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Cited by 150Fatty Acid Research and HealthLipid metabolism and biosynthesisCancer, Lipids, and Metabolism

Biological Role of Unsaturated Fatty Acid Desaturases in Health and Disease

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Czumaj, Aleksandra, Śledziński, Tomasz·2020·Nutrients
DOI 10.3390/nu12020356PMC PMC7071289
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Abstract

Polyunsaturated fatty acids (PUFAs) are considered one of the most important components of cells that influence normal development and function of many organisms, both eukaryotes and prokaryotes. Unsaturated fatty acid desaturases play a crucial role in the synthesis of PUFAs, inserting additional unsaturated bonds into the acyl chain. The level of expression and activity of different types of desaturases determines profiles of PUFAs. It is well recognized that qualitative and quantitative changes in the PUFA profile, resulting from alterations in the expression and activity of fatty acid desaturases, are associated with many pathological conditions. Understanding of underlying mechanisms of fatty acid desaturase activity and their functional modification will facilitate the development of novel therapeutic strategies in diseases associated with qualitative and quantitative disorders of PUFA.

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  • Several clinical trials have shown beneficial effects of n-3 PUFA supplementation in ASD and ADHD, but not all results are consistent.

    “Several clinical trials have shown beneficial effects of n-3 PUFA supplementation in ASD and ADHD, but not all results are consistent and the ratio of EPA and DHA in n-3 PUFA supplements and the overall dietary intake of FAs may affect the clinical outcome62–65.”

    From An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis (2023) · cites this paper as [65]

    Section 3.3 links FADS gene variants to ADHD but does not report n-3 PUFA supplementation trials for ADHD or ASD. Its discussion of inconsistent supplementation results concerns schizophrenia, not either condition in the claim. Searches for ASD and ADHD supplementation trials found no passage addressing the claimed clinical outcomes. (LLM, conf=0.73)

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Authors
Czumaj, A., & Śledziński, T.
Affiliations
Gdańsk Medical University (PL)
Corresponding author
Czumaj, Aleksandra
ORCID
Venue
Nutrients
Publisher
MDPI AG
Published
2020-01-29
Volume
12
Issue
2
Pages
356
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu12020356
PMC
PMC7071289
OpenAlex
W3003824382
Cited by
150
References
229
Citations by year
2026: 17 · 2025: 32 · 2024: 26 · 2023: 27 · 2022: 25 · 2021: 18 · 2020: 4 · 2019: 1
FWCI
2.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Nutrients (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Narodowe Centrum Nauki (NCN 2016/22/E/NZ4/00665)
  • European Union through the European Social Fund under the Operational Programme Knowledge Education Development (POWR.03.02.00-00-I026/17-00)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
Keywords
polyunsaturated fatty acids, lipid metabolism disorders, treatment options
MeSH terms
Fatty Acids, Unsaturated, Humans, Plants, Fatty Acid Desaturases

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