Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

THE UBIQUITIN SYSTEM

Hershko, A., & Ciechanover, A. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.425 · Cited by 8,840

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

Schafer, F. Q., & Buettner, G. R. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00480-4 · Cited by 4,587

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction

Glickman, M. H., & Ciechanover, A. J. (2002) · Physiological Reviews · doi:10.1152/physrev.00027.2001 · Cited by 4,296

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172398899 · Cited by 1,947

Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

Hayes, J. D., & McLellan, L. I. (1999) · Free Radical Research · doi:10.1080/10715769900300851 · Cited by 1,528

The Proteasome: Paradigm of a Self-Compartmentalizing Protease

Baumeister, W. P., Walz, J., Zühl, F., & Seemüller, E. (1998) · Cell · doi:10.1016/s0092-8674(00)80929-0 · Cited by 1,497

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,473

The ubiquitin–proteasome pathway: on protein death and cell life

Ciechanover, A. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.24.7151 · Cited by 1,419

Responses of the Nrf2/Keap1 signaling pathway in Mugilogobius abei (M. abei) exposed to environmentally relevant concentration aspirin

Wang, Y., Wang, C., Bao, S., & Nie, X. (2020) · Environmental Science and Pollution Research · doi:10.1007/s11356-020-07912-3 · Cited by 15

Essential role of Nrf2 in sulforaphane-induced protection against angiotensin II-induced aortic injury

Wang, H., Tian, Y., Zhang, Q., Liu, W., Meng, L., Jiang, X. M., & Xin, Y. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120780 · Cited by 14

Plk2-mediated phosphorylation and translocalization of Nrf2 activates anti-inflammation through p53/Plk2/p21cip1 signaling in acute kidney injury

Kim, D., Byeon, H.-E., Kim, D., Kim, S. G., & Yim, H. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09741-1 · Cited by 14

Different Inhibition of Nrf2 by Two Keap1 Isoforms α and β to Shape Malignant Behaviour of Human Hepatocellular Carcinoma

Chen, F., Xiao, M., Feng, J., Wufuer, R., Liu, K., Hu, S., & Zhang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810342 · Cited by 13

Induction of DNA damage in human urothelial cells by the brominated flame retardant 2,2-bis(bromomethyl)-1,3-propanediol: Role of oxidative stress

Kong, W., Kuester, R. K., Gallegos, A. C., & Sipes, I. G. (2011) · Toxicology · doi:10.1016/j.tox.2011.10.006 · Cited by 14

CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus

Kim, M.-J., Park, H., Choi, S.-H., Kong, M.-J., Kim, J.-E., & Kang, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194862 · Cited by 14

Molecular changes in glaucomatous trabecular meshwork. Correlations with retinal ganglion cell death and novel strategies for neuroprotection

Saccà, S. C., Vernazza, S., Iorio, E. L., Tirendi, S., Bassi, A. M., Gandolfi, S., & Izzotti, A. (2020) · Progress in brain research · doi:10.1016/bs.pbr.2020.06.003 · Cited by 14

Downregulation of Nrf2 and HO-1 expression contributes to oxidative stress in type 2 diabetes mellitus: A study in Juana Koslay City, San Luis, Argentina

Siewert, S., González, I., Santillan, L. D. C., Lucero, R. O., Ojeda, M. S., & Giménez, M. S. (2013) · Journal of Diabetes Mellitus · doi:10.4236/jdm.2013.32011 · Cited by 14

Constitutive activation of nuclear factor‐E2‐related factor 2 induces biotransformation enzyme and transporter expression in livers of mice with hepatocyte‐specific deletion ofKelch‐like ECH‐associated protein 1

Cheng, Q., Taguchi, K., Aleksunes, L. M., Manautou, J. E., Cherrington, N. J., Yamamoto, M. P., & Slitt, A. L. (2011) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20392 · Cited by 14

Selective Toxicity of Investigational Ixazomib for Human Leukemia Cells Expressing Mutant Cytoplasmic NPM1: Role of Reactive Oxygen Species

