Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer

Metformin and reduced risk of cancer in diabetic patients

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

Porstmann, T., Santos, C. R., Griffiths, B., Cully, M., Wu, M., Leevers, S., Griffiths, J. R., Chung, Y.-L., & Schulze, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.007 · Cited by 1,413

New Users of Metformin Are at Low Risk of Incident Cancer

Libby, G., Donnelly, L. A., Donnan, P. T., Alessi, D. R., Morris, A. D., & Evans, J. M. M. (2009) · Diabetes Care · doi:10.2337/dc08-2175 · Cited by 996

Systemic Treatment with the Antidiabetic Drug Metformin Selectively Impairs p53-Deficient Tumor Cell Growth

Buzzai, M., Jones, R. G., Amaravadi, R. K., Lum, J. J., DeBerardinis, R. J., Zhao, F., Viollet, B., & Thompson, C. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4447 · Cited by 949

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M.-C., Hortobagyi, G. N., & Gonzalez-Angulo, A. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.19.6410 · Cited by 880

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Sahra, I. B., Laurent, K., Loubat, A., Giorgetti-Peraldi, S., Colosetti, P., Auberger, P., Tanti, J. F., Le Marchand-Brustel, Y., & Bost, F. (2008) · Oncogene · doi:10.1038/sj.onc.1211024 · Cited by 861

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1

Ben Sahra, I., Regazzetti, C., Robert, G., Laurent, K., Le Marchand-Brustel, Y., Auberger, P., Tanti, J.-F., Giorgetti-Peraldi, S., & Bost, F. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-1769 · Cited by 616

EGF Receptor is Required for KRAS-induced Pancreatic Tumorigenesis

Ardito, C. M., Grüner, B., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P., DelGiorno, K. E., Carpenter, E. S., Halbrook, C., Hall, J. C., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.07.024 · Cited by 522

Metformin as a tool to target aging

Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096

Aging and age‐related diseases: from mechanisms to therapeutic strategies

Li, Z., Zhang, Z., Ren, Y., Wang, Y., Fang, J., Yue, H., Ma, S., & Guan, F. (2021) · Biogerontology · doi:10.1007/s10522-021-09910-5 · Cited by 702

Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

Madeo, F., Carmona-Gutierrez, D., Hofer, S. J., & Kroemer, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.018 · Cited by 630

Metformin reduces all-cause mortality and diseases of ageing independent of its effect on diabetes control: A systematic review and meta-analysis

Campbell, J. M., Bellman, S. M., Stephenson, M. D., & Lisy., K. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.08.003 · Cited by 455

Sp1 transcription factor: A long-standing target in cancer chemotherapy

Vizcaíno, C., Mansilla, S., & Portugal, J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.05.008 · Cited by 377

A framework for selection of blood-based biomarkers for geroscience-guided clinical trials: report from the TAME Biomarkers Workgroup

Justice, J. N., Ferrucci, L., Newman, A. B., Aroda, V. R., Bahnson, J. L., Divers, J., Espeland, M. A., Marcovina, S., Pollak, M. N., Kritchevsky, S. B., et al. (2018) · GeroScience · doi:10.1007/s11357-018-0042-y · Cited by 359

Metformin: a review of its potential indications

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A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278

Role of AMPK mediated pathways in autophagy and aging

Ge, Y., Zhou, M., Chen, C., Wu, X., & Wang, X. (2021) · Biochimie · doi:10.1016/j.biochi.2021.11.008 · Cited by 262

Obesity and aging: Molecular mechanisms and therapeutic approaches

Santos, A. L., & Sinha, S. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101268 · Cited by 249

(Ir)relevance of Metformin Treatment in Patients with Metastatic Pancreatic Cancer: An Open-Label, Randomized Phase II Trial

Reni, M., Dugnani, E., Cereda, S., Belli, C., Balzano, G., Nicoletti, R., Liberati, D., Pasquale, V., Scavini, M., Maggiora, P. M., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1722 · Cited by 174

Taurine up‐regulated gene 1 functions as a master regulator to coordinate glycolysis and metastasis in hepatocellular carcinoma

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Attenuation of CD4+CD25+ Regulatory T Cells in the Tumor Microenvironment by Metformin, a Type 2 Diabetes Drug

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Aging and Caloric Restriction Research: A Biological Perspective with Translational Potential

Balasubramanian, P., Howell, P. R., & Anderson, R. M. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.06.015 · Cited by 148

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages

Incio, J., Suboj, P., Chin, S. M., Vardam-Kaur, T., Liu, H., Hato, T., Babykutty, S., Chen, I. X., Deshpande, V., Jain, R. K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141392 · Cited by 145

