The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Mechanism of Human SIRT1 Activation by Resveratrol
Open accessAbstract
The NAD+-dependent protein deacetylase family, Sir2 (or sirtuins), is important for many cellular processes including gene silencing, regulation of p53, fatty acid metabolism, cell cycle regulation, and life span extension. Resveratrol, a polyphenol found in wines and thought to harbor major health benefits, was reported to be an activator of Sir2 enzymes in vivo and in vitro. In addition, resveratrol was shown to increase life span in three model organisms through a Sir2-dependent pathway. Here, we investigated the molecular basis for Sir2 activation by resveratrol. Among the three enzymes tested (yeast Sir2, human SIRT1, and human SIRT2), only SIRT1 exhibited significant enzyme activation ( approximately 8-fold) using the commercially available Fluor de Lys kit (BioMol). To examine the requirements for resveratrol activation of SIRT1, we synthesized three p53 acetylpeptide substrates either lacking a fluorophore or containing a 7-amino-4-methylcoumarin (p53-AMC) or rhodamine 110 (p53-R110). Although SIRT1 activation was independent of the acetylpeptide sequence, resveratrol activation was completely dependent on the presence of a covalently attached fluorophore. Substrate competition studies indicated that the fluorophore decreased the binding affinity of the peptide, and, in the presence of resveratrol, fluorophore-containing substrates bound more tightly to SIRT1. Using available crystal structures, a model of SIRT1 bound to p53-AMC peptide was constructed. Without resveratrol, the coumarin of p53-AMC peptide is solvent-exposed and makes no significant contacts with SIRT1. We propose that binding of resveratrol to SIRT1 promotes a conformational change that better accommodates the attached coumarin group.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In yeast, resveratrol has demonstrated its capacity to extend lifespan, implicating the potential of resveratrol as an anti-aging agent [81] with potential clinical implications.”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [81]
In the citing paper
“A key property of resveratrol is the activation of SIRT1, enhancing SIRT1-dependent cellular processes such as axonal protection, fat mobilization, and inhibition of NFκB-dependent transcription [81].”
From Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds (2024) · cites this paper as [81]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling
Guex, N., & Peitsch, M. C. (1997) · Electrophoresis · doi:10.1002/elps.1150181505 · Cited by 11,297
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
Vaziri, H., Dessain, S. K., Eaton, E. N., Imai, S., Frye, R. A., Pandita, T. K., Guarente, L., & Weinberg, R. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00527-x · Cited by 2,690
Kaeberlein, M., McVey, M., & Guarente, L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2570 · Cited by 2,253
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
Picard, F., Kurtev, M. V., Chung, N., Topark‐Ngarm, A., Senawong, T., de Oliveira, R. M., Leid, M. E., McBurney, M. W., & Guarente, L. (2004) · Nature · doi:10.1038/nature02583 · Cited by 1,943
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Wood, J. G., Rogina, B., Lavu, S., Howitz, K., Helfand, S. L., Tatar, M., & Sinclair, D. (2004) · Nature · doi:10.1038/nature02789 · Cited by 1,868
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
Tissenbaum, H. A., & Guarente, L. (2001) · Nature · doi:10.1038/35065638 · Cited by 1,603
Extrachromosomal rDNA circles—a cause of aging in yeast
Sinclair, D. A., & Guarente, L. (1997) · Cell · doi:10.1016/s0092-8674(00)80493-6 · Cited by 1,500
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
Frye, R. A. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3000 · Cited by 1,409
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., & Takada, Y. (2004) · PubMed · Cited by 1,386
Mammalian SIRT1 Represses Forkhead Transcription Factors
