Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

Glickman, M. H., & Ciechanover, A. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00027.2001 · Cited by 4,296

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

Hayes, J. D., & McLellan, L. I. (1999) · Free Radical Research · doi:10.1080/10715769900300851 · Cited by 1,528

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

Baumeister, W. P., Walz, J., Zühl, F., & Seemüller, E. (1998) · Cell · doi:10.1016/s0092-8674(00)80929-0 · Cited by 1,497

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,473

The ubiquitin–proteasome pathway: on protein death and cell life

Ciechanover, A. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.24.7151 · Cited by 1,419

HDAC Inhibitors Increase NRF2-Signaling in Tumour Cells and Blunt the Efficacy of Co-Adminstered Cytotoxic Agents

McMahon, M. J., Campbell, K. H., MacLeod, A. K., McLaughlin, L. A., Henderson, C. J., & Wolf, C. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114055 · Cited by 24

Limited expression of Nrf2 in neurons across the central nervous system

Levings, D. C., Pathak, S. S., Yang, Y., & Slattery, M. G. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102830 · Cited by 23

Autophagy-dependent survival is controlled with a unique regulatory network upon various cellular stress events

Kapuy, O., Holczer, M., Márton, M., & Korcsmáros, T. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03599-7 · Cited by 24

Fluorescent tagging of endogenous Heme oxygenase-1 in human induced pluripotent stem cells for high content imaging of oxidative stress in various differentiated lineages

Snijders, K. E., Fehér, A., Táncos, Z., Bock, I., Téglási, A., van den Berk, L., Niemeijer, M., Bouwman, P., Dévédec, S. E. L., Moné, M. J., et al. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03127-8 · Cited by 23

Mercury can be transported into marine copepod by polystyrene nanoplastics but is not bioaccumulated: An increased risk?

Xie, D., Wei, H., Lee, J., & Wang, M. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.119170 · Cited by 23

Development, characterization of naringenin-loaded promising microemulsion formulations, and demonstration of anti-aging efficacy by in vitro enzyme activity and gene expression

Şahin, D., Çağlar, E. Ş., Boran, T., Karadağ, A. E., Özhan, G., & Okur, N. Ü. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104422 · Cited by 23

Sedanolide Activates KEAP1–NRF2 Pathway and Ameliorates Hydrogen Peroxide-Induced Apoptotic Cell Death

Tabei, Y., Abe, H., Suzuki, S., Takeda, N., Arai, J.-I., & Nakajima, Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216532 · Cited by 23

The role of 17β-estradiol in the regulation of antioxidant enzymes via the Nrf2–Keap1 pathway in the livers of CBA/H mice

Sobočanec, S., Šarić, A., Šafranko, Ž. M., Hadžija, M. P., Abramić, M., & Balog, T. (2015) · Life Sciences · doi:10.1016/j.lfs.2015.03.014 · Cited by 23

Metabolic contribution of hepatic autophagic proteolysis: Old wine in new bottles

Ueno, T., Ezaki, J., & Kominami, E. (2011) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2011.06.019 · Cited by 23

Cytochrome P450 2A5 and bilirubin: Mechanisms of gene regulation and cytoprotection

Kim, S. D., Antenos, M., Squires, E. J., & Kirby, G. M. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.04.013 · Cited by 24

Macrophage Migration Inhibitory Factor as an Emerging Drug Target to Regulate Antioxidant Response Element System

Yukitake, H., Takizawa, M., & Kimura, H. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8584930 · Cited by 23

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

McMahon, M. J., Ding, S., Acosta-Jimenez, L., Frangova, T. G., Henderson, C. J., & Wolf, C. R. (2017) · The Journal of Physiology · doi:10.1113/jp274915 · Cited by 21

Casticin alleviates lipopolysaccharide‐induced inflammatory responses and expression of mucus and extracellular matrix in human airway epithelial cells through Nrf2/Keap1 and NF‐κB pathways