Anticancer mechanisms of metformin: A review of the current evidence

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Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development

Safe, S. H., Abbruzzese, J. L., Abdelrahim, M., & Hedrick, E. (2018) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-17-0407 · Cited by 120

SP and KLF Transcription Factors in Digestive Physiology and Diseases

Kim, C.-K., He, P., Bialkowska, A. B., & Yang, V. W. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.035 · Cited by 112

The double-edged sword of AMPK signaling in cancer and its therapeutic implications

Jeon, S., & Hay, N. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0549-z · Cited by 119

Towards natural mimetics of metformin and rapamycin

Aliper, A. M., Jellen, L. C., Cortese, F., Artemov, A. V., Karpinsky‐Semper, D., Moskalev, A., Swick, A. G., & Zhavoronkov, A. A. (2017) · Aging · doi:10.18632/aging.101319 · Cited by 112

A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells

Xue, R., Jia, K., Wang, J., Yang, L., Wang, Y., Gao, L., & Hao, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00754 · Cited by 113

Metformin inhibits human breast cancer cell growth by promoting apoptosis via a ROS-independent pathway involving mitochondrial dysfunction: pivotal role of superoxide dismutase (SOD)

Sharma, P., & Kumar, S. (2018) · Cellular Oncology · doi:10.1007/s13402-018-0398-0 · Cited by 102

Metformin therapy and risk of colorectal adenomas and colorectal cancer in type 2 diabetes mellitus patients: A systematic review and meta-analysis

Liu, F., Yan, L., Wang, Z., Lu, Y., Chu, Y., Li, X., Liu, Y., Rui, D., Nie, S., & Xiang, H. (2017) · Oncotarget · doi:10.18632/oncotarget.13762 · Cited by 99

Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells

Hedrick, E., Cheng, Y., Jin, U.-H., Kim, K., & Safe, S. H. (2016) · Oncotarget · doi:10.18632/oncotarget.7925 · Cited by 100

Current nutritional and pharmacological anti-aging interventions

Ros, M., & Carrascosa, J. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165612 · Cited by 86

Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years

Oaks, Z., Winans, T., Huang, N., Bánki, K., & Perl, A. (2016) · Current Rheumatology Reports · doi:10.1007/s11926-016-0622-8 · Cited by 93

Metformin: A Novel but Controversial Drug in Cancer Prevention and Treatment

Sui, X., Xu, Y., Wang, X., Han, W., Pan, H., & Xiao, M. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00577 · Cited by 95

Dissecting the role of AMP-activated protein kinase in human diseases

Li, J., Zhong, L., Wang, F., & Zhu, H. (2017) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.12.003 · Cited by 90

Pleiotropic Effects of Metformin on Cancer

Schulten, H.-J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102850 · Cited by 87

Dysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinoma

Cai, Y., Dodhia, S., & Su, G. H. (2017) · Oncotarget · doi:10.18632/oncotarget.14729 · Cited by 88

Metformin enhances anti-mycobacterial responses by educating CD8+ T-cell immunometabolic circuits

Böhme, J., Martínez, N., Li, S., Lee, A., Marzuki, M., Tizazu, A. M., Ackart, D. F., Haugen, J. D., Todd, A., Lachmandas, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-19095-z · Cited by 84

Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms

Cifarelli, V., Lashinger, L. M., Devlin, K. L., Dunlap, S. M., Huang, J. C., Kaaks, R., Pollak, M., & Hursting, S. D. (2015) · Diabetes · doi:10.2337/db14-1132 · Cited by 85

Metformin and Breast Cancer: Molecular Targets

Faria, J., Negalha, G. D. C., Azevedo, A., & Martel, F. (2019) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-019-09429-z · Cited by 79

Metformin Increases Sensitivity of Pancreatic Cancer Cells to Gemcitabine by Reducing CD133+ Cell Populations and Suppressing ERK/P70S6K Signaling

Chai, X.-Q., Chu, H., Yang, X., Meng, Y.-P., Shi, P., & Gou, S. (2015) · Scientific Reports · doi:10.1038/srep14404 · Cited by 74

Obesity and Cancer: An Angiogenic and Inflammatory Link

Fukumura, D., Incio, J., Shankaraiah, R. C., & Jain, R. K. (2016) · Microcirculation · doi:10.1111/micc.12270 · Cited by 69

Diabetes, pancreatic cancer, and metformin therapy

Gong, J., Robbins, L., Lugea, A., Waldron, R. T., Jeon, C. Y., & Pandol, S. J. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00426 · Cited by 71

