Cited by 32Neuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment ResearchTryptophan and brain disorders

The relationship between inflammatory markers and voxel-based gray matter volumes in nondemented older adults

Zhang, Haobo, Sachdev, Perminder S., Wen, Wei, Crawford, John D., Brodaty, Henry, Baune, Bernard T., Kochan, Nicole A., Slavin, Melissa J. +3 more·2016·Neurobiology of Aging

Abstract

Ageing is characterized by chronically elevated inflammatory markers (IMs). Peripheral IM levels have been found in negative correlations with brain structural measures including global and lobar volumes and the hippocampus. This study investigated the relationship between 10 peripheral IMs and voxel-based gray matter (GM) volumes in nondemented older adults (n = 463). Two proinflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukin-1β) and 2 vascular IMs (vascular cellular adhesion molecule-1 and plasminogen activator inhibitor-1) were negatively correlated with regional GM volumes. TNF-α and interleukin-1β were both significantly correlated with GM volumes in the left occipitotemporal area, left superior occipital gyrus, and left inferior parietal lobule; TNF-α was also significantly correlated with the bilateral medial prefrontal cortices and approached significance for the correlations with the bilateral hippocampi. Significant GM correlations with vascular cellular adhesion molecule-1 were located in the bilateral anterior cingulate cortices, and with plasminogen activator inhibitor-1 in the cerebellum and right hippocampus. The neuroanatomical correlation patterns of 2 proinflammatory cytokines and 2 vascular IMs might be reflective of the effects of neurodegenerative and vascular pathological processes in the ageing brain.

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Crossref · 10.1016/j.neurobiolaging.2015.10.008

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  • Neuroimaging studies have confirmed volumetric changes in brain regions of the elderly.

    “Neuroimaging studies have confirmed volumetric changes in brain regions of the elderly (Storsve et al, 2014;Zhang et al, 2016).”

    From Microglia Priming with Aging and Stress (2017) · cites this paper as Zhang et al, 2016

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Authors
Zhang, H., Sachdev, P. S., Wen, W., Crawford, J. D., Brodaty, H., Baune, B. T., Kochan, N. A., Slavin, M. J., Reppermund, S., Kang, K., & Trollor, J. N.
Affiliations
  • UNSW Sydney (AU)
  • The University of Adelaide (AU)
Corresponding author
Trollor, Julian N.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2016-01
Volume
37
Pages
138-146
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2191494866
Cited by
32
References
85
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 4
FWCI
2.13
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders
  • National Health and Medical Research Council of Australia (350833, 510175)
  • Australian Research Council (DP0774213)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
inflammatory markers, gray matter volume, older adults, inflammatory cytokines, TNF-α, IL-1β, VCAM-1, plasminogen activator inhibitor-1, brain aging, hippocampus, medial prefrontal cortex, anterior cingulate cortex, cerebellum, neurodegeneration, vascular pathology
MeSH terms
Aged, Aged, 80 and over, Aging, Brain, Female, Humans, Male, Organ Size, Tumor Necrosis Factor-alpha, Biomarkers, Cytokines, Plasminogen Activator Inhibitor 1, Inflammation Mediators, Vascular Cell Adhesion Molecule-1, Diffusion Magnetic Resonance Imaging, Gray Matter

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