Garcia, J. S., Huang, M., Medeiros, B. C., & Mitchell, B. S. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1440 · Cited by 14

The role of modulation of antioxidant enzyme systems in the treatment of neurodegenerative diseases

Obuobi, S. A. O., Karatayev, S., Chai, C. L. L., Ee, P. L. R., & Mátyus, P. (2016) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2016.1205047 · Cited by 15

The effects of phototherapy and melanocytes on keratinocytes

Tang, L., Wu, W., Fu, W., & Hu, Y. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.5807 · Cited by 14

Genomic Discovery Reveals a Molecular System for Resistance to Oxidative and Endoplasmic Reticulum Stress in Cultured Glioma

Fathallah‐Shaykh, H. M. (2005) · Archives of Neurology · doi:10.1001/archneur.62.2.233 · Cited by 14

Dynamics of Metabolic Pathways and Stress Response Patterns during Human Neural Stem Cell Proliferation and Differentiation

Semkova, V., Haupt, S., Segschneider, M., Bell, C., Ingelman‐Sundberg, M., Hajo, M., Weykopf, B., Muthukottiappan, P., Till, A., & Brüstle, O. (2022) · Cells · doi:10.3390/cells11091388 · Cited by 15

Esculeoside A alleviates reproductive toxicity in streptozotocin-diabetic rats’ s model by activating Nrf2 signaling

ALTAMIMI, J. Z., AlFaris, N. A., Alshammari, G. M., Alagal, R. I., ALJABRYN, D. H., & Yahya, M. A. (2023) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2023.103780 · Cited by 13

Phillyrin inhibits oxidative stress and neutrophil extracellular trap formation through the KEAP1/NRF2 pathway in gouty arthritis

Xu, X., Lu, Y., Shen, R., & Fang, L. (2024) · Immunologic Research · doi:10.1007/s12026-024-09548-8 · Cited by 13

Reinforcing Nrf2 Signaling: Help in the Alzheimer’s Disease Context

la Torre, A., Vecchio, F. L., Angelillis, V. S., Gravina, C., D’Onofrio, G., & Greco, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031130 · Cited by 13

2-Methoxy-7-Acetonyljuglone Isolated from Reynoutria japonica Increases the Activity of Nuclear Factor Erythroid 2-Related Factor-2 through Inhibition of Ubiquitin Degradation in HeLa Cells

Kim, J. H., Khalil, A. A. K., Kim, H.-J., Kim, S., & Ahn, M. (2019) · Antioxidants · doi:10.3390/antiox8090398 · Cited by 13

The preventive effect of Se-methylselenocysteine on γ-radiation-induced oxidative stress in rat lungs

Shin, H., Yang, W.-J., & Choi, E. (2012) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2012.09.003 · Cited by 13

Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells

Park, J., Kim, D., Na, H., & Surh, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.10289 · Cited by 13

The Interplay between Autophagy and Redox Signaling in Cardiovascular Diseases

Boťanská, B., Dovinová, I., & Barančı́k, M. (2022) · Cells · doi:10.3390/cells11071203 · Cited by 13

Nrf2 in Host Defense: Over the Rainbow

Cho, H., Kwak, M., & Pi, J. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/975839 · Cited by 13

Homo-oxidized HSPB1 protects H9c2 cells against oxidative stress via activation of KEAP1/NRF2 signaling pathway

Wang, N., Liu, X., Liu, K., Wang, K., & Zhang, H. (2023) · iScience · doi:10.1016/j.isci.2023.107443 · Cited by 12

Comparative analysis of the molecular and physiological consequences of constitutive SKN-1 activation

Ramos, C. M., & Curran, S. P. (2023) · GeroScience · doi:10.1007/s11357-023-00937-9 · Cited by 12

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Luo, J., Alkhalidy, H., Jia, Z., & Liu, D. (2024) · Foods · doi:10.3390/foods13071055 · Cited by 12