Wang, J. (2018) · Phytotherapy Research · doi:10.1002/ptr.6067 · Cited by 23

Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression

Bousquet, M. S., Ratnayake, R., Pope, J. L., Chen, Q.-Y., Zhu, F., Chen, S., Carney, T. J., Gharaibeh, R. Z., Jobin, C., Paul, V. J., et al. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.013 · Cited by 23

Hsp90α promotes chemoresistance in pancreatic cancer by regulating Keap1-Nrf2 axis and inhibiting ferroptosis

Liu, B., Chen, Z., Li, Z., Zhao, X., Zhang, W., Zhang, A., Wen, L., Wang, X., Zhou, S., & Qian, D. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024138 · Cited by 25

Binding of Disordered Peptides to Kelch: Insights from Enhanced Sampling Simulations

Do, T. N., Choy, W., & Karttunen, M. (2015) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.5b00868 · Cited by 22

Combinations of Phytochemicals More Efficiently than Single Components Activate Nrf2 and Induce the Expression of Antioxidant Enzymes in Pancreatic Cancer Cells

Cykowiak, M., Krajka‐Kuźniak, V., & Baer‐Dubowska, W. (2021) · Nutrition and Cancer · doi:10.1080/01635581.2021.1933097 · Cited by 22

Partial inhibition of the ubiquitin–proteasome system ameliorates cardiac dysfunction following ischemia–reperfusion in the presence of high glucose

Adams, B., Mapanga, R. F., & Essop, M. F. (2015) · Cardiovascular Diabetology · doi:10.1186/s12933-015-0258-4 · Cited by 22

Lannea coromandelica (Houtt.) Merr. Induces Heme Oxygenase 1 (HO-1) Expression and Reduces Oxidative Stress via the p38/c-Jun N-Terminal Kinase–Nuclear Factor Erythroid 2-Related Factor 2 (p38/JNK–NRF2)-Mediated Antioxidant Pathway

Alam, M. B., Kwon, K.-R., Lee, S.-H., & Lee, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020266 · Cited by 22

Glutaredoxin 2 protects cardiomyocytes from hypoxia/reoxygenation-induced injury by suppressing apoptosis, oxidative stress, and inflammation via enhancing Nrf2 signaling

Li, C., Xin, H., Shi, Y., & Mu, J. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107428 · Cited by 22

7,8-Dihydroxyflavone Suppresses Oxidative Stress-Induced Base Modification in DNA via Induction of the Repair Enzyme 8-Oxoguanine DNA Glycosylase-1

Kim, K. C., Lee, I. K., Kang, K. A., Cha, J. W., Cho, S. J., Na, S. Y., Chae, S., Kim, H. S., Kim, S., & Hyun, J. W. (2013) · BioMed Research International · doi:10.1155/2013/863720 · Cited by 22

Emerging Therapeutic Targets in Oncologic Photodynamic Therapy

Manda, G., Hinescu, M. E., Neagoe, I. V., Ferreira, L. F. V., Boscencu, R., Vasos, P. R., Basaga, S. H., & Cuadrado, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190122163832 · Cited by 23

Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane

Sharma, R., Sharma, A., Chaudhary, P., Sahu, M., Jaiswal, S., Awasthi, S., & Awasthi, Y. C. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.012 · Cited by 21

Obesity-induced sympathoexcitation is associated with Nrf2 dysfunction in the rostral ventrolateral medulla

Balasubramanian, P., Asirvatham‐Jeyaraj, N., Monteiro, R., Sivasubramanian, M. K., Hall, D., & Subramanian, M. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00206.2019 · Cited by 21

Redox-dependent regulation of satellite cells following aseptic muscle trauma: Implications for sports performance and nutrition

Παπανικολάου, Κ., Veskoukis, A. S., Draganidis, D., Baloyiannis, I., Deli, C. K., Poulios, A., Jamurtas, A. Z., & Fatouros, I. G. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.10.001 · Cited by 22

Antioxidant defense response during hibernation and arousal in Chinese soft-shelled turtle Pelodiscus sinensis juveniles

