The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Severe Hypercholesterolemia, Impaired Fat Tolerance, and Advanced Atherosclerosis in Mice Lacking Both Low Density Lipoprotein Receptor-related Protein 5 and Apolipoprotein E
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Inactivation of LRP1 or LRP5 in hepatocytes has no effect on fasting plasma triglyceride levels.
“However, inactivation of LRP1 or LRP5 in hepatocytes has no effect on fasting plasma triglyceride levels (61, 63)”
From Syndecan-1 is the primary heparan sulfate proteoglycan mediating hepatic clearance of triglyceride-rich lipoproteins in mice (2009) · cites this paper as [63]
The Results (page unavailable) report that 16 hours of fasting increased VLDL-triglyceride in LRP5-knockout mice, contrary to the claimed lack of an effect. The study used LRP5-knockout mice, not hepatocyte-specific inactivation, and does not establish the LRP1 part of the sentence. (LLM, conf=0.86)
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Experimental — accuracy not yet measuredInactivation of LRP1 in the liver or systemic inactivation of LRP5 has no effect on lipoprotein clearance under normal physiological conditions.
“LDLR deficiency leads to a large increase in levels of apoB-100-bearing cholesterol-rich LDL and an increase in the level of triglyceride-rich particles (49), whereas inactivation of LRP1 in the liver (15) or systemic inactivation of LRP5 has no effect on lipoprotein clearance under normal physiological conditions (58).”
From Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members (2007) · cites this paper as [58]
The Results (page unavailable) report that LRP5 deficiency alone had no significant effect on plasma cholesterol levels in mice fed normal chow. That does not establish unchanged lipoprotein clearance: the Results also report markedly impaired clearance of triglycerides after fat loading in LRP5-knockout mice. The paper does not address the sentence’s separate claim about liver LRP1 inactivation. (LLM, conf=0.86)
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Citations
Cites
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Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
Small, S. A., & Duff, K. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.007 · Cited by 546
Stanford, K. I., Bishop, J. R., Foley, E. M., Gonzales, J. C., Niesman, I. R., Witztum, J. L., & Esko, J. D. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38251 · Cited by 226
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Functional Roles of the Interaction of APP and Lipoprotein Receptors
Pohlkamp, T., Wasser, C. R., & Herz, J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00054 · Cited by 92
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
Caruso, A., Motolese, M., Iacovelli, L., Caraci, F., Copani, A., Nicoletti, F., Terstappen, G. C., Gaviraghi, G., & Caricasole, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03867.x · Cited by 101
Wnt/β-Catenin Signaling in Alzheimer’s Disease
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Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Li, Y., Chen, J., Lu, W., McCormick, L. M., Wang, J., & Bu, G. (2005) · Journal of Cell Science · doi:10.1242/jcs.02651 · Cited by 53
Metadata
- Authors
- Magoori, K., Kang, M.-J., Ito, M. R., Kakuuchi, H., Ioka, R. X., Kamataki, A., Kim, D.-H., Asaba, H., Iwasaki, S., Takei, Y. A., Sasaki, M., Usui, S., Okazaki, M., Takahashi, S., Ono, M., Nose, M., Sakai, J., Fujino, T., & Yamamoto, T. T.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-03
- Volume
- 278
- Issue
- 13
- Pages
- 11331-11336
- ISSN
- 0021-9258
- Cited by
- 111
- References
- 5
- Language
- en
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