Chlorogenic Acid Plays an Important Role in Improving the Growth and Antioxidant Status and Weakening the Inflammatory Response of Largemouth Bass (Micropterus salmoides)

Xia, Z., Mi, H., Ren, M., Huang, D., Aboseif, A. M., Liang, H., & Zhang, L. (2024) · Animals · doi:10.3390/ani14192871 · Cited by 12

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Chang, S., Lee, J.-S., Yun, U. J., & Park, K. W. (2021) · Biomedicines · doi:10.3390/biomedicines9091196 · Cited by 14

Nrf2 activation in the human brain after stroke due to supratentorial intracerebral haemorrhage: a case–control study

Christopher, E., Loan, J. J., Samarasekera, N., McDade, K., Rose, J. L., Barrington, J., Hughes, J., Smith, C., & Salman, R. A. (2022) · BMJ Neurology Open · doi:10.1136/bmjno-2021-000238 · Cited by 12

Lipophilic compounds in garlic decrease the toxicity of methylmercury by forming sulfur adducts

Abiko, Y., Katayama, Y., Akiyama, M., & Kumagai, Y. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112061 · Cited by 12

Potency of isothiocyanates to induce luciferase reporter gene expression via the electrophile-responsive element from murine glutathione S-transferase Ya

Vermeulen, M., Boerboom, A.-M. J. F., Blankvoort, B. M. G., Aarts, J. M. M. J. G., Rietjens, I. M. C. M., van BLADEREN, P. J., & Vaes, W. H. J. (2009) · Toxicology in Vitro · doi:10.1016/j.tiv.2009.02.005 · Cited by 12

Protein disulfide isomerase regulates renal AT1 receptor function and blood pressure in rats

Wang, X., & Asghar, M. (2017) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00580.2016 · Cited by 12

Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells

Betharia, S., Rondón-Ortiz, A. N., & Brown, D. A. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02823-3 · Cited by 10

Glutathione Transferases

Armstrong, R. N. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00416-4 · Cited by 12

Increased BTB-Kelch type substrate adaptor protein immunoreactivity associates with advanced stage and poor differentiation in renal cell carcinoma

Vaarala, M. H. (2009) · Oncology Reports · doi:10.3892/or_00000383 · Cited by 12

Ameliorating Effect of Sodium Selenite on Developmental and Molecular Response of Bovine Cumulus-Oocyte Complexes Matured in Vitro Under Heat Stress Condition

Toosinia, S., Davoodian, N., Arabi, M., & Kadivar, A. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03678-0 · Cited by 11

NRF2 has a splicing regulatory function involving the survival of motor neuron (SMN) in non-small cell lung cancer

Cui, Q., Wang, W., Namani, A., Wang, H., Hammad, A., Huang, P., Gao, Y., Elshaer, M., Wu, Y., Wang, X. J., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02799-z · Cited by 11

Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications

Luo, N., Chen, C., Zhou, W., Hao, J., He, S., Liu, Y., Ku, Y., Huang, L., Zhang, C., Shu, Y., et al. (2025) · MedComm · doi:10.1002/mco2.70387 · Cited by 12

An antioxidant response element regulates the HIF1α axis in breast cancer cells

Lacher, S. E., Skon-Hegg, C., Ruis, B. L., Krznarich, J., & Slattery, M. G. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.05.003 · Cited by 12

Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents

Brown, D. A., Betharia, S., Yen, J.-H. J., Kuo, P., & Mistry, H. (2016) · Chemistry Central Journal · doi:10.1186/s13065-016-0210-z · Cited by 11

Dissecting the Keap1/Nrf2 pathway through proteomics

Tamir, T. Y., Mulvaney, K. M., & Major, M. B. (2016) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2016.10.007 · Cited by 11

Sulforaphane Alters β-Naphthoflavone-Induced Changes in Activity and Expression of Drug-Metabolizing Enzymes in Rat Hepatocytes