Tang, Z., Chen, B.-J., & Niu, C.-J. (2021) · Cryobiology · doi:10.1016/j.cryobiol.2021.01.015 · Cited by 24

Celastrol alleviates oxidative stress induced by multi-walled carbon nanotubes through the Keap1/Nrf2/HO-1 signaling pathway

Qing, T.-L., Yan, L., Wang, S., Dai, X., Ren, L., Zhang, J., Shi, W., Zhang, X., Wang, M.-T., Chen, J., et al. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114623 · Cited by 21

Nrf2-Mediated Heme Oxygenase-1 Upregulation as Adaptive Survival Response to Glucose Deprivation-Induced Apoptosis in HepG2 Cells

Lee, H. G., Li, M., Joung, E.-J., Na, H., Cha, Y., & Surh, Y. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3226 · Cited by 21

Chapter 7 Xenobiotic receptors in fish: Structural and functional diversity and evolutionary insights

Hahn, M. E., Merson, R. R., & Karchner, S. I. (2005) · Biochemistry and molecular biology of fishes · doi:10.1016/s1873-0140(05)80010-4 · Cited by 21

Revisiting the role of hypoxia-inducible factors and nuclear factor erythroid 2-related factor 2 in regulating macrophage inflammation and metabolism

Ting, K. K. Y. (2024) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2024.1403915 · Cited by 20

CDDO-Me Inhibits Microglial Activation and Monocyte Infiltration by Abrogating NFκB- and p38 MAPK-Mediated Signaling Pathways Following Status Epilepticus

Kim, J., Park, H., Lee, J., & Kang, T. (2020) · Cells · doi:10.3390/cells9051123 · Cited by 21

The Impact of Endoplasmic Reticulum-Associated Protein Modifications, Folding and Degradation on Lung Structure and Function

Nakada, E. M., Sun, R., Fujii, U., & Martin, J. G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.665622 · Cited by 22

Depleted uranium causes renal mitochondrial dysfunction through the ETHE1/Nrf2 pathway

Liu, S., Wang, S., Zhao, Y., Li, J., Shu, C., Li, Y., Li, J., Lu, B., Xu, Z., Ran, Y., et al. (2023) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2023.110356 · Cited by 20

Redox-dependent signaling system Nrf2/ARE in inflammation

Брониславовна, М. Е., Tkachev, V., & Зенков, Н. К. (2010) · Molecular Biology · doi:10.1134/s0026893310030015 · Cited by 20

Marburg Virus VP24 Protein Relieves Suppression of the NF–κB Pathway Through Interaction With Kelch-like ECH-Associated Protein 1

Edwards, M. R., & Basler, C. F. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv050 · Cited by 21

Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice

Ano, S., Panariti, A., Allard, B., O’Sullivan, M. J., McGovern, T. K., Hamamoto, Y., Ishii, Y., Yamamoto, M. P., Powell, W. S., & Martin, J. G. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.017 · Cited by 20

Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy

Yoshizaki, Y., Mori, T., Ishigami‐Yuasa, M., Kikuchi, E., Takahashi, D., Zeniya, M., Nomura, N., Mori, Y., Araki, Y., Ando, F., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-04233-3 · Cited by 20

Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice

Komeno, M., Pang, X., Shimizu, A., Molla, M. R., Yasuda‒Yamahara, M., Kume, S., Rahman, N. I. A., Soh, J. E. C., Nguyen, L. K. C., Amin, M. K. B. A., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100761 · Cited by 21

Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy

Ma, L., Li, C., Lian, S., Xu, B., Lv, H., Liu, Y., Lu, J., Ji, H. L., Li, S., Guo, J., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16733 · Cited by 19

Apigenin-7-O-β-D-(-6”-p-coumaroyl)-glucopyranoside treatment elicits a neuroprotective effect through GSK-3β phosphorylation-mediated Nrf2 activation