Effect of Metformin and Statin Use on Survival in Pancreatic Cancer Patients: a Systematic Literature Review and Meta-analysis

Jian‐Yu, E., Graber, J. M., Lu, S., Lin, Y., Lu‐Yao, G. L., & Tan, X. (2017) · Current Medicinal Chemistry · doi:10.2174/0929867324666170412145232 · Cited by 71

Calorie Restriction for Cancer Prevention and Therapy: Mechanisms, Expectations, and Efficacy

Vidoni, C., Ferraresi, A., Esposito, A., Maheshwari, C., Dhanasekaran, D. N., Mollace, V., & Isidoro, C. (2021) · Journal of Cancer Prevention · doi:10.15430/jcp.2021.26.4.224 · Cited by 72

Metformin Induces Cell Cycle Arrest, Reduced Proliferation, Wound Healing Impairment In Vivo and Is Associated to Clinical Outcomes in Diabetic Foot Ulcer Patients

Ochoa-González, F. D. L., Cervantes-Villagrana, A. R., Fernández-Ruiz, J. C., Nava-Ramirez, H. S., Hernandez-Correa, A. C., Enciso‐Moreno, J. A., & Castañeda‐Delgado, J. E. (2016) · PLoS ONE · doi:10.1371/journal.pone.0150900 · Cited by 64

Metformin-induced anticancer activities: recent insights

Safe, S. H., Nair, V., & Karki, K. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0271 · Cited by 62

Sp1-mediated transcriptional regulation of MALAT1 plays a critical role in tumor

Li, S., Wang, Q., Qiang, Q., Shan, H., Shi, M., Chen, B., Zhao, S., & Yuan, L. (2015) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-015-1951-0 · Cited by 62

Growth Factors, Reactive Oxygen Species, and Metformin—Promoters of the Wound Healing Process in Burns?

Miricescu, D., Bădoiu, S. C., Stănescu-Spînu, I.-I., Totan, A., Ștefani, C., & Greabu, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179512 · Cited by 62

Metformin: A Dual-Role Player in Cancer Treatment and Prevention

Galal, M. A., Al-Rimawi, M., Hajeer, A., Dahman, H., Alouch, S. S., & Aljada, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25074083 · Cited by 73

Metformin sensitizes AML cells to chemotherapy through blocking mitochondrial transfer from stromal cells to AML cells

You, R., Wang, B., Chen, P., Zheng, X., Hou, D., Wang, X., Zhang, B., Chen, L., Li, D., Lin, X., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215582 · Cited by 56

Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling

Kawakita, E., Yang, F., Kumagai, A., Takagaki, Y., Kitada, M., Yoshitomi, Y., Ikeda, T., Nakamura, Y., Ishigaki, Y., Kanasaki, K., et al. (2020) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-20-0115 · Cited by 57

The expanding role of metformin in cancer: an update on antitumor mechanisms and clinical development

Gong, J., Kelekar, G., Shen, J., Shen, J., Kaur, S., & Mita, M. M. (2016) · Targeted Oncology · doi:10.1007/s11523-016-0423-z · Cited by 56

Menthol in electronic cigarettes: A contributor to respiratory disease?

Nair, V., Tran, M., Behar, R. Z., Zhai, S., Cui, X., Phandthong, R., Wang, Y., Pan, S., Luo, W., Pankow, J. F., et al. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115238 · Cited by 53

Specificity Proteins (Sp) and Cancer

Safe, S. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065164 · Cited by 56

Caloric restriction induced epigenetic effects on aging

Zhai, J., Kongsberg, W. H., Pan, Y., Hao, C., Wang, X., & Sun, J. Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1079920 · Cited by 56

Metformin attenuates hyperoxia-induced lung injury in neonatal rats by reducing the inflammatory response

Chen, X., Walther, F. J., Sengers, R. M. A., Laghmani, E. H., Salam, A., Folkerts, G., Pera, T., & Wagenaar, G. T. M. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00389.2014 · Cited by 51

Metformin and cancer: Between the bioenergetic disturbances and the antifolate activity

Jara, J. A., & López‐Muñoz, R. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.06.014 · Cited by 50

Metformin: review of epidemiology and mechanisms of action in pancreatic cancer

Eibl, G., & Rozengurt, E. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-09977-z · Cited by 51

Metformin targets Axl and Tyro3 receptor tyrosine kinases to inhibit cell proliferation and overcome chemoresistance in ovarian cancer cells

Kim, N., Lee, H., & Lee, C. (2015) · International Journal of Oncology · doi:10.3892/ijo.2015.3004 · Cited by 45

Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy

Yue, W., Wang, T., Zachariah, E., Lin, Y., Yang, C. S., Xu, Q., DiPaola, R. S., & Tan, X. (2015) · Scientific Reports · doi:10.1038/srep13390 · Cited by 43

Toward Repurposing Metformin as a Precision Anti-Cancer Therapy Using Structural Systems Pharmacology

Hart, T. D., Dider, S., Han, W., Xu, H., Zhao, Z., & Xie, L. (2016) · Scientific Reports · doi:10.1038/srep20441 · Cited by 44

Metformin Activates the Protective Effects of the AMPK Pathway in Acute Lung Injury Caused by Paraquat Poisoning

Wu, L., Cen, Y., Feng, M., Zhou, Y., Tang, H. J., Liao, X., Wang, Y., Wang, M., & Zhou, M. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1709718 · Cited by 41

Metformin and cognition from the perspectives of sex, age, and disease

Chaudhari, K., Reynolds, C. D., & Yang, S.-H. (2020) · GeroScience · doi:10.1007/s11357-019-00146-3 · Cited by 43

Repurposing metformin for the treatment of gastrointestinal cancer

Júnior, A. D. D. C., Bragagnoli, A. S. C., Costa, F. O., & Carvalheira, J. B. C. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i17.1883 · Cited by 42

Drug Repurposing, an Attractive Strategy in Pancreatic Cancer Treatment: Preclinical and Clinical Updates

De Lellis, L., Veschi, S., Tinari, N., Mokini, Z., Carradori, S., Brocco, D., Florio, R., Grassadonia, A., & Cama, A. (2021) · Cancers · doi:10.3390/cancers13163946 · Cited by 40

Function of selected natural antidiabetic compounds with potential against cancer via modulation of the PI3K/AKT/mTOR cascade

Nurcahyanti, A. D. R., Jap, A., Lady, J., Prismawan, D., Sharopov, F. S., Daoud, R., Wink, M., & Sobeh, M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112138 · Cited by 41

Metabolic reprogramming by driver mutation-tumor microenvironment interplay in pancreatic cancer: new therapeutic targets

Andersen, H. B., Ialchina, R., Pedersen, S. F., & Czaplińska, D. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10004-4 · Cited by 40

Physiological Systems in Promoting Frailty

Perazza, L. R., Brown‐Borg, H. M., & Thompson, L. V. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210034 · Cited by 69

Effect of Metformin Use on Survival in Resectable Pancreatic Cancer: A Single-Institution Experience and Review of the Literature

Ambe, C. M., Mahipal, A., Fulp, J., Chen, L., & Malafa, M. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151632 · Cited by 39

The Cutting Edge: The Role of mTOR Signaling in Laminopathies

Chiarini, F., Evangelisti, C., Cenni, V., Fazio, A., Paganelli, F., Martelli, A. M., & Lattanzi, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040847 · Cited by 36

Crosstalk Between Senescent Bone Cells and the Bone Tissue Microenvironment Influences Bone Fragility During Chronological Age and in Diabetes

Teissier, T., Temkin, V., Pollak, R. D., & Cox, L. S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.812157 · Cited by 35

Metformin in pancreatic cancer treatment: from clinical trials through basic research to biomarker quantification

Bhaw‐Luximon, A., & Jhurry, D. (2016) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-016-2178-4 · Cited by 34

Altered steady state and activity-dependent de novo protein expression in fragile X syndrome

Bowling, H. L., Bhattacharya, A., Zhang, G., Alam, D. H., Lebowitz, J. Z., Bohm-Levine, N., Lin, D., Singha, P., Mamcarz, M., Puckett, R. E., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09553-8 · Cited by 33

Molecular inhibition of RAS signalling to target ageing and age-related health

Laskovs, M., Partridge, L., & Slack, C. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049627 · Cited by 36

Action Mechanism of Metformin and Its Application in Hematological Malignancy Treatments: A Review

Zhang, Y., Zhou, F., Guan, J., Zhou, L., & Chen, B. (2023) · Biomolecules · doi:10.3390/biom13020250 · Cited by 38

Metformin enhances radiation response of ECa109 cells through activation of ATM and AMPK

Feng, T., Li, L., Ling, S., Fan, N., Fang, M., Zhang, H., Fang, X. H., Lan, W., Hou, Z., Meng, Q.-C., et al. (2014) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2014.11.021 · Cited by 31

Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells

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TYRO3: A potential therapeutic target in cancer

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Transcription Factor Sp1 in the Expression of Genes Encoding Components of Mapk, JAK/STAT, and PI3K/Akt Signaling Pathways