Lněničková, K., Dymáková, A., Szotáková, B., & Boušová, I. (2017) · Molecules · doi:10.3390/molecules22111983 · Cited by 11

Dr. Jekyll and Mr. Hyde: Oxidizable phenol-generated reactive oxygen species enhance sulforaphane's antioxidant response element activation, even as they suppress Nrf2 protein accumulation

Bauman, B. M., Jeong, C., Savage, M., Briker, A., Janigian, N. G., Nguyen, L. L., Kemmerer, Z. A., & Eggler, A. L. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.06.039 · Cited by 11

Tissue metabolic profiling shows that saccharopine accumulates during renal ischemic-reperfusion injury, while kynurenine and itaconate accumulate in renal allograft rejection

Beier, U. H., Hartung, E. A., Concors, S. J., Hernandez, P. T., Wang, Z., Perry, C. E., Baur, J. A., Denburg, M., Hancock, W. W., Gade, T. P. F., et al. (2020) · Metabolomics · doi:10.1007/s11306-020-01682-2 · Cited by 11

Synergism and Antagonism of Two Distinct, but Confused, Nrf1 Factors in Integral Regulation of the Nuclear-to-Mitochondrial Respiratory and Antioxidant Transcription Networks

Zhang, S., Deng, Y., Xiang, Y., Hu, S., Qiu, L., & Zhang, Y. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/5097109 · Cited by 11

Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice

Song, C., Kim, N., Nam, R. H., Choi, S. I., Kang, C., Jang, J. Y., Nho, H., Shin, E. H., & Lee, H. (2021) · Journal of Cancer Prevention · doi:10.15430/jcp.2021.26.1.41 · Cited by 11

Cellular targets in diabetic retinopathy therapy

Rodríguez, M. L., Millán, I., & Ortega, Á. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i9.1442 · Cited by 12

Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan-2-yl-3-pyridin-2-yl-propenone: implication in anti-inflammatory function by Nrf2 activator

Manandhar, S., You, A., Lee, E.-S., Kim, J., & Kwak, M. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.7.0009 · Cited by 11

Involvement of mitogen-activated protein kinases and protein kinase C in regulation of antioxidant response element activity in human keratinocytes

Zhu, M., Zhang, Y., & Bowden, G. T. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.12.023 · Cited by 11

Triphlorethol-A from Ecklonia cava Up-Regulates the Oxidant Sensitive 8-Oxoguanine DNA Glycosylase 1

Kim, K., Lee, I., Kang, K. A., Piao, M. J., Ryu, M., Kim, J. H., Lee, N. H., & Hyun, J. W. (2014) · Marine Drugs · doi:10.3390/md12115357 · Cited by 11

Involvement of MEK-ERK1-2 pathway in the anti-oxidant response in C6 glioma cells after diesel exhaust particles exposure

Farina, F., Milani, C., Botto, L., Lonati, E., Bulbarelli, A., & Palestini, P. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.04.008 · Cited by 11

Antioxidant and skin anti-aging effects of the aqueous ethanol extract of Ginkgo biloba leaf: an in vitro study using HaCaT keratinocytes

Kim, D., Hwang, I., Ku, B., & Choi, E.-M. (2021) · Toxicology and Environmental Health Sciences · doi:10.1007/s13530-021-00088-4 · Cited by 10

Kinase signalling adaptation supports dysfunctional mitochondria in disease

Skalka, G., Tsakovska, M., & Murphy, D. J. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1354682 · Cited by 12

Mitochondrial damage and clearance in retinal pigment epithelial cells

Gurubaran, I. S. (2024) · Acta Ophthalmologica · doi:10.1111/aos.16661 · Cited by 11

Benzyl isothiocyanate ameliorates cognitive function in mice of chronic temporal lobe epilepsy

Xiaoyu, C., Zhou, H., Nan, P., Tengwei, G., Yanan, G., Yan, G., Haiyan, L., Li, M., Haiya, W., Yujun, W., et al. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1330102 · Cited by 10

Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs

Lee, S. (2024) · Antioxidants · doi:10.3390/antiox13060656 · Cited by 14

Multi-omics reveals new links between Fructosamine-3-Kinase (FN3K) and core metabolic pathways

Shrestha, S., Taujale, R., Katiyar, S., & Kannan, N. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00390-0 · Cited by 10

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Li, H., Bao, L., Pan, Y., Zhu, X., Cheng, J. R., Zhang, J., & Chu, W. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116863 · Cited by 10

EPA-enriched lipid from Apostichopus japonicus byproducts mitigates UVB-induced oxidative stress and inflammation by gut-skin axis

Qu, C., Liang, S., Wang, K., He, Y., Ju, W., Sun, Y., & Miao, J. (2025) · Food Research International · doi:10.1016/j.foodres.2025.116085 · Cited by 11

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Kigoshi, Y., Fukuda, T., Endo, T., Hayasaka, N., Iemura, S., Natsume, T., Tsuruta, F., & Chiba, T. (2015) · Scientific Reports · doi:10.1038/srep12857 · Cited by 9

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Lee, D.-S., & Kim, J.-E. (2022) · Antioxidants · doi:10.3390/antiox11040778 · Cited by 12

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Dai, Y., Chen, H., Pan, Y., & Song, H. (2022) · BioMed Research International · doi:10.1155/2022/9418332 · Cited by 10

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Sanati, M., Afshari, A. R., Kesharwani, P., & Sahebkar, A. (2023) · European Polymer Journal · doi:10.1016/j.eurpolymj.2023.112444 · Cited by 10

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Melnikov, F., Botta, D., White, C. C., Schmuck, S. C., Winfough, M., Schaupp, C. M., Gallagher, E. P., Brooks, B. W., Williams, E. S., Coish, P., et al. (2018) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00259 · Cited by 10

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Adebayo, A. K., & Nakshatri, H. (2022) · Cancer Research · doi:10.1158/0008-5472.can-22-2311 · Cited by 12

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Nagle, A. A., Reddy, S. A., Bertrand, H. C., Tajima, H., Dang, T., Wong, S. C., Hayes, J. D., Wells, G., & Chew, E. (2014) · ChemMedChem · doi:10.1002/cmdc.201402038 · Cited by 10

Evaluation of the antioxidant properties of carexanes in AGS cells transfected with the Helicobacter pylori 's protein HspB

Buommino, E., D’Abrosca, B., Donnarumma, G., Parisi, A., Scognamiglio, M., Fiorentino, A., & Luca, A. D. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2017.05.007 · Cited by 10

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Menon, R., & Peltier, M. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176139 · Cited by 10

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Li, J., Lee, J., Johnson, D. A., & Johnson, J. A. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)78019-2 · Cited by 10

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Zhang, M., Liu, J., Yu, Y., Ren, W., Yuan, R., Liu, X., Shang, X., Du, Z., Xu, M., & Zhang, T. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105631 · Cited by 10

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Wang, X., Song, S., Lu, W., Zhao, Y., Lv, R., He, Y., Dong, N., Yu, Q., & Yue, H. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177380 · Cited by 10

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Buranasudja, V., Vimolmangkang, S., Sanookpan, K., Binalee, A., Nguyen, A. B., Thach, U. D., Do, B. H., Đặng, V. S., Minh, K., & Nguyen, H. M. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202201096 · Cited by 9

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Chowdhury, S., Mukhopadhyay, R., Saha, S. T., Mishra, A., Sengupta, S., Roy, S., & Majumder, H. K. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.539742 · Cited by 9

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Cen, Y., Zou, X., Zhong, Q., Chen, Y., Lin, Y., Feng, Q., Wang, X., & Zheng, S. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.03.016 · Cited by 9

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Gurubaran, I. S., Hytti, M., Kaarniranta, K., & Kauppinen, A. (2022) · Antioxidants · doi:10.3390/antiox11071288 · Cited by 8

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