Wang, J., Wang, S., Sun, S., Lu, Y., Gao, K., Guo, C., Li, R., Li, W., Zhao, X., Tang, H., et al. (2020) · Aging · doi:10.18632/aging.104050 · Cited by 19

Flavonoid Extract from Seed Residues of Hippophae rhamnoides ssp. sinensis Protects against Alcohol-Induced Intestinal Barrier Dysfunction by Regulating the Nrf2 Pathway

Wei, J., Zhao, J., Su, T., Li, S., Wenjun, S., Feng, L., & Bi, Y. (2023) · Antioxidants · doi:10.3390/antiox12030562 · Cited by 20

Transcription Factor NRF2 in Shaping Myeloid Cell Differentiation and Function

Pfefferlé, M., & Vallelian, F. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-62731-6_8 · Cited by 18

Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP

Hayes, J. D., Ebisine, K., Sharma, R. S., Chowdhry, S., Dinkova‐Kostova, A. T., & Sutherland, C. D. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.10.003 · Cited by 19

Nrf2 Activation as a Protective Feedback to Limit Cell Death in High Glucose‐Exposed Cardiomyocytes

Tsai, C., Wen, S., Cheng, S., Wang, C., Yang, Y., Viswanadha, V. P., Huang, C., & Kuo, W. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25785 · Cited by 19

Inhibition of Nrf2 promotes the antitumor effect of Pinelliae rhizome in papillary thyroid cancer

Du, Z., Wang, Q., Ma, G., Jiao, J., Jiang, D., Zheng, X., Qiu, M., & Liu, S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28069 · Cited by 19

Repression of Nrf2/ARE regulated antioxidant genes and dysregulation of the cellular redox environment by the HIV Transactivator of Transcription

Simenauer, A., Assefa, B., Rios-Ochoa, J., Geraci, K. P., Hybertson, B. M., Gao, B., McCord, J. M., Elajaili, H. B., Nozik‐Grayck, E., & Cota‐Gomez, A. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.06.015 · Cited by 19

Progressive Rotavirus Infection Downregulates Redox-Sensitive Transcription Factor Nrf2 and Nrf2-Driven Transcription Units

Patra, U., Mukhopadhyay, U., Mukherjee, A., Sarkar, R., & Chawla‐Sarkar, M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/7289120 · Cited by 19

Astaxanthin Protects Human Granulosa Cells against Oxidative Stress through Activation of NRF2/ARE Pathway and Its Downstream Phase II Enzymes.

Eslami, M., Esfandyari, S., Aghahosseini, M., Rashidi, Z., Hosseinishental, S. H., Brenjian, S., Sobhani, A., & Amidi, F. (2021) · PubMed Central · doi:10.22074/cellj.2021.7222 · Cited by 19

Total saponins from Rosa laevigata Michx fruit attenuates hepatic steatosis induced by high-fat diet in rats

Dong, D., Qi, Y., Xu, L., Yin, L., Xu, Y., Han, X., Zhao, Y., & Peng, J. (2014) · Food & Function · doi:10.1039/c4fo00491d · Cited by 19

Role of nuclear factor erythroid 2-related factor 2 (Nrf2) in female and male fertility

Valipour, J., Taghizadeh, F., Esfahani, R., Ramesh, M., & Rastegar, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e29752 · Cited by 19

Ferroptosis and Nrf2 Signaling in Head and Neck Cancer: Resistance Mechanisms and Therapeutic Prospects

Lee, J., Seo, Y. J., & Roh, J. (2025) · Antioxidants · doi:10.3390/antiox14080993 · Cited by 18

Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative Disorders

Jin, W., Qazi, T. J., Quan, Z., Li, N., & Qing, H. (2018) · The Neuroscientist · doi:10.1177/1073858418811787 · Cited by 17

Protective Effects of Ginsenosides (20R)‐Rg3 on H2O2‐Induced Myocardial Cell Injury by Activating Keap‐1/Nrf2/HO‐1 Signaling Pathway

Zhao, Y. D., Wang, Y., Zhang, M., Gao, Y., & Yan, Z. (2021) · Chemistry & Biodiversity · doi:10.1002/cbdv.202001007 · Cited by 18

