, D. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1478786 · Cited by 8 · see citing works

Natural and bio-engineered stem cell-derived extracellular vesicles for spinal cord injury repair: A meta-analysis with trial sequential analysis

Su, H., Chen, Y., Tang, B., Xiao, F., Sun, Y., Chen, J., Deng, L., He, A., Li, G., Luo, Y., et al. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.10.018 · Cited by 7 · see citing works

Inhibition of neuronal necroptosis via disruption of RIPK1-RIPK3 Interactions: The role of neural stem cell-derived exosomes in spinal cord injury recovery

Li, S., Chen, G., Tong, K., Che, Y., Xie, Y., Shi, W., Huang, A., Wang, Y., Li, J., Jiao, G., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.06.042 · Cited by 7 · see citing works

Efficacy of extracellular vesicles of different cell origins in traumatic brain injury: A systematic review and network meta-analysis

Yang, Z., Liang, Z., Lin, Y., Lin, F., Rao, J., Xu, X., Wang, C., & Chen, C. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1147194 · Cited by 7 · see citing works

Biomaterial‐Based Gene Delivery to Central Nervous System Cells for the Treatment of Spinal Cord Injury

McGuire, T. K., Stasiewicz, M., Woods, I., Dervan, A. G., & O’Brien, F. J. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300030 · Cited by 7 · see citing works

Extracellular Vesicle-Based Biomarkers in Spinal Cord Injury: A State-of-the-Art Review on Diagnostic and Prognostic Advances

Vo, T. N., Shin, H. E., Kim, Y., & Han, I. B. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27042079 · Cited by 6 · see citing works

Targeted microbiota dysbiosis repair: An important approach to health management after spinal cord injury

Ju, C., Liu, R., Ma, Y., Dong, H., Xu, R., Hu, H., & Hao, D. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102648 · Cited by 6 · see citing works

Exosome-mediated repair of spinal cord injury: cellular sources, mechanisms of action, and combined therapeutic strategies

Cha, Z., Yu, L., Pu, J., Zhang, Y., Lu, Q., Huang, W., Li, T., & Lu, X. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1645457 · Cited by 5 · see citing works

Cerebrospinal fluid extracellular vesicle-derived miR-9-3p in spinal cord injury with neuroprotective implications and biomarker development

Tanaka, T., Morimoto, S., Ito, K., Yasutake, K., Kato, C., Shinozaki, M., Suda, K., Maeda, T., Yato, Y., Nakamura, M., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08947-3 · Cited by 5 · see citing works

Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity

Dutta, D., Pirolli, N. H., Levy, D. H., Tsao, J., Seecharan, N., Wang, Z., Xu, X., Jia, X., & Jay, S. M. (2023) · Biomaterials Science · doi:10.1039/d3bm00340j · Cited by 5 · see citing works

A New Paradigm in Spinal Cord Injury Therapy: from Cell-free Treatment to Engineering Modifications

Qin, B., Hu, X., Huang, Y., Yang, R.-H., & Xiong, K. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230418090857 · Cited by 5 · see citing works

In silico techniques, artificial intelligence, and machine learning for enhanced efficacy of extracellular vesicle–based diagnosis and therapeutics

Jain, Y., Maharsh, J., Kamble, S. S., Guldhe, A., & Bastikar, V. A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23891-8.00013-5 · Cited by 5 · see citing works

Roles for Exosomes from Various Cellular Sources in Spinal Cord Injury

Mao, W., Liu, X., Chen, C., Luo, T., Zheng, Y., Wu, L., & An, Z. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05040-y · Cited by 5 · see citing works

Extracellular Vesicle-Mediated Precision Delivery of Paclitaxel Activates Mitophagy to Promote Repair after Spinal Cord Injury

Zhao, S., Duan, L., Lv, Z., Han, Z., Xu, W., Zhang, K., Liu, W. C., Bai, J., Cai, W., Zhang, W., et al. (2026) · ACS Nano · doi:10.1021/acsnano.5c21273 · Cited by 4 · see citing works

Engineering nanomedicines for neuroprotection and neuroregeneration in spinal cord injury

Jiang, Y., Chen, Z., Zhang, J., Xu, Z., Zhou, X., Yuan, X., Yao, X. X., & Guo, S. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102643 · Cited by 4 · see citing works

Age-related changes in plasma extracellular vesicles influence neuroinflammation in the brain and neurological outcome after traumatic spinal cord injuryPreprint

Lei, Z., Krishnamachary, B., Ritzel, R. M., Khan, N., Li, Y., Li, H., Brunner, K., Faden, A. I., & Wu, J. (2023) · Research Square · doi:10.21203/rs.3.rs-2821858/v1 · Cited by 4 · see citing works

Temporal and Severity-Dependent Alterations in Plasma Extracellular Vesicle Profiles Following Spinal Cord Injury

Cooper, J., Airey, S. T., Patino, E., Andriot, T., Ghosh, M., & Pearse, D. D. (2025) · Cells · doi:10.3390/cells14141065 · Cited by 3 · see citing works

Salidroside-Pretreated Small Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Promote Blood-Spinal Cord Barrier Repair After Spinal Cord Injury in Mice

Wang, J., Zhu, Q., Chan, P., Zhu, Z., Zheng, M., Mao, Z., Gu, M., Ren, Z., Cui, M., Liu, J., et al. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05410-6 · Cited by 3 · see citing works

Biofluid Biomarkers of Acute Traumatic Spinal Cord Injury: A Systematic Review

Schaeffer, E. A., Levy, A. S., Errante, E. L., Costello, M. C., Smartz, T., Levi, A. D., Burks, S. S., & Papa, L. (2025) · Journal of Neurotrauma · doi:10.1177/08977151251401222 · Cited by 4 · see citing works

MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury

Kimura, T., & Horikoshi, Y. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.346480 · Cited by 3 · see citing works

Progress in exosome-related research supported by the National Natural Science Foundation of China

Wang, Y., Yang, Q., Fang, D., Sun, L., Zheng, L., & Dou, D. (2023) · Fundamental Research · doi:10.1016/j.fmre.2023.05.018 · Cited by 3 · see citing works

RPS3‐Enriched Extracellular Vesicles Mediate Liver‐Spinal Cord Inter‐Organ Communication

Song, P., Wu, Z., Dong, Y., Fang, Y., Bian, S., Wang, D., Fang, H., Liu, Y., Ying, W., Qian, J., et al. (2026) · Advanced Science · doi:10.1002/advs.202517019 · Cited by 2 · see citing works

Isoquercitrin-loaded adipose-derived stem cell exosomes synchronize immunomodulation and neurovascular remodeling to accelerate spinal cord regeneration

Xia, W., Liu, S., Gao, T., Xue, F., Guo, Q., Lou, Z., & He, Y. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127072 · Cited by 2 · see citing works

Exploration for sorting serum exosome as a measure of spinal cord injury severity

Li, Y., Guo, C., Huang, Q., Zhou, N., Wang, J., Huang, Y., Shen, X., Yu, X.-M., & Shen, H. (2024) · Journal of Radiation Research and Applied Sciences · doi:10.1016/j.jrras.2024.101048 · Cited by 2 · see citing works

Angiopep-2-engineered extracellular vesicles derived from spinal cord injury-responsive brown adipose tissue for targeted neuroinflammation modulation

Xiang, S., Qin, T., Qin, Y., Sun, Y., Zhou, M., Tang, Y., Liu, P., & Hu, S. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04163-1 · Cited by 1 · see citing works

Severity Prediction of Traumatic Cervical Spinal Cord Injury With an AI Model Based on MRI Radiomics

Wu, C., Li, C., Xu, G., Chen, J., Wang, L., Gu, H., Zhang, J., Hong, H., Ji, C., & Cui, Z. (2026) · JOR Spine · doi:10.1002/jsp2.70167 · Cited by 1 · see citing works

From neural stem cells to cell-free exosome nanotherapy: reprogramming the injured spinal cord microenvironment for regeneration

Zhang, C., Liu, X., Zhao, B., Luo, J., Liu, W., Hao, Y., 胡付恒, Li, S., Jin, L., Huang, W., et al. (2026) · Journal of Materials Chemistry B · doi:10.1039/d6tb01356b · Cited by 1 · see citing works

The role of astrocytes response triggered by hyperglycaemia during spinal cord injury

Sámano, C., & Mazzone, G. L. (2023) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2023.2264538 · Cited by 1 · see citing works

Spinal Cord Injury Affects Gene Expression of Transmembrane Proteins in Tissue and Release of Extracellular Vesicle in Blood: In Silico and In Vivo Analysis.

Mirzaalikhan, Y., Eslami, N., Izadi, A., Shekari, F., & Kiani, S. (2023) · PubMed Central · doi:10.22074/cellj.2023.2004115.1320

An Injectable Decellularized Extracellular Matrix Hydrogel with Cortical Neurons-Derived Exosomes Enhances Tissue Repair Following Traumatic Spinal Cord InjuryPreprint

Wang, G., Li, Q., Liu, S., Mo, L., Liu, B., Zhao, T., Liu, B., & Chen, Z. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4795960

Additional file 2 of Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

Liu, C., Hu, F., Jiao, G., Guo, Y., Zhou, P., Zhang, Y., Zhang, Z., Yi, J., You, Y., Li, Z., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19113039

Additional file 1 of Dental pulp stem cell-derived exosomes suppress M1 macrophage polarization through the ROS-MAPK-NFκB P65 signaling pathway after spinal cord injury

Liu, C., Hu, F., Jiao, G., Guo, Y., Zhou, P., Zhang, Y., Zhang, Z., Yi, J., You, Y., Li, Z., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19113036

Additional file 1 of Sexually dimorphic extracellular vesicle responses after chronic spinal cord injury are associated with neuroinflammation and neurodegeneration in the aged brain

Li, Y., Khan, N., Ritzel, R. M., Lei, Z., Allen, S., Faden, A. I., & Wu, J. (2024) · Figshare · doi:10.6084/m9.figshare.26614090

Extracellular Vesicles in the Pathogenesis, Treatment, and Diagnosis of Spinal Cord Injury: A Mini-Review

Wang, Y., Xu, H., Wang, J., Yi, H., & Song, Y. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220330005937 · Cited by 14 · see citing works

A New Paradigm in Spinal Cord Injury Therapy: from Cell-free Treatment to Engineering Modifications

Qin, B., Hu, X., Huang, Y., Yang, R.-H., & Xiong, K. (2023) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527322666230418090857 · Cited by 5 · see citing works

Extracellular Vesicles as Emerging Therapeutic Strategies in Spinal Cord Injury: Ready to Go

Jiang, J., Wang, Z., Bao, Q., Chen, S., Xu, W., & Jiang, J. (2025) · Biomedicines · doi:10.3390/biomedicines13051262 · Cited by 10 · see citing works

Extracellular Vesicles: Therapeutic Potential in Central Nervous System Trauma by Regulating Cell Death

Chen, Y., Zhang, H., Hu, X., Cai, W., Jiang, L., Wang, Y., Wu, Y., Wang, X., Ni, W., & Zhou, K. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03501-w · Cited by 11 · see citing works

Mesenchymal stem cell-derived extracellular vesicles: emerging concepts in the treatment of spinal cord injury.

Wang, S., Du, C., & Li, G. (2023) · PubMed Central · Cited by 4 · see citing works