Motta, M. C., Divecha, N., Lemieux, M. E., Kamel, C., Chen, D., Gu, W. J., Bultsma, Y., McBurney, M. W., & Guarente, L. (2004) · Cell · doi:10.1016/s0092-8674(04)00126-6 · Cited by 1,366
Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription
Gottschling, D. E., Aparicio, O. M., Billington, B. L., & Zakian, V. A. (1990) · Cell · doi:10.1016/0092-8674(90)90141-z · Cited by 1,325
Enzymes: a practical introduction to structure, mechanism, and data analysis
(2001) · Choice Reviews Online · doi:10.5860/choice.38-3881 · Cited by 1,062
Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
Araki, T., Sasaki, Y., & Milbrandt, J. (2004) · Science · doi:10.1126/science.1098014 · Cited by 1,060
Bitterman, K. J., Anderson, R. M., Cohen, H. Y., Latorre-Esteves, M., & Sinclair, D. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205670200 · Cited by 1,002
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
Landry, J., Sutton, A., Tafrov, S. T., Heller, R. C., Stebbins, J., Pillus, L., & Sternglanz, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.110148297 · Cited by 970
Human SIR2 deacetylates p53 and antagonizes PML/p53‐induced cellular senescence
Langley, E., Pearson, M., Faretta, M., Bauer, U., Frye, R. A., Minucci, S., Pelicci, P. G., & Kouzarides, T. (2002) · The EMBO Journal · doi:10.1093/emboj/21.10.2383 · Cited by 859
Frye, R. A. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0897 · Cited by 809
Smith, J. S., Brachmann, C. B., Celic, I., Kenna, M. A., Muhammad, S., Starai, V. J., Avalos, J. L., Escalante-Semerena, J. C., Grubmeyer, C., Wolberger, C., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6658 · Cited by 718
Rine, J., & Herskowitz, I. (1987) · Genetics · doi:10.1093/genetics/116.1.9 · Cited by 704
Shou, W., Seol, J. H., Shevchenko, A., Baskerville, C., Moazed, D., Chen, Z. W. S., Jang, J., Shevchenko, A., Charbonneau, H., & Deshaies, R. J. (1999) · Cell · doi:10.1016/s0092-8674(00)80733-3 · Cited by 702
Aparicio, O. M., Billington, B. L., & Gottschling, D. E. (1991) · Cell · doi:10.1016/0092-8674(91)90049-5 · Cited by 697
SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast.Preprint
Strahl‐Bolsinger, S., Hecht, A., Luo, K., & Grunstein, M. R. (1997) · Genes & Development · doi:10.1101/gad.11.1.83 · Cited by 679
Calorie restriction extends yeast life span by lowering the level of NADH
Lin, S.-J., Ford, E., Haigis, M., Liszt, G., & Guarente, L. (2004) · Genes & Development · doi:10.1101/gad.1164804 · Cited by 632
Sir2 Regulates Skeletal Muscle Differentiation as a Potential Sensor of the Redox State
Fulco, M., Schiltz, R. L., Iezzi, S., King, M. T., Zhao, P., Kashiwaya, Y., Hoffman, E. P., Veech, R. L., & Sartorelli, V. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00226-0 · Cited by 591
An unusual form of transcriptional silencing in yeast ribosomal DNA.Preprint
Smith, J. S., & Boeke, J. D. (1997) · Genes & Development · doi:10.1101/gad.11.2.241 · Cited by 588
Sir2-dependent activation of acetyl-CoA synthetase by deacetylation of active lysine
Starai, V. J., Celic, I., Cole, R. N., Boeke, J. D., & Escalante-Semerena, J. C. (2002) · Science · doi:10.1126/science.1077650 · Cited by 564
Tanner, K. G., Landry, J. W., Sternglanz, R., & Denu, J. M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.250422697 · Cited by 557
Self-citationGrozinger, C. M., Chao, E. D., Blackwell, H. E., Moazed, D., & Schreiber, S. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106779200 · Cited by 533
Role for Human SIRT2 NAD-Dependent Deacetylase Activity in Control of Mitotic Exit in the Cell Cycle
Dryden, S. C., Nahhas, F. A., Nowak, J. E., Goustin, A. S., & Tainsky, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.9.3173-3185.2003 · Cited by 506
Sir2-Independent Life Span Extension by Calorie Restriction in Yeast
Kaeberlein, M., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020296 · Cited by 441
Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast.Preprint