Bromophenol Bis (2,3,6-Tribromo-4,5-dihydroxybenzyl) Ether Protects HaCaT Skin Cells from Oxidative Damage via Nrf2-Mediated Pathways

Dong, H., Liu, M., Wang, L., Liu, Y., Lu, X., Stagos, D., Lin, X., & Liu, M. (2021) · Antioxidants · doi:10.3390/antiox10091436 · Cited by 18

Redox Biology in Adipose Tissue Physiology and Obesity

Yu, J., Qiu, J., Zhang, Z., Cui, X., Guo, W., Sheng, M., Gao, M., Wang, D., Xu, L., & Ma, X. (2023) · Advanced Biology · doi:10.1002/adbi.202200234 · Cited by 20

Omega-3 polyunsaturated fatty acids protect against cisplatin-induced nephrotoxicity by activating the Nrf2 signaling pathway

Zhang, Z., Liu, Y., Feng, W., Mao, P., Yang, J., Zhao, Z., Zhou, S., Zhao, A. Z., Li, F., & Mu, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137457 · Cited by 20

Cross-talk between redox regulation and the ubiquitin–proteasome system in mammalian cell differentiation

Demasi, M., Simões, V., & Bonatto, D. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.10.031 · Cited by 20

Sulforaphane suppresses the viability and metastasis, and promotes the apoptosis of bladder cancer cells by inhibiting the expression of FAT‑1

Wang, F., Liu, P., An, H., & Zhang, Y. L. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4665 · Cited by 18

15‐Deoxy‐Δ12,14‐prostaglandin J2Induces Upregulation of Multidrug Resistance‐Associated Protein 1 via Nrf2 Activation in Human Breast Cancer Cells

Song, N., Kim, D., Kim, E., Na, H., & Surh, Y. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04914.x · Cited by 19

Pterocarpus santalinus L. extract mitigates gamma radiation-inflicted derangements in BALB/c mice by Nrf2 upregulation

Ghali, E. N. H. K., Kumar, S. S., Meriga, B., Maurya, D. K., & Kesavulu, M. M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111801 · Cited by 18

Time to Reset: The Interplay Between Circadian Rhythms and Redox Homeostasis in Skeletal Muscle Ageing and Systemic Health

Sutton, E. R., & Pekovic‐Vaughan, V. (2025) · Antioxidants · doi:10.3390/antiox14091132 · Cited by 20

A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90

Ngo, V., Brickenden, A. M., Liu, H., Yeung, C., Choy, W., & Duennwald, M. L. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049258 · Cited by 16

Regulation of nuclear factor erythroid-2-related factor 2 as a potential therapeutic target in intracerebral hemorrhage

Zhang, Y., Yu, W., Liu, Y., Chang, W., Wang, M., & Zhang, L. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.995518 · Cited by 17

Age-Dependent Changes in Nrf2/Keap1 and Target Antioxidant Protein Expression Correlate to Lipoxidative Adducts, and Are Modulated by Dietary N-3 LCPUFA in the Hippocampus of Mice

Díaz, M. L., Valdés‐Baizabal, C., Pereda, D., & Marín, R. (2024) · Antioxidants · doi:10.3390/antiox13020206 · Cited by 17

The novel arsenical Darinaparsin circumvents BRG1-dependent, HO-1-mediated cytoprotection in leukemic cells

Garnier, N. M., Petruccelli, L. A., Molina, M. F., Kourelis, M., Kwan, S., Diaz, Z., Schipper, H. M., Gupta, A., Rincon, S. V. D., Mann, K. K., et al. (2013) · Leukemia · doi:10.1038/leu.2013.54 · Cited by 17

The therapeutic potential of sulforaphane on light-induced photoreceptor degeneration through antiapoptosis and antioxidant protection

Kong, L., Liu, B., Zhang, C., Wang, B., Wang, H., Song, X., Yang, Y., Ren, X. S., Yin, L., Kong, H., et al. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.011 · Cited by 17

