Aging and Caloric Restriction Research: A Biological Perspective with Translational Potential
Open accessAbstract
Aging as a research pursuit is fairly new compared with traditional lines of medical research. A growing field of investigators is focused on understanding how changes in tissue biology, physiology, and systemic homeostasis, conspire to create increased vulnerability to disease as a function of age. Aging research as a discipline is necessarily broad; in part because aging itself is multi-faceted and in part because different model systems are employed to define the underlying biology. In this review we outline aspects of aging research that are likely to uncover the pivotal events leading to age-related disease vulnerability. We focus on studies of human aging and discuss the value of research on caloric restriction, an intervention with proven efficacy in delaying aging. We propose that studies such as these will deliver target factors and processes that create vulnerability in human aging, an advance that would potentially be transformative in clinical care.
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509 · see citing works
Genetic studies of body mass index yield new insights for obesity biology
Study, T. L. C., Locke, A. E., The ADIPOGen Consortium, The AGEN-BMI Working Group, The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The, G. L. G. C., The, I. C. B. P., The MAGIC Investigators, The MuTHER Consortium, et al. (2015) · Nature · doi:10.1038/nature14177 · Cited by 4,534 · see citing works
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290 · see citing works
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
Ageing populations: the challenges ahead
Christensen, K., Doblhammer, G., Rau, R., & Vaupel, J. W. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61460-4 · Cited by 3,764 · see citing works
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,702 · see citing works
Geroscience: Linking Aging to Chronic Disease
Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277 · see citing works
Self-citationThe Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
McCay, C. M., Crowell, M. F., & Maynard, L. A. (1935) · The Journal of Nutrition · doi:10.1093/jn/10.1.63 · Cited by 2,264 · see citing works
New genetic loci link adipose and insulin biology to body fat distribution
The ADIPOGen Consortium, Shungin, D., The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GEFOS Consortium, The GENIE Consortium, The, G. L. G. C., The, I. C. B. P., The International Endogene Consortium, Study, T. L. C., et al. (2015) · Nature · doi:10.1038/nature14132 · Cited by 1,580 · cited 1× · see citing works
“Studies investigating genetic determinants of body fat distribution identified numerous new genes of interest, confirming the long suspected links between adipose tissue and metabolic dysfunction (Locke et al., 2015; Shungin et al., 2015).”
BackgroundMetformin: from mechanisms of action to therapies
Foretz, M., Guigas, B., Bertrand, L., Pollak, M., & Viollet, B. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.09.018 · Cited by 1,501 · see citing works
NAD+ and sirtuins in aging and disease
Imai, S.-I., & Guarente, L. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.002 · Cited by 1,481 · see citing works
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Fontana, L., & Partridge, L. (2015) · Cell · doi:10.1016/j.cell.2015.02.020 · Cited by 1,245 · see citing works
Pearson, K. J., Baur, J. A., Lewis, K. N., Peshkin, L., Price, N. L., Labinskyy, N., Swindell, W. R., Kamara, D., Minor, R. K., Perez, E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.011 · Cited by 1,162 · see citing works
Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study
Mattison, J. A., Roth, G. S., Beasley, T. M., Tilmont, E. M., Handy, A. M., Herbert, R. L., Longo, D. L., Allison, D. B., Young, J. E., Bryant, M., et al. (2012) · Nature · doi:10.1038/nature11432 · Cited by 1,145 · see citing works
Metformin as a tool to target aging
Barzilai, N., Crandall, J. P., Kritchevsky, S. B., & Espeland, M. A. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.011 · Cited by 1,096 · cited 1× · see citing works
“Of particular interest is the TAME trail, “targeting aging with metformin”, which is the first of its kind in that aging itself is the process under investigation, with as emergence of comorbidity as the indexed outcome (Barzilai et al., 2016).”
BackgroundGenetic associations with human longevity at the APOE and ACE loci
Schächter, F., Faure-Delanef, L., Guénot, F., Rouger, H., Froguel, P., Lesueur-Ginot, L., & Cohen, D. (1994) · Nature Genetics · doi:10.1038/ng0194-29 · Cited by 1,095 · see citing works
FOXO3A genotype is strongly associated with human longevity
Willcox, B. J., Donlon, T. A., He, Q., Chen, R., Grove, J. S., Yano, K., Masaki, K. H., Willcox, D. C., Rodriguez, B., & Curb, J. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801030105 · Cited by 983 · see citing works
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
Aulchenko, Y. S., Janssens, A. C. J. W., Albert Hofman, D., Isaacs, A. J., Sijbrands, E. J. G., Witteman, J. C. M., van Duijn, C. M., Ripatti, S., Lindqvist, I., Perola, M., et al. (2008) · Nature Genetics · doi:10.1038/ng.269 · Cited by 846 · see citing works
Caloric restriction improves health and survival of rhesus monkeys
Mattison, J. A., Colman, R. J., Beasley, T. M., Allison, D. B., Kemnitz, J. W., Roth, G. S., Ingram, D. K., Weindruch, R., de Cabo, R., & Anderson, R. M. (2017) · Nature Communications · doi:10.1038/ncomms14063 · Cited by 838 · cited 1× · see citing works
“This turned out to be the case (Mattison et al., 2017).”