Bryk, M., Banerjee, M., Murphy, M. N., Knudsen, K. E., Garfinkel, D. J., & Curcio, M. J. (1997) · Genes & Development · doi:10.1101/gad.11.2.255 · Cited by 371
Identification of a small molecule inhibitor of Sir2p
Bedalov, A., Gatbonton, T., Irvine, W. P., Gottschling, D. E., & Simon, J. A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261574398 · Cited by 344
The red wine antioxidant resveratrol protects isolated rat hearts from ischemia reperfusion injury
Ray, P. S., Maulik, G., Cordis, G. A., Bertelli, A. A. E., Bertelli, A., & Das, D. K. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00063-5 · Cited by 343
Frémont, L., Belguendouz, L., & Delpal, S. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00209-x · Cited by 336
Chemistry of Gene Silencing: The Mechanism of NAD+-Dependent Deacetylation Reactions
Sauve, A. A., Celic, I., Avalos, J. L., Deng, H., Boeke, J. D., & Schramm, V. L. (2001) · Biochemistry · doi:10.1021/bi011858j · Cited by 301
A Fluorogenic Histone Deacetylase Assay Well Suited for High-Throughput Activity Screening
Wegener, D., Wirsching, F., Riester, D., & Schwienhorst, A. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(02)00305-8 · Cited by 283
Stojanović, S., SPRINZ, H., & Brede, O. (2001) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2001.2388 · Cited by 275
Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA
Fritze, C. E., Verschueren, K., Strich, R., & Esposito, R. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.21.6495 · Cited by 275
Tanny, J. C., & Moazed, D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.415 · Cited by 253
Mechanism of Nicotinamide Inhibition and Transglycosidation by Sir2 Histone/Protein Deacetylases
Jackson, M. D., Schmidt, M. T., Oppenheimer, N. J., & Denu, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m306552200 · Cited by 240
Self-citationStructure of a Sir2 Enzyme Bound to an Acetylated p53 Peptide
Avalos, J. L., Celic, I., Muhammad, S., Cosgrove, M. S., Boeke, J. D., & Wolberger, C. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00628-7 · Cited by 237
Borra, M. T., Langer, M. R., Slama, J. T., & Denu, J. M. (2004) · Biochemistry · doi:10.1021/bi049592e · Cited by 217
Self-citationSauve, A. A., & Schramm, V. L. (2003) · Biochemistry · doi:10.1021/bi034959l · Cited by 213
Jackson, M. D., & Denu, J. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200671200 · Cited by 212
Self-citationMolecular basis of chemoprevention by resveratrol: NF-κB and AP-1 as potential targets
Kundu, J. K., & Surh, Y. (2004) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.05.019 · Cited by 212
Gescher, A. J., & Steward, W. P. (2003) · PubMed · Cited by 210
Acetylation of TAFI68, a subunit of TIF‐IB/SL1, activates RNA polymerase I transcription
Muth, V., Nadaud, S., Grummt, I., & Voit, R. (2001) · The EMBO Journal · doi:10.1093/emboj/20.6.1353 · Cited by 201
Silencing and Heritable Domains of Gene Expression
Loo, S., & Rine, J. (1995) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cb.11.110195.002511 · Cited by 195
Inhibitors of Sir2: Evaluation of Splitomicin Analogues
Posakony, J., Hirao, M., Stevens, S. D., Simon, J. A., & Bedalov, A. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030473r · Cited by 160
Coenzyme Specificity of Sir2 Protein Deacetylases
Schmidt, M. T., Smith, B. C., Jackson, M. D., & Denu, J. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m407484200 · Cited by 150
Self-citationBurkitt, M. J., & Duncan, J. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1973 · Cited by 144
Shou, W., Sakamoto, K. M., Keener, J., Morimoto, K. W., Traverso, E. E., Azzam, R., Hoppe, G. J., Feldman, R. M. R., DeModena, J. A., Moazed, D., et al. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00291-x · Cited by 136
Antioxidant Activity of Resveratrol Compared with Common Food Additives
Murcia, M. A., & Martínez‐Tomé, M. (2001) · Journal of Food Protection · doi:10.4315/0362-028x-64.3.379 · Cited by 110
Mellot‐Draznieks, C., Girard, S., Férey, G., Schön, J. C., Čančarević, Ž., & Jansen, M. (2002) · Chemistry - A European Journal · doi:10.1002/1521-3765(20020916)8:18 · Cited by 110