Kelch-like ECH-associated Protein 1-dependent Nuclear Factor-E2–related Factor 2 Activation in Relation to Antioxidation Induced by Sevoflurane Preconditioning

Cai, M., Li, T., Dong, B., Hou, W., Shi, L., & Dong, H. (2016) · Anesthesiology · doi:10.1097/aln.0000000000001485 · Cited by 17

Targeting Autophagy In Disease: Recent Advances In Drug Discovery

Kim, D., Hwang, H., & Kwon, H. J. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1773429 · Cited by 17

Endogenous production of ω-3 polyunsaturated fatty acids mitigates cisplatin-induced myelosuppression by regulating NRF2-MDM2-p53 signaling pathway

Xu, Q., Zhang, Z., Tang, M., Xing, C., Chen, H., Zheng, K., Zhao, Z., Zhou, S., Zhao, A. Z., Li, F., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.03.005 · Cited by 16

Role of Protein Phosphorylation in the Regulation of NF-E2–Related Factor 2 Activity

Sherratt, P. J., Huang, H., Nguyen, T., & Pickett, C. B. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)78022-2 · Cited by 17

Oxidative stress in asthma pathogenesis: mechanistic insights and implications for airway smooth muscle dysfunction

Li, K., Ji, X., Tian, S., Li, J., Tian, Y., Ma, X., Huan-ping, L., Zhang, H., Chen, C.-T., & Gu, W. (2025) · Cell and Tissue Research · doi:10.1007/s00441-025-03953-7 · Cited by 18

Role of oxeiptosis in disease mechanisms and therapeutic opportunities

Bhuvaneshwari, K., Harithpriya, K., Ganesan, K., Xu, B., & Ramkumar, K. M. (2025) · APOPTOSIS · doi:10.1007/s10495-025-02087-z · Cited by 16

NRF2-dependent suppression of selenoprotein P expression promotes intracellular selenium metabolic remodeling and upregulation of antioxidant selenoproteins in hepatocellular carcinoma

Arisawa, K., Natori, M., Hiranuma, T., Shimizu, M., Yamazaki, Y., Miki, Y., Toyama, T., & Saito, Y. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103821 · Cited by 16

The Keap1-Nrf2 pathway: From mechanism to medical applications

Baird, L., & Yamamoto, M. P. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00009-2 · Cited by 16

Standardized Aronia melanocarpa extract regulates redox status in patients receiving hemodialysis with anemia

Milosavljevic, I. M., Jakovljevic, V. L., Petrović, D., Draginic, N. D., Jeremic, J. N., Mitrović, M., Zivkovic, V. I., Srejovic, I. M., Stojić, V., Bolevich, S., et al. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04225-y · Cited by 16

Matrine promotes mitochondrial biosynthesis and reduces oxidative stress in experimental optic neuritis

Song, Y., Wang, M., Zhao, S., Tian, Y., & Zhang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.936632 · Cited by 16

Comprehensive Effect of Carbon Tetrachloride and Reversal of Gandankang Formula in Mice Liver: Involved in Oxidative Stress, Excessive Inflammation, and Intestinal Microflora

Wei, Y., Wang, H., Zhang, Y., Gu, J., Zhang, X., Gong, X.-H., & Hao, Z. (2022) · Antioxidants · doi:10.3390/antiox11112234 · Cited by 16

Regulation of PGC-1α of the Mitochondrial Energy Metabolism Pathway in the Gills of Indian Medaka (Oryzias dancena) under Hypothermal Stress

Ranasinghe, N., Chen, W., Hu, Y.-C., Gamage, L., Lee, T., & Ho, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216187 · Cited by 16

Crosstalk between inflammasomes, inflammation, and Nrf2: Implications for gestational diabetes mellitus pathogenesis and therapeutics

Gayatri, V., Prasad, M. K., Mohandas, S., Nagarajan, S., Kumaran, K., & Ramkumar, K. M. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.176241 · Cited by 17