BackgroundSelf-citationSlowing ageing by design: the rise of NAD+ and sirtuin-activating compounds
Bonkowski, M. S., & Sinclair, D. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.93 · Cited by 834 · see citing works
PPAR and human metabolic disease
Semple, R. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28003 · Cited by 823 · see citing works
Mitochondria are required for pro-ageing features of the senescent phenotype
Correia‐Melo, C., Marques, F. D., Anderson, R., Hewitt, G., Hewitt, R., Cole, J., Carroll, B. M., Miwa, S., Birch, J., Merz, A., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201592862 · Cited by 796 · see citing works
Self-citationmTOR inhibition improves immune function in the elderly
Mannick, J. B., Del Giudice, G., Lattanzi, M., Valiante, N. M., Praestgaard, J., Huang, B., Lonetto, M. A., Maecker, H. T., Kovarik, J., Carson, S., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009892 · Cited by 786 · see citing works
Macroeconomic implications of population ageing and selected policy responses
Bloom, D. E., Chatterji, S., Kowal, P., Lloyd-Sherlock, P., McKee, M., Rechel, B., Rosenberg, L., & Smith, J. P. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61464-1 · Cited by 769 · see citing works
Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys
Colman, R. J., Beasley, T. M., Kemnitz, J. W., Johnson, S. C., Weindruch, R., & Anderson, R. M. (2014) · Nature Communications · doi:10.1038/ncomms4557 · Cited by 711 · see citing works
Self-citationThe effect of retarded growth upon the length of life span and upon the ultimate body size. 1935.
Cm, M., Crowell, M. F., & MAYNARD, L. A. (1989) · PubMed · Cited by 670 · see citing works
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol
Um, J.-H., Park, S.-J., Kang, H., Yang, S., Foretz, M., McBurney, M. W., Kim, M. K., Viollet, B., & Chung, J. H. (2010) · Diabetes · doi:10.2337/db09-0482 · Cited by 647 · see citing works
Interventions to slow aging in humans: are we ready?
Longo, V. D., Antebi, A., Bartke, A., Barzilai, N., Brown‐Borg, H. M., Caruso, C., Curiel, T. J., Cabo, R., Franceschi, C., Gems, D., et al. (2015) · Aging Cell · doi:10.1111/acel.12338 · Cited by 592 · see citing works
Unique Lipoprotein Phenotype and Genotype Associated With Exceptional Longevity
Barzilai, N. (2003) · JAMA · doi:10.1001/jama.290.15.2030 · Cited by 576 · see citing works
Fabbri, E., Zoli, M., González‐Freire, M., Salive, M. E., Studenski, S. A., & Ferrucci, L. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.03.013 · Cited by 560 · see citing works
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis
Reznick, R. M., Zong, H., Li, J., Morino, K., Moore, I. K., Yu, H. J., Liu, Z.-X., Dong, J., Mustard, K. J., Hawley, S. A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.008 · Cited by 555 · see citing works
The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging
Kennedy, B. K., & Lamming, D. W. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.009 · Cited by 544 · see citing works
Calorie restriction in humans: An update
Most, J., Tosti, V., Redman, L. M., & Fontana, L. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.005 · Cited by 530 · see citing works
Ravussin, E., Redman, L. M., Rochon, J., Das, S. K., Fontana, L., Kraus, W. E., Romashkan, S., Williamson, D. A., Meydani, S. N., Villareal, D. T., et al. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv057 · Cited by 489 · see citing works
Simonsick, E. M., Newman, A. B., Nevitt, M. C., Kritchevsky, S. B., Ferrucci, L., Guralnik, J. M., Harris, T. B., & for the Health ABC Study Group (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.10.m644 · Cited by 478 · see citing works
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice
Bitto, A., Ito, T. K., Pineda, V. V., LeTexier, N. J., Huang, H. Z., Sutlief, E., Tung, H., Vizzini, N., Chen, B., Smith, K., et al. (2016) · eLife · doi:10.7554/elife.16351 · Cited by 474 · see citing works
Genetic signatures of exceptional longevity in humans
Sebastiani, P., Solovieff, N., DeWan, A. T., Walsh, K. M., Puca, A., Hartley, S. W., Melista, E., Andersen, S., Dworkis, D. A., Wilk, J. B., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029848 · Cited by 464 · see citing works
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
Kickstein, E., Krauß, S., Thornhill, P., Rutschow, D., Zeller, R., Sharkey, J., Williamson, R., Fuchs, M., Köhler, A., Glossmann, H. H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912793107 · Cited by 432 · see citing works
Cohort Profile: The Lothian Birth Cohorts of 1921 and 1936
Deary, I. J., Gow, A. J., Pattie, A., & Starr, J. M. (2011) · International Journal of Epidemiology · doi:10.1093/ije/dyr197 · Cited by 410 · see citing works
Mitochondria in Cell Senescence: Is Mitophagy the Weakest Link?
