Transforming Growth Factor β-regulated MicroRNA-29a Promotes Angiogenesis through Targeting the Phosphatase and Tensin Homolog in Endothelium
Open accessAbstract
The TGF-β pathway plays an important role in physiological and pathological angiogenesis. MicroRNAs (miRNAs) are a class of 18- to 25-nucleotide, small, noncoding RNAs that function by regulating gene expression. A number of miRNAs have been found to be regulated by the TGF-β pathway. However, the role of endothelial miRNAs in the TGF-β-mediated control of angiogenesis is still largely unknown. Here we investigated the regulation of endothelial microRNA-29a (miR-29a) by TGF-β signaling and the potential role of miR-29a in angiogenesis. MiR-29a was directly up-regulated by TGF-β/Smad4 signaling in human and mice endothelial cells. In a chick chorioallantoic membrane assay, miR-29a overexpression promoted the formation of new blood vessels, and miR-29a suppression completely blocked TGF-β1-stimulated angiogenesis. Consistently, miR-29a overexpression increased tube formation and migration in endothelial cultures. Mechanistically, miR-29a directly targeted the phosphatase and tensin homolog (PTEN) in endothelial cells, leading to activation of the AKT pathway. PTEN knockdown recapitulated the role of miR-29a in endothelial migration, whereas AKT inhibition completely attenuated the stimulating role of miR-29a in angiogenesis. Taken together, these results reveal a crucial role of a TGF-β-regulated miRNA in promoting angiogenesis by targeting PTEN to stimulate AKT activity.
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TGFβ family members stimulate astrocyte responses and modify angiogenesis and neuroinflammation.
“TGFβ family members stimulate astrocyte responses and modify angiogenesis and neuroinflammation30,31.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [31]
The Discussion reports that TGF-β signaling promotes angiogenesis by up-regulating miR-29a in endothelial cells. The paper does not address astrocyte responses or neuroinflammation (searched: astrocyte responses, neuroinflammation, brain inflammation), so it supports only the angiogenesis part of the sentence. (LLM, conf=0.88)
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- Authors
- Wang, J., Wang, Y., Wang, Y., Ma, Y., Lan, Y., & Yang, X.
- Affiliations
- State Key Laboratory of Proteomics (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Lan, Yu
- Yang, Xiao
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 288
- Issue
- 15
- Pages
- 10418-10426
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3624424
- OpenAlex
- W1999532467
- Cited by
- 64
- References
- 63
- Citations by year
- 2025: 2 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 6 · 2016: 7 · 2015: 11 · 2014: 5 · 2013: 5
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31030040, 31171410)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- miR-29a, TGF-beta signaling, angiogenesis, endothelial cells, PTEN, AKT pathway, SMAD4, endothelial cell migration, tube formation, chick chorioallantoic membrane assay, microRNA regulation
- MeSH terms
- Animals, Cell Line, Cell Movement, Chick Embryo, Humans, Signal Transduction, Neovascularization, Physiologic, MicroRNAs, Proto-Oncogene Proteins c-akt, PTEN Phosphohydrolase, Mice, Smad4 Protein, Transforming Growth Factor beta1, Gene Knockdown Techniques, Human Umbilical Vein Endothelial Cells
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