Dopaminergic REST/NRSF is protective against manganese-induced neurotoxicity in mice

Pajarillo, E. A. B., Kim, S. H., Digman, A., Ajayi, I., Nyarko‐Danquah, I., Son, D., Aschner, M., & Lee, E.-S. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107707 · Cited by 16

Development of a Cell-Based High Throughput Luciferase Enzyme Fragment Complementation Assay to Identify Nuclear-Factor-E2-Related Transcription Factor 2 Activators

Xie, W., Pao, C. S., Graham, T. L., Dul, E., Lu, Q., Sweitzer, T. D., Ames, R. S., & Li, H. (2012) · Assay and Drug Development Technologies · doi:10.1089/adt.2011.436 · Cited by 16

Nuclear Cytoplasmic Trafficking of Proteins is a Major Response of Human Fibroblasts to Oxidative Stress

Baqader, N. O., Radulović, M., Crawford, M., Stoeber, K., & Godovac‐Zimmermann, J. (2014) · Journal of Proteome Research · doi:10.1021/pr500638h · Cited by 16

Nrf2-Dependent and -Independent Effects of tert-Butylhydroquinone, CDDO-Im, and H2O2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing

Zagorski, J. W., Maser, T. P., Liby, K. T., & Rockwell, C. E. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.116.238899 · Cited by 16

Phenethyl isothiocyanate protects against H2O2-induced insulin resistance in 3T3-L1 adipocytes

Nagami, M., Ito, Y., & Nagasawa, T. (2017) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2017.1372181 · Cited by 16

Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2

VanDenBerg, K. R., Freeborn, R. A., Liu, S., Kennedy, R. C. M., Zagorski, J. W., & Rockwell, C. E. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185579 · Cited by 16

Integrated data analysis reveals significant associations of KEAP1 mutations with DNA methylation alterations in lung adenocarcinomas

Elshaer, M., ElManawy, A. I., Hammad, A., Namani, A., Wang, X. J., & Tang, X. (2020) · Aging · doi:10.18632/aging.103068 · Cited by 16

Extract of Ginkgo biloba induces glutathione-S-transferase subunit-P1 in vitro

Liu, X., Goldring, C. E., Wang, H.-Y., Copple, I. M., Kitteringham, N. R., & Park, B. K. (2009) · Phytomedicine · doi:10.1016/j.phymed.2008.11.001 · Cited by 16

Pin1 Plays Essential Roles in NASH Development by Modulating Multiple Target Proteins

Inoue, M.-K., Nakatsu, Y., Yamamotoya, T., Hasei, S., Kanamoto, M., Naitou, M., Matsunaga, Y., Sakoda, H., Fujishiro, M., Ono, H., et al. (2019) · Cells · doi:10.3390/cells8121545 · Cited by 16

Purification, crystallization and preliminary X-ray diffraction analysis of the Kelch-like motif region of mouse Keap1

Padmanabhan, B., Scharlock, M., Tong, K. I., Nakamura, Y., Kang, M.-I., Kobayashi, A., Matsumoto, T., Tanaka, A., Yamamoto, M., & Yokoyama, S. (2004) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309104032506 · Cited by 16

Effects of Cyclopentenone Prostaglandins on the Expression of Heme Oxygenase‐1 in MCF‐7 Cells

Kim, E. H., Kim, D., Na, H., & Surh, Y. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.061 · Cited by 16

Nitroalkene fatty acids mediate activation of Nrf2/ARE-dependent and PPARγ-dependent transcription by distinct signaling pathways and with significantly different potencies

Bates, D. J. P., Smitherman, P. K., Townsend, A. J., King, S. B., & Morrow, C. S. (2011) · Biochemistry · doi:10.1021/bi2005784 · Cited by 15

Arsenic-induced differential inflammatory responses in mouse thymus involves NF-κB/STAT-3 disruption, Treg bias and autophagy activation