Ivanenko, K. A., Prassolov, V., & Khabusheva, E. (2022) · Molecular Biology · doi:10.1134/s0026893322050089 · Cited by 29

Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment

Vitali, E., Boemi, I., Tarantola, G., Piccini, S., Zerbi, A., Veronesi, G., Baldelli, R., Mazziotti, G., Smiroldo, V., Lavezzi, E., et al. (2020) · Cancers · doi:10.3390/cancers12082143 · Cited by 27

Anticancer Activities of the Quinone-Methide Triterpenes Maytenin and 22-β-hydroxymaytenin Obtained from Cultivated Maytenus ilicifolia Roots Associated with Down-Regulation of miRNA-27a and miR-20a/miR-17-5p

Hernandes, C., Miguita, L., de Sales, R. O., Silva, E. D. P., de Mendonça, P. O. R., da Silva, B. L., Klingbeil, M. F. G., Mathor, M. B., Rangel, É. B., Marti, L. C., et al. (2020) · Molecules · doi:10.3390/molecules25030760 · Cited by 23

Therapeutics That Can Potentially Replicate or Augment the Anti-Aging Effects of Physical Exercise

Lages, A. D. S., Lopes, V., Horta, J., Espregueira‐Mendes, J., Andrade, R., & Rebelo‐Marques, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179957 · Cited by 23

Identification of an Autophagy-Related Pair Signature for Predicting Prognoses and Immune Activity in Pancreatic Adenocarcinoma

Zhang, Q., Lv, L., Ma, P., Zhang, Y., Deng, J., & Zhang, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.743938 · Cited by 22

Effect of metformin on the epigenetic age of peripheral blood in patients with diabetes mellitus

Li, M., Bao, L., Zhu, P., & Wang, S. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.955835 · Cited by 21

Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome

Saxena, S., & Kumar, S. (2020) · GeroScience · doi:10.1007/s11357-020-00167-3 · Cited by 23

Metformin inhibited esophageal squamous cell carcinoma proliferation in vitro and in vivo and enhanced the anti-cancer effect of cisplatin

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Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions

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Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach

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An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma

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Pharmacological Approaches to Decelerate Aging: A Promising Path

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Metformin: A Promising Antidiabetic Medication for Cancer Treatment

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Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells

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A novel insight into the anticancer mechanism of metformin in pancreatic neuroendocrine tumor cells

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PDGFR Signaling Mediates Hyperproliferation and Fibrotic Responses of Subsynovial Connective Tissue Cells in Idiopathic Carpal Tunnel Syndrome

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The Histone Methyltransferase Gene G9A Is Regulated by Nuclear Receptor 4A1 in Alveolar Rhabdomyosarcoma Cells

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Metformin extends the chronological lifespan of fission yeast by altering energy metabolism and stress resistance capacity

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In vitro evaluation of effects of metformin on morphine and methadone tolerance through mammalian target of rapamycin signaling pathway

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Beyond diabetes mellitus: role of metformin in non-muscle-invasive bladder cancer

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Metformin as a disease-modifying therapy in osteoarthritis: bridging metabolism and joint health

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Resistance Training’s Ability to Prevent Cancer-induced Muscle Atrophy Extends Anabolic Stimulus

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Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells

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Metformin exerts anti-tumor effects via Sonic hedgehog signaling pathway by targeting AMPK in HepG2 cells

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Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer

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Current trends and future prospects of drug repositioning in gastrointestinal oncology

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Analysis of Important Gene Ontology Terms and Biological Pathways Related to Pancreatic Cancer

Yin, H., Wang, S., Zhang, Y., Cai, Y., & Liu, H. (2016) · BioMed Research International · doi:10.1155/2016/7861274 · Cited by 13

Hyperglycaemia Induced by Novel Anticancer Agents: An Undesirable Complication or a Potential Therapeutic Opportunity?

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Mechanisms of Action of Metformin as an Anti-cancer Agent

Ramachandran Nair Vasanthakum, V. (2014) · OakTrust (Texas A&M University Libraries)

Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors

Nair, V., Pathi, S. S., Jutooru, I., Sreevalsan, S., Basha, R. M., Abdelrahim, M., Samudio, I. J., & Safe, S. H. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt231 · Cited by 99

Metformin-induced anticancer activities: recent insights

Safe, S. H., Nair, V., & Karki, K. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0271 · Cited by 62

Abstract 2881: RET signaling in pancreatic cancer: A novel target by metformin to suppress cancer progression

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Metformin and Pancreatic Cancer Metabolism

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