Korolchuk, V. I., Miwa, S., Carroll, B., & von Zglinicki, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.020 · Cited by 409 · cited 2× · see citing works
“Specifically, mitochondrial integrity is important for maintenance of pluripotency of stem cell populations (Xu et al., 2013) and multiple aspects of mitochondrial function have been implicated in cellular senescence (Correia-Melo et al., 2016; Korolchuk et al., 2017).”
BackgroundAndersen, S. L., Paola Sebastiani, B., Dworkis, D. A., Feldman, L., & Perls, T. T. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr223 · Cited by 382 · see citing works
Mitochondrial Regulation in Pluripotent Stem Cells
Xu, X., Duan, S., Yi, F., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.06.005 · Cited by 370 · see citing works
The metabolic regulation of aging
Finkel, T. (2015) · Nature Medicine · doi:10.1038/nm.3998 · Cited by 325 · see citing works
Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study
Anselmi, C. V., Malovini, A. L., Roncarati, R., Novelli, V., Villa, F., Condorelli, G., Bellazzi, R., & Puca, A. A. (2009) · Rejuvenation Research · doi:10.1089/rej.2008.0827 · Cited by 298 · see citing works
Calorie restriction as an intervention in ageing
López‐Lluch, G., & Navas, P. (2015) · The Journal of Physiology · doi:10.1113/jp270543 · Cited by 290 · see citing works
Calorie Restriction: Is AMPK a Key Sensor and Effector
Cantó, C., & Auwerx, J. (2011) · Physiology · doi:10.1152/physiol.00010.2011 · Cited by 282 · see citing works
Zheng, Z., Chen, H., Li, J., Li, T., Zheng, B., Zheng, Y., Jin, H., He, Y., Gu, Q., & Xu, X. (2012) · Diabetes · doi:10.2337/db11-0416 · Cited by 282 · see citing works
Cohort Profile: Wisconsin longitudinal study (WLS)
Herd, P., Carr, D., & Roan, C. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dys194 · Cited by 261 · see citing works
Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease
Beecham, G. W., Martin, E. R., Li, Y.-J., Slifer, M. A., Gilbert, J. R., Haines, J. L., & Pericak-Vance, M. A. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.12.008 · Cited by 260 · see citing works
Bodkin, N. L., Alexander, T. M., Ortmeyer, H. K., Johnson, E., & Hansen, B. C. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.b212 · Cited by 250 · see citing works
Advances in Geroscience: Impact on Healthspan and Chronic Disease
Burch, J. B., Augustine, A. D., Frieden, L. A., Hadley, E., Howcroft, T. K., Johnson, R. L., Khalsa, P. S., Kohanski, R. A., Li, X. L., Macchiarini, F., et al. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu041 · Cited by 209 · see citing works
PPAR gamma and human metabolic disease
Chatterjee, K. (2006) · 8th European Congress of Endocrinology incorporating the British Endocrine Societies · Cited by 209 · see citing works
Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study
Ramsey, J. J., Colman, R. J., Binkley, N., Christensen, J. D., Gresl, T. A., Kemnitz, J. W., & Weindruch, R. H. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00166-2 · Cited by 199 · see citing works
The hitchhiker’s guide to PGC-1α isoform structure and biological functions
Martínez-Redondo, V., Pettersson, A. T., & Ruas, J. (2015) · Diabetologia · doi:10.1007/s00125-015-3671-z · Cited by 191 · see citing works
A new rhesus macaque assembly and annotation for next-generation sequencing analyses
Zimin, A. V., Cornish, A. S., Maudhoo, M. D., Gibbs, R. M., Zhang, X., Pandey, S., Meehan, D. T., Wipfler, K., Bosinger, S. E., Johnson, Z. P., et al. (2014) · Biology Direct · doi:10.1186/1745-6150-9-20 · Cited by 177 · see citing works
Radler, B. (2014) · Open Health Data · doi:10.5334/ohd.ai · Cited by 164 · see citing works
Collerton, J. C., Barrass, K., Bond, J., Eccles, M., Jagger, C., James, O., Martin-Ruiz, C. M., Robinson, L. A., von Zglinicki, T., & Kirkwood, T. B. L. (2007) · BMC Geriatrics · doi:10.1186/1471-2318-7-14 · Cited by 163 · see citing works
