The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Transcriptional Co-activators CREB-binding Protein and p300 Regulate Chondrocyte-specific Gene Expression via Association with Sox9
Open accessAbstract
Chondrocytes are critical components for the precise patterning of a developing skeletal framework and articular joint formation. Sox9 is a key transcription factor that is essential for chondrocyte differentiation and chondrocyte-specific gene expressions; however, the precise transcriptional activation mechanism of Sox9 is not fully understood. Here we demonstrate that Sox9 utilizes a cAMP-response element-binding protein (CREB)-binding protein (CBP)/p300 to exert its effects. Sox9 associates with CBP/p300 in the chondrosarcoma cell line SW1353 via its carboxyl termini activation domain in a cell type-specific manner. In promoter assays, CBP/p300 enhances Col2a1, which encodes cartilage-specific type II collagen gene promoter activity via Sox9. Chromatin immunoprecipitation shows that p300 is bound to the Col2a1 promoter region. Furthermore, the CBP/Sox9 complex disrupter peptide suppresses Col2a1 gene expression and chondrogenesis from mesenchymal stem cells. These data demonstrate that CBP and p300 function as co-activators of Sox9 for cartilage tissue-specific gene expression and chondrocyte differentiation.
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Cites
Phosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052
CBP/p300 in cell growth, transformation, and development
Goodman, R. H., & Smolik, S. (2000) · Genes & Development · doi:10.1101/gad.14.13.1553 · Cited by 1,778
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP
Petrif, F., Giles, R. H., Dauwerse, H. G., Saris, J. J., Hennekam, R. C. M., Masuno, M., Tommerup, N., van Ommen, G.-J. B., Goodman, R. H., Peters, D. J. M., et al. (1995) · Nature · doi:10.1038/376348a0 · Cited by 1,217
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
Sekiya, I., Vuoristo, J. T., Larson, B. L., & Prockop, D. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052716199 · Cited by 648
A family of transcriptional adaptor proteins targeted by the E1A oncoprotein
Arany, Z., Newsome, D., Oldread, E., Livingston, D. M., & Eckner, R. (1995) · Nature · doi:10.1038/374081a0 · Cited by 533
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Establishing neural crest identity: a gene regulatory recipe
Simões-Costa, M., & Bronner, M. E. (2015) · Development · doi:10.1242/dev.105445 · Cited by 649
535 East 70th Street, C. R. B., Goldring, M., Otero, M., Plumb, D., Dragomir, C., Favero, M., EI Hachem, K., Hashimoto, K., Roach, H., Olivotto, E., et al. (2011) · European Cells and Materials · doi:10.22203/ecm.v021a16 · Cited by 489
Control of chondrogenesis by the transcription factor Sox9
Akiyama, H. (2008) · Modern Rheumatology · doi:10.1007/s10165-008-0048-x · Cited by 285
Culture media for the differentiation of mesenchymal stromal cells
Vater, C., Kasten, P., & Stiehler, M. (2011) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.07.037 · Cited by 279
SOX9 in cartilage development and disease
Lefebvre, V., Angelozzi, M., & Haseeb, A. (2019) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2019.07.008 · Cited by 268
Metadata
- Authors
- Tsuda, M., Takahashi, S., Takahashi, Y., & Asahara, H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-07
- Volume
- 278
- Issue
- 29
- Pages
- 27224-27229
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1980965358
- Cited by
- 207
- References
- 6
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tsuda, M., Takahashi, S., Takahashi, Y., & Asahara, H. (2003). Transcriptional Co-activators CREB-binding Protein and p300 Regulate Chondrocyte-specific Gene Expression via Association with Sox9. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.m303471200
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