The relationship between inflammatory markers and voxel-based gray matter volumes in nondemented older adults
Abstract
Ageing is characterized by chronically elevated inflammatory markers (IMs). Peripheral IM levels have been found in negative correlations with brain structural measures including global and lobar volumes and the hippocampus. This study investigated the relationship between 10 peripheral IMs and voxel-based gray matter (GM) volumes in nondemented older adults (n = 463). Two proinflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukin-1β) and 2 vascular IMs (vascular cellular adhesion molecule-1 and plasminogen activator inhibitor-1) were negatively correlated with regional GM volumes. TNF-α and interleukin-1β were both significantly correlated with GM volumes in the left occipitotemporal area, left superior occipital gyrus, and left inferior parietal lobule; TNF-α was also significantly correlated with the bilateral medial prefrontal cortices and approached significance for the correlations with the bilateral hippocampi. Significant GM correlations with vascular cellular adhesion molecule-1 were located in the bilateral anterior cingulate cortices, and with plasminogen activator inhibitor-1 in the cerebellum and right hippocampus. The neuroanatomical correlation patterns of 2 proinflammatory cytokines and 2 vascular IMs might be reflective of the effects of neurodegenerative and vascular pathological processes in the ageing brain.
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Neuroimaging studies have confirmed volumetric changes in brain regions of the elderly.
“Neuroimaging studies have confirmed volumetric changes in brain regions of the elderly (Storsve et al, 2014;Zhang et al, 2016).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Zhang et al, 2016
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Microglia Priming with Aging and Stress
Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398 · see citing works
- Authors
- Zhang, H., Sachdev, P. S., Wen, W., Crawford, J. D., Brodaty, H., Baune, B. T., Kochan, N. A., Slavin, M. J., Reppermund, S., Kang, K., & Trollor, J. N.
- Affiliations
- UNSW Sydney (AU)
- The University of Adelaide (AU)
- Corresponding author
- Trollor, Julian N.
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2016-01
- Volume
- 37
- Pages
- 138-146
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2191494866
- Cited by
- 32
- References
- 85
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 1 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 4
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- National Health and Medical Research Council of Australia (350833, 510175)
- Australian Research Council (DP0774213)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- inflammatory markers, gray matter volume, older adults, inflammatory cytokines, TNF-α, IL-1β, VCAM-1, plasminogen activator inhibitor-1, brain aging, hippocampus, medial prefrontal cortex, anterior cingulate cortex, cerebellum, neurodegeneration, vascular pathology
- MeSH terms
- Aged, Aged, 80 and over, Aging, Brain, Female, Humans, Male, Organ Size, Tumor Necrosis Factor-alpha, Biomarkers, Cytokines, Plasminogen Activator Inhibitor 1, Inflammation Mediators, Vascular Cell Adhesion Molecule-1, Diffusion Magnetic Resonance Imaging, Gray Matter
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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