Liu, B., Fan, Z., Edgerton, S. M., Yang, X., Lind, S. E., & Thor, A. D. (2011) · Cell Cycle · doi:10.4161/cc.10.17.16359 · Cited by 146 · see citing works
Adiponectin Levels and Genotype: A Potential Regulator of Life Span in Humans
Atzmon, G., Pollin, T. I., Crandall, J. P., Tanner, K., Schechter, C. B., Scherer, P. E., Rincón, M., Siegel, G., Katz, M., Lipton, R. B., et al. (2008) · The Journals of Gerontology Series A · doi:10.1093/gerona/63.5.447 · Cited by 145 · see citing works
The caloric restriction paradigm: Implications for healthy human aging
Anderson, R. M., & Weindruch, R. H. (2012) · American Journal of Human Biology · doi:10.1002/ajhb.22243 · Cited by 144 · see citing works
Self-citationIntermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J Mice
Apelo, S. I. A., Pumper, C. P., Baar, E. L., Richardson, N. E., & Lamming, D. W. (2016) · The Journals of Gerontology Series A · doi:10.1093/gerona/glw064 · Cited by 134 · see citing works
Nair, V., Sreevalsan, S., Basha, R., Abdelrahim, M., Abudayyeh, A., Rodrigues Hoffman, A., & Safe, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.592576 · Cited by 129 · see citing works
Lu, J., Shi, J., Li, M., Gui, B., Fu, R., Yao, G., Duan, Z., Lv, Z., Yang, Y., Chen, Z., et al. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.01.042 · Cited by 119 · see citing works
Generalized atherosclerosis, cognitive decline, and depressive symptoms in old age
Vinkers, D. J., Stek, M. L., van der Mast, R. C., de Craen, A. J. M., le Cessie, S., Jolles, J., Westendorp, R. G. J., & Gussekloo, J. (2005) · Neurology · doi:10.1212/01.wnl.0000167544.54228.95 · Cited by 105 · see citing works
Moaddel, R., Fabbri, E., Khadeer, M. A., Carlson, O. D., Gonzalez-Freire, M., Zhang, P., Semba, R. D., & Ferrucci, L. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glw046 · Cited by 99 · see citing works
Meta-analysis of genetic variants associated with human exceptional longevity
Paola Sebastiani, B., Bae, H. T., Sun, F. X., Andersen, S. L., Daw, E. W., Malovini, A. L., Kojima, T., Hirose, N., Schupf, N., Puca, A. A., et al. (2013) · Aging · doi:10.18632/aging.100594 · Cited by 91 · see citing works
Program for testing biological interventions to promote healthy aging
Warner, H. R., Ingram, D. K., Miller, R. A., Nadon, N. L., & Richardson, A. G. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00118-4 · Cited by 81 · see citing works
Genetic evidence for common pathways in human age‐related diseases
Johnson, S. C., Dong, X., Vijg, J., & Suh, Y. (2015) · Aging Cell · doi:10.1111/acel.12362 · Cited by 78 · see citing works
Cut Points for Clinical Muscle Weakness Among Older Americans
Duchowny, K. A., Peterson, M. D., & Clarke, P. J. (2017) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2016.12.022 · Cited by 71 · see citing works
Nonhuman Primate Calorie Restriction
Colman, R. J., & Anderson, R. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3224 · Cited by 68 · see citing works
Self-citationGWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium
Matteini, A. M., Tanaka, T., Karasik, D., Atzmon, G., Chou, W., Eicher, J. D., Johnson, A. D., Arnold, A. M., Callisaya, M. L., Davies, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12468 · Cited by 64 · see citing works
Yamada, Y., Colman, R. J., Kemnitz, J. W., Baum, S. T., Anderson, R. M., Weindruch, R. H., & Schoeller, D. A. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.08.002 · Cited by 61 · see citing works
Self-citationWillcox, B. J., Willcox, D. C., & Suzuki, M. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.11.001 · Cited by 61 · see citing works
Elliot, A. J., & Chapman, B. P. (2016) · Health Psychology · doi:10.1037/hea0000392 · Cited by 56 · see citing works
Edwards, I. J., Rudel, L. L., Terry, J. G., Kemnitz, J. W., Weindruch, R. H., & Cefalu, W. T. (1998) · The Journals of Gerontology Series A · doi:10.1093/gerona/53a.6.b443 · Cited by 55 · see citing works
Ramsey, J. J., Laatsch, J. L., & Kemnitz, J. W. (2000) · Journal of Medical Primatology · doi:10.1034/j.1600-0684.2000.290102.x · Cited by 53 · see citing works