Das, A., Chowdhury, O., Gupta, P., Das, N., Mitra, A., Ghosh, S., Ghosh, S., Sarkar, S., Bandyopadhyay, D., & Chattopadhyay, S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121290 · Cited by 15

Lansoprazole protects hepatic cells against cisplatin-induced oxidative stress through the p38 MAPK/ARE/Nrf2 pathway

Yamagishi, N., Yamamoto, Y., Nishi, T., Ito, T., & Kanai, Y. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287788 · Cited by 16

High Expression of NRF2 and Low Expression of KEAP1 Predict Worse Survival in Patients With Operable Triple-Negative Breast Cancer

Lee, Y. S., Kang, J. K., Jung, E. S., & Lee, A. (2023) · Journal of Breast Cancer · doi:10.4048/jbc.2023.26.e42 · Cited by 15

Toxicity and oxidative stress of HepG2 and HL-7702 cells induced by PAH4 using oil as a carrier

Liu, G., Zhou, W., Zhang, X., Zhu, J., Xu, X., Li, Y., Zhang, J., Wen, C., Liang, L., Liu, X., et al. (2024) · Food Research International · doi:10.1016/j.foodres.2024.113988 · Cited by 15

Physiological and molecular predictors of cycling sprint performance

Galván-Álvarez, V., Gallego-Selles, Á., Martinez‐Canton, M., Pérez-Suárez, I., García-Gonzalez, E., Martín-Rincón, M., & Calbet, J. A. L. (2024) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.14545 · Cited by 15

Polarization of Low-Grade Inflammatory Monocytes Through TRAM-Mediated Up-Regulation of Keap1 by Super-Low Dose Endotoxin

Rahtes, A., & Li, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01478 · Cited by 15

Prominent role of exopeptidase DPP III in estrogen-mediated protection against hyperoxia in vivo

Sobočanec, S., Filić, V., Matovina, M., Majhen, D., Šafranko, Ž. M., Hadžija, M. P., Krsnik, Ž., Kurilj, A. G., Šarić, A., Abramić, M., et al. (2016) · Redox Biology · doi:10.1016/j.redox.2016.01.003 · Cited by 15

Protective Effects of Astragaloside IV Combined with Budesonide in Bronchitis in Rats by Regulation of Nrf2/Keap1 Pathway

Zhang, Z., Cheng, X., Ge, D., Wang, S., & Qi, B. (2018) · Medical Science Monitor · doi:10.12659/msm.911150 · Cited by 15

Measuring the Interaction of Transcription Factor Nrf2 with Its Negative Regulator Keap1 in Single Live Cells by an Improved FRET/FLIM Analysis

Dikovskaya, D., Appleton, P. L., Bento‐Pereira, C., & Dinkova‐Kostova, A. T. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00354 · Cited by 15

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

Kobayashi, A., Kang, M.-I., Okawa, H., Ohtsuji, M., Zenke, Y., Chiba, T., Igarashi, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.16.7130-7139.2004 · Cited by 2,224

Keap1 Controls Postinduction Repression of the Nrf2-Mediated Antioxidant Response by Escorting Nuclear Export of Nrf2

Sun, Z., Zhang, S., Chan, J. Y., & Zhang, D. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00630-07 · Cited by 332

Keep Harm at Bay: Oxidative Phosphorylation Induces Nrf2-Driven Antioxidant Response Via ERK5/MEF2/miR-23a Signaling to Keap-1

Danilenko, M., & Studzinski, G. P. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.01.009 · Cited by 9

Chapter 3 Site-Specific Modification of the Electrophile Sensor Protein Keap1 and Activation of Nrf2-Dependent Gene Expression

Liebler, D. C., Hong, F., Sekhar, K. R., & Freeman, M. L. (2006) · Advances in molecular toxicology · doi:10.1016/s1872-0854(06)01003-4 · Cited by 3

Mechanistic Study of Nucleocytoplasmic Trafficking and Reversible Acetylation in Modulating the NRF2-Dependent Antioxidant Response

Sun, Z. (2008) · UA Campus Repository (The University of Arizona)