Resveratrol Is a Potent Inhibitor of the Dioxygenase Activity of Lipoxygenase
Pinto, M. C., García-Barrado, J. A., & Macı́as, P. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf990448n · Cited by 97
Marcotte, P. A., Richardson, P. R., Guo, J., Barrett, L. W., Xu, N., Gunasekera, A. H., & Glaser, K. B. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.05.039 · Cited by 83
Hirao, M., Posakony, J., Nelson, M., Hruby, H., Jung, M., Simon, J. A., & Bedalov, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308966200 · Cited by 73
SIRT1 Shows No Substrate Specificity in Vitro
Blander, G., Olejnik, J., Krzymańska-Olejnik, E., McDonagh, T., Haigis, M. C., Yaffe, M. B., & Guarente, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414080200 · Cited by 72
Pleiotropic effects of resveratrol
Granados‐Soto, V. (2003) · Drug News & Perspectives · doi:10.1358/dnp.2003.16.5.829318 · Cited by 71
Antioxidant activity of resveratrol in endotoxin-stimulated blood platelets
Olas, B., Wachowicz, B., Saluk, J., Zieliński, T., Kaca, W., & Buczyński, A. (2001) · Cell Biology and Toxicology · doi:10.1023/a:1010962222305 · Cited by 69
Quantitative Assays for Characterization of the Sir2 Family of NAD+-Dependent Deacetylases
Borra, M. T., & Denu, J. M. (2003) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(03)76011-x · Cited by 42
Self-citationIntracellular targeting and functional analysis of single-chain Fv fragments in mammalian cells
Cardinale, A. (2004) · Methods · doi:10.1016/j.ymeth.2004.04.006 · Cited by 33
Resveratrol May Be a Powerful Cancer-Fighting Ally
Schultz, J. (2004) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/96.20.1497 · Cited by 9
Flagged first, then by citations
Research works printed but not linked: 2
- Aggarwal, 2004, Anticancer Res., 24, 2783
- Gescher, 2003, Cancer Epidemiol. Biomarkers Prev., 12, 953
Cited by
Sorted by citations
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
Quideau, S., Deffieux, D., Douat, C., & Pouységu, L. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201000044 · Cited by 2,874
Price, N. L., Gomes, A. P., Ling, A. J. Y., Duarte, F. V., Martin-Montalvo, A., North, B. J., Agarwal, B., Ye, L., Ramadori, G., Teodoro, J. S., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.003 · Cited by 1,602
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
Park, S. J., Ahmad, F., Philp, A., Baar, K., Williams, T., Luo, H., Ke, H., Rehmann, H., Taussig, R., Brown, A. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.017 · Cited by 1,370
Metadata
- Authors
- Borra, M. T., Smith, B. C., & Denu, J. M.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Denu, John M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 280
- Issue
- 17
- Pages
- 17187-17195
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2007842741
- Cited by
- 1,065
- References
- 68
- Citations by year
- 2026: 27 · 2025: 29 · 2024: 29 · 2023: 39 · 2022: 62 · 2021: 45 · 2020: 59 · 2019: 58 · 2018: 62 · 2017: 35 · 2016: 52 · 2015: 72 · 2014: 48 · 2013: 73 · 2012: 72
- FWCI
- 18.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (NIH 5 T32)
- National Institute of General Medical Sciences (T32GM008349, F31GM066366, NIH 5T32 GM08349, R01GM065386)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Keywords
- SIRT1, resveratrol, NAD+-dependent deacetylase, p53 acetylation, substrate affinity, conformational change, lifespan extension
- MeSH terms
- Resveratrol, Antioxidants, Binding Sites, Binding, Competitive, Cell Cycle, Chromatography, High Pressure Liquid, Coumarins, Coloring Agents, Histidine, Histone Deacetylases, Humans, Kinetics, Models, Chemical, Models, Molecular, Peptides, Protein Binding, Protein Conformation, Rhodamines, Stilbenes, Substrate Specificity, Time Factors, Tumor Suppressor Protein p53, Crystallography, X-Ray, Gene Silencing, Sirtuins, Immunoprecipitation, Sirtuin 1, Sirtuin 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