Mezuk, B. R., Lohman, M. C., Rock, A., & Payne, M. E. (2016) · Obesity · doi:10.1002/oby.21572 · Cited by 52 · see citing works
Beavers, K. M., Hsu, F., Houston, D. K., Beavers, D. P., Harris, T. B., Hue, T. F., Kim, L. J., Koster, A., Penninx, B. W. J. H., Simonsick, E. M., et al. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls213 · Cited by 47 · see citing works
Dietary restriction and the pursuit of effective mimetics
Selman, C. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003832 · Cited by 43 · see citing works
Barger, J. L., Anderson, R. M., Newton, M. A., da Silva, C., Vann, J. M., Pugh, T. D., Someya, S., Prolla, T. A., & Weindruch, R. H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120738 · Cited by 36 · see citing works
Self-citationThe complex genetics of gait speed: genome-wide meta-analysis approach
Ben-Avraham, D., Karasik, D., Verghese, J., et al. (2016) · Aging · doi:10.18632/aging.101151 · Cited by 29 · see citing works
Influences of calorie restriction and age on energy expenditure in the rhesus monkey
Raman, A., Ramsey, J. J., Kemnitz, J. W., Baum, S. T., Newton, W., Colman, R. J., Weindruch, R. H., Beasley, T. M., & Schoeller, D. A. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00127.2006 · Cited by 25 · see citing works
Sitzmann, B. D., Mattison, J. A., Ingram, D. K., et al. (2010) · Open Longevity Science · doi:10.2174/1876326x00903010038 · Cited by 14 · see citing works
Roszkowska-Gancarz, M., Bartoszewicz, Z., Połosak, J., Kuryłowicz, A., Jonas, M. I., Mossakowska, M., Franek, E., & Puzianowska‐Kuźnicka, M. (2012) · PubMed · Cited by 12 · see citing works
Influence of Altered Body Weight on Energy Expenditure
Kinney, J. M. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1995.tb05484.x · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pak, H. H., Haws, S. A., Green, C. L., Koller, M., Lavarias, M. T., Richardson, N. E., Yang, S. E., Dumas, S. N., Sonsalla, M., Bray, L., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00466-9 · Cited by 171 · see citing works
Sardeli, A. V., Komatsu, T. R., Mori, M. A., Gáspari, A. F., & Chacon-Mikahil, M. P. T. (2018) · Nutrients · doi:10.3390/nu10040423 · Cited by 138 · see citing works
“Retrospective studies also demonstrate an association between CR and health span in humans [3].”
BackgroundLévesque, S., Le Naour, J., Pietrocola, F., Paillet, J., Kremer, M., Castoldi, F., Baracco, E. E., Wang, Y., Vacchelli, E., Stoll, G., et al. (2019) · OncoImmunology · doi:10.1080/2162402x.2019.1657375 · Cited by 86 · see citing works
ATP-dependent chromatin remodelers in ageing and age-related disorders
Swer, P. B., & Sharma, R. (2021) · Biogerontology · doi:10.1007/s10522-020-09899-3 · Cited by 25 · see citing works
- Authors
- Balasubramanian, P., Howell, P. R., & Anderson, R. M.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Anderson, Rozalyn M.
- Venue
- EBioMedicine
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 21
- Pages
- 37-44
- ISSN
- 2352-3964 (ISSN-L)
- PMC
- PMC5514430
- OpenAlex
- W2672544374
- Cited by
- 148
- References
- 91
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 7 · 2023: 14 · 2022: 19 · 2021: 19 · 2020: 23 · 2019: 27 · 2018: 21 · 2017: 2
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- EBioMedicine (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- NIH (AG047358, AG040178)
- NIA
- Glenn Foundation for Medical Research
- American Federation for Aging Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- aging, caloric restriction, age-related diseases, tissue biology, homeostasis, systemic homeostasis, human aging, translational research, aging interventions
- MeSH terms
- Aging, Animals, Energy Metabolism, Humans, Signal Transduction, Caloric Restriction, Translational Research, Biomedical
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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